106685-40-9 | Adapalene

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$7.00	$5.00
250mg	99%	in stock	$13.00	$9.00
1g	99%	in stock	$37.00	$26.00
5g	99%	in stock	$150.00	$105.00
25g	99%	in stock	$506.00	$355.00

Description

• Catalog Number: AB50559
• Chemical Name: Adapalene
• CAS Number: 106685-40-9
• Molecular Formula: C28H28O3
• Molecular Weight: 412.5201
• MDL Number: MFCD03106112
• SMILES: COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

Computed Properties

• Complexity: 645
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 7.7

Literature

• Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling.

  Microbes and infection 20140201

• Successful treatment with adapalene of cetuximab-induced acneiform eruptions.

  The Journal of dermatology 20120901

• Digital videography assessment of patients' experiences using adapalene-benzoyl peroxide gel in the treatment of acne vulgaris.

  Journal of drugs in dermatology : JDD 20120801

• Randomized, observer-blind, split-face study to compare the irritation potential of 2 topical acne formulations over a 14-day treatment period.

  Cutis 20120801

• Effects of topical retinoid therapy on acne lesions: a psychometric assessment.

  Cutis 20120701

• Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris.

  The Journal of dermatological treatment 20120601

• Multicenter randomized controlled trial on combination therapy with 0.1% adapalene gel and oral antibiotics for acne vulgaris: comparison of the efficacy of adapalene gel alone and in combination with oral faropenem.

  The Journal of dermatology 20120601

• Effects of benzoyl peroxide 5% clindamycin combination gel versus adapalene 0.1% on quality of life in patients with mild to moderate acne vulgaris: a randomized single-blind study.

  Journal of drugs in dermatology : JDD 20120601

• Low intrinsic drug activity and dominant vehicle (placebo) effect in the topical treatment of acne vulgaris.

  International journal of clinical pharmacology and therapeutics 20120601

• The Tolerability Profile of Clindamycin 1%/Benzoyl Peroxide 5% Gel vs. Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel for Facial Acne: Results of Two Randomized, Single-Blind, Split-Face Studies.

  The Journal of clinical and aesthetic dermatology 20120501

• Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents.

  Clinical and experimental dermatology 20120301

• Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris.

  The Journal of dermatological treatment 20120201

• Clinical efficacy of adapalene (differin(®)) 0.3% gel in Chilean women with cutaneous photoaging.

  The Journal of dermatological treatment 20120201

• A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.

  The Journal of dermatological treatment 20120201

• Short-term combination therapy and long-term relapse prevention in the treatment of severe acne vulgaris.

  Journal of drugs in dermatology : JDD 20120201

• Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.

  Journal of medicinal chemistry 20120112

• Long-term engraftment of multipotent mesenchymal stromal cells that differentiate to form myogenic cells in dogs with Duchenne muscular dystrophy.

  Molecular therapy : the journal of the American Society of Gene Therapy 20120101

• Safe and successful treatment of acne vulgaris with isotretinoin in a patient with chronic granulomatous disease.

  Pediatric dermatology 20120101

• Contact dermatitis to the combination gel of adapalene 0.1% and benzoyl peroxide (PBO) 2.5%.

  European journal of dermatology : EJD 20120101

• The effect of reminder systems on patients' adherence to treatment.

  Patient preference and adherence 20120101

• Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4-bromophenol, a key intermediate of adapalene.

  Beilstein journal of organic chemistry 20120101

• Generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris.

  Indian journal of dermatology 20120101

• Fox-Fordyce disease: response to adapalene 0.1%.

  Anais brasileiros de dermatologia 20120101

• Roles of adapalene in the treatment of pityriasis versicolor.

  Dermatology (Basel, Switzerland) 20120101

• Double-blinded, vehicle-controlled proof of concept study to investigate the recurrence of inflammatory and noninflammatory acne lesions using tretinoin gel (microsphere) 0.04% in male patients after oral isotretinoin use.

  Dermatology research and practice 20120101

• Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

  Indian journal of dermatology 20120101

• The atypical retinoid E-3-(3'-Adamantan-1-yl-4'-methoxybiphenyl-4-yl)-2-propenoic acid (ST1898) displays comedolytic activity in the rhino mouse model.

