1063-77-0 | Nomilin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
10mg	98%	in stock	$45.00	$31.00
25mg	98%	in stock	$69.00	$48.00
50mg	98%	in stock	$116.00	$81.00
100mg	98%	in stock	$196.00	$137.00

Description

• Catalog Number: AD43227
• Chemical Name: Nomilin
• CAS Number: 1063-77-0
• Molecular Formula: C28H34O9
• Molecular Weight: 514.5642
• MDL Number: MFCD00075979
• SMILES: CC(=O)OC1CC(=O)OC(C2C1(C)C1CCC3(C4(C1(C(=O)C2)C)OC4C(=O)OC3c1ccoc1)C)(C)C

Computed Properties

• Complexity: 1080
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1
• XLogP3: 2.6

Upstream Synthesis Route

The compound ($name$) has demonstrated significant utility in chemical synthesis as a versatile building block. Its unique structural features, including a furanyl group and a trione moiety, enable it to participate in a variety of synthetic transformations. Specifically, the acetyloxy group provides a handle for selective functional group interconversions, while the trione scaffold offers potential sites for further derivatization through various chemoselective reactions. Furthermore, the complex bridged polycyclic structure of the molecule presents opportunities for the construction of diverse molecular architectures and the exploration of new synthetic methodologies. In the realm of chemical synthesis, ($name$) serves as a valuable tool for the creation of novel compounds with potential applications in pharmaceuticals, materials science, and other fields requiring the precise manipulation of molecular structures.

Literature

• Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet.

  Biochemical and biophysical research communications 20110708

• Antiviral activity of seed extract from Citrus bergamia towards human retroviruses.

  Bioorganic & medicinal chemistry 20110315

• Effect of Liberibacter infection (huanglongbing or 'greening' disease) of citrus on orange juice flavor quality by sensory evaluation.

  Journal of food science 20100501

• In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids.

  BMC complementary and alternative medicine 20100101

• Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside.

  Journal of agricultural and food chemistry 20060531

• Mass spectrometry and tandem mass spectrometry of citrus limonoids.

  Analytical chemistry 20031015

• Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells.

  Planta medica 20031001

• Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

• Electron ionization mass spectrometry of citrus limonoids.

  Rapid communications in mass spectrometry : RCM 20030101

• Citrus limonoids and their semisynthetic derivatives as antifeedant agents against Spodoptera frugiperda larvae. A structure-activity relationship study.

  Journal of agricultural and food chemistry 20021106

• Differential inhibition of human cancer cell proliferation by citrus limonoids.

  Nutrition and cancer 20010101

• Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes.

  Biochemical pharmacology 19910601