105628-07-7 | Fasudil HCl

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$7.00	$5.00
100mg	98%	in stock	$17.00	$12.00
250mg	98%	in stock	$21.00	$15.00
1g	98%	in stock	$67.00	$47.00
5g	98%	in stock	$225.00	$157.00
25g	96%	in stock	$954.00	$668.00

Description

• Catalog Number: AI06782
• Chemical Name: Fasudil HCl
• CAS Number: 105628-07-7
• Molecular Formula: C14H17ClN3O2S
• Molecular Weight: 327.8296
• MDL Number: MFCD00943198
• SMILES: O=S(=O)(c1cccc2c1ccnc2)N1CCNCCC1.[Cl-].[H+]

Computed Properties

• Complexity: 421
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2

Literature

• Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice.

  Molecular vision 20150101

• Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.

  The Journal of surgical research 20121101

• Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.

  Hypertension (Dallas, Tex. : 1979) 20121101

• Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect.

  CNS neuroscience & therapeutics 20121101

• RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.

  Toxicology and industrial health 20121001

• Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.

  Cellular and molecular neurobiology 20121001

• Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.

  The Journal of pharmacology and experimental therapeutics 20121001

• A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.

  Neuroscience 20120918

• Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats.

  European journal of pharmacology 20120915

• Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.

  American journal of physiology. Endocrinology and metabolism 20120915

• Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20120901

• Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.

  European journal of pharmacology 20120815

• Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.

  European journal of applied physiology 20120801

• Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.

  Recent patents on cardiovascular drug discovery 20120801

• [Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801

• Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.

  Biochemical and biophysical research communications 20120727

• ROCK1 feedback regulation of the upstream small GTPase RhoA.

  Cellular signalling 20120701

• Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon.

  Arthritis care & research 20120601

• Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

• Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.

  Toxicology letters 20120601

• The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.

  Cancer chemotherapy and pharmacology 20120601

• Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.

  The American journal of pathology 20120601

• Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway.

  Stem cells and development 20120501

• Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.

  Oncology reports 20120501

• Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.

  Lupus 20120501

• Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.

  Atherosclerosis 20120501

• The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401

• Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.

  Journal of cellular physiology 20120301

• [Progress in pharmacotherapy of pulmonary arterial hypertension in children].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301

• Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.

  European journal of clinical pharmacology 20120201

• Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.

  Stroke 20120201

• Effects of fasudil in patients with high-altitude pulmonary hypertension.

  The European respiratory journal 20120201

• Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride.

  Neuroscience 20120103

• Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.

  Neuroradiology 20120101

• Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.

  Journal of hepatology 20120101

• Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats.

  Journal of atherosclerosis and thrombosis 20120101

• [Fasudil improves erectile function of hypertensive rats].

  Zhonghua nan ke xue = National journal of andrology 20120101

• Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.

  Cancer biology & therapy 20120101

• Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.

  BMC medicine 20120101

• High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.

  Cardiovascular diabetology 20120101

• Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.

  Swiss medical weekly 20120101

• ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.

  Cardiovascular diabetology 20120101

• Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

  International journal of molecular sciences 20120101

• Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.

  PloS one 20120101

• Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.

  Molecular and cellular biochemistry 20111201

• Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.

  American journal of physiology. Lung cellular and molecular physiology 20111201

• Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.

  The Journal of clinical endocrinology and metabolism 20111201

• Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.

  The Journal of surgical research 20111201

• Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201

• Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage.

  Genetics and molecular research : GMR 20111129

• Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

• Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

  American journal of physiology. Lung cellular and molecular physiology 20111101

• Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.

  Plastic and reconstructive surgery 20111101

• [Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].

  Nippon Ganka Gakkai zasshi 20111101

• [Fasudil(Rho-kinase inhibitor)].

  Nihon rinsho. Japanese journal of clinical medicine 20111101

• The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20111028

• Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.

  Journal of neurosurgery 20111001

• Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.

  Clinical and experimental pharmacology & physiology 20111001

• Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.

  Arteriosclerosis, thrombosis, and vascular biology 20111001

• Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.

  Chinese medical journal 20111001

• Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901

• The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.

