1113-41-3 | L-Penicillamine

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$16.00	$11.00
250mg	95%	in stock	$24.00	$17.00
1g	95%	in stock	$58.00	$41.00
5g	95%	in stock	$178.00	$125.00
25g	≥ 99% (Assay)	in stock	$723.00	$506.00
100g	≥ 99% (Assay)	in stock	$2,572.00	$1,800.00

Description

• Catalog Number: AB46390
• Chemical Name: L-Penicillamine
• CAS Number: 1113-41-3
• Molecular Formula: C5H11NO2S
• Molecular Weight: 149.2113
• MDL Number: MFCD00064303
• SMILES: N[C@@H](C(S)(C)C)C(=O)O
• NSC Number: 757265

Computed Properties

• Complexity: 124
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1.8

Literature

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Separation and determination of chiral composition in penicillamine tablets by capillary electrophoresis in a broad pH range.

  Electrophoresis 20120701

• Peroxynitrite has potent pulmonary vasodilator activity in the rat.

  Canadian journal of physiology and pharmacology 20120401

• Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.

  Frontiers in psychiatry 20120101

• Application of an unusual ninhydrin-based reaction for the indirect chiral resolution of D,L-penicillamine.

  Talanta 20110930

• Rational creation of chiral multinuclear and metallosupramolecular compounds from thiol-containing amino acids.

  Dalton transactions (Cambridge, England : 2003) 20110728

• Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation.

  Clinical rheumatology 20110401

• Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.

  Medical gas research 20110101

• Penicillamine neurotoxicity: an hypothesis.

  ISRN neurology 20110101

• Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: structure activity study.

  Amino acids 20100501

• Isolation and quantitative analysis of peroxynitrite scavengers from Artemisia princeps var. orientalis.

  Archives of pharmacal research 20100501

• Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.

  Bioorganic & medicinal chemistry letters 20091115

• Cadmium(II) complex formation with cysteine and penicillamine.

  Inorganic chemistry 20090706

• A multinuclear coordination system of L-cysteine and L-penicillamine that induce opposite chiralities at metal centers.

  Angewandte Chemie (International ed. in English) 20090101

• [Wilson's disease in paediatric age: diagnosis and treatment. Recent advances].

  Recenti progressi in medicina 20081101

• Enantiomeric reversed-phase high-performance liquid chromatography resolution of D-/L-penicillamine after spirocyclization with ninhydrin and by using copper(II)-L-proline complex as a chiral selector in the mobile phase.

  Journal of chromatography. A 20080926

• Chiral functionalization of optically inactive monolayer-protected silver nanoclusters by chiral ligand-exchange reactions.

  Langmuir : the ACS journal of surfaces and colloids 20080318

• Withdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson's disease: promising, safe and cheap.

  Journal of the neurological sciences 20080115

• Chiral highly luminescent CdS quantum dots.

  Chemical communications (Cambridge, England) 20071014

• Indirect resolution of enantiomers of penicillamine by TLC and HPLC using Marfey's reagent and its variants.

  Biomedical chromatography : BMC 20071001

• Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.

  Journal of neuroscience research 20070801

• One-electron reduction of S-nitrosothiols in aqueous medium.

  Free radical biology & medicine 20061015

• Electrochemical behavior of dopamine at a penicillamine self-assembled gold electrode and its analytical application.

  Archiv der Pharmazie 20060701

• Antimelanoma activity of apoptogenic carbonyl scavengers.

  The Journal of pharmacology and experimental therapeutics 20060201

• A pilot trial testing the feasibility of administering D-penicillamine to extremely low birth weight neonates.

  Journal of perinatology : official journal of the California Perinatal Association 20060201

• Large optical activity of gold nanocluster enantiomers induced by a pair of optically active penicillamines.

  Journal of the American Chemical Society 20051109

• Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors.

  The journal of peptide research : official journal of the American Peptide Society 20051101

• Electrochemical determination of thiols at single-wall carbon nanotubes and PQQ modified electrodes.

  Frontiers in bioscience : a journal and virtual library 20050101

• N-Salicylideneamino acidato complexes of oxovanadium(IV). The cysteine and penicillamine complexes.

  Dalton transactions (Cambridge, England : 2003) 20040921

• Effects of nitric oxide on morphology of isolated cochlear outer hair cells: possible involvement in sensorineural hearing loss.

  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20030701

• Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents.

  Archiv der Pharmazie 20030401

• Electrocatalytic oxidation of nitric oxide at indium hexacyanoferrate film-modified electrodes.

  Analytical and bioanalytical chemistry 20030101

• Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1.

  FEBS letters 20020410

• Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress.

  Biochemical pharmacology 20020201

• Electrochemical response of dopamine at a penicillamine self-assembled gold electrode.

  Bioelectrochemistry (Amsterdam, Netherlands) 20011101

• Specific sensitization of Lyt-1+2- T cells to spleen cells modified by the drug D-penicillamine or a stereoisomer.

  Journal of immunology (Baltimore, Md. : 1950) 19860101

• Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products.

  The Journal of experimental medicine 19601130