106-28-5 | (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$6.00	$4.00
5g	98%	in stock	$13.00	$9.00
10g	97%	in stock	$18.00	$13.00
25g	97%	in stock	$35.00	$25.00
100g	97%	in stock	$137.00	$96.00

Description

• Catalog Number: AB47167
• Chemical Name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol
• CAS Number: 106-28-5
• Molecular Formula: C15H26O
• Molecular Weight: 222.3663
• MDL Number: MFCD00002918
• SMILES: OC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C

Computed Properties

• Complexity: 265
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 4.8

Literature

• An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.

  Toxicology in vitro : an international journal published in association with BIBRA 20170401

• Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.

  Toxicology and applied pharmacology 20160401

• Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer.

  Investigational new drugs 20121201

• Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes.

  Veterinary microbiology 20121012

• Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production.

  Inflammation 20121001

• Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans.

  Eukaryotic cell 20121001

• A convergent stereocontrolled total synthesis of (-)-terpestacin.

  Organic & biomolecular chemistry 20120728

• HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.

  Blood 20120726

• Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

  Journal of proteomics 20120716

• Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism.

  Journal of applied microbiology 20120701

• Atorvastatin attenuates TNF-α-induced increase of glucose oxidation through PGC-1α upregulation in cardiomyocytes.

  Journal of cardiovascular pharmacology 20120601

• Miconazole, a pharmacological barrier to skin fungal infections.

  Expert opinion on pharmacotherapy 20120601

• Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton.

  Oncotarget 20120601

• Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells.

  Biochemical and biophysical research communications 20120504

• Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis.

  Medical mycology 20120501

• Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.

  Journal of natural products 20120427

• Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis.

  International journal of cancer 20120315

• Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis).

  Journal of experimental botany 20120301

• Terpene alcohols inhibit de novo sphingolipid biosynthesis.

  Planta medica 20120301

• Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition.

  Anticancer research 20120301

• FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice.

  Cell death & disease 20120301

• Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid.

  Digestive diseases and sciences 20120201

• Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol.

  Experimental lung research 20120201

• Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes.

  Oncotarget 20120201

• Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.

  Neuroscience 20120127

• Candida and invasive candidiasis: back to basics.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120101

• Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin.

  BMC research notes 20120101

• Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production.

  PloS one 20120101

• Functional characterization of the small heat shock protein Hsp12p from Candida albicans.

  PloS one 20120101

• Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin.

  Pediatric research 20111201

• Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals.

  Current opinion in microbiology 20111201

• Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii.

  FEMS yeast research 20111201

• [Analysis on the compositions of volatile oil of Alpinia henryi with GC-MS method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111201

• Hepatic FXR: key regulator of whole-body energy metabolism.

  Trends in endocrinology and metabolism: TEM 20111101

• Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

  American journal of physiology. Endocrinology and metabolism 20111101

• Zap1 control of cell-cell signaling in Candida albicans biofilms.

  Eukaryotic cell 20111101

• Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response.

  Eukaryotic cell 20111101

• Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans.

  Molecular microbiology 20111101

• Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release.

  Inflammation 20111001

• Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor.

  The Journal of investigative dermatology 20111001

• Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix.

  Current microbiology 20111001

• Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans.

  Biochemical Society transactions 20111001

• Quorum sensing in fungi: Q&A.

  PLoS pathogens 20111001

• Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum.

  Biochemistry 20110913

• Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans.

  Caries research 20110901

• Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies.

  Bioprocess and biosystems engineering 20110801

• Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling.

  Molecular cancer therapeutics 20110801

• Modulation of morphogenesis in Candida albicans by various small molecules.

  Eukaryotic cell 20110801

• The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans.

  Eukaryotic cell 20110801

• Roles for farnesol and ABA in Arabidopsis flower development.

  Plant signaling & behavior 20110801

• Effect of farnesol on mevalonate pathway of Staphylococcus aureus.

  The Journal of antibiotics 20110801

• A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801

• Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats.

  Chemico-biological interactions 20110715

• Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains.

  Mutation research 20110714

• The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity.

  Bioorganic & medicinal chemistry letters 20110701

• ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways.

  Biochemical and biophysical research communications 20110617

• Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis.

  The Plant journal : for cell and molecular biology 20110601

• Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol.

