1003-07-2 | 3(2H)-Isothiazolone

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$11.00	$8.00
250mg	95%	in stock	$12.00	$9.00
1g	95%	in stock	$28.00	$20.00
5g	95%	in stock	$131.00	$92.00
25g	95%	in stock	$520.00	$364.00

Description

• Catalog Number: AA01739
• Chemical Name: 3(2H)-Isothiazolone
• CAS Number: 1003-07-2
• Molecular Formula: C3H3NOS
• Molecular Weight: 101.1270
• MDL Number: MFCD09834764
• SMILES: O=c1ccs[nH]1
• NSC Number: 93489

Computed Properties

• Complexity: 99
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: -0.1

Literature

• A patient's drawing helped the physician to make the correct diagnosis: occupational contact allergy to isothiazolinone.

  Contact dermatitis 20120901

• Effects of parabens and isothiazolinone on the microbiological quality of baby shampoo: the challenge test.

  Biocontrol science 20120101

• Kinetic migration of isothiazolinone biocides from paper packaging to Tenax and Porapak.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110901

• Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors.

  Bioorganic & medicinal chemistry 20110615

• Biocide-containing varnish for the protection of sandstone: comparison of formulations and laboratory test methods.

  Current microbiology 20110601

• [Determination of 3 isothiazolinone preservatives in toys using liquid chromatography-tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20110601

• Analysis of isothiazolinone biocides in paper for food packaging by ultra-high-performance liquid chromatography-tandem mass spectrometry.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20101201

• Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.

  Environmental health : a global access science source 20100101

• The Hand Eczema Trial (HET): Design of a randomised clinical trial of the effect of classification and individual counselling versus no intervention among health-care workers with hand eczema.

  BMC dermatology 20100101

• Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase.

  European journal of medicinal chemistry 20091201

• Analyzing cytotoxic effects of selected isothiazol-3-one biocides using the toxic ratio concept and structure-activity relationship considerations.

  Chemical research in toxicology 20091201

• The epidemiology of contact allergy. Allergen exposure and recent trends.

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20091001

• The efficacy of biocides and other chemical additives in cooling water systems in the control of amoebae.

  Journal of applied microbiology 20090301

• Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).

  Bioorganic & medicinal chemistry 20090115

• Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.

  Bioorganic & medicinal chemistry 20080901

• Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2.

  Toxicology 20080418

• Crystal structure and antitumor activity of the novel zwitterionic complex of tri-n-butyltin(IV) with 2-thiobarbituric acid.

  Bioinorganic chemistry and applications 20080101

• Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells.

  European journal of dermatology : EJD 20080101

• Occupational contact dermatitis.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101

• Analysis of isothiazolinones in environmental waters by gas chromatography-mass spectrometry.

  Journal of chromatography. A 20070914

• Differences in kinetics of structurally related competitive GABA(A) receptor antagonists.

  Neuropharmacology 20070301

• Comparison of reactivity to allergens using the TRUE Test and IQ chamber system.

  Contact dermatitis 20070301

• In vitro antifungal activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones.

  Folia microbiologica 20070101

• A sensitive radioimmunoassay of insulin autoantibody: reduction of non-specific binding of [125I]insulin.

  Journal of autoimmunity 20060301

• Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

  Journal of medicinal chemistry 20060223

• Cyclic and acyclic sulfonimides in reactions with Rh(II)-ketocarbenoids: a new access to chemoselective O-functionalization of the imidic carbonyl groups.

  Organic & biomolecular chemistry 20051121

• Structure-activity relationships in 3-isothiazolones.

  Organic & biomolecular chemistry 20051021

• The relative cytotoxicity of personal care preservative systems in Balb/C 3T3 clone A31 embryonic mouse cells and the effect of selected preservative systems upon the toxicity of a standard rinse-off formulation.

  Toxicology in vitro : an international journal published in association with BIBRA 20051001

• Investigation of biocide efficacy by photoacoustic biofilm monitoring.

  Water research 20040301

• From knowledge generation to knowledge archive. A general strategy using TOPS-MODE with DEREK to formulate new alerts for skin sensitization.

  Journal of chemical information and computer sciences 20040101

• Co-existing sensitivity to metronidazole and isothiazolinone.

  Clinical and experimental dermatology 20030901

• On the short carbonyl bond in bis[mu-1,2-benzisothiazol-3(2H)-one 1,1-dioxido-kappa2N:O]bis[[1,2-benzisothiazol-3(2H)-one 1,1-dioxido-kappaN]bis(imidazole)copper(II)].

  Acta crystallographica. Section C, Crystal structure communications 20010901