  International journal of molecular medicine 20110901

• [Rho-kinase inhibitors].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901

• Rho kinase as a therapeutic target in cardiovascular disease.

  Future cardiology 20110901

• Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats.

  Die Pharmazie 20110901

• Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

  Biochemical and biophysical research communications 20110812

• Agonist-induced periodic vasomotion in rat isolated pulmonary artery.

  Fundamental & clinical pharmacology 20110801

• Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.

  The Journal of thoracic and cardiovascular surgery 20110801

• Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.

  International journal of molecular medicine 20110801

• Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.

  Arteriosclerosis, thrombosis, and vascular biology 20110801

• Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.

  Journal of the neurological sciences 20110715

• Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.

  American journal of physiology. Cell physiology 20110701

• Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.

  Journal of cellular biochemistry 20110701

• Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.

  The Journal of pharmacology and experimental therapeutics 20110701

• Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.

  The Journal of pharmacology and experimental therapeutics 20110701

• Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.

  Mycopathologia 20110701

• [The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].

  Zhonghua nei ke za zhi 20110701

• Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.

  Medical oncology (Northwood, London, England) 20110601

• The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.

  British journal of pharmacology 20110601

• Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.

  Cellular & molecular biology letters 20110601

• Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.

  Clinical and experimental pharmacology & physiology 20110601

• [Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601

• ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.

  Microvascular research 20110501

• Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid.

  International journal of cardiology 20110414

• Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.

  Journal of applied physiology (Bethesda, Md. : 1985) 20110401

• Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.

  Cellular and molecular neurobiology 20110301

• Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

  Bioorganic & medicinal chemistry letters 20110215

• Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.

  The journal of sexual medicine 20110201

• Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

  Kidney international 20110201

• Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.

  Brain research bulletin 20110201

• HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.

  Cancer science 20110201

• Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.

  Science signaling 20110125

• Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.

  Investigative ophthalmology & visual science 20110105

• Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.

  Life sciences 20110103

• Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.

  Pediatric pulmonology 20110101

• Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.

  Toxicology and applied pharmacology 20110101

• Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.

  Atherosclerosis 20110101

• Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.

  Urologia internationalis 20110101

• Rho kinase inhibition in diabetic nephropathy.

  Current opinion in nephrology and hypertension 20110101

• Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.

  Cellular immunology 20110101

• Advances in treatment of cerebral vasospasm: an update.

  Acta neurochirurgica. Supplement 20110101

• Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.

  Acta neurochirurgica. Supplement 20110101

• Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.

  Acta neurochirurgica. Supplement 20110101

• Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

  Neurology India 20110101

• Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

  Neurology India 20110101

• Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.

  International journal of molecular sciences 20110101

• Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101

• Vasodilatation produced by fasudil mesylate in vivo and in vitro.

  Vascular pharmacology 20110101

• Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.

  Renal failure 20110101

• Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

  PloS one 20110101

• Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.

  Renal failure 20110101

• Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.

  Neurologia medico-chirurgica 20110101

• Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.

  Biological & pharmaceutical bulletin 20110101

• Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20101201

• Urotensin II alters vascular reactivity in animals subjected to volume overload.

  Peptides 20101101

• Identification of small molecules enhancing autophagic function from drug network analysis.

  Autophagy 20101101

• [Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target].

  Nippon Ganka Gakkai zasshi 20101101

• [Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101

• Characterization of Fasudil in preclinical models of pain.

  The journal of pain : official journal of the American Pain Society 20101001

• Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.

  The European respiratory journal 20101001

• Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery.

  Journal of ethnopharmacology 20100915

• Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.

  The Journal of pharmacology and experimental therapeutics 20100901

• Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

  Hypertension research : official journal of the Japanese Society of Hypertension 20100901

• Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

  Journal of neurochemistry 20100901

• Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.

  Canadian journal of physiology and pharmacology 20100901

• NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.

  American journal of physiology. Heart and circulatory physiology 20100801

• Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.

  Brain research 20100716

• Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100701

• Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20100605

• Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.

  Neuropathology : official journal of the Japanese Society of Neuropathology 20100601

• Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.

  Journal of neuroscience research 20100601

• Modulation of cerebral malaria by fasudil and other immune-modifying compounds.

