1115-70-4 | 1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$6.00	$4.00
10g	97%	in stock	$7.00	$5.00
25g	97%	in stock	$11.00	$8.00
100g	97%	in stock	$13.00	$9.00
500g	99%	in stock	$55.00	$38.00

Description

• Catalog Number: AB75390
• Chemical Name: 1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
• CAS Number: 1115-70-4
• Molecular Formula: C4H12ClN5
• Molecular Weight: 165.6246
• MDL Number: MFCD00012582
• SMILES: CN(C(=N)NC(=N)N)C.Cl

Computed Properties

• Complexity: 132
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 2

Literature

• Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.

  Chemico-biological interactions 20180801

• d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.

  Toxicology letters 20180601

• Sulfenamide and sulfonamide derivatives of metformin can exert anticoagulant and profibrinolytic properties.

  Chemico-biological interactions 20180325

• Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20180301

• Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801

• Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35 cells and augment anticancer activity of Cisplatin via cell cycle regulation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801

• Multidrug and toxin extrusion proteins mediate cellular transport of cadmium.

  Toxicology and applied pharmacology 20170101

• Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness.

  Journal of Korean medical science 20170101

• Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.

  Toxicological sciences : an official journal of the Society of Toxicology 20161201

• Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model.

  Chemico-biological interactions 20161025

• Metformin Improves Metabolic Memory in High Fat Diet (HFD)-induced Renal Dysfunction.

  The Journal of biological chemistry 20161014

• Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

  Antimicrobial agents and chemotherapy 20160901

• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

  Nature genetics 20160901

• Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.

  Chemico-biological interactions 20160725

• Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.

  Journal of diabetes investigation 20160501

• Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice.

  Chemico-biological interactions 20160405

• Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.

  Toxicology letters 20160105

• Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages.

  Oncotarget 20151103

• Preventing Allograft Rejection by Targeting Immune Metabolism.

  Cell reports 20151027

• Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.

  Oncotarget 20151020

• Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.

  Oncotarget 20150922

• Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension.

  Diabetes, obesity & metabolism 20150601

• Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.

  Toxicology and applied pharmacology 20150415

• Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20150401

• Metformin aggravates immune-mediated liver injury in mice.

  Archives of toxicology 20150301

• Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective.

  Scientific reports 20150101

• Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

  Pharmacological research 20141101

• Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.

  Toxicology and applied pharmacology 20141001

• Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.

  European journal of pharmacology 20140815

• Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells.

  Journal of viral hepatitis 20140801

• A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.

  British journal of clinical pharmacology 20140701

• Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.

  Biochemical and biophysical research communications 20140613

• Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury.

  Chemico-biological interactions 20140605

• Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial.

  Diabetes care 20140601

• Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.

  British journal of pharmacology 20140501

• Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).

  Toxicology and applied pharmacology 20131115

• Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways.

  Toxicology and applied pharmacology 20130901

• Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein.

  Reproductive toxicology (Elmsford, N.Y.) 20130801

• Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis.

  Molecular human reproduction 20130501

• Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.

  PloS one 20130101

• Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids.

  The Analyst 20121207

• Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20121201

• Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.

  Aging 20121201

• Type of preadmission antidiabetic treatment and outcome among patients with ischemic stroke: a nationwide follow-up study.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101

• Population PK/PD analysis of metformin using the signal transduction model.

  British journal of clinical pharmacology 20121101

• Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.

  Journal of psychiatry & neuroscience : JPN 20121101

• Time to failure of oral therapy in children with type 2 diabetes: a single center retrospective chart review.

  Pediatric diabetes 20121101

• Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin.

  Diabetes, obesity & metabolism 20121101

• Metformin pathways: pharmacokinetics and pharmacodynamics.

  Pharmacogenetics and genomics 20121101

• The effect of metformin on insulin resistance and exercise parameters in patients with heart failure.

  European journal of heart failure 20121101

• Metformin exposure affects human and mouse fetal testicular cells.

  Human reproduction (Oxford, England) 20121101

• Patient education on the benefit and risks of medications goes beyond metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20121101

• Binding studies of the antidiabetic drug, metformin to calf thymus DNA using multispectroscopic methods.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

• Metformin targets ovarian cancer stem cells in vitro and in vivo.

  Gynecologic oncology 20121101

• A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.

  Diabetologia 20121101

• Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.

  Human reproduction (Oxford, England) 20121101

• Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero.

  Scandinavian journal of clinical and laboratory investigation 20121101

• Metformin does not alter the risk of lung cancer: a case-control analysis.

  Lung cancer (Amsterdam, Netherlands) 20121101

• Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner.

  Biochimica et biophysica acta 20121101

• Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women.

  Cancer causes & control : CCC 20121101

• Effects of metformin on insulin resistance in heart failure. Which came first: the chicken or the egg?

  European journal of heart failure 20121101

• Metformin's effect on first-year weight gain: a follow-up study.

  Pediatrics 20121101

• Fitness, fatness, and metformin.

  Medicine and science in sports and exercise 20121101

• Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.

