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Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton.
Organic & biomolecular chemistry 20120521
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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
Nature biotechnology 20120219
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Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal of enzyme inhibition and medicinal chemistry 20111201
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PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Multiple sclerosis (Houndmills, Basingstoke, England) 20110701
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Synthesis and evaluation of C-ring aromatized analogues of phenanthridone alkaloids.
Archives of pharmacal research 20110701
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Effects of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord.
Cellular and molecular neurobiology 20110501
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One-pot formation of C-C and C-N bonds through palladium-catalyzed dual C-H activation: synthesis of phenanthridinones.
Angewandte Chemie (International ed. in English) 20110207
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A highly sensitive RP-HPLC-fluorescence method to study aldehyde oxidase activity.
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Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro.
Frontiers in cellular neuroscience 20110101
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Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
International journal of critical illness and injury science 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.
Bioorganic & medicinal chemistry letters 20090501
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Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors.
Research communications in molecular pathology and pharmacology 20090101
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Chronic exposure of the oligochaete Lumbriculus variegatus to polycyclic aromatic compounds (PACs): bioavailability and effects on reproduction.
Environmental science & technology 20080501
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A novel spectrophotometric method for determination of kinetic constants of aldehyde oxidase using multivariate calibration method.
Journal of biochemical and biophysical methods 20080424
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Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.
Organic letters 20080207
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Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Bioorganic & medicinal chemistry letters 20071115
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A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 20070701
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Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family.
The Journal of organic chemistry 20070330
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Effects of proximity on the relaxation dynamics of flindersine and 6(5H)-phenanthridinone.
The journal of physical chemistry. A 20070118
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6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells.
Research communications in molecular pathology and pharmacology 20070101
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Journal of medicinal chemistry 20050811
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Fungal biotransformation of benzo[f]quinoline, benzo[h]quinoline, and phenanthridine.
Applied microbiology and biotechnology 20050501
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The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways.
Toxicology and applied pharmacology 20050101
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Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1.
The Biochemical journal 20040815
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An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors.
Analytical biochemistry 20040301
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Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis.
Research communications in molecular pathology and pharmacology 20040101
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Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries.
Bioorganic & medicinal chemistry 20030815
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Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
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Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
The Journal of pharmacology and experimental therapeutics 20030601
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Nicotinamide is a potent inhibitor of proinflammatory cytokines.
Clinical and experimental immunology 20030101
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Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.
British journal of pharmacology 20021101
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Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Critical care medicine 20020501
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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
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A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study.
Chemical communications (Cambridge, England) 20020321
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Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
Cell death and differentiation 20010901
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Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors.
Bioorganic & medicinal chemistry letters 20010709
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Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.
Cancer research 20010515
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Comparative metabolism of phenanthridine by carp (Cyprinus carpio) and midge larvae (Chironomus riparius).
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Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase.
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N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis.
Biochemical pharmacology 19960503