-
Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.
Journal of medicinal chemistry 20120913
-
Transferable potentials for phase equilibria-united atom description of five- and six-membered cyclic alkanes and ethers.
The journal of physical chemistry. B 20120913
-
Intersex effect of lamotrigine on the pharmacokinetic parameters of CDRI-97/78, a novel trioxane antimalarial compound, in rats.
Arzneimittel-Forschung 20120601
-
1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.
Acta crystallographica. Section E, Structure reports online 20120301
-
Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.
PLoS neglected tropical diseases 20120201
-
Formaldehyde encapsulated in lithium-decorated metal-organic frameworks: a density functional theory study.
Chemphyschem : a European journal of chemical physics and physical chemistry 20120116
-
Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity.
International immunopharmacology 20120101
-
Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.
Journal of biomedicine & biotechnology 20120101
-
Synthetic peroxides as potent antimalarials. News and views.
Current topics in medicinal chemistry 20120101
-
Profiling of volatile impurities in tetramethylenedisulfotetramine (TETS) for synthetic-route determination.
Forensic science international 20110715
-
A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.
Bioorganic & medicinal chemistry letters 20110501
-
Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.
Virology journal 20110101
-
Pharmacokinetic study of the novel, synthetic trioxane antimalarial compound 97-78 in rats using an LC-MS/MS method for quantification.
Arzneimittel-Forschung 20110101
-
Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.
International journal of molecular sciences 20110101
-
Medicinal chemistry perspectives of trioxanes and tetraoxanes.
Current medicinal chemistry 20110101
-
Liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of compound 97/78 and its in vivo metabolite 97/63, a novel trioxane antimalarial, in human plasma and its application to a protein binding study.
Arzneimittel-Forschung 20110101
-
An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.
PloS one 20110101
-
Prediction of human absorption of a trioxane antimalarial drug (CDRI 99/411) using an in-house validated in situ single-pass intestinal perfusion model.
Arzneimittel-Forschung 20110101
-
A greatly under-appreciated fundamental principle of physical organic chemistry.
International journal of molecular sciences 20110101
-
Trioxaquines: hybrid molecules for the treatment of malaria.
Drug news & perspectives 20101201
-
Synthesis and antimalarial assessment of a new series of orally active amino-functionalized spiro 1,2,4-trioxanes.
Journal of medicinal chemistry 20101111
-
A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst.
Molecular diversity 20101101
-
Interspecies comparison of the pharmacokinetics and oral bioavailability of 99-357, a potent synthetic trioxane antimalarial compound.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009
-
Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins.
The Journal of biological chemistry 20100820
-
Chain branching and termination in the low-temperature combustion of n-alkanes: 2-pentyl radical + O2, isomerization and association of the second O2.
The journal of physical chemistry. A 20100729
-
(1R,3S,4R,4aS,7R,7aS,10R,12aR)-3-Azido-4,7,10-trimethyl-1,10-epidioxy-per-hydropyrano[4,3-j][1,2]benzodiox-epine.
Acta crystallographica. Section E, Structure reports online 20100701
-
Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.
Journal of medicinal chemistry 20100513
-
Formaldehyde in the indoor environment.
Chemical reviews 20100414
-
Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.
PloS one 20100101
-
The pharmaceutical death-ride of dihydroartemisinin.
Malaria journal 20100101
-
Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.
Journal of medicinal chemistry 20091210
-
Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid.
Chemistry and physics of lipids 20090801
-
Liquid chromatographic tandem mass spectrometric assay for quantification of 97/78 and its metabolite 97/63: a promising trioxane antimalarial in monkey plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715
-
Antimalarial peroxide dyads from natural artemisinin and hydroxyalkylated 1,2,4-trioxanes.
Journal of medicinal chemistry 20090528
-
Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.
Journal of medicinal chemistry 20090226
-
Diastereoselective preparation of substituted delta-valerolactones. synthesis of (3R,4S)- and (3R,4R)-simplactones.
The Journal of organic chemistry 20090206
-
Ferrocenium salts mediate para-tert-butylcalixarene synthesis.
Chemical communications (Cambridge, England) 20081130
-
New strategy for the construction of epoxy-bridged tetrahydropyran frameworks from trioxane precursors: application to a concise synthesis of a Riesling acetal.
The Journal of organic chemistry 20081107
-
Piperidine dispiro-1,2,4-trioxane analogues.