  The Journal of biological chemistry 20121026

• AMP-activated protein kinase: a target for drugs both ancient and modern.

  Chemistry & biology 20121026

• Central anti-diabetic action of biguanide and thizolidinediones in D-glucose fed and streptozotocin-treated mouse models.

  Neuroscience letters 20121018

• Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.

  The Cochrane database of systematic reviews 20121017

• Removal of charged micropollutants from water by ion-exchange polymers -- effects of competing electrolytes.

  Water research 20121015

• Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells.

  Biochemical and biophysical research communications 20121012

• AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.

  Biochemical and biophysical research communications 20121012

• Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.

  Life sciences 20121005

• TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

  Cell metabolism 20121003

• Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection.

  Biomedical chromatography : BMC 20121001

• [Metformin associates lactic acidosis].

  Presse medicale (Paris, France : 1983) 20121001

• Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: a report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study.

  Diabetes & vascular disease research 20121001

• Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.

  Biochimica et biophysica acta 20121001

• Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20121001

• A primary care register for impaired glucose handling (IGH): impact on cardiometabolic profile.

  Primary care diabetes 20121001

• Metformin therapy in patients with chronic kidney disease.

  Diabetes, obesity & metabolism 20121001

• Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.

  Diabetes, obesity & metabolism 20121001

• A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.

  Clinical lymphoma, myeloma & leukemia 20121001

• Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients.

  Diabetes research and clinical practice 20121001

• Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition.

  Diabetes care 20121001

• Metformin inhibits growth hormone-mediated hepatic PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner.

  Diabetes 20121001

• Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.

  Gynecologic oncology 20121001

• Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment.

  Water research 20121001

• Add-on therapies to metformin in type 2 diabetes: what modulates the respective decrements in postprandial and basal glucose?

  Diabetes technology & therapeutics 20121001

• Is there a dose-response relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study.

  Human reproduction (Oxford, England) 20121001

• Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue.

  The Journal of clinical endocrinology and metabolism 20121001

• Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001

• Different antidiabetic regimens and the development of renal dysfunction in US Veterans with type 2 diabetes mellitus.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001

• Continuous glucose profiles with vildagliptin versus sitagliptin in add-on to metformin: results from the randomized Optima study.

  Diabetes & metabolism 20121001

• Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair.

  Oncology reports 20121001

• Diabetes and pancreatic cancer.

  Endocrine-related cancer 20121001

• Metformin and breast cancer risk: a meta-analysis and critical literature review.

  Breast cancer research and treatment 20121001

• Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials.

  Diabetologia 20121001

• Diabetes: Add-on to metformin in T2DM--linagliptin or glimepiride?

  Nature reviews. Endocrinology 20121001

• Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.

  Breast cancer research and treatment 20121001

• Rejuvenating regeneration: metformin activates endogenous adult stem cells.

  Cell cycle (Georgetown, Tex.) 20121001

• Status of clomiphene citrate and metformin for infertility in PCOS.

  Trends in endocrinology and metabolism: TEM 20121001

• Metformin for schizophrenia: an editorial comment to Curtis J, Newall H, Shiers D, Samaras K. 'Considering metformin in cardiometabolic protection in psychosis'.

  Acta psychiatrica Scandinavica 20121001

• Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.

  The American journal of medicine 20121001

• Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones.

  Heart failure clinics 20121001

• Cost-utility analysis of liraglutide versus glimepiride as add-on to metformin in type 2 diabetes patients in China.

  International journal of technology assessment in health care 20121001

• Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study.

  Current medical research and opinion 20121001

• Safety of exenatide once weekly in patients with type 2 diabetes mellitus treated with a thiazolidinedione alone or in combination with metformin for 2 years.

  Clinical therapeutics 20121001

• Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients.

  Chinese medical journal 20121001

• [Continuous glucose monitoring in glimipiride plus metformin treated type 2 diabetic patients during the month of Ramadan].

  La Tunisie medicale 20121001

• [Proposal for the modification of metformin use in patients with chronic kidney disease].

  Orvosi hetilap 20120930

• What's preventing us from preventing type 2 diabetes?

  The New England journal of medicine 20120927

• Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

  American journal of physiology. Gastrointestinal and liver physiology 20120915

• Glycemic control in youth with type 2 diabetes.

  The New England journal of medicine 20120913

• Linagliptin: a review of its use in the management of type 2 diabetes mellitus.

  Drugs 20120910

• Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells.

  Biochemical and biophysical research communications 20120907

• Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.

  Diabetic medicine : a journal of the British Diabetic Association 20120901

• Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial.

  Metabolism: clinical and experimental 20120901

• Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis.

  Diabetes, obesity & metabolism 20120901

• Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis.

  Diabetes, obesity & metabolism 20120901

• Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients.

  Diabetes, obesity & metabolism 20120901

• Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901

• Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.

  Pharmacological research 20120901

• Metformin interacts with AMPK through binding to γ subunit.

  Molecular and cellular biochemistry 20120901

• Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.

  Biochimica et biophysica acta 20120901

• The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes.

  Journal of diabetes 20120901

• Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).