  Chemico-biological interactions 20110530

• Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster.

  General and comparative endocrinology 20110515

• Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity.

  Journal of medicinal chemistry 20110512

• Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms.

  International journal of oral science 20110401

• Drimenol: A versatile synthon for compounds with trans-drimane skeleton.

  Natural product communications 20110401

• Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro.

  The American journal of the medical sciences 20110301

• Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications.

  Journal of materials science. Materials in medicine 20110301

• Chemoprevention of hepatocellular carcinoma. Proof of concept in animal models.

  Acta gastro-enterologica Belgica 20110301

• Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.

  FEBS letters 20110204

• Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy.

  International journal of cancer 20110201

• In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I.

  Experimental parasitology 20110201

• Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20110201

• The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.

  Eukaryotic cell 20110201

• Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines.

  Acta oncologica (Stockholm, Sweden) 20110101

• Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro.

  Journal of pharmaceutical sciences 20110101

• Linking quorum sensing regulation and biofilm formation by Candida albicans.

  Methods in molecular biology (Clifton, N.J.) 20110101

• The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine.

  Biochimica et biophysica acta 20110101

• Alkynyl-farnesol reporters for detection of protein S-prenylation in cells.

  Molecular bioSystems 20110101

• The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.

  BMC biochemistry 20110101

• Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein.

  Bioscience, biotechnology, and biochemistry 20110101

• The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy.

  PloS one 20110101

• Ras inhibition induces insulin sensitivity and glucose uptake.

  PloS one 20110101

• Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans.

  PloS one 20110101

• Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione.

  PloS one 20110101

• The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice.

  Journal of neuroimmunology 20101215

• Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L.

  Immunopharmacology and immunotoxicology 20101201

• The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance.

  Fungal genetics and biology : FG & B 20101201

• Allergic contact dermatitis caused by farnesol: clinical relevance.

  Cutaneous and ocular toxicology 20101201

• Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

  Molecular microbiology 20101201

• Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.

  Biophysical journal 20101117

• Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection.

  Journal of chromatography. A 20101112

• Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins.

  The Journal of biological chemistry 20101105

• Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans.

  Journal of pharmaceutical and biomedical analysis 20101102

• In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line.

  Medical mycology 20101101

• Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis.

  Plant physiology 20101101

• Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis.

  Molecules (Basel, Switzerland) 20101029

• Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.

  Biotechnology and bioengineering 20101015

• Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line.

  FEMS immunology and medical microbiology 20101001

• Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains.

  Microbiology (Reading, England) 20101001

• The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species.

  Yeast (Chichester, England) 20100901

• Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase.

  Cell research 20100801

• 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic).

  Journal of chemical ecology 20100801

• Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.

  Molecular cancer therapeutics 20100801

• Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus.

  Molecular microbiology 20100601

• Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.

  American journal of physiology. Cell physiology 20100601

• Salirasib in the treatment of pancreatic cancer.

  Future oncology (London, England) 20100601

• Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc.

  International journal of cancer 20100515

• Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents.

  Bioorganic & medicinal chemistry 20100515

• Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway.

  Eukaryotic cell 20100401

• Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.

  Bioorganic & medicinal chemistry 20100401

• Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

  Chemico-biological interactions 20100330

• Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells.

  Biochemical pharmacology 20100301

• Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100201

• Molecular mechanisms involved in farnesol-induced apoptosis.

  Cancer letters 20100128

• Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.

  Oncogene 20100121

• The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat.

  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20100101

• Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering.

  Journal of biomedical materials research. Part A 20100101

• Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors.

  Cancer chemotherapy and pharmacology 20100101

• In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum.

  Mycologia 20100101

• Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition.

  Molecular cancer 20100101

• Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans.

  Future microbiology 20091201

• Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20091109

• The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study.

  The Journal of bone and joint surgery. American volume 20091101

• Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.

  Bulletin of experimental biology and medicine 20090901

• Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice.

  European journal of pharmacology 20090815

• Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis.

  Current microbiology 20090801

• Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.

  Cardiovascular research 20090801

• Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.

  Life sciences 20090731

• The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats.

  European journal of cancer (Oxford, England : 1990) 20090701

• Alkaline pH enhances farnesol production by Saccharomyces cerevisiae.

