108050-54-0 | Tilmicosin

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$50.00	$35.00
5g	95%	in stock	$139.00	$97.00
10g	95%	in stock	$203.00	$142.00
25g	95%	in stock	$299.00	$209.00
100g	95%	in stock	$760.00	$532.00

Description

• Catalog Number: AD78177
• Chemical Name: Tilmicosin
• CAS Number: 108050-54-0
• Molecular Formula: C46H80N2O13
• Molecular Weight: 869.1330
• MDL Number: MFCD00864842
• SMILES: CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](OC2OC(C)C(C(C2O)N(C)C)O)[C@@H](CCN2C[C@H](C)C[C@@H](C2)C)C[C@H](C(=O)/C=C/C(=C/[C@@H]1COC1OC(C)C(C(C1OC)OC)O)/C)C

Computed Properties

• Complexity: 1420
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 19
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 61
• Hydrogen Bond Acceptor Count: 15
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 12
• XLogP3: 3.6

Literature

• Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica.

  Veterinary microbiology 20121109

• Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.

  ACS chemical biology 20120817

• Use estimates of in-feed antimicrobials in swine production in the United States.

  Foodborne pathogens and disease 20120301

• Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs.

  Journal of agricultural and food chemistry 20120111

• Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo.

  Veterinary journal (London, England : 1997) 20120101

• Comparison of enrofloxacin and ceftiofur sodium for the treatment of relapse of undifferentiated fever/bovine respiratory disease in feedlot cattle.

  The Canadian veterinary journal = La revue veterinaire canadienne 20120101

• Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration.

  Journal of veterinary pharmacology and therapeutics 20111201

• Anti-inflammatory effects of tilmicosin in a noninfectious mouse model of allergic asthma.

  Immunopharmacology and immunotoxicology 20111201

• Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota.

  Journal of animal science 20111201

• Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease.

  Journal of the American Veterinary Medical Association 20110701

• Immunosuppressive activity of tilmicosin on the immune responses in mice.

  Immunopharmacology and immunotoxicology 20110601

• The controlled release of tilmicosin from silica nanoparticles.

  Drug development and industrial pharmacy 20110601

• Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from clinical outbreaks of porcine respiratory diseases.

  Veterinary microbiology 20110512

• Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography.

  Analytica chimica acta 20110401

• Human health hazards of veterinary medications: information for emergency departments.

  The Journal of emergency medicine 20110201

• Generation of reduced macrolide analogs by regio-specific biotransformation.

  The Journal of antibiotics 20110101

• Characterization of in vivo-acquired resistance to macrolides of Mycoplasma gallisepticum strains isolated from poultry.

  Veterinary research 20110101

• Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles.

  Particle and fibre toxicology 20110101

• Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits.

  Veterinary research communications 20100601

• Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions.

  Veterinary parasitology 20100528

• Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications.

  Journal of separation science 20100501

• Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20100101

• [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products].

  Revista Argentina de microbiologia 20100101

• Control of Ornithobacterium rhinotracheale in poultry.

  The Veterinary record 20091128

• Assessment of humoral and cellular-mediated immune response in chickens treated with tilmicosin, florfenicol, or enrofloxacin at the time of Newcastle disease vaccination.

  Poultry science 20091001

• Administration of micotil.

  The Veterinary record 20090919

• Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies.

  Journal of veterinary pharmacology and therapeutics 20090401

• Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle.

  Journal of the American Veterinary Medical Association 20090115

• Adverse outcome of using tilmicosin in a lamb with multiple ventricular septal defects.

  The Canadian veterinary journal = La revue veterinaire canadienne 20090101

• Pharmacokinetics and tissue depletion of tilmicosin in turkeys.

  Journal of veterinary pharmacology and therapeutics 20081201

• American association of poison control centers database characterization of human tilmicosin exposures, 2001-2005.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201

• Effectiveness of tilmicosin against Paenibacillus larvae, the causal agent of American Foulbrood disease of honeybees.

  Veterinary microbiology 20081125

• Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease.

  Journal of veterinary pharmacology and therapeutics 20081001

• Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers.

  Journal of animal science 20080801

• Identification of the related substances of tilmicosin by liquid chromatography/ion trap mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080601

• Pharmacokinetics of tilmicosin in equine tissues and plasma.

  Journal of veterinary pharmacology and therapeutics 20080201

• Diagnosis | pasteurellosis.

  Lab animal 20080101

• Comparison of short-term health and performance effects related to prophylactic administration of tulathromycin versus tilmicosin in long-hauled, highly stressed beef stocker calves.

  Veterinary therapeutics : research in applied veterinary medicine 20080101

• Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease.

  Veterinary therapeutics : research in applied veterinary medicine 20080101

• Minimal inhibitory concentration of tilmicosin against isolates of Histophilus somni from Australian cattle.

  Australian veterinary journal 20071201

• Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves.

  American journal of veterinary research 20071201

• Micotil: safe use and administration.

  The Veterinary record 20071124

• Early detection and treatment of vesicular adenitis in bulls.

  Animal reproduction science 20071001

• Quantitative determination of tilmicosin in canine serum by high performance liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915

• Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens.

  Veterinary research communications 20070501

• The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070401

• Evaluation of the efficacy of tulathromycin as a metaphylactic antimicrobial in feedlot calves.

  Veterinary therapeutics : research in applied veterinary medicine 20070101

• Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens.