Bioorganic & medicinal chemistry letters 20081101
-
Accretion reactions of octanal catalyzed by sulfuric acid: product identification, reaction pathways, and atmospheric implications.
Environmental science & technology 20081001
-
Elucidation of the natural artemisinin decomposition route upon iron interaction: a fine electronic redistribution promotes reactivity.
Physical chemistry chemical physics : PCCP 20080901
-
1,2,5,10,11,14-hexaoxadispiro[5.2.5.2]hexadecanes: novel spirofused bis-trioxane peroxides.
Molecules (Basel, Switzerland) 20080819
-
Redetermination of 2,4,6-tricyclo-hexyl-1,3,5-trioxane.
Acta crystallographica. Section E, Structure reports online 20080701
-
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Journal of medicinal chemistry 20080410
-
A sensitive and selective liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of novel trioxane antimalarials in different biomatrices using sample-pooling approach for high throughput pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315
-
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
Journal of medicinal chemistry 20080227
-
Hybrid molecules with a dual mode of action: dream or reality?
Accounts of chemical research 20080101
-
Photoinduced oxygen capture on immobilized dienone systems. First solid-phase synthesis of trioxane scaffolds.
Journal of combinatorial chemistry 20080101
-
Evaluation of some adamantane-based synthetic trioxanes against Plasmodium knowlesi in rhesus monkeys.
Life sciences 20071110
-
Conversion of antimalarial drug artemisinin to a new series of tricyclic 1,2,4-trioxanes1.
Organic letters 20071011
-
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
Journal of medicinal chemistry 20070517
-
New adamantane-based spiro 1,2,4-trioxanes orally effective against rodent and simian malaria.
Journal of medicinal chemistry 20070208
-
Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate.
PloS one 20070101
-
Ensuring sustained ACT production and reliable artemisinin supply.
Malaria journal 20070101
-
[Synthesis and antiviral activity of lupane triterpenoids with modified cycle E].
Bioorganicheskaia khimiia 20070101
-
Reactions of artemisinin and arteether with acid: implications for stability and mode of antimalarial action.
Journal of medicinal chemistry 20061005
-
Quantitative NMR spectroscopy of complex technical mixtures using a virtual reference: chemical equilibria and reaction kinetics of formaldehyde-water-1,3,5-trioxane.
Analytical and bioanalytical chemistry 20060701
-
8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria.
Bioorganic & medicinal chemistry letters 20060201
-
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.
Chembiochem : a European journal of chemical biology 20051101
-
New orally active spiro 1,2,4-trioxanes with high antimalarial potency.
Bioorganic & medicinal chemistry letters 20051015
-
Conformational pathways of saturated six-membered rings. A static and dynamical density functional study.
The journal of physical chemistry. A 20050915
-
A high throughput approach for simultaneous estimation of multiple synthetic trioxane derivatives using sample pooling for pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis 20050207
-
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities.
Bioorganic & medicinal chemistry letters 20050201
-
Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes.
Bioorganic & medicinal chemistry 20041115
-
HPLC-UV method for assaying 99/357, a synthetic trioxane antimalarial derivative in rat and rabbit serum.
Journal of pharmaceutical and biomedical analysis 20041029
-
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
Organic letters 20040902
-
Synthesis and antimalarial activity of trioxaquine derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 20040402
-
Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo.
British journal of clinical pharmacology 20040401
-
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.
Journal of medicinal chemistry 20040226
-
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
Journal of medicinal chemistry 20040226
-
Development of artemisinin and its structurally simplified trioxane derivatives as antimalarial drugs.
Acta tropica 20040201
-
Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.
Organic & biomolecular chemistry 20030821
-
Chloroquine and artemisinin: six decades of research--what next?
IDrugs : the investigational drugs journal 20030701
-
Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.
International journal for parasitology 20021204
-
Malaria: new chemotherapeutic peroxide drugs.
Mini reviews in medicinal chemistry 20021201
-
Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.
Journal of medicinal chemistry 20020829
-
From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs.
Accounts of chemical research 20020301
-
Biodegradation of formaldehyde and its derivatives in industrial wastewater with methylotrophic yeast Hansenula polymorpha and with the yeast-bioaugmented activated sludge.
Biodegradation 20020101
-
Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.
Journal of medicinal chemistry 20010913
-
Quantitative (13)C NMR analysis of lignins with internal standards.
Journal of agricultural and food chemistry 20010801