  Journal of molecular and cellular cardiology 20120901

• Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.

  IUBMB life 20120901

• Effects of frequency of follow-up on quality of life of type 2 diabetes patients on oral hypoglycemics.

  Diabetes technology & therapeutics 20120901

• Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.

  Pharmacogenetics and genomics 20120901

• The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.

  Diabetes care 20120901

• Metformin inhibits the development and metastasis of ovarian cancer.

  Oncology reports 20120901

• Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.

  Diabetes research and clinical practice 20120901

• Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.

  European journal of endocrinology 20120901

• Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain.

  Endocrinology 20120901

• Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.

  Clinical obstetrics and gynecology 20120901

• Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials--common patterns in TRITON, RECORD, and PLATO?

  Thrombosis and haemostasis 20120901

• Targeting the consequences of the metabolic syndrome in the Diabetes Prevention Program.

  Arteriosclerosis, thrombosis, and vascular biology 20120901

• Investigating metformin for cancer prevention and treatment: the end of the beginning.

  Cancer discovery 20120901

• AMP-activated protein kinase acts as a negative regulator of high glucose-induced RANKL expression in human periodontal ligament cells.

  Chinese medical journal 20120901

• Comparative efficacy of thiazolidinediones and metformin for polycystic ovary syndrome.

  Saudi medical journal 20120901

• A report of the James Watson lecture at Yale University.

  The Yale journal of biology and medicine 20120901

• Early, aggressive treatment is effective in treating diabetes. Risk of long-term complications reduced significantly.

  DukeMedicine healthnews 20120901

• Momordica charantia for type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20120815

• Diabetes, metformin, and breast cancer in postmenopausal women.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810

• Diabetes, metformin, and breast cancer: lilac time?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810

• Gliptin versus a sulphonylurea as add-on to metformin.

  Lancet (London, England) 20120804

• 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial.

  Lancet (London, England) 20120804

• The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus.

  International journal of cancer 20120801

• Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study.

  Clinical endocrinology 20120801

• Evaluation of dibutyrylchitin as new excipient for sustained drug release.

  Drug development and industrial pharmacy 20120801

• A case of hypoglycemic hemiparesis and literature review.

  Upsala journal of medical sciences 20120801

• The risk of overall mortality in patients with Type 2 diabetes receiving different combinations of sulfonylureas and metformin: a retrospective analysis.

  Diabetic medicine : a journal of the British Diabetic Association 20120801

• Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study.

  Pediatric diabetes 20120801

• The effect of linagliptin on glycaemic control and tolerability in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.

  Diabetes, obesity & metabolism 20120801

• Glucose-lowering treatment and clinical results in 163 121 patients with type 2 diabetes: an observational study from the Swedish national diabetes register.

  Diabetes, obesity & metabolism 20120801

• Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study.

  Pediatric diabetes 20120801

• Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20120801

• Relation between diabetes, metformin treatment and the occurrence of malignancies in a Belgian primary care setting.

  Diabetes research and clinical practice 20120801

• The influence of antidiabetic medications on the development and progression of prostate cancer.

  Cancer epidemiology 20120801

• Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats.

  Diabetes research and clinical practice 20120801

• Effect of lifestyle modification and metformin therapy on emerging cardiovascular risk factors in overweight Indian women with polycystic ovary syndrome.

  Metabolic syndrome and related disorders 20120801

• Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20120801

• Links among type 2 diabetes, cancer and metformin use: what have we learned?

  Diabetes research and clinical practice 20120801

• Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression.

  The journal of obstetrics and gynaecology research 20120801

• A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.

  Cellular signalling 20120801

• Cancer risk in type 2 diabetes.

  Current diabetes reports 20120801

• Effects of metformin on the expression of GLUT4 in endometrium of obese women with polycystic ovary syndrome.

  Biology of reproduction 20120801

• Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

  Diabetes 20120801

• Cardioprotective effects of metformin and vildagliptin in adult rats with insulin resistance induced by a high-fat diet.

  Endocrinology 20120801

• The treatment of infertility in polycystic ovary syndrome: a brief update.

  The Australian & New Zealand journal of obstetrics & gynaecology 20120801

• Thyreotropin levels in diabetic patients on metformin treatment.

  European journal of endocrinology 20120801

• In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

  Journal of pharmaceutical sciences 20120801

• Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.

  European journal of endocrinology 20120801

• Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.

  Diabetes 20120801

• Lower risk of hypoglycemia with sitagliptin compared to glipizide when either is added to metformin therapy: a pre-specified analysis adjusting for the most recently measured HbA(1c) value.

  Current medical research and opinion 20120801

• Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study.

  The American journal of psychiatry 20120801

• Insulin resistance in type 2 diabetic youth.

  Current opinion in endocrinology, diabetes, and obesity 20120801

• A single-dose, crossover study comparing the pharmacokinetics and pharmacodynamics of 2 formulations of metformin in healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20120801

• Overview of metformin: special focus on metformin extended release.

  Expert opinion on pharmacotherapy 20120801

• Combination treatment with ipragliflozin and metformin: a randomized, double-blind, placebo-controlled study in patients with type 2 diabetes mellitus.

