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Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells.
Translational research : the journal of laboratory and clinical medicine 20150701
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Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Journal of neurophysiology 20130515
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Why mouse airway submucosal gland serous cells do not secrete fluid in response to cAMP stimulation.
The Journal of biological chemistry 20121102
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Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20121031
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Mechanisms of bicarbonate secretion: lessons from the airways.
Cold Spring Harbor perspectives in medicine 20120801
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Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory.
Behavioural brain research 20120615
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Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.
Journal of signal transduction 20120101
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K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.
Frontiers in pharmacology 20120101
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Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.
Journal of toxicology 20120101
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Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels.
Nature communications 20120101
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SK2 channels are neuroprotective for ischemia-induced neuronal cell death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20111201
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Calcium-activated potassium channel KCa3.1 in lung dendritic cell migration.
American journal of respiratory cell and molecular biology 20111101
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Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.
Toxicology 20111028
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Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.
Neuropharmacology 20110601
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Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.
Molecular pharmacology 20110601
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Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.
Biological psychiatry 20110401
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Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110301
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Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide.
The Journal of pharmacology and experimental therapeutics 20110301
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Use of intermediate/small conductance calcium-activated potassium-channel activator for endothelial protection.
The Journal of thoracic and cardiovascular surgery 20110201
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Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.
PloS one 20110101
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An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis.
PloS one 20110101
-
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.
PloS one 20110101
-
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
Circulation 20101102
-
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Small conductance calcium-activated potassium channels: from structure to function.
Progress in neurobiology 20100701
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Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.
Neuron 20100311
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In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.
Neuropharmacology 20100301
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Expression of Ca2+ -activated K+ channels in human dermal fibroblasts and their roles in apoptosis.
Skin pharmacology and physiology 20100101
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Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations.
Neuropharmacology 20100101
-
K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.
Respiratory research 20100101
-
Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium.
American journal of physiology. Gastrointestinal and liver physiology 20091101
-
Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment.
Molecular pharmacology 20090901
-
A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
The Journal of pharmacology and experimental therapeutics 20090101
-
Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.
Journal of medicinal chemistry 20081211
-
SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.
Journal of neurophysiology 20081101
-
Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.
Cellular and molecular life sciences : CMLS 20081001
-
Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.
European journal of immunology 20080901
-
Temporal processing across multiple topographic maps in the electrosensory system.
Journal of neurophysiology 20080801
-
IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells.
American journal of physiology. Cell physiology 20080601
-
Calcium-activated potassium currents differentially modulate respiratory rhythm generation.
The European journal of neuroscience 20080601
-
Openers of calcium-activated potassium channels and endothelium-dependent hyperpolarizations in the guinea pig carotid artery.
Naunyn-Schmiedeberg's archives of pharmacology 20080401
-
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.
British journal of pharmacology 20070701
-
Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.
Journal of neurochemistry 20070601
-
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
European journal of immunology 20070601
-
Calcium and small-conductance calcium-activated potassium channels in gonadotropin-releasing hormone neurons before, during, and after puberty.
Endocrinology 20070501
-
Inhibition of intermediate-conductance Ca2+-activated K+ channel and cytoprotective properties of 4-piperidinomethyl-2-isopropyl-5-methylphenol.
The Journal of pharmacy and pharmacology 20070501
-
Ca2+ release-dependent hyperpolarizations modulate the firing pattern of juvenile GABA neurons in mouse substantia nigra pars reticulata in vitro.
The Journal of physiology 20061215
-
Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and bicarbonate secretion.
American journal of physiology. Gastrointestinal and liver physiology 20061201
-
Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 20061101
-
Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.
Molecular pharmacology 20061101
-
Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery.
British journal of pharmacology 20061101
-
Exposure to sodium butyrate leads to functional downregulation of calcium-activated potassium channels in human airway epithelial cells.
Pflugers Archiv : European journal of physiology 20061101
-
Distinct K+ conductive pathways are required for Cl- and K+ secretion across distal colonic epithelium.
American journal of physiology. Cell physiology 20061001
-
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
European journal of pharmacology 20060928
-
SK Ca2+-activated K+ channel ligands alter the firing pattern of dopamine-containing neurons in vivo.
Neuroscience 20060630
-
Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats.
British journal of pharmacology 20060601
-
Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
European journal of pharmacology 20060524
-
Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Biochemical and biophysical research communications 20060512
-
Impairment of PAR-2-mediated relaxation system in colonic smooth muscle after intestinal inflammation.
British journal of pharmacology 20060501
-
Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia.
Nature neuroscience 20060301
-
DCEBIO stimulates Cl- secretion in the mouse jejunum.
American journal of physiology. Cell physiology 20060101
-
Interactions of N-terminal and C-terminal parts of the small conductance Ca2+ activated K+ channel, hSK3.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101
-
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
The Journal of biological chemistry 20051216
-
Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons.
Brain research 20051214
-
Ion transport regulated by protease-activated receptor 2 in human airway Calu-3 epithelia.
British journal of pharmacology 20051001
-
Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration.
