100643-71-8 | 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene

Packsize	Purity	Availability	Price	Discounted Price
50mg	98%	in stock	$6.00	$4.00
100mg	98%	in stock	$7.00	$5.00
1g	98%	in stock	$9.00	$6.00
5g	98%	in stock	$31.00	$22.00
10g	98%	in stock	$60.00	$42.00
25g	98%	in stock	$122.00	$86.00
100g	98%	in stock	$441.00	$309.00
500g	98%(HPLC)	in stock	$885.00	$620.00

Description

• Catalog Number: AA03121
• Chemical Name: 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene
• CAS Number: 100643-71-8
• Molecular Formula: C19H19ClN2
• Molecular Weight: 310.8206
• MDL Number: MFCD00871949
• SMILES: Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1

Computed Properties

• Complexity: 425
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 4.5

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  Journal of the European Academy of Dermatology and Venereology : JEADV 20080101

• A new evaluation method for +Gz tolerance with loratadine by using a near-infrared spectroscopy.

  Dynamic medicine : DM 20080101

• Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.

  Clinical pharmacokinetics 20080101

• Non-interventional study comparing treatment satisfaction in patients treated with antihistamines.

  Clinical drug investigation 20080101

• Individual case safety reports in children in commonly used drug groups - signal detection.

  BMC clinical pharmacology 20080101

• Quantitative evaluation of signaling events in Drosophila S2 cells.

  Biological procedures online 20080101

• Behavioral conditioning of antihistamine effects in patients with allergic rhinitis.

  Psychotherapy and psychosomatics 20080101

• Antihistaminic effects of rupatadine and PKPD modelling.

  European journal of drug metabolism and pharmacokinetics 20080101

• [Linear verrucous lesions of the trunk and limbs].

  Annales de dermatologie et de venereologie 20080101

• Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test.

  Indian journal of dermatology, venereology and leprology 20080101

• Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine.

  Journal of investigational allergology & clinical immunology 20080101

• Neurotrophins: are they meaningful in chronic spontaneous urticaria?

  Asian Pacific journal of allergy and immunology 20080101

• In vitro effects of budesonide on eosinophil-basophil lineage commitment.

  The open respiratory medicine journal 20080101

• New spectrofluorimetric method with enhanced sensitivity for determination of paroxetine in dosage forms and plasma.

  Analytical chemistry insights 20080101

• Psychological factors in asthma.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101

• Development and validation of high-throughput liquid chromatography-tandem mass spectrometric method for simultaneous quantification of loratadine and desloratadine in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071215

• Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine.

  The Journal of laryngology and otology 20071201

• Spectrophotometric, spectrofluorometric and HPLC determination of desloratadine in dosage forms and human plasma.

  Chemical & pharmaceutical bulletin 20071201

• Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults.

  Clinical therapeutics 20071201

• Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.

  Journal of pharmaceutical and biomedical analysis 20071130

• Desloratadine improves quality of life and symptom severity in patients with allergic rhinitis.

  Allergy 20071101

• Validated ion pair liquid chromatography/fluorescence detection method for assessing the variability of the loratadine metabolism occurring in bioequivalence studies.

  Biomedical chromatography : BMC 20071001

• Response normalized liquid chromatography nanospray ionization mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20071001

• Multiple-dose pharmacokinetics and safety of desloratadine in subjects with moderate hepatic impairment.

  Journal of clinical pharmacology 20071001

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20070901

• Desloratadine treatment for intermittent and persistent allergic rhinitis: a review.

  Clinical therapeutics 20070901

• Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults.

  British journal of clinical pharmacology 20070801

• Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.

  Journal of pharmaceutical and biomedical analysis 20070727

• Disposition of loratadine in healthy volunteers.

  Xenobiotica; the fate of foreign compounds in biological systems 20070701

• Disposition of desloratadine in healthy volunteers.

  Xenobiotica; the fate of foreign compounds in biological systems 20070701

• The effect of regular versus on-demand desloratadine treatment in children with allergic rhinitis.

  International journal of pediatric otorhinolaryngology 20070601

• Pharmacokinetics of desloratadine in children between 2 and 11 years of age.

  British journal of clinical pharmacology 20070501

• Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults.

  Clinical therapeutics 20070501

• Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.

  Clinical therapeutics 20070501

• The nose - from symptoms to evidence-based medicine.

  Allergy 20070401

• Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials.

  Allergy 20070401

• Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent.

  Journal of pharmaceutical and biomedical analysis 20070312

• Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study.

  Journal of pharmaceutical and biomedical analysis 20070312

• Selective inhibition of Kir currents by antihistamines.