  Journal of bioscience and bioengineering 20090701

• A two-component female-produced pheromone of the spider Pholcus beijingensis.

  Journal of chemical ecology 20090701

• Novel farnesylthiosalicylate (FTS)-eluting composite structures.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628

• Farnesol-induced apoptosis in Candida albicans.

  Antimicrobial agents and chemotherapy 20090601

• Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress.

  Microbiology and immunology 20090601

• Ras inhibition attenuates myocardial ischemia-reperfusion injury.

  Biochemical pharmacology 20090515

• Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme.

  Proteomics 20090301

• Biofilm formation by Pneumocystis spp.

  Eukaryotic cell 20090201

• Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production.

  Cytokine 20090201

• New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models.

  Journal of medicinal chemistry 20090108

• Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli.

  Bioscience, biotechnology, and biochemistry 20090101

• Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis.

  Annals of clinical microbiology and antimicrobials 20090101

• Lipid signaling in pathogenic fungi.

  Annual review of microbiology 20090101

• Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography.

  Biotechnology progress 20090101

• [Biofilm caused by fungi--structure, quorum sensing, morphogenetic changes, resistance to drugs].

  Wiadomosci parazytologiczne 20090101

• Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms.

  Advances in dental research 20090101

• Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats.

  Acta cirurgica brasileira 20090101

• Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms.

  BMC microbiology 20090101

• Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus.

  Molecules (Basel, Switzerland) 20081209

• Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model.

  Journal of enzyme inhibition and medicinal chemistry 20081201

• [Quorum sensing in fungal pathogenesis].

  Nihon rinsho. Japanese journal of clinical medicine 20081201

• Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention.

  Chemico-biological interactions 20081125

• Fragrance material review on farnesol.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081101

• Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats.

  Molecular cancer therapeutics 20081101

• Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

  Molecular microbiology 20081001

• Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms.

  Applied microbiology and biotechnology 20080901

• Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells.

  Neoplasia (New York, N.Y.) 20080901

• Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols.

  Journal of bioscience and bioengineering 20080901

• Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency.

  Pediatric research 20080801

• Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma.

  Cancer investigation 20080801

• Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents.

  Infection control and hospital epidemiology 20080801

• Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride.

  Journal of pharmaceutical and biomedical analysis 20080715

• Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes.

  Lipids 20080701

• C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.

  Journal of natural products 20080701

• Protective effects of farnesol against oral candidiasis in mice.

  Microbiology and immunology 20080701

• Strategies to enhance the biological effects of fluoride on dental biofilms.

  Advances in dental research 20080701

• [Chemical constituents from the seed of Chimonanthus praecox extracted by supercritical carbon dioxide].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

• Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615

• NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.

  The Journal of biological chemistry 20080613

• The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

• Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction.

  Eukaryotic cell 20080601

• N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells.

  European journal of immunology 20080601

• Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans.

  Journal of medical microbiology 20080501

• Competition between native liver and graft in auxiliary liver transplantation in a rat model.

  Transplantation proceedings 20080501

• Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.

  The Journal of biological chemistry 20080411

• Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal.

  The Journal of organic chemistry 20080404

• The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells.

  Digestive diseases and sciences 20080401

• Activation of TRPA1 by farnesyl thiosalicylic acid.

  Molecular pharmacology 20080401

• Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis.

  Journal of chemical ecology 20080401

• Influence of farnesol on the morphogenesis of Aspergillus niger.

  Journal of basic microbiology 20080401

• Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface.

  Colloids and surfaces. B, Biointerfaces 20080315

• Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans.

  Bioorganic & medicinal chemistry 20080215

• Inhibition of Fusarium graminearum growth and development by farnesol.

  FEMS microbiology letters 20080201

• Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation.

  Breast cancer research and treatment 20080101

• Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats.

  Clinical science (London, England : 1979) 20080101

• Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice.

  Cancer chemotherapy and pharmacology 20080101

• Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis.

  Molecular microbiology 20080101

• Inhibitors of chronically active ras: potential for treatment of human malignancies.

  Recent patents on anti-cancer drug discovery 20080101

• The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.

  Methods in enzymology 20080101

• [Farnesol as a quorum-sensing molecule in Candida albicans].

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20080101

• Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro.

  Planta medica 20071001

• Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry.

