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Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.
European journal of medicinal chemistry 20181005
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Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
The Journal of biological chemistry 20170623
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Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism.
Toxicology 20160831
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Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution.
Journal of medicinal chemistry 20160512
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The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis.
Biological & pharmaceutical bulletin 20150101
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Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.
Bioorganic & medicinal chemistry 20140301
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A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Toxicological sciences : an official journal of the Society of Toxicology 20140101
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation.
Molecular pharmaceutics 20130107
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Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase.
British journal of pharmacology 20121001
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Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Toxicological sciences : an official journal of the Society of Toxicology 20121001
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Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice.
Diabetes 20120901
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Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.
Bioorganic & medicinal chemistry 20120815
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Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.
Current medicinal chemistry 20120801
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Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry 20120601
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Higher prevalence of obesity among children with asthma.
Obesity (Silver Spring, Md.) 20120501
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Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Bioorganic & medicinal chemistry 20120501
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Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.
Experimental eye research 20120501
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Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
Journal of medicinal chemistry 20120426
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Idiosyncratic reactions and metabolism of sulfur-containing drugs.
Expert opinion on drug metabolism & toxicology 20120401
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CYFRA 21-1 as a prognostic and predictive marker in advanced non-small-cell lung cancer in a prospective trial: CALGB 150304.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120401
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Management of chronic urticaria in Asia: 2010 AADV consensus guidelines.
Asia Pacific allergy 20120401
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Role of basic science in the development of new medicines: examples from the eicosanoid field.
The Journal of biological chemistry 20120323
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Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Journal of medicinal chemistry 20120322
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SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 20120301
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[Sjögren-Larsson syndrome: 2 case reports].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20120201
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The role of transient receptor potential channel blockers in human gastric cancer cell viability.
Canadian journal of physiology and pharmacology 20120201
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Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system.
Retrovirology 20120101
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Achieving symptom control in patients with moderate asthma.
Clinical medicine insights. Circulatory, respiratory and pulmonary medicine 20120101
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Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization.
Journal of allergy 20120101
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Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence.
Respiratory research 20120101
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A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.
Oncotarget 20120101
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Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.
PloS one 20120101
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Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer.
PloS one 20120101
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Smoking and idiopathic pulmonary fibrosis.
Pulmonary medicine 20120101
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Role of leukotrienes on protozoan and helminth infections.
Mediators of inflammation 20120101
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Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.
Mediators of inflammation 20120101
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LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
PloS one 20120101
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Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1.
Journal of neuroinflammation 20120101
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Difficult asthma: assessment and management, Part 2.
Allergy and asthma proceedings 20120101
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5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Journal of medicinal chemistry 20111208
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
PLoS computational biology 20111201
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Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.
European journal of medicinal chemistry 20111001
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Chronic rhinosinusitis: therapeutic efficacy of anti-inflammatory and antibiotic approaches.
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Deutsche medizinische Wochenschrift (1946) 20111001
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Effects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestine.
Molecules and cells 20110831
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Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Journal of natural products 20110826
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Association between leukotriene-modifying agents and suicide: what is the evidence?
Drug safety 20110701
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Novel therapeutic approaches for pulmonary fibrosis.
British journal of pharmacology 20110501
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Pranlukast attenuates hydrogen peroxide-induced necrosis in endothelial cells by inhibiting oxygen reactive species-mediated collapse of mitochondrial membrane potential.
Journal of cardiovascular pharmacology 20110401
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Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
The American journal of pathology 20110401
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[5-lipoxygenase is involved in rotenone-induced injury in PC12 cells].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20110301
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5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.
Science translational medicine 20110209
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Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization.
COPD 20110201
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Hyperalgesic and edematogenic effects of peptides isolated from the venoms of honeybee (Apis mellifera) and neotropical social wasps (Polybia paulista and Protonectarina sylveirae).
Amino acids 20110101
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Aspirin-exacerbated respiratory disease: evaluation and management.
Allergy, asthma & immunology research 20110101
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Canadian clinical practice guidelines for acute and chronic rhinosinusitis.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101
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Asthma in sickle cell disease: implications for treatment.
Anemia 20110101
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Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.
Cell communication and signaling : CCS 20110101
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The role of fatty aldehyde dehydrogenase in epidermal structure and function.
Dermato-endocrinology 20110101
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ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-α-induced endothelial E-selectin, ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX-independent mechanism.
Vascular pharmacology 20110101
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Pharmacotherapy of patients with mild persistent asthma: strategies and unresolved issues.
Frontiers in pharmacology 20110101
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5-Lipoxygenase contributes to the progression of hepatocellular carcinoma.