  European journal of dermatology : EJD 20120101

• Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: a randomized, open label, active-controlled, multicentric, phase IV clinical trial.

  Indian journal of dermatology, venereology and leprology 20120101

• A comparison of the tolerability of adapalene 0.1% cream and adapalene 0.1% lotion in healthy individuals.

  Skinmed 20120101

• Assessing the bioequivalence of topical retinoid products by pharmacodynamic assay.

  Skin pharmacology and physiology 20120101

• Use of topical tretinoin and the development of noncutaneous adverse events: evidence from a systematic review of the literature.

  Journal of the American Academy of Dermatology 20111201

• Enriching and characterizing cancer stem cell sub-populations in the WM115 melanoma cell line.

  Biomaterials 20111201

• Adapalene 0.1%/benzoyl peroxide 2.5% gel: a review of its use in the treatment of acne vulgaris in patients aged ≥ 12 years.

  American journal of clinical dermatology 20111201

• Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: a randomized study.

  The Journal of dermatology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Mesenchymal stromal cells derived from CD271(+) bone marrow mononuclear cells exert potent allosuppressive properties.

  Cytotherapy 20111101

• Synergy and its clinical reievance in topical acne therapy.

  The Journal of clinical and aesthetic dermatology 20111101

• Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions.

  Experimental dermatology 20111001

• Newer approaches in topical combination therapy for acne.

  Skin therapy letter 20111001

• Low-cumulative dose isotretinoin treatment in mild-to-moderate acne: efficacy in achieving stable remission.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20110901

• [Treatment of rosacea].

  Annales de dermatologie et de venereologie 20110901

• Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients.

  The Journal of dermatological treatment 20110801

• Immediate intramyocardial bone marrow-derived mononuclear cells implantation in minipig myocardium after permanent coronary artery ligation: magnetic resonance imaging with histopathologic and immunochemical correlation.

  Investigative radiology 20110801

• Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study.

  The British journal of dermatology 20110801

• New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid.

  Bioorganic chemistry 20110801

• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

  Journal of medicinal chemistry 20110714

• Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.

  Journal of medicinal chemistry 20110609

• The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions.

  Journal of the American Academy of Dermatology 20110601

• A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial.

  The British journal of dermatology 20110601

• Maintenance therapy: acne as a chronic disease.

  The British journal of dermatology 20110601

• Evidence-based review: fixed-combination therapy and topical retinoids in the treatment of acne.

  Journal of drugs in dermatology : JDD 20110601

• Analysis of cell characterization using cell surface markers in the dermis.

  Journal of dermatological science 20110501

• In-vivo Effectiveness of Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel on Antibiotic-sensitive and Resistant Propionibacterium acnes.

  The Journal of clinical and aesthetic dermatology 20110501

• A randomized controlled pilot study of strategies to increase adherence in teenagers with acne vulgaris.

  Journal of the American Academy of Dermatology 20110401

• Effect of adapalene on cetuximab-induced painful periungual inflammation.

  Journal of the American Academy of Dermatology 20110201

• Local treatment of acne.

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110107

• Successful treatment of Darier's disease with adapalene gel.

  Pediatric dermatology 20110101

• Acne vulgaris.

  BMJ clinical evidence 20110101

• Acne vulgaris treatment : the current scenario.

  Indian journal of dermatology 20110101

• Management strategies for acne vulgaris.

  Clinical, cosmetic and investigational dermatology 20110101

• Evaluation of LHP® (1% hydrogen peroxide) cream versus petrolatum and untreated controls in open wounds in healthy horses: a randomized, blinded control study.

  Acta veterinaria Scandinavica 20110101

• Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene.

  Case reports in dermatology 20110101

• Retinoid plus antimicrobial combination treatments for acne.

  Clinical, cosmetic and investigational dermatology 20110101

• A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.

  European journal of dermatology : EJD 20110101

• A simple HPLC-DAD method for determination of adapalene in topical gel formulation.

  Journal of chromatographic science 20110101

• Plantar warts treated with topical adapalene.

  Indian journal of dermatology 20110101

• Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized.