  Journal of chromatography. A 20070921

• Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion.

  Cancer research 20070815

• Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response.

  Cancer research 20070815

• Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus.

  FEMS microbiology letters 20070801

• Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue.

  Yeast (Chichester, England) 20070801

• Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa.

  Molecular microbiology 20070801

• Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats.

  Journal of neurotrauma 20070801

• Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.

  The Plant journal : for cell and molecular biology 20070601

• The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes.

  Phytochemistry 20070601

• Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).

  Molecular cancer therapeutics 20070601

• The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.

  Cell death and differentiation 20070501

• The effect of terpene concentrations on the skin penetration of diclofenac sodium.

  International journal of pharmaceutics 20070420

• Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).

  Cancer research 20070401

• Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.

  The Journal of pharmacology and experimental therapeutics 20070301

• Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator.

  Genetics 20070301

• Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus.

  The Journal of antimicrobial chemotherapy 20070301

• In vivo and in vitro anaerobic mating in Candida albicans.

  Eukaryotic cell 20070301

• A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway.

  The Journal of biological chemistry 20070216

• Effect of farnesol on Candida dubliniensis morphogenesis.

  Letters in applied microbiology 20070201

• Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model.

  Infection control and hospital epidemiology 20070201

• Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.

  Journal of thrombosis and haemostasis : JTH 20070101

• Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells.

  Pharmacology 20070101

• 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070101

• Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells.

  Endothelium : journal of endothelial cell research 20070101

• Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20070101

• Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium.

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101

• Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe.

  Journal of biochemistry 20061201

• Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance.

  FEMS yeast research 20061101

• The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand.

  The FEBS journal 20061101

• Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design.

  Neurology 20061010

• Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.

  Molecular reproduction and development 20061001

• Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development.

  Eukaryotic cell 20061001

• The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

• Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride.

  International journal of hygiene and environmental health 20060901

• Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis.

  Molecular cancer therapeutics 20060901

• Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells.

  Biochemical pharmacology 20060814

• E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition.

  International journal of cancer 20060801

• Using non-mammalian hosts to study fungal virulence and host defense.

  Current opinion in microbiology 20060801

• In vitro synergistic effect of farnesol and human gingival cells against Candida albicans.

  Yeast (Chichester, England) 20060715

• Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase.

  Carcinogenesis 20060601

• Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro.

  Biomaterials 20060601

• Anticancer effects of zoledronic acid against human osteosarcoma cells.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601

• Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke.

  Bioorganic & medicinal chemistry 20060515

• Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA.

  Genetics 20060501

• Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats.

  Human & experimental toxicology 20060501

• Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells.

  Biochemical and biophysical research communications 20060428

• Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog.

  Archives of biochemistry and biophysics 20060415

• Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells.

  Cell death and differentiation 20060401

• Talking to themselves: autoregulation and quorum sensing in fungi.

  Eukaryotic cell 20060401

• Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens.

  Genome 20060401

• 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium.

  Journal of ethnopharmacology 20060220

• Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi.

  Molecular microbiology 20060201

• A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol.

  Applied biochemistry and biotechnology 20060201

• Farnesylthiosalicylic acid: inhibition of proliferation and enhancement of apoptosis of hormone-dependent breast cancer cells.

  Anti-cancer drugs 20060101

• Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory.

  The European journal of neuroscience 20060101

• Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.

  American journal of nephrology 20060101

• Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101

• Using inhibitors of prenylation to block localization and transforming activity.

  Methods in enzymology 20060101

• Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans.

  Journal of basic microbiology 20060101

• Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha).

  The Biochemical journal 20051215

• Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells.

  International journal of cancer 20051210

• Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation.

  Biochemical pharmacology 20051205

• Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis.

  The Journal of antimicrobial chemotherapy 20051201

• Inhibition of Ras attenuates the course of experimental autoimmune neuritis.

  Journal of neuroimmunology 20051101

• Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries.

  Journal of dental research 20051101

• Synthesis of farnesol isomers via a modified Wittig procedure.

  Organic letters 20051027

• Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction.

  The FEBS journal 20051001

• Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance.

  Eukaryotic cell 20051001

• Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol.

  Alcoholism, clinical and experimental research 20050901

• SMGA gels for the skin permeation of haloperidol.