  Experimental parasitology 20100601

• Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.

  Cancer biology & therapy 20100601

• Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.

  Current opinion in critical care 20100401

• Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.

  Bone 20100401

• Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.

  British journal of pharmacology 20100401

• Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.

  Medical science monitor : international medical journal of experimental and clinical research 20100401

• Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.

  The Thoracic and cardiovascular surgeon 20100401

• Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.

  Stem cell reviews 20100301

• Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.

  Heart and vessels 20100301

• Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.

  Regulatory peptides 20100225

• Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.

  Neuroscience letters 20100205

• Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.

  Pediatric research 20100201

• Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.

  Molecular and cellular neurosciences 20100201

• The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201

• Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.

  Journal of vascular surgery 20100201

• Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.

  Brain research bulletin 20100115

• The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101

• Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.

  Arthritis and rheumatism 20100101

• Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

  Neurologia medico-chirurgica 20100101

• Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.

  Endocrine journal 20100101

• HA1077 enhances the cytokeratin expression of mesenchymal stem cells.

  Journal of burn care & research : official publication of the American Burn Association 20100101

• The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.

  Experimental diabetes research 20100101

• Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.

  Journal of Alzheimer's disease : JAD 20100101

• Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.

  Journal of biochemical and molecular toxicology 20100101

• Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.

  PloS one 20100101

• Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

  PloS one 20100101

• Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients.

  Atherosclerosis 20091201

• Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.

  International journal of urology : official journal of the Japanese Urological Association 20091201

• Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201

• Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.

  Canadian journal of physiology and pharmacology 20091201

• A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201

• Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.

  Neurochemistry international 20091101

• Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.

  Brain, behavior, and immunity 20091101

• Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice.

  Atherosclerosis 20091101

• Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.

  Prostaglandins & other lipid mediators 20091101

• Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.

  American journal of physiology. Heart and circulatory physiology 20091101

• Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.

  Brain research 20091027

• Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.

  Journal of viral hepatitis 20091001

• Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.

  Cardiovascular & hematological agents in medicinal chemistry 20091001

• [Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].

  Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901

• [Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro].

  Sheng li xue bao : [Acta physiologica Sinica] 20090825

• Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.

  Canadian journal of physiology and pharmacology 20090801

• Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.

  International journal of molecular medicine 20090701

• Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.

  The Journal of pharmacology and experimental therapeutics 20090501

• Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.

  American journal of physiology. Renal physiology 20090501

• Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.

  American journal of physiology. Heart and circulatory physiology 20090501

• Vascular dysfunction in septic shock--any ROCKing news?

  Critical care medicine 20090501

• Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease.

  Pediatric cardiology 20090401

• Rho GTPases in hepatocellular carcinoma.

  Biochimica et biophysica acta 20090401

• Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.

  Cellular and molecular neurobiology 20090301

• Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.

  Clinica chimica acta; international journal of clinical chemistry 20090301

• Increased leukocyte ROCK activity in patients after acute ischemic stroke.

  Brain research 20090227

• Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

  Circulation journal : official journal of the Japanese Circulation Society 20090201

• Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.

  Brain : a journal of neurology 20090201

• Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.

  Archives of pharmacal research 20090201

• Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.

  Ai zheng = Aizheng = Chinese journal of cancer 20090201

• Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.

  Biochemical pharmacology 20090115

• Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.

  European journal of pharmacology 20090114

• Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

  Diabetes 20090101

• Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

  American journal of physiology. Endocrinology and metabolism 20090101

• Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.

  Pharmacology 20090101

• In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.

  Neonatology 20090101

• The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.

  Current eye research 20090101

• Signaling through Rho GTPase pathway as viable drug target.

  Current medicinal chemistry 20090101

• Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.

  Surgery today 20090101

• Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.

  Cardiovascular diabetology 20090101

• RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.

  Journal of cardiac surgery 20090101

• Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.

  Current topics in medicinal chemistry 20090101

• A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.

  The Journal of thoracic and cardiovascular surgery 20081201

• A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.

  Journal of computer-aided molecular design 20081101

• Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.

  Arthritis and rheumatism 20081101

• Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.

  European journal of pharmacology 20081010

• Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.