  Cancer cell 20101116

• Treatment of 2,453 acne vulgaris patients aged 12-17 years with the fixed-dose adapalene-benzoyl peroxide combination topical gel: efficacy and safety.

  Journal of drugs in dermatology : JDD 20101101

• [Retinoids: mechanisms of action].

  Annales de dermatologie et de venereologie 20101101

• Basic study of retinal stem/progenitor cell separation from mouse iris tissue.

  Medical molecular morphology 20100901

• The Expression of Toll-like Receptors in Dermatological Diseases and the Therapeutic Effect of Current and Newer Topical Toll-like Receptor Modulators.

  The Journal of clinical and aesthetic dermatology 20100901

• Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel.

  Journal of drugs in dermatology : JDD 20100801

• A Meta-analysis to Investigate the Relation Between Fitzpatrick Skin Types and Tolerability of Adapalene-Benzoyl Peroxide Topical Gel in Subjects with Mild or Moderate Acne.

  The Journal of clinical and aesthetic dermatology 20100801

• Adapalene 0.1% lotion in the treatment of acne vulgaris: results from two placebo-controlled, multicenter, randomized double-blind, clinical studies.

  Journal of drugs in dermatology : JDD 20100601

• Randomized comparison of the safety and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris.

  Journal of drugs in dermatology : JDD 20100501

• [Topical retinoids in acne--an evidence-based overview].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20100301

• Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg.

  Cutis 20100201

• Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study.

  Journal of drugs in dermatology : JDD 20100101

• The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans.

  PloS one 20100101

• Darier disease: beware the cyst that smells.

  Ophthalmic plastic and reconstructive surgery 20100101

• Problems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris.

  Trials 20100101

• Community study of fixed-combination adapalene 0.1% and benzoyl peroxide 2.5% in acne.

  Skinmed 20100101

• MSCA-1/TNAP selection of human jaw periosteal cells improves their mineralization capacity.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Spotlight on adapalene.

  Expert opinion on drug metabolism & toxicology 20091201

• Efficacy, safety, and tolerability of microsphere adapalene vs. conventional adapalene for acne vulgaris.

  International journal of dermatology 20091201

• Methyl 1-bromo-2-naphthoate.

  Acta crystallographica. Section E, Structure reports online 20091201

• Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients.

  The British journal of dermatology 20091101

• Benzoyl peroxide and adapalene fixed combination: a novel agent for acne.

  The British journal of dermatology 20091101

• Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris.

  Cutis 20091001

• A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne.

  Cutis 20090801

• Adamantane-1-thio-amide.

  Acta crystallographica. Section E, Structure reports online 20090801

• [Pharmacological and clinical profiles of adapalene (Differin) gel 0.1%].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20090701

• Laser and other light therapies for the treatment of acne vulgaris: systematic review.

  The British journal of dermatology 20090601

• Adapalene-benzoyl peroxide (Epiduo) for acne.

  The Medical letter on drugs and therapeutics 20090420

• Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel.

  Journal of drugs in dermatology : JDD 20090401

• Prospective, open-label, comparative study of clindamycin 1%/benzoyl peroxide 5% gel with adapalene 0.1% gel in Asian acne patients: efficacy and tolerability.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20090301

• Successful treatment of linear Darier's disease with topical adapalene.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20090201

• Changing the face of acne therapy.

  Cutis 20090201

• Adapalene 0.1% and benzoyl peroxide 2.5%: a novel combination for treatment of acne vulgaris.

  Skin therapy letter 20090101

• Adapalene gel 0.1% is better tolerated than tretinoin gel 0.025% among healthy volunteers of various ethnic origins.

  The Journal of dermatological treatment 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.

  Indian journal of dermatology 20090101

• Generalized eruptive syringomas.

  Indian journal of dermatology 20090101

• Topical treatment of melasma.

  Indian journal of dermatology 20090101

• An update on the management of acne vulgaris.

  Clinical, cosmetic and investigational dermatology 20090101

• Topical retinoids in acne--an evidence-based overview.

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20081201

• Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse.

  Veterinary dermatology 20081201

• Treatment-seeking behaviors and related epidemiological features in Korean acne patients.

