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Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology 20121101
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Toward rational design of amine solutions for PCC applications: the kinetics of the reaction of CO2(aq) with cyclic and secondary amines in aqueous solution.
Environmental science & technology 20120703
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Simultaneous determination of four plant hormones in bananas by molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography.
The Analyst 20120621
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5-Methyl-3,3-bis-(4-methyl-piperazin-1-yl)-1-[2-(4-methyl-piperazin-1-yl)eth-yl]indolin-2-one.
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12-{[4-(2-Fluoro-phen-yl)piperazin-1-yl]-meth-yl}-9α-hy-droxy-4,8-dimethyl-3,14-dioxatricyclo-[9.3.0.0]tetra-dec-7-en-13-one.
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Novel benzothiazole, benzimidazole and benzoxazole derivatives as potential antitumor agents: synthesis and preliminary in vitro biological evaluation.
Molecules (Basel, Switzerland) 20120117
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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
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Divalent-metal-stabilized aluminophosphates exhibiting a new zeolite framework topology.
Inorganic chemistry 20120102
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New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.
European journal of medicinal chemistry 20120101
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2-(5-Fluoro-2,3-dioxoindolin-1-yl)ethyl 4-methyl-piperazine-1-carbodithio-ate.
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Structure and electronic properties of Alq3 derivatives with electron acceptor/donor groups at the C4 positions of the quinolate ligands: a theoretical study.
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(2R)-4-[(9H-Fluoren-9-ylmeth-oxy)carbon-yl]-2-methyl-piperazin-1-ium chloride.
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Polymorphic form IV of olanzapine.
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1-Methyl-piperazine-1,4-diium tetra-chloridozincate hemihydrate.
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4-(4-Methyl-piperazin-1-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-7-(trifluoro-meth-yl)quinoline.
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Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib.
Investigational new drugs 20111001
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Determination of ofloxacin and lomefloxacin in chicken muscle using molecularly imprinted solid-phase extraction coupled with liquid chromatography.
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N-(4-Chloro-phen-yl)-4-methyl-piperazine-1-carboxamide.
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Bis(1-methyl-piperazine-1,4-diium) tetra-bromidocuprate(II).
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Bis(1-methyl-piperazine-1,4-diium) tetra-chloridocuprate(II).
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Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety.
Bioorganic & medicinal chemistry 20110401
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5-Nitroimidazole-based 1,3,4-thiadiazoles: heterocyclic analogs of metronidazole as anti-Helicobacter pylori agents.
Archiv der Pharmazie 20110301
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Synthesis of 1H-pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line.
Archiv der Pharmazie 20110301
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1-[4-(3-{[5-(4-Chloro-phen-yl)furan-2-yl]methyl-idene-amino}-2,5-dioxoimidazol-idin-1-yl)but-yl]-4-methyl-piperazine-1,4-diium dichloride hemihydrate.
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Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia.
Cancer management and research 20110101
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Studies on the anthelmintic property of aminobenzylated mannich bases.
Journal of young pharmacists : JYP 20110101
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Combined pharmacophore modeling, docking, and 3D-QSAR studies of PLK1 inhibitors.
International journal of molecular sciences 20110101
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3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors.
International journal of molecular sciences 20110101
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Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.
Bioorganic & medicinal chemistry letters 20101115
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Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Bioorganic & medicinal chemistry 20100915
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Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.
Journal of medicinal chemistry 20100909
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In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
PLoS neglected tropical diseases 20100901
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Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines.
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Determination of individual proton affinities of ofloxacin from its UV-Vis absorption, fluorescence and charge-transfer spectra: effect of inclusion in beta-cyclodextrin on the proton affinities.
The journal of physical chemistry. B 20100805
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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
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Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.
Protein expression and purification 20100501
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A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.
Molecular & cellular proteomics : MCP 20100501
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Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.
Molecules (Basel, Switzerland) 20100408
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Conjugate addition of nucleophiles to the vinyl function of 2-chloro-4-vinylpyrimidine derivatives.
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Detection of nitric oxide in tissue samples by ESI-MS.
The Analyst 20100201
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Sulfonamide-1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies.
Chemical & pharmaceutical bulletin 20100201
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Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
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Theoretical and experimental studies of the isomeric protonation in solution for a prototype aliphatic ring containing two nitrogens.
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Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors.
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[Synthesis, modifications, and antimicrobial activity of the methylpiperazinyl amides of triterpenic acids].