  Clinical therapeutics 20120801

• Metformin is synthetically lethal with glucose withdrawal in cancer cells.

  Cell cycle (Georgetown, Tex.) 20120801

• Metformin is synthetically lethal with glucose withdrawal in cancer cells.

  Cell cycle (Georgetown, Tex.) 20120801

• Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy.

  Obstetrics and gynecology 20120801

• Severe hyperandrogenemia and insulin resistance in a 12-year-old girl.

  Journal of pediatric and adolescent gynecology 20120801

• Metformin as a treatment for antipsychotic drug side effects: special focus on women with schizophrenia.

  The American journal of psychiatry 20120801

• HbA1C - overall glycemia marker and hemolytic anemia indicator.

  Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina 20120801

• Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study.

  Chinese medical journal 20120801

• Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.

  PLoS genetics 20120801

• What comes after metformin for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20120723

• Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

• Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

• Cracking open window of opportunity trials.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

• Antidiabetic II drug metformin in plants: uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes.

  Journal of agricultural and food chemistry 20120718

• Illuminating the diabetes-cancer link.

  Journal of the National Cancer Institute 20120718

• Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model.

  International journal of pharmaceutics 20120715

• Cardiopulmonary and endothelial effects of metformin treatment in an insulin resistant population.

  International journal of cardiology 20120712

• Risk identification and interventions to prevent type 2 diabetes in adults at high risk: summary of NICE guidance.

  BMJ (Clinical research ed.) 20120712

• An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.

  Cell stem cell 20120706

• Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

  Cell stem cell 20120706

• Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

  Nature medicine 20120706

• Oral pharmacologic treatment of type 2 diabetes mellitus.

  Annals of internal medicine 20120703

• Oral pharmacologic treatment of type 2 diabetes mellitus.

  Annals of internal medicine 20120703

• Oral pharmacologic treatment of type 2 diabetes mellitus.

  Annals of internal medicine 20120703

• The burden of hospitalization related to diabetes mellitus: a population-based study.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120701

• Cost-effectiveness of saxagliptin (Onglyza®) in type 2 diabetes in Sweden.

  Primary care diabetes 20120701

• Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20120701

• Cost and clinical implications of diabetes prevention in an Australian setting: a long-term modeling analysis.

  Primary care diabetes 20120701

• Sitagliptin promotes macrophage-to-faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.

  Diabetes, obesity & metabolism 20120701

• A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.

  American journal of physiology. Cell physiology 20120701

• Fasting plasma glucose 6-12 weeks after starting insulin glargine predicts likelihood of treatment success: a pooled analysis.

  Diabetic medicine : a journal of the British Diabetic Association 20120701

• Metformin, metabolic stress, and mitochondria. Focus on 'A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells'.

  American journal of physiology. Cell physiology 20120701

• A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

  Diabetologia 20120701

• Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort.

  Parkinsonism & related disorders 20120701

• Use of thiazolidinedione and cancer risk in Type 2 diabetes: the Hong Kong diabetes registry.

  Diabetes research and clinical practice 20120701

• The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients.

  Diabetes technology & therapeutics 20120701

• Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis.

  The Journal of clinical endocrinology and metabolism 20120701

• Metformin-based treatment for obesity-related hypertension: a randomized, double-blind, placebo-controlled trial.

  Journal of hypertension 20120701

• Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function.

  Laboratory investigation; a journal of technical methods and pathology 20120701

• Diabetes and cancer II: role of diabetes medications and influence of shared risk factors.

  Cancer causes & control : CCC 20120701

• Efficacy and safety of taspoglutide in patients with type 2 diabetes inadequately controlled with metformin plus pioglitazone over 24 weeks: T-Emerge 3 trial.

  The Journal of clinical endocrinology and metabolism 20120701

• Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study.

  Current medical research and opinion 20120701

• Antiproliferative action of metformin in human lung cancer cell lines.

  Oncology reports 20120701

• Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.

  Diabetes care 20120701

• Identification of anti-melanogenic natural compounds from Galega officinalis and further drug repositioning.

  Journal of dermatological science 20120701

• Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation.

  Fertility and sterility 20120701

• Drug-induced hypoglycaemia in type 2 diabetes.

  Expert opinion on drug safety 20120701

• Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone, a thiazolidinedione antihyperglycemic agent, in healthy subjects.

  Current medical research and opinion 20120701

• Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/osteoprotegerin.

  Journal of endodontics 20120701

• β-cell function preservation after 3.5 years of intensive diabetes therapy.

  Diabetes care 20120701

• Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients.

  Diabetes care 20120701

• Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

  Aging 20120701

• Metformin, but not glimepiride, improves carotid artery diameter and blood flow in patients with type 2 diabetes mellitus.

  Clinics (Sao Paulo, Brazil) 20120701

• Initial combination therapy with metformin plus colesevelam in drug-naïve Hispanic patients with early type 2 diabetes.

  Postgraduate medicine 20120701

• The link between polycystic ovarian syndrome and type 2 diabetes: preventive and therapeutic approach in Israel.