  The Journal of pharmacology and experimental therapeutics 20081001

• Fasudil inhibits the myogenic response in the fetal pulmonary circulation.

  American journal of physiology. Heart and circulatory physiology 20081001

• [Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].

  No shinkei geka. Neurological surgery 20081001

• Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.

  Molecular and cellular endocrinology 20080910

• G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

  Cardiovascular research 20080901

• Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.

  British journal of pharmacology 20080901

• Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

  Journal of hypertension 20080901

• Chronic stable angina pectoris.

  Disease-a-month : DM 20080901

• Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.

  Cardiovascular drugs and therapy 20080801

• Activated RHOA and peripheral axon regeneration.

  Experimental neurology 20080801

• Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.

  The British journal of surgery 20080801

• Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.

  Anesthesia and analgesia 20080601

• Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

  Molecular cancer therapeutics 20080601

• Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.

  Neurologia medico-chirurgica 20080601

• Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.

  Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601

• Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.

  American journal of physiology. Lung cellular and molecular physiology 20080401

• Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401

• Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia.

  The Journal of infectious diseases 20080401

• Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.

  Brain research 20080327

• Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

  Diabetes 20080301

• Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.

  Hepatology (Baltimore, Md.) 20080301

• Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20080301

• Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.

  The American journal of pathology 20080301

• Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina.

  Coronary artery disease 20080301

• Rho kinase inhibition: a new approach for treating diabetic nephropathy?

  Diabetes 20080301

• Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.

  Journal of cardiovascular pharmacology 20080301

• Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.

  Brain research 20080208

• [Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].

  No shinkei geka. Neurological surgery 20080201

• Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.

  Journal of cardiovascular pharmacology 20080201

• Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.

  Journal of cardiovascular pharmacology 20080101

• Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.

  Japanese journal of ophthalmology 20080101

• In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.

  Methods in enzymology 20080101

• Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.

  American journal of physiology. Lung cellular and molecular physiology 20071101

• Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.

  Journal of neurochemistry 20071001

• Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20071001

• Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.

  Hypertension (Dallas, Tex. : 1979) 20071001

• [Advances in the study of Rho kinase and its inhibitors].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• [Exercise-induced vasospastic angina].

  Nihon rinsho. Japanese journal of clinical medicine 20070928

• Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.

  Life sciences 20070922

• Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.

  British journal of pharmacology 20070901

• Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.

  Spine 20070901

• Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.

  European journal of pharmacology 20070827

• Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.

  Journal of neuroscience research 20070815

• Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.

  Biochemical pharmacology 20070815

• The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

  Leukemia 20070801

• A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.

  Surgical neurology 20070801

• Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.

  Nature reviews. Drug discovery 20070801

• Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats.

  Journal of cardiovascular pharmacology 20070801

• Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.

  Journal of cardiovascular pharmacology 20070801

• [Effects of fasudil on neuropathic pain-like state in mice].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801

• The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

  European journal of pharmacology 20070730

• Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide.

  American journal of physiology. Heart and circulatory physiology 20070701

• Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

  Brain research 20070618

• Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

  American journal of physiology. Heart and circulatory physiology 20070601

• The RISK of ROCK.

  American journal of physiology. Heart and circulatory physiology 20070601

• Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

• Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.

  Journal of hypertension 20070501

• Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.

  Molecular cancer therapeutics 20070501

• Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

  Circulation 20070403

• Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.

  American journal of physiology. Heart and circulatory physiology 20070401

• Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.

  The Tohoku journal of experimental medicine 20070401

• Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401

• Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

  Circulation research 20070330

• RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.

  The Journal of biological chemistry 20070316

• Progress of the study of rho-kinase and future perspective of the inhibitor.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301

• A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.

  The Journal of endocrinology 20070301

• Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.

  Journal of cardiovascular pharmacology 20070301

• Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.

  Journal of the American College of Cardiology 20070213

• The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system.

  Plastic and reconstructive surgery 20070201

• Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.

  Journal of cardiovascular pharmacology 20070201

• Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

  Brain research 20070112

• Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.

  Chinese medical journal 20070105

• Design and synthesis of Rho kinase inhibitors (II).