  European journal of pharmacology 20070308

• Effectiveness of desloratadine 5 mg once daily in patients with symptoms of seasonal allergic rhinitis: results of a Canadian multicenter, open-label trial.

  Clinical therapeutics 20070301

• Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study.

  Therapeutics and clinical risk management 20070301

• Effects of desloratadine and alcohol coadministration on psychomotor performance.

  Current medical research and opinion 20070201

• The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis.

  Pulmonary pharmacology & therapeutics 20070101

• Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial.

  American journal of clinical dermatology 20070101

• Efficacy of fexofenadine versus desloratadine in suppressing histamine-induced wheal and flare.

  Allergy and asthma proceedings 20070101

• A sensitive spectrophotometric method for the determination of desloratadine in tablets.

  Journal of AOAC International 20070101

• Direct injection liquid chromatographic technique for simultaneous determination of two antihistaminic drugs and their main metabolites in serum.

  Journal of AOAC International 20070101

• Premedication with montelukast reduces local reactions of allergen immunotherapy.

  International archives of allergy and immunology 20070101

• A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.

  Clinical drug investigation 20070101

• Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review.

  Allergy and asthma proceedings 20070101

• Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy.

  American journal of clinical dermatology 20070101

• Eosinophil recruiting chemokines are down-regulated in peripheral blood mononuclear cells of allergic patients treated with deflazacort or desloratadine.

  International journal of immunopathology and pharmacology 20070101

• [Antihistamines in allergic rhinitis].

  Otolaryngologia polska = The Polish otolaryngology 20070101

• Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.

  Drug metabolism letters 20070101

• Desloratadine in combination with montelukast suppresses the dermographometer challenge test papule, and is effective in the treatment of delayed pressure urticaria: a randomized, double-blind, placebo-controlled study.

  The British journal of dermatology 20061201

• Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.

  European annals of allergy and clinical immunology 20061201

• New antihistamines: a critical view.

  Jornal de pediatria 20061101

• Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

• [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060901

• Bacillus aerius sp. nov., Bacillus aerophilus sp. nov., Bacillus stratosphericus sp. nov. and Bacillus altitudinis sp. nov., isolated from cryogenic tubes used for collecting air samples from high altitudes.

  International journal of systematic and evolutionary microbiology 20060701

• Diphenhydramine vs desloratadine comparisons must consider risk-benefit ratio.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060701

• Combining desloratadine and pseudoephedrine in the treatment of seasonal allergic rhinitis.

  Expert review of clinical immunology 20060701

• Form I of desloratadine, a tricyclic antihistamine.

  Acta crystallographica. Section C, Crystal structure communications 20060601

• The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers.

  European journal of clinical pharmacology 20060601

• Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.

  Southern medical journal 20060601

• Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060601

• A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060601

• Antimuscarinic actions of antihistamines on the heart.

  Journal of biomedical science 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060501

• Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria.

  International journal of dermatology 20060401

• Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060401

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060401

• Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety.

  Expert opinion on drug safety 20060301

• Desloratadine 5 mg once daily improves the quality of life of patients with chronic idiopathic urticaria.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20060301

• Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability.

  Journal of managed care pharmacy : JMCP 20060301

• Desloratadine therapy for symptoms associated with perennial allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060301

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060301

• Desloratadine for allergic rhinitis.

  Expert review of clinical immunology 20060301

• Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.

  Journal of pharmaceutical and biomedical analysis 20060224

• Effect of desloratadine therapy on symptom scores and measures of nasal patency in seasonal allergic rhinitis: results of a single-center, placebo-controlled trial.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060201

• Changes in pH differently affect the binding properties of histamine H1 receptor antagonists.

  European journal of pharmacology 20060120

• Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060101

• Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy.

  Current medical research and opinion 20060101

• A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

  Clinical therapeutics 20060101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060101

• The role of antihistamines in asthma management.

  Treatments in respiratory medicine 20060101

• Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies.

  Drugs 20060101

• Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines.

  International archives of allergy and immunology 20060101

• Stimulating effects of H1-antagonists.

  Current pharmaceutical design 20060101

• Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis.

  Allergy and asthma proceedings 20060101

• Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.

  Drug safety 20060101

• Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

  Allergy and asthma proceedings 20060101

• Selecting the optimal oral antihistamine for patients with allergic rhinitis.

  Drugs 20060101

• A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.

  PloS one 20060101

• Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.

  Mediators of inflammation 20060101

• Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study.

  International immunopharmacology 20051201

• Treatment for allergic rhinitis and chronic idiopathic urticaria: focus on oral antihistamines.