  The Israel Medical Association journal : IMAJ 20120701

• [Basal insulin and GLP-1 agonist potentiate each other (interview by Dr. med Dirk Einecke)].

  MMW Fortschritte der Medizin 20120628

• Diabetes: insulin plus metformin for T2DM--are there benefits?

  Nature reviews. Endocrinology 20120626

• [AMPK: a novel target controlling inflammation].

  Sheng li xue bao : [Acta physiologica Sinica] 20120625

• Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial.

  Lancet (London, England) 20120616

• Choosing a blood-glucose-lowering agent after metformin.

  Lancet (London, England) 20120616

• Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.

  Lancet (London, England) 20120616

• Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells.

  Cell cycle (Georgetown, Tex.) 20120615

• A clinical trial to maintain glycemic control in youth with type 2 diabetes.

  The New England journal of medicine 20120614

• TODAY--a stark glimpse of tomorrow.

  The New England journal of medicine 20120614

• Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.

  The Journal of biological chemistry 20120608

• Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway.

  Biochemical and biophysical research communications 20120608

• [Metformin associated with lactic acidosis in treatment of type 2 diabetes].

  Ugeskrift for laeger 20120604

• [Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy].

  Ugeskrift for laeger 20120604

• [Treatment of metformin-associated lactate acidosis by haemodialysis].

  Ugeskrift for laeger 20120604

• Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin.

  Medical oncology (Northwood, London, England) 20120601

• Metformin and cancer: new applications for an old drug.

  Medical oncology (Northwood, London, England) 20120601

• Metformin-associated lactic acidosis in a patient with normal kidney function.

  Diabetes research and clinical practice 20120601

• Myo-inositol may prevent gestational diabetes in PCOS women.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120601

• The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients.

  Diabetes, obesity & metabolism 20120601

• Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.

  Journal of physiology and biochemistry 20120601

• Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.

  British journal of pharmacology 20120601

• Effect of antiandrogen treatment on bone density and bone geometry in adolescents with polycystic ovary syndrome.

  Journal of pediatric and adolescent gynecology 20120601

• Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus.

  European journal of clinical pharmacology 20120601

• Persistence with oral contraceptive pills versus metformin in women with polycystic ovary syndrome.

  Journal of women's health (2002) 20120601

• Metformin in cancer: translational challenges.

  Journal of molecular endocrinology 20120601

• Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study.

  Diabetes, obesity & metabolism 20120601

• Intensifying insulin therapy with insulin analog premixes: transitioning from basal insulin in type 2 diabetes.

  Diabetes technology & therapeutics 20120601

• Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.

  Acta obstetricia et gynecologica Scandinavica 20120601

• Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.

  Endocrine-related cancer 20120601

• AMP-activated protein kinase, stress responses and cardiovascular diseases.

  Clinical science (London, England : 1979) 20120601

• Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.

  Expert opinion on pharmacotherapy 20120601

• Metformin for treatment of antipsychotic-induced weight gain: a randomized, placebo-controlled study.

  Schizophrenia research 20120601

• Metformin use among individuals at risk for type 2 diabetes.

  Current diabetes reports 20120601

• Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

  Drug metabolism and disposition: the biological fate of chemicals 20120601

• Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.

  Pharmacology, biochemistry, and behavior 20120601

• Atypical protein kinase C in cardiometabolic abnormalities.

  Current opinion in lipidology 20120601

• Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20120601

• Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway.

  Oncology reports 20120601

• Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.

  Trends in pharmacological sciences 20120601

• Microvascular diseases: is a new era coming?

  Cardiovascular & hematological agents in medicinal chemistry 20120601

• The effect of metformin on the efficacy of antiviral therapy in patients with genotype 1 chronic hepatitis C and insulin resistance.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120601

• The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.

  Hepatology (Baltimore, Md.) 20120601

• Cellular responses to the metal-binding properties of metformin.

  Diabetes 20120601

• Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes.

  Diabetes care 20120601

• Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice.

  The Journal of biological chemistry 20120601

• Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients.

  Diabetes technology & therapeutics 20120601

• The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.

  Diabetes technology & therapeutics 20120601

• The role of combination therapy in type 2 diabetes in the post-ACCORD era.

  Current diabetes reports 20120601

• Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients.

  Advances in medical sciences 20120601

• Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats.

  Investigative ophthalmology & visual science 20120601

• Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study.

  Clinical breast cancer 20120601

• Long-term effects of adding exenatide to a regimen of metformin and/or sulfonylurea in type 2 diabetes: an uncontrolled, open-label trial in Hungary.

  Clinical therapeutics 20120601

• Altering hirsutism through ovulation induction in women with polycystic ovary syndrome.

  Obstetrics and gynecology 20120601

• Statin is a reasonable treatment option for patients with Polycystic Ovary Syndrome: a meta-analysis of randomized controlled trials.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120601

• Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis.

  The oncologist 20120601

• Cardiovascular disease and oral agent glucose-lowering therapies in the management of type 2 diabetes.