British journal of pharmacology 20051001
-
1-Ethyl-2-benzimidazolinone (EBIO) suppresses epileptiform activity in in vitro hippocampus.
Neuropharmacology 20050901
-
Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.
Circulation research 20050819
-
Cl- secretory effects of EBIO in the rabbit conjunctival epithelium.
American journal of physiology. Cell physiology 20050701
-
Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model.
Journal of pharmacological sciences 20050701
-
Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050601
-
Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats.
Kidney international 20050601
-
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050406
-
Genistein stimulates electrogenic Cl(-) secretion in mouse jejunum.
American journal of physiology. Cell physiology 20041201
-
Reduction of airway anion secretion via CFTR in sphingomyelin pathway.
Biochemical and biophysical research communications 20041112
-
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).
Biochimica et biophysica acta 20041011
-
A 'virtual gland' method for quantifying epithelial fluid secretion.
American journal of physiology. Lung cellular and molecular physiology 20041001
-
Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells.
The Journal of biological chemistry 20040910
-
The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.
The Journal of allergy and clinical immunology 20040701
-
Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.
American journal of physiology. Lung cellular and molecular physiology 20040601
-
ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells.
American journal of respiratory cell and molecular biology 20040301
-
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.
Molecular pharmacology 20040301
-
Inhibition of endothelium-dependent vasorelaxation by extracellular K(+): a novel controlling signal for vascular contractility.
American journal of physiology. Heart and circulatory physiology 20040101
-
Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.
BMC dermatology 20040101
-
Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension.
European journal of pharmacology 20031114
-
Role of endothelial intermediate conductance KCa channels in cerebral EDHF-mediated dilations.
American journal of physiology. Heart and circulatory physiology 20031001
-
Calcium activates SK channels in the intact human lens.
Investigative ophthalmology & visual science 20030901
-
Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030820
-
Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.
European journal of pharmacology 20030627
-
Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia.
Pediatric research 20030401
-
Inhibition of EDHF by two new combinations of K+-channel inhibitors in rat isolated mesenteric arteries.
British journal of pharmacology 20030301
-
Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation.
The Journal of biological chemistry 20030131
-
Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.
Brain research 20030103
-
SK4/IK1-like channels mediate TEA-insensitive, Ca2+-activated K+ currents in bovine parotid acinar cells.
American journal of physiology. Cell physiology 20030101
-
Expression and activity of potassium ion channels in human prostate cancer.
Cancer letters 20021201
-
Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF.
British journal of pharmacology 20021201
-
Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells.
Toxicology and applied pharmacology 20020915
-
Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo.
The Journal of physiology 20020801
-
Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.
British journal of pharmacology 20020801
-
Bisphenol A inhibits Cl(-) secretion by inhibition of basolateral K+ conductance in human airway epithelial cells.
The Journal of pharmacology and experimental therapeutics 20020701
-
Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line.
Brain research 20020607
-
Regulation of a calcium-sensitive K+ channel (cIK1) by protein kinase C.
The Journal of membrane biology 20020501
-
Characterization of an apamin-sensitive small-conductance Ca(2+)-activated K(+) channel in porcine coronary artery endothelium: relevance to EDHF.
British journal of pharmacology 20020301
-
Physiological role of calcium-activated potassium currents in the rat lateral amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301
-
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
The Journal of physiology 20020201
-
Activation of endothelial cell IK(Ca) with 1-ethyl-2-benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery.
British journal of pharmacology 20011201
-
Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 20011101
-
Novel effects of minocycline on Ca(2+)-dependent Cl(-) secretion in human airway epithelial Calu-3 cells.
Toxicology and applied pharmacology 20011015
-
Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium.
Molecular pharmacology 20011001
-
Phenanthrolines--a new class of CFTR chloride channel openers.
British journal of pharmacology 20011001
-
Regulation of anion secretion by nitric oxide in human airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 20010801
-
Comparison of effects of diabetes mellitus on an EDHF-dependent and an EDHF-independent artery.
American journal of physiology. Heart and circulatory physiology 20010701
-
Microelectrode and impedance analysis of anion secretion in Calu-3 cells.
JOP : Journal of the pancreas 20010701
-
EDHF is not K+ but may be due to spread of current from the endothelium in guinea pig arterioles.
American journal of physiology. Heart and circulatory physiology 20010601
-
Pharmacological modulation of SK3 channels.
Neuropharmacology 20010601
-
Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515
-
Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels.
The Journal of biological chemistry 20010330
-
NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion.
American journal of physiology. Cell physiology 20010301
-
Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.
The Journal of pharmacology and experimental therapeutics 20010301
-
Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.
British journal of pharmacology 20010201
-
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
The Journal of pharmacology and experimental therapeutics 20010201
-
Expression and biological significance of Ca2+-activated ion channels in human keratinocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101
-
Characterisation of the rat SK4/IK1 K(+) channel.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101
-
EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.
Pflugers Archiv : European journal of physiology 20010101
-
Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.
American journal of physiology. Cell physiology 20000301
-
Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.
The American journal of physiology 19980901