  Bioorganic & medicinal chemistry 20070101

• Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

  Pharmacological research 20070101

• Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.

  Diabetes 20070101

• Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract.

  Journal of clinical pharmacology 20070101

• Fasudil: a potential addition to the anti-arthritis weaponry.

  Medical hypotheses 20070101

• Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.

  The Journal of veterinary medical science 20070101

• RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.

  Neurourology and urodynamics 20070101

• Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

  Japanese journal of ophthalmology 20070101

• Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.

  Circulation research 20061208

• Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.

  Cardiovascular research 20061201

• Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.

  Journal of cardiovascular pharmacology 20061201

• [Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201

• Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.

  American journal of physiology. Lung cellular and molecular physiology 20061101

• The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20061101

• Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.

  The journal of sexual medicine 20061101

• [Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101

• ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.

  Circulation research 20061013

• Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.

  Journal of the peripheral nervous system : JPNS 20060901

• [Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901

• The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.

  Molecular cancer therapeutics 20060901

• Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.

  Neurologia medico-chirurgica 20060901

• Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901

• Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.

  Experimental neurology 20060801

• Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.

  Journal of the American Society of Nephrology : JASN 20060801

• In vivo X-ray angiography in the mouse brain using synchrotron radiation.

  Stroke 20060701

• Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20060601

• Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.

  Journal of vascular surgery 20060601

• [Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].

  Zhonghua yi xue za zhi 20060516

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.

  Journal of leukocyte biology 20060501

• Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.

  Autonomic & autacoid pharmacology 20060401

• Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris.

  Circulation journal : official journal of the Japanese Circulation Society 20060401

• Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060301

• Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.

  Biological & pharmaceutical bulletin 20060301

• Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.

  Structure (London, England : 1993) 20060301

• Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.

  American journal of physiology. Lung cellular and molecular physiology 20060201

• Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension.

  Circulation journal : official journal of the Japanese Circulation Society 20060201

• Involvement of Rho-kinase in experimental vascular endothelial dysfunction.

  Molecular and cellular biochemistry 20060201

• The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.

  The Journal of biological chemistry 20060106

• Rho-kinase as a molecular target for insulin resistance and hypertension.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101

• Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.

  Journal of pharmacological sciences 20060101

• Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis.

  Journal of pharmacological sciences 20060101

• Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

  Protein and peptide letters 20060101

• Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats.

  Pharmacology 20060101

• Effect of fasudil on macrovascular disorder-induced endothelial dysfunction.

  Canadian journal of physiology and pharmacology 20060101

• Development of specific Rho-kinase inhibitors and their clinical application.

  Biochimica et biophysica acta 20051230

• Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.

  European journal of pharmacology 20051219

• Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.

  British journal of pharmacology 20051201

• Smoking, endothelial function, and Rho-kinase in humans.

  Arteriosclerosis, thrombosis, and vascular biology 20051201

• Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.

  Journal of the neurological sciences 20051115

• Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial.

  Journal of the American College of Cardiology 20051115

• Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.

  American journal of physiology. Heart and circulatory physiology 20051101

• Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.

  British journal of pharmacology 20051101

• Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

  Stroke 20051001

• [Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].

  No to shinkei = Brain and nerve 20050901

• Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.

  Liver international : official journal of the International Association for the Study of the Liver 20050801

• Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.

  Arteriosclerosis, thrombosis, and vascular biology 20050701

• Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.

  American journal of physiology. Heart and circulatory physiology 20050601

• Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.

  American journal of physiology. Heart and circulatory physiology 20050601

• Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.

  Circulation 20050531

• Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.

  Circulation 20050503

• Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

  European journal of pharmacology 20050411

• Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.

  European journal of pharmacology 20050411

• Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.

  Hypertension (Dallas, Tex. : 1979) 20050401

• Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

  American journal of respiratory and critical care medicine 20050301

• Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.

  Heart (British Cardiac Society) 20050301

• Small guanine nucleotide-binding protein Rho and myocardial function.

  Acta pharmacologica Sinica 20050301

• Rho-kinase and myosin II activities are required for cell type and environment specific migration.

  Genes to cells : devoted to molecular & cellular mechanisms 20050201

• [Intra-arterial administration of fasudil hydrochloride: duration of action].