  Diabetes technology & therapeutics 20120601

• Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20120601

• Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance.

  Mayo Clinic proceedings 20120601

• Does metformin increase paraoxonase activity in patients with the metabolic syndrome? Additional data from the MEFISTO study.

  Clinical and translational science 20120601

• Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.

  Nature communications 20120529

• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  The Cochrane database of systematic reviews 20120516

• [Prevention of type 2 diabetes mellitus].

  MMW Fortschritte der Medizin 20120516

• Metformin and pancreatic cancer: a clue requiring investigation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120515

• Metformin use is associated with better survival of diabetic patients with pancreatic cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120515

• Evaluation of guidelines on diabetes medication.

  Annals of internal medicine 20120515

• Evaluation of guidelines on diabetes medication.

  Annals of internal medicine 20120515

• Discrepancies among consensus documents, guidelines, clinical practice and the legal framework for the treatment of type 2 diabetes mellitus patients.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120514

• Inhibition of hepatic uptake transporters by flavonoids.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

• Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta.

  Biochemical and biophysical research communications 20120511

• Investigation of an active film coating to prepare new fixed-dose combination tablets for treatment of diabetes.

  International journal of pharmaceutics 20120510

• [Relationship between the degree of glycemic control and diabetes characteristics and hyperglycemia treatment in type 2 diabetes. DIABES Study].

  Medicina clinica 20120505

• Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.

  Journal of endocrinological investigation 20120501

• A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy.

  BJU international 20120501

• Lifestyle intervention improves fitness independent of metformin in obese adolescents.

  Medicine and science in sports and exercise 20120501

• Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20120501

• Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells.

  Diabetes research and clinical practice 20120501

• Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

  Gynecologic oncology 20120501

• Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model.

  Diabetes 20120501

• MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.

  International journal of molecular medicine 20120501

• Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.

  Journal of pharmaceutical sciences 20120501

• Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.

  Diabetologia 20120501

• Metformin-associated lactic acidosis masquerading as ischemic bowel.

  The American journal of medicine 20120501

• Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.

  Schizophrenia research 20120501

• Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial.

  International journal of clinical practice 20120501

• Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.

  Xenobiotica; the fate of foreign compounds in biological systems 20120501

• Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial.

  The Journal of clinical endocrinology and metabolism 20120501

• Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20120501

• Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year.

  Pharmacoepidemiology and drug safety 20120501

• Glycemic control over 5 years in 4,900 people with type 2 diabetes: real-world diabetes therapy in a clinical trial cohort.

  Diabetes care 20120501

• Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120501

• Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients.

  Diabetes care 20120501

• Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.

  Journal of the American Geriatrics Society 20120501

• Worry vs. knowledge about treatment-associated hypoglycaemia and weight gain in type 2 diabetic patients on metformin and/or sulphonylurea.

  Current medical research and opinion 20120501

• A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome.

  Current medical research and opinion 20120501

• High-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the analysis of antidiabetic drugs in aqueous environmental samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

• Therapeutic effects of calcium & vitamin D supplementation in women with PCOS.

  Complementary therapies in clinical practice 20120501

• Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.

  Obstetrics and gynecology 20120501

• Reweighted Mahalanobis distance matching for cluster-randomized trials with missing data.

  Pharmacoepidemiology and drug safety 20120501

• Metformin in obesity, cancer and aging: addressing controversies.

  Aging 20120501

• Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.

  Anticancer research 20120501

• A retrospective in vitro study of the impact of anti-diabetics and cardioselective pharmaceuticals on breast cancer.

  Anticancer research 20120501

• [Metformin-associated lactic acidosis: incidence, diagnosis, prognostic factors and treatment].

  Revista espanola de anestesiologia y reanimacion 20120501

• [Medicines for type 2 diabetes: fine tuning rather than redesign].

  Medizinische Monatsschrift fur Pharmazeuten 20120501

• [Biguanide].

  Nihon rinsho. Japanese journal of clinical medicine 20120501

• Association between sitagliptin adherence and self-monitoring of blood glucose.

  Journal of diabetes science and technology 20120501

• In type 2 diabetes patients, insulin glargine is associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment.

  Journal of diabetes science and technology 20120501

• Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract.

  Molecules (Basel, Switzerland) 20120430

• [Vitamin B12 deficiency in diabetic patients taking metformin].

  Medicina clinica 20120428

• Report was overpositive about their benefits.

  BMJ (Clinical research ed.) 20120424

• Prescribed with gusto despite 'uncertain' benefits.

  BMJ (Clinical research ed.) 20120424

• Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses.

  BMJ (Clinical research ed.) 20120419

• Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer.

  British journal of cancer 20120410

• A phase I study of temsirolimus and metformin in advanced solid tumours.

  Investigational new drugs 20120401

• Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.

  Primary care diabetes 20120401

• Adherence to hypoglycaemic medication among people with type 2 diabetes in primary care.

  Primary care diabetes 20120401

• Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells.

  Nanomedicine (London, England) 20120401

• Longitudinal change in HbA1c after insulin initiation in primary care patients with type 2 diabetes: a database analysis in UK and Germany.

