1045792-66-2 | CAY10603

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$53.00	$37.00
5mg	≥95%	in stock	$227.00	$159.00
10mg	≥95%	in stock	$417.00	$292.00
25mg	≥95%	in stock	$744.00	$521.00

Description

• Catalog Number: AD70132
• Chemical Name: CAY10603
• CAS Number: 1045792-66-2
• Molecular Formula: C22H30N4O6
• Molecular Weight: 446.4968
• MDL Number: MFCD17010286
• SMILES: ONC(=O)CCCCCCNC(=O)c1noc(c1)c1ccc(cc1)NC(=O)OC(C)(C)C

Computed Properties

• Complexity: 616
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 12
• XLogP3: 2.6

Literature

• An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

  The Journal of pharmacology and experimental therapeutics 20170101

• Development and therapeutic implications of selective histone deacetylase 6 inhibitors.

  Journal of medicinal chemistry 20130822

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Inhibitors selective for HDAC6 in enzymes and cells.

  Bioorganic & medicinal chemistry letters 20101201

• Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

  Journal of medicinal chemistry 20080814