  Journal of Korean medical science 20081201

• Retinoids, 585-nm laser, and carbon dioxide laser: a numeric comparison of neocollagen formation in photoaged hairless mouse skin.

  Aesthetic plastic surgery 20081101

• A review of adapalene in the treatment of acne vulgaris.

  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 20081101

• Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.

  Journal of medicinal chemistry 20080925

• [Simultaneous determination of adapalene, 2-phenoxyethanol and methyl-4-hydroxybenzoate in adapalene gels using high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20080901

• Cumulative irritation potential of topical retinoid formulations.

  Journal of drugs in dermatology : JDD 20080801

• 2-(1-Adamant-yl)-4-bromo-anisole at 123 K.

  Acta crystallographica. Section E, Structure reports online 20080701

• Benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne.

  Journal of drugs in dermatology : JDD 20080601

• Intracranial hypertension in a patient using topical adapalene.

  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20080601

• Journal of Drugs in Dermatology: New methods and Techniques. Managing acne with adapalene 0.1% and 0.3% gels. Introduction.

  Journal of drugs in dermatology : JDD 20080601

• Efficacy and tolerability of adapalene 0.3% gel compared to tazarotene 0.1% gel in the treatment of acne vulgaris.

  Journal of drugs in dermatology : JDD 20080601

• Is switching retinoids a sound strategy for the treatment of acne vulgaris?

  Journal of drugs in dermatology : JDD 20080601

• Adapalene 0.1% gel compared to tazarotene 0.1% cream in the treatment of acne vulgaris.

  Journal of drugs in dermatology : JDD 20080601

• Long-term safety and efficacy study of adapalene 0.3% gel.

  Journal of drugs in dermatology : JDD 20080601

• [A fixed combination of adapalene and benzoyl peroxide simplifies acne therapy].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20080501

• Adapalene gel 0.1% is effective and safe for Japanese patients with acne vulgaris: a randomized, multicenter, investigator-blinded, controlled study.

  Journal of dermatological science 20080301

• Drug treatments for skin disease introduced in 2007.

  Skin therapy letter 20080301

• Adapalene-benzoyl peroxide once-daily, fixed-dose combination gel for the treatment of acne vulgaris: a randomized, bilateral (split-face), dose-assessment study of cutaneous tolerability in healthy participants.

  Cutis 20080301

• Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug.

  Pharmaceutical research 20080201

• In vivo methods for the assessment of topical drug bioavailability.

  Pharmaceutical research 20080101

• A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris.

  The British journal of dermatology 20080101

• Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.

  Indian journal of dermatology, venereology and leprology 20080101

• Adapalene gel 0.1% in the treatment of infantile acne: an open clinical study.

  Pediatric dermatology 20080101

• Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy.

  European journal of dermatology : EJD 20080101

• Topical retinoids in acne vulgaris: update on efficacy and safety.

  American journal of clinical dermatology 20080101

• Adventage of mesenchymal stem cells (MSC) expansion directly from purified bone marrow CD105+ and CD271+ cells.

  Folia histochemica et cytobiologica 20080101

• Prescription refills and healthcare costs associated with topical metronidazole in Medicaid enrolled patients with rosacea.

  The Journal of dermatological treatment 20080101

• Acne vulgaris.

  BMJ clinical evidence 20080101

• Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study.

  Archives of dermatological research 20071201

• Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study.

  Journal of the American Academy of Dermatology 20071101

• Long-term safety and efficacy of a unique fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2.5% for the treatment of acne vulgaris.

  Journal of drugs in dermatology : JDD 20070901

• A review of the use of adapalene for the treatment of acne vulgaris.

  Therapeutics and clinical risk management 20070801

• Treatment of molluscum contagiosum: a brief review and discussion of a case successfully treated with adapelene.

  Dermatology online journal 20070713

• Control of microcomedone formation throughout a maintenance treatment with adapalene gel, 0.1%.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20070701

• Community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne.

  Cutis 20070701

• Utilizing combination therapy for ethnic skin.

  Cutis 20070701

• Novel markers for the prospective isolation of human MSC.