  Journal of controlled release : official journal of the Controlled Release Society 20050818

• The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid.

  Kidney international 20050801

• The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans.

  Canadian journal of microbiology 20050801

• Effects of farnesol on the physical properties of DMPC membranes.

  Biochimica et biophysica acta 20050715

• Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth.

  Eukaryotic cell 20050701

• Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth.

  Eukaryotic cell 20050701

• Getting at MYC through RAS.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

• Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

• A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics.

  Journal of dermatological science 20050601

• A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin.

  Journal of dermatological science 20050601

• Biologically active fluorescent farnesol analogs.

  Chemistry & biology 20050601

• Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.

  The Journal of biological chemistry 20050422

• Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol.

  Chemico-biological interactions 20050415

• Phenotype switching affects biofilm formation by Candida parapsilosis.

  Microbiology (Reading, England) 20050401

• Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix.

  Contact dermatitis 20050401

• Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products.

  Contact dermatitis 20050401

• Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.

  The Biochemical journal 20050215

• Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.

  Cancer research 20050201

• Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract.

  Toxicology and applied pharmacology 20050115

• Lipid-mediated, reversible misfolding of a sterol-sensing domain protein.

  The EMBO journal 20050112

• Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex.

  Molecular endocrinology (Baltimore, Md.) 20050101

• Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies.

  Journal of the American Society of Nephrology : JASN 20050101

• Partial morphological and functional characterization of the corpus allatum-corpus cardiacum complex from the two-spotted stinkbug, Perillus bioculatus (Hemiptera: Pentatomidae).

  In vitro cellular & developmental biology. Animal 20050101

• Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes.

  Molecular membrane biology 20050101

• Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms.

  Immunobiology 20050101

• Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice.

  Redox report : communications in free radical research 20050101

• Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1.

  The Biochemical journal 20041215

• A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology.

  Molecular microbiology 20041201

• Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle.

  Insect biochemistry and molecular biology 20041101

• Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp.

  Organic letters 20041028

• Activated H-Ras regulates hematopoietic cell survival by modulating Survivin.

  Biochemical and biophysical research communications 20041015

• Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.

  The British journal of dermatology 20041001

• The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action.

  FEMS microbiology letters 20040815

• The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.

  Journal of neurochemistry 20040801

• Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid.

  Journal of hepatology 20040801

• The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans.

  Eukaryotic cell 20040801

• Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.

  The Journal of biological chemistry 20040716

• Omega-hydroxylation of farnesol by mammalian cytochromes p450.

  Biochimica et biophysica acta 20040601

• Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees.

  Chirality 20040505

• Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade.

  Biological & pharmaceutical bulletin 20040501

• Farnesol-DMPC phase behaviour: a (2)H-NMR study.

  Biochimica et biophysica acta 20040309

• The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro.

  The Prostate 20040301

• Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella.

  Journal of chemical ecology 20040301

• Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK.

  Contact dermatitis 20040301

• Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7.

  Biochemistry 20040224

• Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor.

  Cell death and differentiation 20040201

• Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.

  Developmental cell 20040201

• Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.

  Biochemical pharmacology 20040115

• Lipid metabolism in zebrafish.

  Methods in cell biology 20040101

• Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells.

  Cancer letters 20031230

• Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

  The Journal of biological chemistry 20031226

• Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.

  The Biochemical journal 20031201

• Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study.

  NeuroImage 20031201

• Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol.

  The Journal of antimicrobial chemotherapy 20031101

• New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp.

  Journal of natural products 20031101

• Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase.

  European journal of biochemistry 20031001

• Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis.

  Basic research in cardiology 20030901

• Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2.

  Journal of biological rhythms 20030801

• Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs.

  Chemistry & biology 20030801

• Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway.

  Cellular signalling 20030701

• Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701

• Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis.

  Lipids 20030701

• Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants.

  Analytical biochemistry 20030615

• The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain.

  Archives of biochemistry and biophysics 20030615

• Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells.

  International journal of cancer 20030610

• Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase.

  Insect biochemistry and molecular biology 20030601

• New approaches to the understanding of tamoxifen action and resistance.

  Endocrine-related cancer 20030601

• The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030601

• Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation.

  Cellular and molecular life sciences : CMLS 20030601

• The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels.