  Primary care diabetes 20120401

• Adding saxagliptin to extended-release metformin vs. uptitrating metformin dosage.

  Diabetes, obesity & metabolism 20120401

• DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.

  Diabetes & metabolism 20120401

• Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.

  Diabetologia 20120401

• Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells.

  Molecular medicine reports 20120401

• Comparative effectiveness of incident oral antidiabetic drugs on kidney function.

  Kidney international 20120401

• Metformin reduces endogenous reactive oxygen species and associated DNA damage.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.

  European journal of endocrinology 20120401

• Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents.

  The Journal of clinical endocrinology and metabolism 20120401

• Use of antidiabetic agents and the risk of pancreatic cancer: a case-control analysis.

  The American journal of gastroenterology 20120401

• Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin.

  Current medical research and opinion 20120401

• Dipeptidyl peptidase-4 inhibitors: 3 years of experience.

  Diabetes technology & therapeutics 20120401

• Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin.

  International journal of biological macromolecules 20120401

• Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.

  International immunopharmacology 20120401

• Metformin prevents the development of chronic heart failure in the SHHF rat model.

  Diabetes 20120401

• Metformin reduces vascular production of vasoconstrictor prostanoids in fructose overloaded rats.

  Autonomic & autacoid pharmacology 20120401

• KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.

  European journal of internal medicine 20120401

• Reply to: Ahren B et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab 2011; 13(9): 775-783 and Ahren B et al. Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin. Diabetes Obes Metab 2011; 13(3): 193-203.

  Diabetes, obesity & metabolism 20120401

• The design of the liraglutide clinical trial programme.

  Diabetes, obesity & metabolism 20120401

• Liraglutide: from clinical trials to clinical practice.

  Diabetes, obesity & metabolism 20120401

• Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.

  Biopharmaceutics & drug disposition 20120401

• Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.

  Cell cycle (Georgetown, Tex.) 20120401

• Steps toward the meaningful translation of prevention strategies for type 2 diabetes.

  Diabetes care 20120401

• The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS.

  Diabetes care 20120401

• Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.

  Diabetes care 20120401

• Metformin and hepatic carcinogenesis.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

  PLoS medicine 20120401

• Recommendations for improving adherence to type 2 diabetes mellitus therapy--focus on optimizing oral and non-insulin therapies.

  The American journal of managed care 20120401

• The role of the nurse practitioner in the diagnosis and early management of type 2 diabetes.

  Journal of the American Academy of Nurse Practitioners 20120401

• Therapeutic choices, and the nurse practitioner's role, in type 2 diabetes when metformin alone is no longer enough.

  Journal of the American Academy of Nurse Practitioners 20120401

• Insulin initiation in type 2 diabetes: what are the treatment regimen options and how can we best help patients feel empowered?

  Journal of the American Academy of Nurse Practitioners 20120401

• Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts.

  Oncotarget 20120401

• Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

  Cancer discovery 20120401

• Lactic acidosis in a diabetic patient treated with metformin undergoing hepatic resection.

  British journal of hospital medicine (London, England : 2005) 20120401

• Competitive CE-UV binding tests for selective recognition of bisphenol A by molecularly imprinted polymer particles.

  Electrophoresis 20120401

• Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention.

  Iranian biomedical journal 20120401

• The role of ATM in response to metformin treatment and activation of AMPK.

  Nature genetics 20120328

• The role of ATM in response to metformin treatment and activation of AMPK.

  Nature genetics 20120328

• The role of ATM in response to metformin treatment and activation of AMPK.

  Nature genetics 20120328

• The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats.

  Brain research 20120320

• Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.

  Cell cycle (Georgetown, Tex.) 20120315

• Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome.

  AIDS (London, England) 20120313

• Phenformin as prophylaxis and therapy in breast cancer xenografts.

  British journal of cancer 20120313

• The role of dipeptidyl peptidase-4 inhibitors.

  BMJ (Clinical research ed.) 20120312

• Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis.

  BMJ (Clinical research ed.) 20120312

• Disposition of metformin: variability due to polymorphisms of organic cation transporters.

  Annals of medicine 20120301

• Familial occurrence of neonatal diabetes with duplications in chromosome 6q24: treatment with sulfonylurea and 40-yr follow-up.

  Pediatric diabetes 20120301

• Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer.

  Cancer 20120301

• Diagnosis and therapy of polycystic ovarian syndrome: results of a survey among German gynecologists with a review on literature.

  Archives of gynecology and obstetrics 20120301

• Impaired gallbladder motility and the effect of metformin therapy in patients with polycystic ovary syndrome.

  Clinical endocrinology 20120301

• Cost-utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20120301

• Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes.

  Diabetes/metabolism research and reviews 20120301

• Discontinuation of statins among patients with type 2 diabetes.

  Diabetes/metabolism research and reviews 20120301

• Improved gall bladder motility in PCOS women treated with metformin--interaction of free fatty acids with circulating cholecystokinin?