  The Annals of pharmacotherapy 20051201

• Sexual dysfunction in patients with allergic rhinoconjunctivitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20051201

• Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine.

  Therapeutics and clinical risk management 20051201

• The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study.

  International archives of allergy and immunology 20051101

• Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders.

  Expert opinion on pharmacotherapy 20051101

• [Isotachophoretic determination of desloratadine in tablets and syrup].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20051101

• Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients.

  Allergy 20051001

• Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen.

  The Journal of allergy and clinical immunology 20051001

• Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice.

  Archives of otolaryngology--head & neck surgery 20051001

• Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects.

  Drug metabolism and disposition: the biological fate of chemicals 20050901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20050901

• Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

• Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.

  Journal of the American Academy of Nurse Practitioners 20050801

• [Desloratadine for chronic idiopathic urticaria].

  Harefuah 20050801

• Review of H1 antihistamines in the treatment of chronic idiopathic urticaria.

  Cutis 20050801

• A treatment for allergic rhinitis: a view on the role of levocetirizine.

  Current medical research and opinion 20050701

• [Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050701

• A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

  Clinical therapeutics 20050701

• Acute cholestasis related to desloratidine.

  World journal of gastroenterology 20050621

• Determination of desloratadine in drug substance and pharmaceutical preparations by liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20050615

• Histamine-mediated mechanisms in the human nasal airway.

  Current opinion in pharmacology 20050601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20050601

• [The effect of desloratadine on the TXB2 and leukotrienes levels in the nasal lavage fluid of allergic rhinitis animal model].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050401

• Evidence of desloratadine syrup efficacy and tolerability in children with pollen-induced allergic rhinitis.

  Allergy 20050301

• Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.

  British journal of clinical pharmacology 20050301

• Increased nasal airflow with budesonide compared with desloratadine during the allergy season.

  Archives of otolaryngology--head & neck surgery 20050301

• Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050301

• [The immunohistochemical observations of NOS in the nasal mucosa of allergic rhinitis animal model of guinea pigs].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050301

• Metabolism and excretion of loratadine in male and female mice, rats and monkeys.

  Xenobiotica; the fate of foreign compounds in biological systems 20050201

• [Effects of budesonide, desloratadine and dexamethasone on interleukine-4 release and expression from human mast cell line].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20050201

• [The effect of desloratadine on use of rescue beta2-agonists and symptoms in patients suffering from seasonal allergic rhinitis and asthma].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050201

• [The influence of desloratadine on course of intermittens allergic rhinitis].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050201

• Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine.

  Allergy 20050101

• Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique.

  Allergy 20050101

• Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.

  Drugs 20050101

• Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport.

  BMC pharmacology 20050101

• Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines.

  Drugs & aging 20050101

• [Preliminary clinical study of fubiding in treatment of perennial allergic rhinitis].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050101

• Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review.

  Drug safety 20050101

• In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine.

  BMC pharmacology 20050101

• [Therapeutic options in idiopathic chronic urticaria].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101

• The safety and efficacy of desloratadine for the management of allergic disease.

  Drug safety 20050101

• Efficacy and safety of desloratadine/pseudoephedrine tablet, 2.5/120 mg two times a day, versus individual components in the treatment of patients with seasonal allergic rhinitis.

  Allergy and asthma proceedings 20050101

• Predicting and establishing the clinical efficacy of a histamine h(1)-receptor antagonist : desloratadine, the model paradigm.

  Clinical drug investigation 20050101

• Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor.

  International archives of allergy and immunology 20041201

• Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1).

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20041201

• Safety of desloratadine syrup in children.

  Current medical research and opinion 20041201

• Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.

  Bioorganic & medicinal chemistry letters 20041115

• Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.

  Journal of clinical pharmacology 20041101

• Homology modelling and binding site mapping of the human histamine H1 receptor.

  European journal of medicinal chemistry 20041101

• Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

  Journal of cardiovascular electrophysiology 20041101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20041101

• Current concepts and therapeutic strategies for allergic rhinitis in school-age children.

  Clinical therapeutics 20041101

• Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.

  International archives of allergy and immunology 20041001

• Desloratadine partially inhibits the augmented bacterial responses in the sinuses of allergic and infected mice.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20041001

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20041001

• Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.

  Biopharmaceutics & drug disposition 20040901

• Anti-inflammatory properties of desloratadine.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040901

• Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040901

• Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria.

  The Journal of allergy and clinical immunology 20040901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040901

• Modern histamine H1-receptor antagonists in the unified airway.

  The Journal of allergy and clinical immunology 20040901

• Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.