Molecular medicine reports 20110101
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Helping patients attain and maintain asthma control: reviewing the role of the nurse practitioner.
Journal of multidisciplinary healthcare 20110101
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Relationship between leukotriene-modifying agent prescriptions dispensed and rate of suicide deaths by county in the US.
Drug, healthcare and patient safety 20110101
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Strategies for reducing or preventing the generation of oxidative stress.
Oxidative medicine and cellular longevity 20110101
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Chronic urticaria.
Indian journal of dermatology 20110101
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Influence of leukotriene biosynthesis inhibition on heart rate in patients with atrial fibrillation.
International journal of cardiology 20101203
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Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas.
Biochimica et biophysica acta 20101201
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals 20101201
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Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma.
Archives of medical science : AMS 20101201
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Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats.
Inflammation 20101001
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5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity.
British journal of pharmacology 20101001
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The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.
British journal of pharmacology 20101001
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Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
ChemMedChem 20100903
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Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
International journal of colorectal disease 20100901
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Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.
Archives of dermatological research 20100801
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Molecular immunology 20100701
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Systemic therapies in managing sinonasal inflammation.
Otolaryngologic clinics of North America 20100601
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Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow.
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Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.
Bioorganic & medicinal chemistry 20100401
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Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.
AAPS PharmSciTech 20100301
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Antileukotriene drugs in the treatment of asthma.
Polskie Archiwum Medycyny Wewnetrznej 20100301
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Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis.
Experimental dermatology 20100201
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Journal of leukocyte biology 20100201
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Simultaneous determination of ABT-888, a poly (ADP-ribose) polymerase inhibitor, and its metabolite in human plasma by liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201
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Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry letters 20100201
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Baicalin attenuates oxygen-glucose deprivation-induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells.
Acta pharmacologica Sinica 20100201
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Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved.
Toxicon : official journal of the International Society on Toxinology 20100101
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The cardioprotective effects of zileuton, a 5-lipoxygenase inhibitor, are mediated by COX-2 via activation of PKC delta.
Cellular signalling 20100101
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Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.
Bioorganic & medicinal chemistry 20100101
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Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Cancer prevention research (Philadelphia, Pa.) 20100101
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Protection of leukotriene receptor antagonist against aspirin-induced bronchospasm in asthmatics.
Allergy, asthma & immunology research 20100101
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Oxidative stress in NSC-741909-induced apoptosis of cancer cells.
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Treatment of congestion in upper respiratory diseases.
International journal of general medicine 20100101
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Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20100101
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Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.
PloS one 20100101
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A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats.
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Mediators of inflammation 20100101
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The employment of leukotriene antagonists in cutaneous diseases belonging to allergological field.
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Lipids in health and disease 20100101
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Pharmacogenomics of pediatric asthma.
Indian journal of human genetics 20100101
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Folia neuropathologica 20100101
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Frontiers in pharmacology 20100101
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Cell cycle (Georgetown, Tex.) 20091101
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Immunology and allergy clinics of North America 20091101
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Neurological research 20091001
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International immunopharmacology 20091001
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CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain.
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Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.
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Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions.
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Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Bioorganic & medicinal chemistry 20090701
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Nature genetics 20090701
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Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
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Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma.
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Chest 20090501
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Xenobiotica; the fate of foreign compounds in biological systems 20090301
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Prostaglandins & other lipid mediators 20090101
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Arthritis research & therapy 20090101
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Mediators of inflammation 20090101
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Indian journal of dermatology 20090101
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Pharmacology, biochemistry, and behavior 20081201
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Journal of leukocyte biology 20060601
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Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation.
British journal of pharmacology 20060601
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In vitro 12(S)-HETE and leukotriene metabolism inhibitory activity of sesquiterpenes of Warburgia ugandensis.
Planta medica 20060601
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Is there a role for antileukotrienes in urticaria?
Clinical and experimental dermatology 20060501
-
Application of the ferrous oxidation-xylenol orange assay for the screening of 5-lipoxygenase inhibitors.
Analytical biochemistry 20060401
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5-lipoxygenase modulates the alteration of paracellular barrier function in mice ileum during experimental colitis.
Shock (Augusta, Ga.) 20060401
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Treatment of asthma with antileukotrienes: first line or last resort therapy?
European journal of pharmacology 20060308
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Lipoxygenase-derived eicosanoids are involved in the inhibitory effect of Crotalus durissus terrificus venom or crotoxin on rat macrophage phagocytosis.
Toxicon : official journal of the International Society on Toxinology 20060301
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The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets?
Inflammopharmacology 20060301
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Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects.
Respiratory medicine 20060201
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Managing asthma in expectant mothers.