  Annals of the New York Academy of Sciences 20070601

• In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.

  Experimental dermatology 20070601

• Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris.

  Journal of drugs in dermatology : JDD 20070601

• Tolerability comparison of adapalene gel, 0.3% versus tazarotene cream, 0.05% in subjects with healthy skin.

  Journal of drugs in dermatology : JDD 20070601

• Acneiform eruptions associated with epidermal growth factor receptor-targeted chemotherapy.

  Journal of the American Academy of Dermatology 20070301

• Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20070301

• Isolation and characterisation of impurities in adapalene.

  Journal of pharmaceutical and biomedical analysis 20070219

• Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma.

  The Journal of dermatology 20070101

• Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline.

  European journal of dermatology : EJD 20070101

• Clinical and microbiological comparisons of isotretinoin vs. tetracycline in acne vulgaris.

  Acta dermato-venereologica 20070101

• Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies.

  Indian journal of dermatology, venereology and leprology 20070101

• Differin (adapalene) Gel, 0.3%.

  Skinmed 20070101

• Isolation and characterization of mesenchymal cells from human fetal membranes.

  Journal of tissue engineering and regenerative medicine 20070101

• Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.

  Clinical interventions in aging 20061201

• Schools of pharmacology: retinoid update.

  Journal of drugs in dermatology : JDD 20061001

• Treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies.

  Journal of drugs in dermatology : JDD 20060901

• Defining criteria used to evaluate response to treatment of acne vulgaris.

  Cutis 20060801

• Combination topical therapy in the treatment of acne.

  Cutis 20060801

• Combining clindamycin 1%-benzoyl peroxide 5% gel with multiple therapeutic options.

  Cutis 20060801

• The results of the MORE trial: overview.

  Cutis 20060701

• The MORE trial: effectiveness of adapalene gel 0.1% in real-world dermatology practices.

  Cutis 20060701

• Safety and tolerability in the MORE trial.

  Cutis 20060701

• Subject preferences for acne treatments containing adapalene gel 0.1%: results of the MORE trial.

  Cutis 20060701

• Acne vulgaris.

  Clinical evidence 20060601

• Treatment of solar lentigines.

  Journal of the American Academy of Dermatology 20060501

• Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study.

  Archives of dermatology 20060501

• Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial.

  Journal of the American Academy of Dermatology 20060201

• The potential risks of nanomaterials: a review carried out for ECETOC.

  Particle and fibre toxicology 20060101

• Cumulative irritancy comparison of topical retinoid and antimicrobial combination therapies.

  Skinmed 20060101

• Retinoid therapy of pigmentary disorders.

  Dermatologic therapy 20060101

• Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats.

  Clinical and experimental dermatology 20050901

• [Rosacea. Clinical features, pathogenesis and therapy].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20050901

• The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: A randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle.

  Cutis 20050801

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Topical retinoids during pregnancy (continued).

  Prescrire international 20050601

• Acne vulgaris.

  Clinical evidence 20050601

• Cumulative irritation potential of adapalene 0.1% cream and gel compared with tazarotene cream 0.05% and 0.1%.

  Cutis 20050501

• Drugs. Adapalene.

  Nursing times 20050401

• Cumulative irritation potential of adapalene 0.1% cream and gel compared with tretinoin microsphere 0.04% and 0.1%.

  Cutis 20050401

• The potential immunomodulatory effects of topical retinoids.

  Dermatology online journal 20050301

• Milia en plaque.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20050301

• Adapalene vs. metronidazole gel for the treatment of rosacea.

  International journal of dermatology 20050301

• Benzoyl peroxide, adapalene, and their combination in the treatment of acne vulgaris.

  The Journal of dermatology 20050301

• Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment.

  Clinical therapeutics 20050201

• Fox fordyce disease in a prepubertal girl.

  Pediatric dermatology 20050101

• Retinoid therapy for acne. A comparative review.

  American journal of clinical dermatology 20050101

• Mechanisms of the comedolytic and anti-inflammatory properties of topical retinoids.

  Journal of drugs in dermatology : JDD 20050101

• Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study.

  Journal of drugs in dermatology : JDD 20050101

• Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination.