  Cell calcium 20030401

• Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis.

  Journal of the American Society of Nephrology : JASN 20030401

• Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe.

  Pest management science 20030401

• Farnesylamine from the ant Monomorium fieldi Forel.

  Journal of natural products 20030301

• Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients.

  The Journal of biological chemistry 20030221

• Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro.

  Calcified tissue international 20030201

• Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.

  Journal of lipid research 20030101

• Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo.

  The Journal of investigative dermatology 20030101

• Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome.

  Immunobiology 20030101

• Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20030101

• Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae).

  Experimental & applied acarology 20030101

• Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans.

  Acta biochimica Polonica 20030101

• The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage.

  Plant physiology 20021201

• Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats.

  Oral microbiology and immunology 20021201

• Antifeedant effects of marine halogenated monoterpenes.

  Journal of agricultural and food chemistry 20021120

• Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.

  The Journal of biological chemistry 20021101

• Evidence for Ras-dependent signal transduction in phenytoin teratogenicity.

  Toxicology and applied pharmacology 20021101

• Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery.

  Journal of the neurological sciences 20021015

• Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.

  Arthritis and rheumatism 20021001

• Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B.

  Chembiochem : a European journal of chemical biology 20020902

• African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol.

  Journal of natural products 20020901

• TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras.

  Journal of molecular and cellular cardiology 20020901

• Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis.

  The Journal of organic chemistry 20020809

• Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.

  Anti-cancer drugs 20020801

• Actions of farnesol and xylitol against Staphylococcus aureus.

  Chemotherapy 20020701

• Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice.

  Circulation 20020521

• Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes.

  Biochemical and biophysical research communications 20020426

• Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta.

  Peptides 20020401

• Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects.

  International journal of cancer 20020401

• Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.

  Bioorganic & medicinal chemistry letters 20020325

• A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway.

  Journal of the American Chemical Society 20020320

• Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells.

  FEBS letters 20020313

• Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes.

  FEBS letters 20020313

• The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020201

• Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells.

  Lipids 20020201

• Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

  Biochemical and biophysical research communications 20020111

• [Oleylamine (long-chain fatty amine)-induced cell death through MAP kinase pathways in human pancreatic cancer cells].

  [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20020101

• Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis.

  Biological research 20020101

• Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.

  Cancer detection and prevention 20020101

• Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention.

  Anticancer research 20020101

• Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS).

  Clinical and experimental immunology 20011201

• Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi.

  European journal of pharmacology 20011130

• The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis.

  Journal of neuroimmunology 20011101

• Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism.

  Metabolism: clinical and experimental 20011101

• Antimycobacterial plant terpenoids.

  Planta medica 20011101

• Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells.

  Biochemical and biophysical research communications 20011019

• (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids.

  Journal of natural products 20011001

• Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury.

  Biochemical and biophysical research communications 20010907

• Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens.

  Experimental eye research 20010801

• Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation.

  Plant & cell physiology 20010801

• Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis.

  The Journal of biological chemistry 20010706

• Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways.

  The Journal of biological chemistry 20010615

• Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets.

  The Journal of biological chemistry 20010511

• Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase.

  Biochemistry 20010403

• Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase.

  Insect biochemistry and molecular biology 20010201

• Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.

  The Journal of biological chemistry 20010126

• The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.

  Biochemical and biophysical research communications 20000402

• Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions.

  Proceedings of the National Academy of Sciences of the United States of America 19991109

• The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

  Cancer research 19981201

• Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.

  Biochemistry 19981124

• Dislodgment and accelerated degradation of Ras.

  Biochemistry 19980203

• Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study.

  Planta medica 19980201

• Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.

  Journal of lipid research 19971101

• Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells.

  Biochimica et biophysica acta 19971030

• Antifungal properties of essential oils and their main components upon Cryptococcus neoformans.

  Mycopathologia 19941201

• N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors.

  Journal of medicinal chemistry 19930514

• Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.

  Journal of medicinal chemistry 19930305

• The gamma subunit of transducin is farnesylated.

  Proceedings of the National Academy of Sciences of the United States of America 19901001

• Squalene synthetase.

  Molecular and cellular biochemistry 19791015

• Biodegradation of acyclic isoprenoids by Pseudomonas species.

  Journal of bacteriology 19780801