Treatments in respiratory medicine 20060101
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Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.
Journal of neuroinflammation 20060101
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Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20060101
-
Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.
Respiratory research 20060101
-
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
Prostaglandins, leukotrienes, and essential fatty acids 20051201
-
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice.
Indian journal of experimental biology 20051201
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Development of an enzyme-modified carbon paste electrode for determining inhibitors of lipoxygenase.
Biosensors & bioelectronics 20051015
-
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Current drug metabolism 20051001
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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Bioorganic & medicinal chemistry letters 20050915
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Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster.
Prostaglandins, leukotrienes, and essential fatty acids 20050801
-
Quantum chemical design of hydroxyurea derivatives for the treatment of sickle-cell anemia.
The journal of physical chemistry. B 20050714
-
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.
Pharmacology, biochemistry, and behavior 20050701
-
Differential effects of hydroxyurea and zileuton on interleukin-13 secretion by activated murine spleen cells: implication on the expression of vascular cell adhesion molecule-1 and vasoocclusion in sickle cell anemia.
Cytokine 20050607
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Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels.
Journal of cellular biochemistry 20050601
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5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration.
Laboratory investigation; a journal of technical methods and pathology 20050601
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The linkage between Churg-Strauss syndrome and leukotriene receptor antagonists: fact or fiction?
Therapeutics and clinical risk management 20050601
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Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050301
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5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.
Bioorganic & medicinal chemistry letters 20050215
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Asthma controller therapy during pregnancy.
American journal of obstetrics and gynecology 20050201
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The effects of a 5-lipoxygenase inhibitor on acute mountain sickness and urinary leukotriene e4 after ascent to high altitude.
Chest 20050201
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Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.
Dermatology (Basel, Switzerland) 20050101
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Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.
Journal of natural products 20050101
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Leukotrienes: their role in the treatment of asthma and seasonal allergic rhinitis.
Pediatric nursing 20050101
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Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain.
Pharmacological reports : PR 20050101
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Role of leukotriene receptor antagonists in the treatment of exercise-induced bronchoconstriction: a review.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101
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Re-establishment of olfactory and taste functions.
GMS current topics in otorhinolaryngology, head and neck surgery 20050101
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Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.
Bioorganic & medicinal chemistry letters 20041115
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Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Journal of leukocyte biology 20041101
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Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Planta medica 20041101
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Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20041015
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The improved survival of experimental animals fed with fish oil is suppressed by a leukotriene inhibitor.
Scandinavian journal of immunology 20041001
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Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 20041001
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Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone.
Circulation 20040907
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Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats.
American journal of physiology. Gastrointestinal and liver physiology 20040801
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Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Molecular pharmacology 20040801
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Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats.
Indian journal of experimental biology 20040701
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Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway.
Blood 20040515
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5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.
Bioorganic & medicinal chemistry letters 20040503
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Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
American journal of physiology. Heart and circulatory physiology 20040501
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Leukotriene modifier use and asthma severity: how is a new medication being used by adults with asthma?
Archives of internal medicine 20040322
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Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.
Clinical & developmental immunology 20040301
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In vitro metabolism of 2-acetylbenzothiophene: relevance to zileuton hepatotoxicity.
Chemical research in toxicology 20040201
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Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches.
Drugs 20040101
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Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan.
Journal of managed care pharmacy : JMCP 20040101
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Effect of zileuton in radicular pain induced by herniated nucleus pulposus in rats.
Inflammopharmacology 20040101
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Advances in therapy with antileukotriene drugs.
Annals of clinical and laboratory science 20040101
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Generalized granuloma annulare in a patient with adult onset diabetes mellitus.
Journal of drugs in dermatology : JDD 20031201
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Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
British journal of cancer 20031117
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Inhibition of neutrophil leukotriene B4 production by a novel synthetic N-3 polyunsaturated fatty acid analogue, beta-oxa 21:3n-3.
Journal of immunology (Baltimore, Md. : 1950) 20031101
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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 20031101
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Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.
American journal of physiology. Lung cellular and molecular physiology 20031001
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Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 20031001
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Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
The American journal of pathology 20031001
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Tenofovir, COX inhibitors and zileuton during cancer immunotherapies: up-regulated TNF-alpha increases antigen driven lymphocyte proliferation.
Molecular immunology 20030901
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Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
American journal of hematology 20030901
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Zileuton reduces respiratory illness and lung inflammation, during respiratory syncytial virus infection, in mice.
The Journal of infectious diseases 20030601
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The role of leukotriene inhibitors in patients with paranasal sinus disease.
