1029712-80-8 | Incb28060

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$28.00	$19.00
5mg	98%	in stock	$44.00	$31.00
10mg	98%	in stock	$62.00	$44.00
25mg	98%	in stock	$110.00	$77.00
50mg	98%	in stock	$126.00	$88.00
100mg	98%	in stock	$180.00	$126.00
250mg	98%	in stock	$360.00	$252.00
1g	98%	in stock	$970.00	$679.00
5g	98%	in stock	$3,395.00	$2,376.00

Description

• Catalog Number: AB53159
• Chemical Name: Incb28060
• CAS Number: 1029712-80-8
• Molecular Formula: C23H17FN6O
• Molecular Weight: 412.4191
• MDL Number: MFCD18633285
• SMILES: CNC(=O)c1ccc(cc1F)c1cnc2n(n1)c(cn2)Cc1ccc2c(c1)cccn2

Computed Properties

• Complexity: 637
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.9

Upstream Synthesis Route

The 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, commonly referred to as $name$, plays a crucial role in chemical synthesis processes. This compound is known for its unique properties that make it a valuable tool in the field of organic chemistry.One of the key applications of $name$ in chemical synthesis is its ability to act as a versatile building block for the construction of complex molecular structures. The presence of the fluoro and methyl substituents, along with the imidazo-triazinyl and benzamide moieties, provides opportunities for selective functional group transformations and rapid diversification of chemical libraries.Furthermore, the quinolinylmethyl group in $name$ can serve as a directing group in various synthetic reactions, enabling precise control over regioselectivity and facilitating the formation of specific bonds. This feature makes $name$ particularly useful in the synthesis of heterocyclic compounds and biologically relevant molecules.Overall, the strategic incorporation of 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide in chemical synthesis processes opens up new avenues for the creation of diverse chemical structures with potential applications in pharmaceuticals, materials science, and other research areas.

Literature

• The novel c-Met inhibitor capmatinib mitigates diethylnitrosamine acute liver injury in mice.

  Toxicology letters 20161102

• A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20111115