102-07-8 | 1,3-Diphenylurea

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$15.00	$10.00
5g	95%	in stock	$16.00	$11.00
25g	95%	in stock	$23.00	$16.00
100g	95%	in stock	$30.00	$21.00
500g	95%	in stock	$95.00	$66.00

Description

• Catalog Number: AA07871
• Chemical Name: 1,3-Diphenylurea
• CAS Number: 102-07-8
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.2472
• MDL Number: MFCD00003017
• SMILES: O=C(Nc1ccccc1)Nc1ccccc1

Computed Properties

• Complexity: 196
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 3

Upstream Synthesis Route

1,3-Diphenylurea is a versatile compound commonly employed in chemical synthesis for its wide range of applications. This organic compound serves as a key building block in the production of various pharmaceuticals, agrochemicals, and materials. In chemical synthesis, 1,3-Diphenylurea acts as a valuable intermediate in the preparation of heterocyclic compounds and as a catalyst in various organic reactions. Its unique structure and reactivity make it a vital component in the creation of novel molecules with diverse functionalities. Additionally, 1,3-Diphenylurea is utilized in the development of advanced materials, such as polymers and coatings, due to its ability to impart specific properties and characteristics. Its significance in chemical synthesis lies in its capacity to facilitate the creation of complex compounds and intricate molecular structures, making it an essential tool for researchers and chemists across various fields.

Literature

• Simultaneous determination of triclosan, triclocarban, and transformation products of triclocarban in aqueous samples using solid-phase micro-extraction-HPLC-MS/MS.

  Journal of separation science 20121001

• Analysis of the infrared and Raman spectra of the symmetrically substituted 1,3-diphenylurea and 1,3-diphenylacetone (dibenzyl ketone).

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

• Current advances in detection and treatment of babesiosis.

  Current medicinal chemistry 20120401

• Fate of triclosan and triclocarban in soil columns with and without biosolids surface application.

  Environmental toxicology and chemistry 20120201

• Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.

  Bioorganic & medicinal chemistry 20120201

• Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease.

  Current Alzheimer research 20120101

• Carbonylation of nitrobenzene in methanol with palladium bidentate phosphane complexes: an unexpectedly complex network of catalytic reactions, centred around a Pd-imido intermediate.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20111118

• The structure-activity relationship of urea derivatives as anti-tuberculosis agents.

  Bioorganic & medicinal chemistry 20110915

• Selectivity of kinase inhibitor fragments.

  Journal of medicinal chemistry 20110728

• Evaluation of mass spectrometric methods for detection of the anti-protozoal drug imidocarb.

  Journal of analytical toxicology 20110501

• Identification of wastewater bacteria involved in the degradation of triclocarban and its non-chlorinated congener.

  Journal of hazardous materials 20101115

• Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.

  Bioorganic & medicinal chemistry 20100801

• Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein.

  The FEBS journal 20090301

• Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps.

  European journal of medicinal chemistry 20081101

• In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens.

  Environmental health perspectives 20080901

• Fate of triclosan and evidence for reductive dechlorination of triclocarban in estuarine sediments.

  Environmental science & technology 20080615

• 3,3'-Diphenyl-1,1'-[2,2'-oxybis(2,1-phenyl-ene)]diurea N,N-dimethyl-formamide disolvate.

  Acta crystallographica. Section E, Structure reports online 20080101

• The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells.

  Cancer research 20070715

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Electrochemically controlled hydrogen bonding. Redox-dependent formation of a 2:1 diarylurea/dinitrobenzene2- complex.

  The Journal of organic chemistry 20051223

• Electrochemically controlled hydrogen bonding. Nitrobenzenes as simple redox-dependent receptors for arylureas.

  Journal of the American Chemical Society 20050504

• Inhibition of neuronal Na+ channels by the novel antiepileptic compound DCUKA: identification of the diphenylureido moiety as an inactivation modifier.

  Experimental neurology 20021101

• Metabolism of diphenylurea by a Marinobacter sp. isolated from a contaminated ephemeral stream bed in the Negev Desert.

  FEMS microbiology letters 20020806