  Allergy 20040801

• Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

  Fundamental & clinical pharmacology 20040801

• [Nasal obstruction on the decline. Antihistamine allows allergic patients to breathe].

  MMW Fortschritte der Medizin 20040708

• Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements.

  European journal of clinical pharmacology 20040701

• Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040701

• Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040601

• Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040601

• [Combination therapy of allergic rhinitis. So that from hay fever asthma won't come].

  MMW Fortschritte der Medizin 20040527

• Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20040501

• Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude.

  Aviation, space, and environmental medicine 20040501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040501

• [Not a minor illness. Hay fever therapy should not be left to the patient].

  MMW Fortschritte der Medizin 20040408

• Improvements in simulated real-world relevant performance for patients with seasonal allergic rhinitis: impact of desloratadine.

  Allergy 20040401

• Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

• Levocetirizine better protects than desloratadine in a nasal provocation with allergen.

  The Journal of allergy and clinical immunology 20040401

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040401

• High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs.

  Journal of pharmaceutical and biomedical analysis 20040310

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040301

• Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.

  Managed care interface 20040201

• Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).

  International journal of clinical practice 20040201

• Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism.

  European annals of allergy and clinical immunology 20040201

• Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.

  Current medical research and opinion 20040101

• Inhibition of cold urticaria by desloratadine.

  The Journal of dermatological treatment 20040101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040101

• Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan.

  Journal of managed care pharmacy : JMCP 20040101

• Pharmacokinetics and bioequivalence study of a generic desloratadine tablet formulation in healthy male volunteers.

  Arzneimittel-Forschung 20040101

• Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines.

  Allergy and asthma proceedings 20040101

• The ARIA/EAACI criteria for antihistamines: an assessment of the efficacy, safety and pharmacology of desloratadine.

  Allergy 20040101

• Reported case of severe hepatotoxicity likely due to fluconazole and not desloratadine.

  Acta haematologica 20040101

• Chronic urticaria: aetiology, management and current and future treatment options.

  Drugs 20040101

• Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase.

  Rapid communications in mass spectrometry : RCM 20040101

• [Autoimmune urticaria. Treatment with methotrexate].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

• Interactions of olopatadine and selected antihistamines with model and natural membranes.

  Ocular immunology and inflammation 20031201

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20031201

• Desloratadine for allergic rhinitis.

  American family physician 20031115

• [Modern antihistaminics against allergic rhinitis. Better breathing without side effects].

  MMW Fortschritte der Medizin 20031030

• Reliable and specific high-performance liquid chromatographic method for simultaneous determination of loratadine and its metabolite in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin.

  British journal of clinical pharmacology 20031001

• Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001

• Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment.

  The Journal of allergy and clinical immunology 20031001

• A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

• Loratadine, desloratadine and pregnancy: don't use, risk of hypospadias.

  Prescrire international 20031001

• Studies on performance and sleepiness with the H1-antihistamine, desloratadine.

  Aviation, space, and environmental medicine 20030801

• Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

• Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men.

  Clinical therapeutics 20030801

• Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

• Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma.

  The Journal of allergy and clinical immunology 20030701

• Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects.

  Acta pharmacologica Sinica 20030701

• Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial.

  Clinical therapeutics 20030701

• Comparison of the effects of desloratadine 5-mg daily and placebo on nasal airflow and seasonal allergic rhinitis symptoms induced by grass pollen exposure.

  Allergy 20030601

• Effects of mediator antagonism on mannitol and adenosine monophosphate challenges.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

• The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis.

  British journal of clinical pharmacology 20030601

• [Clinical aspects of anti-inflammatory action of antihistamines].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

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• First do no harm: managing antihistamine impairment in patients with allergic rhinitis.

  The Journal of allergy and clinical immunology 20030501

• Efficacy and safety of desloratadine 5 mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial.

  Journal of the American Academy of Dermatology 20030401

• Comparative effects of desloratadine versus montelukast on asthma symptoms and use of beta 2-agonists in patients with seasonal allergic rhinitis and asthma.

  International archives of allergy and immunology 20030401

• [Older antihistaminics often act as sedatives. Hay fever gone -- reaction capacity, too].

  MMW Fortschritte der Medizin 20030327

• P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis.

  The Journal of allergy and clinical immunology 20030301

• Decongestant effects of antihistamines: a class effect?

  The Journal of allergy and clinical immunology 20030301

• Double-stranded RNA viruses in a mycocinogenic strain of Cystofilobasidium infirmominiatum.

  FEMS yeast research 20030301

• Gateways to clinical trials. March 2003.

