1072944-53-6 | 5-Amino-8-trifluoromethoxyquinoline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$137.00	$96.00
5g	98%	in stock	$386.00	$270.00
10g	98%	in stock	$665.00	$466.00

Description

• Catalog Number: AB68787
• Chemical Name: 5-Amino-8-trifluoromethoxyquinoline
• CAS Number: 1072944-53-6
• Molecular Formula: C10H7F3N2O
• Molecular Weight: 228.1706
• MDL Number: MFCD11504893
• SMILES: Nc1ccc(c2c1cccn2)OC(F)(F)F

Computed Properties

• Complexity: 247
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.9

Upstream Synthesis Route

8-(Trifluoromethoxy)quinolin-5-amine is a versatile compound widely used in chemical synthesis as a key building block for the development of various pharmaceuticals, agrochemicals, and functional materials. Its unique structure, featuring a quinoline ring with a trifluoromethoxy group at the 8-position and an amine group at the 5-position, imparts valuable properties that make it essential in synthetic pathways.In chemical synthesis, 8-(Trifluoromethoxy)quinolin-5-amine serves as a valuable starting material for the introduction of functional groups through various synthetic methodologies. The trifluoromethoxy group, in particular, is known for its ability to enhance the biological activity of molecules by influencing their physicochemical properties. This makes the compound particularly useful in medicinal chemistry for the development of bioactive molecules with improved pharmacokinetic properties.Additionally, the presence of the amine group in 8-(Trifluoromethoxy)quinolin-5-amine allows for further derivatization through various chemical transformations such as reductive amination, nucleophilic substitution, and transition metal-catalyzed reactions. This versatility enables the synthesis of diverse chemical entities with tailored properties for specific applications in drug discovery, material science, and agrochemical research.Overall, the strategic incorporation of 8-(Trifluoromethoxy)quinolin-5-amine in chemical synthesis offers an invaluable tool for the development of innovative compounds with enhanced biological activity and diverse applications in the field of chemistry.