10463-20-4 | 4-Hydroxy-3-nitrophenylacetic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$19.00	$13.00
5g	95%	in stock	$49.00	$34.00
25g	95%	in stock	$210.00	$147.00
100g	95%	in stock	$782.00	$547.00

Description

• Catalog Number: AB45023
• Chemical Name: 4-Hydroxy-3-nitrophenylacetic acid
• CAS Number: 10463-20-4
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.1449
• MDL Number: MFCD00007122
• SMILES: OC(=O)Cc1ccc(c(c1)[N+](=O)[O-])O

Computed Properties

• Complexity: 236
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 1.5

Literature

• Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts.

  European journal of immunology 20111201

• Characterization of memory B cells responsible for affinity maturation of anti- (4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies.

  International immunology 20110401

• IL-21 receptor is critical for the development of memory B cell responses.

  Journal of immunology (Baltimore, Md. : 1950) 20110115

• A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.

  PloS one 20110101

• Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20100715

• The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.

  European journal of immunology 20100701

• Augmented antibody response with premature germinal center regression in CD40L transgenic mice.

  Journal of immunology (Baltimore, Md. : 1950) 20100701

• A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.

  Journal of immunology (Baltimore, Md. : 1950) 20100701

• The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody.

  Molecular immunology 20100101

• Effects of antibody affinity and antigen valence on molecular forms of immune complexes.

  Molecular immunology 20091201

• Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry.

  Journal of clinical biochemistry and nutrition 20090101

• Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.

  Journal of immunology (Baltimore, Md. : 1950) 20081101

• Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate.

  Journal of bacteriology 20080901

• A role for DRAK2 in the germinal center reaction and the antibody response.

  Autoimmunity 20080801

• ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction.

  Journal of immunology (Baltimore, Md. : 1950) 20080215

• IgM-mediated signaling is required for the development of a normal B cell memory response.

  Molecular immunology 20080201

• Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infants.

  Neonatology 20080101

• Thymus-independent class switch recombination is affected by APRIL.

  Immunology and cell biology 20080101

• Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.

  Methods in enzymology 20080101

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens.

  Journal of immunology (Baltimore, Md. : 1950) 20070815

• Correction of age-associated deficiency in germinal center response by immunization with immune complexes.

  Clinical immunology (Orlando, Fla.) 20070801

• Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.

  European journal of immunology 20070601

• Analysis of antigen-stimulated B cell migration into germinal centers during the early stage of a T-dependent immune response.

  Immunology letters 20070315

• Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten.

  Molecular immunology 20070301

• Germinal-center-derived B-cell memory.

  Advances in experimental medicine and biology 20070101

• Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library.

  Journal of bioscience and bioengineering 20061101

• pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach.

  Free radical biology & medicine 20060915

• Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice.

  Journal of immunology (Baltimore, Md. : 1950) 20060815

• Re-evaluating the recycling hypothesis in the germinal centre.

  Immunology and cell biology 20060801

• Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 20060701

• Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060607

• Analysis of antigen-specific and naturally occurring IgM and IgA steady-state levels in J-chain negative C57BL/6 mice.

  Scandinavian journal of immunology 20060601

• Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation.

  Molecular immunology 20060401

• Biodegradation of 3-nitrotyrosine by Burkholderia sp. strain JS165 and Variovorax paradoxus JS171.

  Applied and environmental microbiology 20060201

• Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin.

  Journal of immunology (Baltimore, Md. : 1950) 20050615

• Quercetin-dependent inhibition of nitration induced by peroxidase/H2O2/nitrite systems in human saliva and characterization of an oxidation product of quercetin formed during the inhibition.

  Journal of agricultural and food chemistry 20050504

• Insulin-like growth factor-1 controls type 2 T cell-independent B cell response.

  Journal of immunology (Baltimore, Md. : 1950) 20050501

• Dynamic assessment of nitration reactions in vivo.

  Methods in enzymology 20050101

• Affinity maturation of secreted IgM pentamers on B cells.

  International immunology 20040501

• Rectification of age-related impairment in Ig gene hypermutation during a memory response.

  International immunology 20040401

• Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag.

  Immunology letters 20040329

• Segmental flexibility and avidity of IgM in the interaction of polyvalent antigens.

  Molecular immunology 20040101

• Analysis of the germinal center reaction and in vivo long-lived plasma cells.

  Methods in molecular biology (Clifton, N.J.) 20040101

• Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses.

  Journal of immunology (Baltimore, Md. : 1950) 20031201

• Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation.

  Journal of immunology (Baltimore, Md. : 1950) 20031115

• Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.

  The Biochemical journal 20030901

• Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center.

  International immunology 20030701

• Estimation of the relative affinity of B cell receptor by flow cytometry.

  Journal of immunological methods 20030501

• Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten.

  Molecular immunology 20030301

• Rapid development of Th2 activity during T cell priming.

  Clinical & developmental immunology 20030301

• Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.

  Journal of cardiovascular pharmacology 20030201

• B cell selection and affinity maturation during an antibody response in the mouse with limited B cell diversity.

  Journal of immunology (Baltimore, Md. : 1950) 20021215

• TRAIL/Apo-2 ligand induces primary plasma cell apoptosis.

  Journal of immunology (Baltimore, Md. : 1950) 20021115

• Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice.

  Journal of immunology (Baltimore, Md. : 1950) 20021101

• Expression of a 4-(hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo.

  Equine veterinary journal 20021101

• Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

  Journal of immunology (Baltimore, Md. : 1950) 20020915

• Altered affinity maturation in primary response to (4-hydroxy-3-nitrophenyl) acetyl (NP) after autologous reconstitution of irradiated C57BL/6 mice.

  Developmental immunology 20020901

• Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa.

  Journal of immunology (Baltimore, Md. : 1950) 20020715

• The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach.

  FEBS letters 20020508

• Role of antigen receptor affinity in T cell-independent antibody responses in vivo.

  Nature immunology 20020401

• [Exploring high affinity monoclonal antibodies for drug invention].

  Nihon rinsho. Japanese journal of clinical medicine 20020301

• The impact of H2-DM on humoral immune responses.

  Journal of immunology (Baltimore, Md. : 1950) 20011201

• Development and maintenance of a B220- memory B cell compartment.

  Journal of immunology (Baltimore, Md. : 1950) 20010801

• Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-Fc epsilon RI alpha-chain receptor antibody: implications for the involvement of the membrane-proximal alpha-chain region in Fc epsilon RI-mediated cell activation.

  Journal of immunology (Baltimore, Md. : 1950) 20010515

• Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications.

  Toxicology 20010307

• Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood.

  Mathematical biosciences 20010301

• The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance.

  Journal of immunology (Baltimore, Md. : 1950) 19980701

• Three-dimensional structures of the Fab fragment of murine N1G9 antibody from the primary immune response and of its complex with (4-hydroxy-3-nitrophenyl)acetate.

  Journal of molecular biology 19951124

• Murine lupus anti-DNA antibodies cross-react with the hapten (4-hydroxy-5-iodo-3-nitrophenyl)acetyl, but immunization-induced anti-DNA antibodies do not.

  European journal of immunology 19870401

• Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses.

  Journal of immunology (Baltimore, Md. : 1950) 19810801

• Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses.

  The Journal of experimental medicine 19801201

• Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.

  Journal of immunology (Baltimore, Md. : 1950) 19801001