  Methods and findings in experimental and clinical pharmacology 20030301

• Desloratadine: a nonsedating antihistamine.

  The Annals of pharmacotherapy 20030201

• Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.

  The Journal of allergy and clinical immunology 20030201

• The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study.

  BMC ophthalmology 20030101

• Chronic urticaria: a role for newer immunomodulatory drugs?

  American journal of clinical dermatology 20030101

• Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.

  BMC family practice 20030101

• Desloratadine: an update of its efficacy in the management of allergic disorders.

  Drugs 20030101

• Severe hepatotoxicity after application of desloratadine and fluconazole.

  Acta haematologica 20030101

• Antihistamines in the treatment of dermatitis.

  Journal of cutaneous medicine and surgery 20030101

• Treatment of allergic rhinitis.

  The American journal of medicine 20021216

• Comparative pharmacology of H1 antihistamines: clinical relevance.

  The American journal of medicine 20021216

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• The new antihistamines--desloratadine and levocetirizine: a review.

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  The Journal of allergy and clinical immunology 20021101

• Safety and efficacy of desloratadine 5 mg in asthma patients with seasonal allergic rhinitis and nasal congestion.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021101

• Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021001

• Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021001

• Desloratidine for the treatment of chronic urticaria.

  Skin therapy letter 20021001

• Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor.

  European journal of pharmacology 20020809

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  MMW Fortschritte der Medizin 20020711

• Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit.

  The Journal of allergy and clinical immunology 20020601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20020501

• Desloratadine (Clarinex).

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• Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

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  MMW Fortschritte der Medizin 20020214

• Antihistamines in late-phase clinical development for allergic disease.

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  Current opinion in allergy and clinical immunology 20020201

• Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.

  Clinical pharmacokinetics 20020101

• 24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139].

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• Desloratadine demonstrates dose proportionality in healthy adults after single doses.

  Clinical pharmacokinetics 20020101

• Oral bioavailability of desloratadine is unaffected by food.

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• A pharmacokinetic profile of desloratadine in healthy adults, including elderly.

  Clinical pharmacokinetics 20020101

• Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine.

  Clinical pharmacokinetics 20020101

• Lack of clinically relevant interaction between desloratadine and erythromycin.

  Clinical pharmacokinetics 20020101

• Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole.

  Clinical pharmacokinetics 20020101

• Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays.

  Rapid communications in mass spectrometry : RCM 20020101

• Efficacy of once-daily desloratadine/pseudoephedrine for relief of nasal congestion.

  Allergy and asthma proceedings 20020101

• Therapeutic points of intervention and clinical implications: role of desloratadine.

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• Poor sleep and daytime somnolence in allergic rhinitis: significance of nasal congestion.

  American journal of respiratory medicine : drugs, devices, and other interventions 20020101

• Second-generation antihistamines in asthma therapy: is there a protective effect?

  American journal of respiratory medicine : drugs, devices, and other interventions 20020101

• Desloratadine reduces nasal congestion in patients with intermittent allergic rhinitis.

  Allergy 20011101

• In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20010901

• Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010901

• Applications of new liquid chromatography-tandem mass spectrometry technologies for drug development support.

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• Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells.

  The Journal of allergy and clinical immunology 20010801

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• Sensitive liquid chromatography-tandem mass spectrometry method for the determination of loratadine and its major active metabolite descarboethoxyloratadine in human plasma.

  Journal of chromatography. A 20010420

• Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes.

  Analytical chemistry 20010415

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• Desloratadine: A new, nonsedating, oral antihistamine.

  The Journal of allergy and clinical immunology 20010401

• Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation.

  Clinical pharmacology and therapeutics 20010301

• Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study.

  Clinical therapeutics 20010301

• Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug.

  Expert opinion on investigational drugs 20010301

• Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis.

  Allergy 20010101

• Desloratadine activity in concurrent seasonal allergic rhinitis and asthma.

  Allergy 20010101

• Desloratadine in the treatment of chronic idiopathic urticaria.

  Allergy 20010101

• Desloratadine: a new approach in the treatment of allergy as a systematic disease--pharmacology and clinical overview. Introduction.

  Allergy 20010101

• The pharmacologic profile of desloratadine: a review.

  Allergy 20010101

• Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.

  International journal of dermatology 20010101

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  Pneumonologia i alergologia polska 20010101

• Chronic idiopathic urticaria treatment.

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• Mediator antagonists in the treatment of allergic disease.

  Allergy and asthma proceedings 20010101

• Sedation with 'non-sedating' antihistamines: four prescription-event monitoring studies in general practice.

  BMJ (Clinical research ed.) 20000429