Bioorganicheskaia khimiia 20100101
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[Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].
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Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex.
Biochemistry 20091229
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[2-(4-Methyl-piperazin-1-ylmeth-yl)phen-yl]diphenyl-phosphane.
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Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
European journal of medicinal chemistry 20090901
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Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.
European journal of medicinal chemistry 20090701
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Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.
Bioorganic & medicinal chemistry letters 20090515
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Manipulation of fluorescent and colorimetric changes of fluorescein derivatives and applications for sensing silver ions.
Chemical communications (Cambridge, England) 20090314
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Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities.
European journal of medicinal chemistry 20090301
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Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies.
European journal of medicinal chemistry 20090201
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Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs.
Journal of pharmaceutical and biomedical analysis 20090115
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Hoechst 33342: the dye that enabled differentiation of living X-and Y-chromosome bearing mammalian sperm.
Theriogenology 20090101
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The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
BMC structural biology 20090101
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Nuclear receptor signaling 20090101
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Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
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Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
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Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.
Inorganic chemistry 20080804
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Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
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Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.
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Improved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation.
Proteome science 20080101
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Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.
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Development and targeted use of nilotinib in chronic myeloid leukemia.
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Indian journal of pharmaceutical sciences 20080101
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Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib.
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Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement.
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Synthesis of o-sulfamidotriazobenzenes from 1,1'-sulfonylbis(benzotriazole).
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DFT and ab initio calculations of the vibrational frequencies and visible spectra of triazenes derived from cyclic amines.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070601
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Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.
Bioorganic & medicinal chemistry letters 20070515
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Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement.
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Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.
Food additives and contaminants 20070201
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Array-based split-pool combinatorial screening of potential catalysts.
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Precise protein quantification based on peptide quantification using iTRAQ.
BMC bioinformatics 20070101
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NS-187 (INNO-406), a Bcr-Abl/Lyn dual tyrosine kinase inhibitor.
Analytical chemistry insights 20070101
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Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue.
Bioorganic & medicinal chemistry 20061201
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Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
Bioorganic & medicinal chemistry 20061015
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7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Bioorganic & medicinal chemistry letters 20060801
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Photoaddition of N-substituted piperazines to C60: an efficient approach to the synthesis of water-soluble fullerene derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 20060717
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Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.
American journal of therapeutics 20060101
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Synthesis and characterization of water-soluble phenylene-vinylene-based singlet oxygen sensitizers for two-photon excitation.
The Journal of organic chemistry 20050902
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Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Molecular endocrinology (Baltimore, Md.) 20050501
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Analysis of cell membrane aminophospholipids as isotope-tagged derivatives.
Journal of lipid research 20050501
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Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.
Bioorganic & medicinal chemistry letters 20050315
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Identification of 4-methylspinaceamine--a Pictet-Spengler condensation reaction product of histamine with acetaldehyde--in human urine.
Life sciences 20050128
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N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan.
Biomacromolecules 20050101
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Structure determination of a sildenafil analogue contained in commercial herb drinks.
Magnetic resonance in chemistry : MRC 20041201
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Solid-phase synthesis and evaluation of libraries of substituted 4,5-dihydropyridazinones as vasodilator agents.
The Journal of pharmacy and pharmacology 20040801
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Structure elucidation of sildenafil analogues in herbal products.
Food additives and contaminants 20040801
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DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
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Isoelectric point separation of proteins by capillary pH-gradient ion-exchange chromatography.
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Biomeditsinskaia khimiia 20040101
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Physicochemical determinants for drug induced blockade of HERG potassium channels: effect of charge and charge shielding.
Current medicinal chemistry. Cardiovascular and hematological agents 20031001
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Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker.
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Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions.
Journal of the American Chemical Society 20021127
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New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
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2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Bioorganic & medicinal chemistry letters 20020805
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NMR characterization of the DNA binding properties of a novel Hoechst 33258 analogue peptide building block.
Bioconjugate chemistry 20020101
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The interaction of 2-phenylbenzimidazole compounds with DNA: the influence of terminal substituents.
Nucleic acids research. Supplement (2001) 20020101
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Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.
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Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.
Bioorganic & medicinal chemistry 20011101
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Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.
Drug metabolism and disposition: the biological fate of chemicals 20011001
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Ofloxacin/beta-cyclodextrin complexation.
Drug development and industrial pharmacy 20010701