  No shinkei geka. Neurological surgery 20050201

• [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].

  Zhonghua xin xue guan bing za zhi 20050101

• Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.

  Naunyn-Schmiedeberg's archives of pharmacology 20041101

• Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.

  British journal of pharmacology 20041001

• [Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].

  Journal of cardiology 20041001

• Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.

  European journal of pharmacology 20040913

• Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.

  Journal of hypertension 20040901

• Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

  Journal of cardiovascular pharmacology 20040901

• Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.

  Brain research 20040820

• [Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

• Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

  Circulation 20040511

• Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

• Rho kinase inhibition initiates apoptosis in human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20040301

• Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.

  American journal of physiology. Heart and circulatory physiology 20040301

• [Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].

  Nihon rinsho. Japanese journal of clinical medicine 20040301

• Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.

  Circulation research 20040220

• [Rho-kinase inhibitor].

  Nihon rinsho. Japanese journal of clinical medicine 20040201

• Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.

  Circulation research 20040109

• Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.

  Arteriosclerosis, thrombosis, and vascular biology 20040101

• Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.

  Journal of vascular surgery 20040101

• The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.

  Drug news & perspectives 20040101

• Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.

  Cell biochemistry and biophysics 20040101

• Rho kinase inhibitors block activation of pancreatic stellate cells.

  British journal of pharmacology 20031201

• Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.

  Kidney international 20031201

• Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

  Structure (London, England : 1993) 20031201

• Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.

  British journal of pharmacology 20031001

• Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.

  The Journal of biological chemistry 20030822

• Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.

  European journal of pharmacology 20030711

• Astrocyte stellation induced by Rho kinase inhibitors in culture.

  Brain research. Developmental brain research 20030612

• Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.

  Kidney international 20030601

• P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.

  Journal of immunology (Baltimore, Md. : 1950) 20030601

• Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.

  Hypertension (Dallas, Tex. : 1979) 20030501

• Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.

  Circulation research 20030418

• Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.

  Biochemical and biophysical research communications 20030411

• Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.

  Journal of enzyme inhibition and medicinal chemistry 20030401

• Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.

  The Journal of physiology 20030315

• Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.

  The Journal of physiology 20030201

• A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

  Brain research 20030103

• Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.

  Journal of the American College of Cardiology 20030101

• Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone.

  Journal of vascular research 20030101

• RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.

  British journal of pharmacology 20021201

• [Basic and clinical studies on coronary vasospasm].

  Masui. The Japanese journal of anesthesiology 20021201

• Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.

  European journal of pharmacology 20021129

• Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.

  Life sciences 20021122

• Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.

  Journal of cardiovascular pharmacology 20021101

• The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein.

  American journal of physiology. Heart and circulatory physiology 20021001

• Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho.

  Circulation research 20020906

• Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.

  Prostaglandins & other lipid mediators 20020901

• [Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].

  Fukuoka igaku zasshi = Hukuoka acta medica 20020801

• Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.

  Biochimica et biophysica acta 20020612

• Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.

  The Biochemical journal 20020601

• Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?

  Circulation 20020402

• Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.

  Circulation 20020402

• Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.

  Life sciences 20020322

• Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.

  Journal of cardiovascular pharmacology 20020301

• Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

  International journal of pharmaceutics 20020131

• The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway.

  Pharmacology & therapeutics 20020101

• Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.

  British journal of pharmacology 20011201

• Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.

  Hypertension (Dallas, Tex. : 1979) 20011201

• Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.

  Mediators of inflammation 20011201

• Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20011101

• Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.

  European journal of pharmacology 20010907

• Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.

  British journal of pharmacology 20010901

• Antiischemic properties of fasudil in experimental models of vasospastic angina.

  Japanese journal of pharmacology 20010901

• Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

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• Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.

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• Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.

  Journal of cellular physiology 20010701

• Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.

  Cardiovascular research 20010701

• Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701

• Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

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• Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.

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• Rho-associated kinase phosphorylates MARCKS in human neuronal cells.

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• Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.

  Journal of muscle research and cell motility 20010101

• Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm.

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• Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.

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• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  The Biochemical journal 20001001

• Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.

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• Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

  British journal of pharmacology 19891201