103177-37-3 | Pranlukast

Packsize	Purity	Availability	Price	Discounted Price
50mg	98%	in stock	$6.00	$4.00
100mg	98%	in stock	$7.00	$5.00
1g	98%	in stock	$31.00	$22.00
5g	98%	in stock	$78.00	$55.00

Description

• Catalog Number: AE08101
• Chemical Name: Pranlukast
• CAS Number: 103177-37-3
• Molecular Formula: C27H23N5O4
• Molecular Weight: 481.5026
• MDL Number: MFCD00864631
• SMILES: O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1

Computed Properties

• Complexity: 778
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 9
• XLogP3: 4.2

Literature

• A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

  Toxicological sciences : an official journal of the Society of Toxicology 20131101

• Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method.

  Drug development and industrial pharmacy 20121101

• Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection.

  The Journal of asthma : official journal of the Association for the Care of Asthma 20120801

• Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.

  Pharmaceutical research 20120601

• Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation.

  Respiratory medicine 20120401

• Pranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO Chamber.

  Allergy and asthma proceedings 20120101

• A silica-induced pulmonary fibrosis model: are we closer to 'real life'?

  International archives of allergy and immunology 20120101

• Pranlukast, a cysteinyl leukotriene type 1 receptor antagonist, attenuates the progression but not the onset of silica-induced pulmonary fibrosis in mice.

  International archives of allergy and immunology 20120101

• Delay of onset of symptoms of Japanese cedar pollinosis by treatment with a leukotriene receptor antagonist.

  Allergology international : official journal of the Japanese Society of Allergology 20111201

• Successful multidrug treatment of a pediatric patient with severe Churg-Strauss syndrome refractory to prednisolone.

  The Tohoku journal of experimental medicine 20111001

• Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110801

• Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages.

  Cytokine 20110701

• α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization.

  International journal of pharmaceutics 20110530

• Pranlukast attenuates hydrogen peroxide-induced necrosis in endothelial cells by inhibiting oxygen reactive species-mediated collapse of mitochondrial membrane potential.

  Journal of cardiovascular pharmacology 20110401

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.

  The Journal of pharmacy and pharmacology 20110401

• Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy.

  Drugs in R&D 20100901

• Serum interleukin-5 levels correlate with disease activity of Churg-Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid.

  Scandinavian journal of rheumatology 20100801

• Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.

  Bioorganic & medicinal chemistry 20100801

• Colloid formation by drugs in simulated intestinal fluid.

  Journal of medicinal chemistry 20100527

• Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.

  Glia 20100401

• Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.

  The Journal of pharmacology and experimental therapeutics 20100401

• Antileukotriene drugs in the treatment of asthma.

  Polskie Archiwum Medycyny Wewnetrznej 20100301

• Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva).

  European journal of pharmacology 20100225

• Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.

  BMC structural biology 20100101

• Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability.

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  Platelets 20100101

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  Allergy and asthma proceedings 20100101

• Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs.

  Biological & pharmaceutical bulletin 20100101

• Additional effects of pranlukast in salmeterol/fluticasone combination therapy for the asthmatic distal airway in a randomized crossover study.

  Pulmonary pharmacology & therapeutics 20091201

• Targeting leukotrienes for the treatment of COPD?

  Inflammation & allergy drug targets 20090901

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  Respirology (Carlton, Vic.) 20090801

• Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.

  Allergology international : official journal of the Japanese Society of Allergology 20090601

• Remodeling of nasal mucosa by allergen exposure in guinea pigs is suppressed by steroid and pranlukast.

  Rhinology 20090601

• In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes.

  Biological & pharmaceutical bulletin 20090401

• Molecular mechanism of the additive effects of leukotriene modifier in asthmatic patients receiving steroid therapy.

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• Pharmacological analysis of antigen-induced late airway response in rats.

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• Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation.

  Journal of cardiovascular pharmacology 20090101

• Cedar and cypress pollinosis and allergic rhinitis: quality of life effects of early intervention with leukotriene receptor antagonists.

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  Journal of investigational allergology & clinical immunology 20090101

• A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.