  Journal of veterinary pharmacology and therapeutics 20061201

• In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin.

  Journal of veterinary science 20061201

• Analysis of reports of human exposure to Micotil 300 (tilmicosin injection).

  Journal of the American Veterinary Medical Association 20061201

• Industry guidance on the administration of tilmicosin.

  The Veterinary record 20060805

• Residue depletion of tilmicosin in cattle after subcutaneous administration.

  Journal of agricultural and food chemistry 20060712

• Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes.

  International journal of antimicrobial agents 20060501

• Influence of the genotype of Staphylococcus aureus, determined by pulsed-field gel electrophoresis, on dry-period elimination of subclinical mastitis in Canadian dairy herds.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20060401

• Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides.

  Bioorganic & medicinal chemistry letters 20060301

• An evaluation of the metaphylactic effect of ceftiofur crystalline free Acid in feedlot calves.

  Veterinary therapeutics : research in applied veterinary medicine 20060101

• Production and characterization of monoclonal antibodies against the antibiotic tilmicosin.

  Journal of agricultural and food chemistry 20051214

• Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA.

  FEMS microbiology letters 20050615

• Pharmacokinetics of tilmicosin after oral administration in swine.

  American journal of veterinary research 20050601

• Human exposures to tilmicosin reported to poison centres, Texas, 1998-2003.

  Human & experimental toxicology 20050501

• Assessment of the efficacy of tilmicosin phosphate to eliminate Actinobacillus pleuropneumoniae from carrier pigs.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20050401

• Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry.

  Journal of agricultural and food chemistry 20050323

• Effects of oral administration of tilmicosin on pulmonary inflammation in piglets experimentally infected with Actinobacillus pleuropneumoniae.

  American journal of veterinary research 20050101

• Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Clinical effectiveness of tulathromycin, a novel triamilide antimicrobial, for the control of respiratory disease in cattle at high risk for developing bovine respiratory disease.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease.

  Journal of veterinary pharmacology and therapeutics 20041001

• A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum.

  Journal of veterinary pharmacology and therapeutics 20041001

• Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20040701

• Change to user warning for Micotil.

  The Veterinary record 20040529

• Efficacy of danofloxacin in the treatment of respiratory disease in European cattle.

  The Veterinary record 20040508

• Residue depletion of tilmicosin in chicken tissues.

  Journal of agricultural and food chemistry 20040505

• Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica.

  American journal of veterinary research 20040501

• Effect of simulated ambient particulate matter exposure on performance, rectal temperature, and leukocytosis of young Spanish goats with or without tilmicosin phosphate.

  Journal of animal science 20040401

• Effect of mass medication with antibiotics at feedlot entry on the health and growth rate of cattle destined for the Australian domestic market.

  Australian veterinary journal 20040301

• Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS.

  Journal of agricultural and food chemistry 20040128

• Metabolism of tilmicosin by rabbit liver microsomes and hepatocytes.

  Veterinary journal (London, England : 1997) 20040101

• Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20040101

• [Immunogenic properties of the colloidal gold].

  Izvestiia Akademii nauk. Seriia biologicheskaia 20040101

• Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression.

  Veterinary research 20040101

• The effects of danofloxacin and tilmicosin on neutrophil function and lung consolidation in beef heifer calves with induced Pasteurella (Mannheimia) haemolytica pneumonia.

  Journal of veterinary pharmacology and therapeutics 20030601

• [Determination of spiramycin and tilmicosin in meat and fish by LC/MS].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20030601

• Facile synthesis of tilmicosin and tylosin related haptens for use as protein conjugates.

  The Journal of antibiotics 20030501

• Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period.

  Journal of dairy science 20030101

• Unintentional human exposure to tilmicosin (Micotil 300).

  Journal of toxicology. Clinical toxicology 20030101

• The efficacy of intramammary tilmicosin at drying-off, and other risk factors for the prevention of new intramammary infections during the dry period.

  Journal of dairy science 20021201

• Tilmicosin administration to young lambs with respiratory infection: safety and efficacy considerations.

  Journal of veterinary pharmacology and therapeutics 20021001

• Minimum inhibitory concentration breakpoints and disk diffusion inhibitory zone interpretive criteria for tilmicosin susceptibility testing against Pasteurella multocida and Actinobacillus pleuropneumoniae associated with porcine respiratory disease.

  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20020901

• Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease.

  American journal of veterinary research 20020801

• A comparison of prophylactic efficacy of tilmicosin and a new formulation of oxytetracycline in feedlot calves.

  The Canadian veterinary journal = La revue veterinaire canadienne 20020501

• The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020501

• Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020301

• Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases.

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease.

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver.

  Journal of AOAC International 20020101

• Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages.

  American journal of veterinary research 20020101

• Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye).

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• A comparative study of the preventive use of tilmicosin phosphate (Pulmotil premix) and Mycoplasma hyopneumoniae vaccination in a pig herd with chronic respiratory disease.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20011201

• Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20011101

• A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease.

  Journal of veterinary pharmacology and therapeutics 20011001

• Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo.

  Journal of the American Veterinary Medical Association 20010901

• Variability in residue concentrations of tilmicosin in cattle muscle.

  The Veterinary record 20010811

• Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20010810

• Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep.

  The Veterinary record 20010623

• Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida.

  International journal of antimicrobial agents 20010601

• Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system.

  Veterinary therapeutics : research in applied veterinary medicine 20010101