  Journal of drugs in dermatology : JDD 20050101

• Prescribing patterns for topical retinoids within NAMCS data.

  Journal of drugs in dermatology : JDD 20050101

• Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study.

  Skinmed 20050101

• Mechanism-based treatment of acne vulgaris: the value of combination therapy.

  Journal of drugs in dermatology : JDD 20050101

• Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria.

  Health and quality of life outcomes 20050101

• Comedolytic effect of a novel RARgamma-specific retinoid, ER36009: comparison with retinoic acid in the rhino mouse model.

  European journal of dermatology : EJD 20050101

• Pseudoacne of the nasal crease in a patient with congenital deafness and pigmentary mosaicism.

  Pediatric dermatology 20050101

• A successful maintenance approach in inflammatory acne with adapalene gel 0.1% after an initial treatment in combination with clindamycin topical solution 1% or after monotherapy with clindamycin topical solution 1%.

  The Journal of dermatological treatment 20041201

• Topical retinoids in the management of acne: the best path to clear results.

  Cutis 20041001

• Meta-analysis of topical tazarotene in the treatment of mild to moderate acne.

  Cutis 20041001

• Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial.

  The British journal of dermatology 20040801

• Topical tretinoin or adapalene in acne vulgaris: an overview.

  The Journal of dermatological treatment 20040701

• Potentiated anticancer effects on hepatoma cells by the retinoid adapalene.

  Cancer letters 20040510

• [The clinical observation of treating acne vulgaris with 'xiao cuo fang'].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040401

• An unusual late onset closed-comedone naevus: successful therapy with light cautery and a topical retinoid.

  The Journal of dermatological treatment 20040101

• Adapalene: a review of its use in the treatment of acne vulgaris.

  Drugs 20040101

• Phototoxic effects of topical azelaic acid, benzoyl peroxide and adapalene were not detected when applied immediately before UVB to normal skin.

  European journal of dermatology : EJD 20040101

• Topical agents used in the management of hyperpigmentation.

  Skin therapy letter 20040101

• Spotlight on adapalene in acne vulgaris.

  American journal of clinical dermatology 20040101

• Comparison of topical retinoids in the treatment of acne.

  Clinics in dermatology 20040101

• Facial tolerability of topical retinoid therapy.

  Journal of drugs in dermatology : JDD 20040101

• Cumulative irritancy potential of adapalene cream 0.1% compared with adapalene gel 0.1% and several tretinoin formulations.

  Cutis 20031201

• The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.

  International journal of cancer 20031110

• Clinical review: topical retinoids.

  Dermatology nursing 20031001

• A review of the use of combination therapies for the treatment of acne vulgaris.

  Journal of the American Academy of Dermatology 20030901

• Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study.

  Journal of the American Academy of Dermatology 20030901

• Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? A comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%, versus lymecycline plus gel vehicle.

  Journal of the American Academy of Dermatology 20030901

• Cumulative irritancy comparison of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents.

  Journal of the American Academy of Dermatology 20030901

• Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks.

  The Journal of dermatological treatment 20030901

• Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial.

  Journal of the American Academy of Dermatology 20030701

• Cumulative irritation comparison of adapalene gel and solution with 2 tazarotene gels and 3 tretinoin formulations.

  Cutis 20030701

• Retinoids: fascinating up-and-coming scenario.

  The Journal of dermatology 20030501

• 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?

  Biochemical and biophysical research communications 20030328

• Management of acne.

  The Journal of family practice 20030101

• The rationale for using a topical retinoid for inflammatory acne.

  American journal of clinical dermatology 20030101

• Topical treatment in acne: current status and future aspects.

  Dermatology (Basel, Switzerland) 20030101

• Optimizing treatment with topical tazarotene.

  American journal of clinical dermatology 20030101

• Current concepts of the pathogenesis of acne: implications for drug treatment.

  Drugs 20030101

• Axillary granular parakeratosis.

  Journal of cutaneous medicine and surgery 20030101

• Safety and efficacy of adapalene gel 0.1% in acne vulgaris: results of a post-marketing surveillance study.