  Allergology international : official journal of the Japanese Society of Allergology 20081201

• Two pharmacological phases in antigen-induced immediate airway response in rats.

  Biological & pharmaceutical bulletin 20081201

• Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin.

  International journal of pharmaceutics 20080122

• Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production.

  American journal of physiology. Gastrointestinal and liver physiology 20080101

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• Correlations of health-related quality of life questionnaire results in asthma and allergic rhinitis: effects of a leukotriene receptor antagonist.

  The Journal of international medical research 20080101

• Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.

  Respiration; international review of thoracic diseases 20080101

• Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers.

  Drug metabolism and pharmacokinetics 20080101

• Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers.

  European journal of pharmacology 20071208

• Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats.

  Inflammopharmacology 20071201

• Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.

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  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

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  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

• Eosinophilic tumor in a patient with bronchial asthma receiving pranlukast.

  European journal of pediatrics 20070201

• Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice.

  The Journal of allergy and clinical immunology 20070101

• Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma.

  Arzneimittel-Forschung 20070101

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• Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, protects mice against brain cold injury.

  European journal of pharmacology 20061107

• Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

  The Journal of pharmacy and pharmacology 20061101

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  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20060701

• Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.

  Drug metabolism and pharmacokinetics 20060401

• Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice.

  Acta pharmacologica Sinica 20060301

• Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20060101

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  Biochemical pharmacology 20051219

• Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers.

  Prostaglandins & other lipid mediators 20051201

• Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast.

  Clinical rheumatology 20051101

• Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050901

• Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice.

  Brain research 20050816

• Effects of various anti-asthmatic agents on mite allergen-pulsed murine bone marrow-derived dendritic cells.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050701

• Delayed-type asthmatic response induced by repeated intratracheal exposure to toluene-2,4-diisocyanate in guinea pigs.

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• Effect of pet removal on pet allergic asthma.

  Chest 20050501

• ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.

  Acta pharmacologica Sinica 20050401

• Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells.

  Pharmacology 20050201

• Pranlukast, a leukotriene receptor antagonist, inhibits interleukin-5 production via a mechanism distinct from leukotriene receptor antagonism.

  International archives of allergy and immunology 20050201

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.

  Pharmacology 20050101

• Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils.

  International archives of allergy and immunology 20050101

• Evaluation of theophylline or pranlukast, a cysteinyl leukotriene receptor 1 antagonist, as add-on therapy in uncontrolled asthmatic patients with a medium dose of inhaled corticosteroids.

  Allergy and asthma proceedings 20050101

• A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung.

  Journal of immunology (Baltimore, Md. : 1950) 20041115

• Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.

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• Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs.

  Prostaglandins & other lipid mediators 20041001

• Urinary leukotriene E4 in Henoch-Schonlein purpura.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

• Pranlukast, a leukotriene receptor antagonist, prolongs the duration of the migrating motor complex in dogs.

  Digestive diseases and sciences 20040801

• Pranlukast regulates tumour growth by attenuating IL-4 production in Kimura disease.

  European journal of pediatrics 20040701

• Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma.

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• Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.

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  Xenobiotica; the fate of foreign compounds in biological systems 20040501

• The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma.

  American journal of respiratory and critical care medicine 20040415

• [Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• Long-term follow-up of pulmonary function in bronchial asthma patients treated with pranlukast.

  Lung 20040101

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• Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig.

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• Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats.

  Acta pharmacologica Sinica 20031201

• Churg-Strauss syndrome (CSS) in a patient receiving pranlukast.

  Clinical rheumatology 20031201

• Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.

  Journal of pharmacological sciences 20031201

• Leukotriene receptor antagonist pranlukast suppresses eosinophil infiltration and cytokine production in human nasal mucosa of perennial allergic rhinitis.

  The Annals of otology, rhinology, and laryngology 20031101

• Formation of fine drug particle by cogrinding with cyclodextrins. Part II. The influence of moisture condition during cogrinding process on fine particle formation.

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  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20031001

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  Annals of internal medicine 20030902

• gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.

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• Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells.

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  Arzneimittel-Forschung 20020101

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  The Journal of investigative dermatology 20010801

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  Molecular pharmacology 19990901

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