1092351-67-1 | Pp242

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
5mg	98%	in stock	$26.00	$18.00
10mg	98%	in stock	$39.00	$27.00
50mg	98%	in stock	$115.00	$80.00
250mg	98%	in stock	$338.00	$236.00

Description

• Catalog Number: AE10356
• Chemical Name: Pp242
• CAS Number: 1092351-67-1
• Molecular Formula: C16H16N6O
• Molecular Weight: 308.3378
• MDL Number: MFCD12196869
• SMILES: Oc1ccc2c(c1)cc([nH]2)c1nn(c2c1c(N)ncn2)C(C)C

Computed Properties

• Complexity: 435
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 2

Upstream Synthesis Route

The compound 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-Indol-5-ol, is a versatile building block used in chemical synthesis. Its unique structure incorporates both an indole and a pyrazolopyrimidine moiety, making it valuable in the development of pharmaceuticals and agrochemicals.This compound can serve as a key intermediate in the synthesis of various biologically active compounds, particularly in the field of medicinal chemistry. By strategically modifying its functional groups, chemists can create novel molecules with desired pharmacological properties. The presence of the aromatic indole ring and the fused heterocyclic pyrazolopyrimidine ring provides opportunities for diversification through structural modifications.In addition, the compound's amino and hydroxyl groups offer points for selective derivatization, allowing for the introduction of different substituents to tailor the compound's properties. This flexibility makes it a valuable tool in the synthesis of analogs and lead compounds for drug discovery efforts.Furthermore, the presence of the isopropyl group attached to the pyrazolopyrimidine ring can enhance the compound's pharmacokinetic properties, such as metabolic stability or membrane permeability, making it a promising candidate for further development in pharmaceutical research.Overall, the compound 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-Indol-5-ol plays a crucial role in the design and synthesis of bioactive molecules, demonstrating its significance in the field of organic chemistry and drug discovery.

Literature

• PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.

  Proceedings of the National Academy of Sciences of the United States of America 20130312

• Comprehensive analysis of kinase inhibitor selectivity.

  Nature biotechnology 20111030

• Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

  Journal of medicinal chemistry 20110310

• Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

  Chemistry & biology 20101124

• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

  Nature chemical biology 20081101