  Indian journal of dermatology, venereology and leprology 20030101

• Prospective study of depressive symptoms and quality of life in acne vulgaris patients treated with isotretinoin compared to antibiotic and topical therapy.

  The Australasian journal of dermatology 20021101

• Efficacy and cutaneous safety of adapalene in black patients versus white patients with acne vulgaris.

  Cutis 20021001

• Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial.

  The British journal of dermatology 20020901

• Adapalene in the treatment of melasma: a preliminary report.

  The Journal of dermatology 20020801

• Perioral dermatitis successfully treated with topical adapalene.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20020301

• A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris.

  Cutis 20020201

• Comparison of the effects of tretinoin, adapalene and collagenase in an experimental model of wound healing.

  European journal of dermatology : EJD 20020101

• Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20020101

• Randomised, controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream 0.05% in patients with acne vulgaris.

  European journal of dermatology : EJD 20020101

• Potential anti-inflammatory effects of topical retinoids and retinoid analogues.

  Advances in therapy 20020101

• Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

  Cutis 20011001

• Randomized, controlled, bilateral (split-face) comparison trial of the tolerability and patient preference of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

  Cutis 20011001

• Polarized light photography and videomicroscopy greatly enhance the capability of estimating the therapeuic response to a topical retinoid (adapalene) in acne vulgaris.

  Cutis 20011001

• Efficacy and tolerance of adapalene cream 0.1% compared with its cream vehicle for the treatment of acne vulgaris.

  Cutis 20011001

• Adapalene gel 0.1% is effective and well tolerated in acne patients in a dermatology practice setting.

  Cutis 20011001

• Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients.

  Cutis 20011001

• Adapalene gel 0.1%: effective and well tolerated in the topical treatment of acne vulgaris in Chinese patients.

  Cutis 20011001

• Adapalene in clinical practice.

  Cutis 20011001

• Developments in topical retinoid therapy for acne.

  Seminars in cutaneous medicine and surgery 20010901

• A comparative trial of two retinoids commonly used in the treatment of acne vulgaris.

  The Journal of dermatological treatment 20010901

• Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents.

  The British journal of dermatology 20010701

• Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Comparison of treatment of acne vulgaris with alternate-day applications of tazarotene 0.1% gel and once-daily applications of adapalene 0.1% gel: a randomized trial.

  Cutis 20010601

• Randomized facial tolerability studies comparing gel formulations of retinoids used to treat acne vulgaris.

  Cutis 20010601

• Are 2 combined antimicrobial mechanisms better than 1 for the treatment of acne vulgaris? Clinical and antimicrobial results of a topical combination product containing 1% clindamycin and 5% benzoyl peroxide. Introduction.

  Cutis 20010201

• Comparison of the cumulative irritation potential of adapalene gel and cream with that of erythromycin/tretinoin solution and gel and erythromycin/isotretinoin gel.

  Clinical therapeutics 20010201

• Acral Darier's disease successfully treated with adapalene.

  Acta dermato-venereologica 20010101

• The modern age of acne therapy: a review of current treatment options.

  The Mount Sinai journal of medicine, New York 20010101

• Retinoids--which dermatological indications will benefit in the near future?

  Skin pharmacology and applied skin physiology 20010101

• Current perspectives on the treatment of acne vulgaris and implications for future directions.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• New photographic techniques for clinical evaluation of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Pivotal clinical trials of adapalene in the treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• An update of recent clinical trials examining adapalene and acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Adapalene in the treatment of African patients.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• The integral role of topical and oral retinoids in the early treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.

  Journal of lower genital tract disease 20010101

• The role of specific retinoid receptors in sebocyte growth and differentiation in culture.

  The Journal of investigative dermatology 20000201

• Pharmacology of adapalene.

  The British journal of dermatology 19981001

• Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers.

  The British journal of dermatology 19981001

• A new concept of drug delivery for acne.

  Dermatology (Basel, Switzerland) 19980101

• Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.

  Journal of medicinal chemistry 19951222

• Comparison of CD271 (adapalene) and all-trans retinoic acid in human skin: dissociation of epidermal effects and CRABP-II mRNA expression.

  The Journal of investigative dermatology 19930901