1078166-57-0 | PF 04418948

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$35.00	$24.00
5mg	98%	in stock	$60.00	$42.00
10mg	98%	in stock	$99.00	$69.00
25mg	98%	in stock	$198.00	$138.00
50mg	98%	in stock	$312.00	$218.00
100mg	98%	in stock	$492.00	$344.00
250mg	98%	in stock	$836.00	$585.00
1g	98%	in stock	$2,219.00	$1,554.00

Description

• Catalog Number: AE11456
• Chemical Name: PF 04418948
• CAS Number: 1078166-57-0
• Molecular Formula: C23H20FNO5
• Molecular Weight: 409.4070031999999
• MDL Number: MFCD24387541
• SMILES: COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O

Computed Properties

• Complexity: 629
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 3.5

Upstream Synthesis Route

PF-04418948 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), an enzyme that breaks down endocannabinoids in the body. In chemical synthesis, PF-04418948 can be used as a valuable tool in the development of novel pharmaceuticals targeting the endocannabinoid system. By inhibiting FAAH, PF-04418948 helps to increase the levels of endocannabinoids, which play crucial roles in various physiological processes such as pain regulation, inflammation, and stress response. This compound can be utilized in the design and synthesis of new drug candidates for conditions such as chronic pain, anxiety disorders, and neurodegenerative diseases. Additionally, PF-04418948 can serve as a valuable research reagent for studying the biochemical pathways involving endocannabinoids, paving the way for innovative drug discovery and development strategies.

Literature

• Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

  British journal of pharmacology 20130101

• At last, a truly selective EP₂ receptor antagonist.

  British journal of pharmacology 20111201

• In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.

  British journal of pharmacology 20111201