Current opinion in otolaryngology & head and neck surgery 20030601
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[Anti-leukotrienes in allergic diseases in children].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601
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Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.
Toxicon : official journal of the International Society on Toxinology 20030501
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A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor.
Archives of dermatology 20030501
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Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome.
Prostaglandins, leukotrienes, and essential fatty acids 20030401
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Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13.
American journal of respiratory cell and molecular biology 20030401
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Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Journal of leukocyte biology 20030301
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Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs.
American journal of physiology. Lung cellular and molecular physiology 20030201
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Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Molecular cancer 20030101
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Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats.
Journal of nephrology 20030101
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Benefit-risk assessment of antileukotrienes in the management of asthma.
Drug safety 20030101
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Recent advances in the management of asthma using leukotriene modifiers.
American journal of respiratory medicine : drugs, devices, and other interventions 20030101
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Leukotrienes antagonists in the management of bronchial asthma.
Romanian journal of internal medicine = Revue roumaine de medecine interne 20030101
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Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.
Biochemical pharmacology 20021215
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Mechanisms of idiosyncratic drug reactions: the case of felbamate.
Chemico-biological interactions 20021110
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Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism.
Biochimica et biophysica acta 20021010
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The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021001
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Mediators of adenosine- and ovalbumen-induced bronchoconstriction of sensitized guinea-pig isolated airways.
European journal of pharmacology 20020906
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Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
Cancer research 20020801
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Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.
Journal of applied physiology (Bethesda, Md. : 1985) 20020701
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Role of Ca(2+)-independent phospholipase A(2) and cyclooxygenase/lipoxygenase pathways in the nitric oxide production by murine macrophages stimulated by lipopolysaccharides.
Nitric oxide : biology and chemistry 20020501
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Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein.
Journal of immunology (Baltimore, Md. : 1950) 20020415
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Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.
The British journal of dermatology 20020401
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Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Bioorganic & medicinal chemistry letters 20020311
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Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
Journal of leukocyte biology 20020301
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Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
The Journal of pharmacology and experimental therapeutics 20020201
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[Anti-leukotriene drugs and Churg Strauss syndrome].
Polskie Archiwum Medycyny Wewnetrznej 20020201
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Pharmacogenetics, pharmacogenomics and airway disease.
Respiratory research 20020101
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[New horizons in the treatment of atopic dermatitis].
Allergologia et immunopathologia 20020101
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Effects of Celebrex and Zyflo on BOP-induced pancreatic cancer in Syrian hamsters.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20020101
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Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters.
Clinical & experimental metastasis 20020101
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Inhibition of 5-LO activating protein (FLAP) activity decreases proteinuria in streptozotocin (STZ)-induced diabetic rats.
Advances in experimental medicine and biology 20020101
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Clinical and biochemical effects of zileuton in patients with the Sjögren-Larsson syndrome.
European journal of pediatrics 20011201
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Role of the IgE-mediated system in eosinophil recruitment triggered by two consecutive cycles of sensitisation and challenge in rats.
International archives of allergy and immunology 20011201
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Involvement of leukotriene B(4) in substance P-induced itch-associated response in mice.
The Journal of investigative dermatology 20011201
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Leukotrienes play protective roles early during experimental VSV encephalitis.
Journal of neuroimmunology 20011101
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Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats.
European journal of pharmacology 20011019
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Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton.
The Journal of pharmacology and experimental therapeutics 20011001
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[Leukotriene modifiers].
Nihon rinsho. Japanese journal of clinical medicine 20011001
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Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
Toxicological sciences : an official journal of the Society of Toxicology 20010901
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Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor.
Pharmacological research 20010901
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Leukotrienes in respiratory disease.
Paediatric respiratory reviews 20010901
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Double-blinded, placebo-controlled, cross-over pilot study on the efficacy of zileuton for canine atopic dermatitis.
Veterinary dermatology 20010801
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Zileuton and atopic dermatitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010801
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Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.
British journal of pharmacology 20010701
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In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
European journal of pharmacology 20010622
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Safety of antileukotriene agents in asthma management.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601
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The role of antileukotrienes in the treatment of asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601
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Discovery of leukotrienes and development of antileukotriene agents.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601
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Efficacy of antileukotriene agents in asthma management.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010601
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Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus.
Biochemical pharmacology 20010415
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N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 20010326
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Clinical predictors of health-related quality of life depend on asthma severity.
American journal of respiratory and critical care medicine 20010301
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Antileukotrienes in asthma: present situation.
Expert opinion on pharmacotherapy 20010301
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Leukotriene modifiers in pediatric asthma management.
Pediatrics 20010201
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Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma.
Expert opinion on pharmacotherapy 20010101
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ABT-761 (Abbott).
Current opinion in investigational drugs (London, England : 2000) 20010101
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Platelet-leukocyte cross talk in whole blood.
Arteriosclerosis, thrombosis, and vascular biology 20001201
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Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma.
The Journal of allergy and clinical immunology 20000901
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Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.
Mayo Clinic proceedings 20000601
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Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics.
American journal of respiratory and critical care medicine 20000401
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Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes.
The Biochemical journal 20000315
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Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
Journal of medicinal chemistry 20000224
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Acute effects of antileukotrienes on sinonasal polyposis and sinusitis.
Ear, nose, & throat journal 20000101
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Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
British journal of pharmacology 20000101
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Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.
Biology of reproduction 19990701
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Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers.
The Journal of biological chemistry 19990122
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Nordihydroguaiaretic acid blocks secretory and endocytic pathways in human dendritic cells.
Journal of leukocyte biology 19981201
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In vivo correlation of neutrophil receptor expression, ischemia-reperfusion injury, and selective 5-lipoxygenase inhibition in guinea pigs.
Archives of otolaryngology--head & neck surgery 19981201
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ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19981001
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Systemic neutrophil intrinsic 5-lipoxygenase activity and CD18 receptor expression linked to reperfusion injury.
The Laryngoscope 19980901
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Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.
The American journal of physiology 19980601
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Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
American journal of respiratory and critical care medicine 19980601
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Safety and clinical efficacy of zileuton in patients with chronic asthma.
The American journal of managed care 19980601
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(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
Journal of medicinal chemistry 19980521
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The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis.
Biochimica et biophysica acta 19980520
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Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release.
The Journal of pharmacology and experimental therapeutics 19980301
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Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages.
The Biochemical journal 19980201
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Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation.
Prostaglandins, leukotrienes, and essential fatty acids 19970601
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Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.
American journal of respiratory and critical care medicine 19970401
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Pharmacological modulation of human platelet leukotriene C4-synthase.
Biochemical pharmacology 19970321
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Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
Journal of medicinal chemistry 19970227
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Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats.
European journal of pharmacology 19961107
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Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.
Journal of medicinal chemistry 19960802
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Hepatic peroxisomal and drug metabolizing activity in CD-1 mice after oral treatment with a novel 5-lipoxygenase inhibitor.
Toxicology and applied pharmacology 19960401
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Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
The Journal of experimental medicine 19960401
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Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
JAMA 19960327
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A controlled trial of the effect of the 5-lipoxygenase inhibitor, zileuton, on lung inflammation produced by segmental antigen challenge in human beings.
The Journal of allergy and clinical immunology 19960201
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Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
European journal of immunology 19960101
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Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma.
The Annals of pharmacotherapy 19960101
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(R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.
Journal of medicinal chemistry 19951124
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5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.
The Journal of biological chemistry 19951103
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Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization.
Biochemistry 19951017
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Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages.
The Journal of biological chemistry 19950915
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Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases.
European journal of gastroenterology & hepatology 19950801
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Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology 19950626
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Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Prostaglandins, leukotrienes, and essential fatty acids 19950601
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Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase.
Journal of cellular biochemistry 19950201
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Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.
The Journal of biological chemistry 19941028
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Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
Journal of lipid mediators and cell signalling 19940901
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Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
Proceedings of the National Academy of Sciences of the United States of America 19940816
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A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice.
Japanese journal of pharmacology 19940801
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The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.
European journal of pharmacology 19940523
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The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
Pulmonary pharmacology 19940401
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Novel bishydroxamic acids as 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry 19940301
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Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells.
International immunology 19940301
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Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation.
The Journal of pharmacology and experimental therapeutics 19940201
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Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi.
American journal of respiratory and critical care medicine 19940101
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LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
Journal of pharmacological and toxicological methods 19931101
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Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Agents and actions 19930901
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Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil.
The Biochemical journal 19930501
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Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
European journal of pharmacology 19930406
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Criteria for the identification of non-redox inhibitors of 5-lipoxygenase.
Biochemical pharmacology 19930224
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Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model.
Agents and actions 19930101
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Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo.
Mediators of inflammation 19930101
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Enantiomeric activation of glucuronidation in dog hepatic microsomes.
The Journal of biological chemistry 19920705
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Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Inflammation 19920601
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5-lipoxygenase inhibitory activity of zileuton.
The Journal of pharmacology and experimental therapeutics 19910301
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Pharmacokinetics, safety, and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase.
Agents and actions. Supplements 19910101
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Hydroxyurea has the capacity to induce damage to human erythrocytes which can be modified by radical scavengers.
Biochemical and biophysical research communications 19840430