  Clinical endocrinology 20120301

• Metformin after bariatric surgery--an acid problem.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301

• Efficacy of metformin for prevention of weight gain in psychiatric populations: a review.

  International clinical psychopharmacology 20120301

• The impact of initiating biphasic human insulin 30 therapy in type 2 diabetes patients after failure of oral antidiabetes drugs.

  Diabetes technology & therapeutics 20120301

• Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs.

  AAPS PharmSciTech 20120301

• Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301

• Altered redox homeostasis in human diabetes saliva.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120301

• Comparing the effects of insulin glargine and thiazolidinediones on plasma lipids in type 2 diabetes: a patient-level pooled analysis.

  Diabetes/metabolism research and reviews 20120301

• Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

  Cancer prevention research (Philadelphia, Pa.) 20120301

• Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.

  Pharmacological research 20120301

• Metformin differentially activates ER stress signaling pathways without inducing apoptosis.

  Disease models & mechanisms 20120301

• Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter.

  Molecular pharmacology 20120301

• Cellular and molecular mechanisms of metformin: an overview.

  Clinical science (London, England : 1979) 20120301

• Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats.

  Pharmaceutical biology 20120301

• Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.

  Cancer science 20120301

• Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies.

  European journal of endocrinology 20120301

• Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.

  Planta medica 20120301

• A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells.

  Oncology reports 20120301

• Weight loss/maintenance as an effective tool for controlling type 2 diabetes: novel methodology to sustain weight reduction.

  Diabetes/metabolism research and reviews 20120301

• Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database.

  Diabetologia 20120301

• The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo.

  Molecular cancer therapeutics 20120301

• Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia.

  Basic research in cardiology 20120301

• Potential risks of metformin in transplant patients.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120301

• Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin.

  The Journal of clinical endocrinology and metabolism 20120301

• Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy.

  Current diabetes reviews 20120301

• Polycystic kidney disease: a 2011 update.

  Current opinion in nephrology and hypertension 20120301

• Cost effectiveness of saxagliptin and metformin versus sulfonylurea and metformin in the treatment of type 2 diabetes mellitus in Germany: a Cardiff diabetes model analysis.

  Clinical drug investigation 20120301

• Metformin versus lifestyle changes in treating women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120301

• Saxagliptin plus metformin combination in patients with type 2 diabetes and renal impairment.

  Expert opinion on drug metabolism & toxicology 20120301

• Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.

  Cell cycle (Georgetown, Tex.) 20120301

• Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation.

  Cell cycle (Georgetown, Tex.) 20120301

• Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.

  The American journal of medicine 20120301

• Metformin-induced hepatotoxicity.

  Diabetes care 20120301

• Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.

  Diabetes care 20120301

• Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.

  Diabetes care 20120301

• Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

  Cell death & disease 20120301

• Low hemoglobin A(1c)--good diabetic control?

  Clinical chemistry 20120301

• Incretin-based therapies in clinical practice: from efficacy to effectiveness. Focus on liraglutide.

  Minerva endocrinologica 20120301

• Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin.

  Minerva endocrinologica 20120301

• Menopausal obesity and metabolic syndrome - PolSenior study.

  Minerva endocrinologica 20120301

• Metformin and cancer stem cells: old drug, new targets.

  Cancer prevention research (Philadelphia, Pa.) 20120301

• The work-up for mixed hyperlipidemia: a case study.

  The Journal of family practice 20120301

• Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model.

  Journal of dietary supplements 20120301

• Better care for PCOS. Studying women's genes to find out what works.

  Diabetes forecast 20120301

• Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: a technical note.

  Archives of pharmacal research 20120301

• [Use of insulin sensitizers in the treatment of infertility in patients with polycystic ovary syndrome (POS)].

  Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20120301

• Prescription patterns for diabetes mellitus and therapeutic implications: a population-based analysis.

  Arquivos brasileiros de endocrinologia e metabologia 20120301

• Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone.

  The Journal of the Association of Physicians of India 20120301

• Metformin associated B12 deficiency.

  The Journal of the Association of Physicians of India 20120301

• Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.

  Biochemical and biophysical research communications 20120217

• Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats.

  Journal of ethnopharmacology 20120215

• Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.

  Annals of internal medicine 20120207

• Summaries for patients: Oral drug treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.

  Annals of internal medicine 20120207

• Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20120201

• Linearization of the MS response function: case study for metformin assay in plasma samples for bioequivalence purposes.

  Biomedical chromatography : BMC 20120201

• Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study.

  The Journal of clinical psychiatry 20120201

• Metformin as a cause of high stomal output.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20120201

• Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120201

• Metformin-induced leukocytoclastic vasculitis: a case report.

  American journal of clinical dermatology 20120201

• Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis.

  Diabetes/metabolism research and reviews 20120201

• ENPP1 mRNA levels in white blood cells and prediction of metformin efficacy in type 2 diabetic patients: a preliminary evidence.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201

• Targeting AMPK in the treatment of malignancies.

  Journal of cellular biochemistry 20120201

• Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.

  Diabetic medicine : a journal of the British Diabetic Association 20120201

• Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice.

  Diabetic medicine : a journal of the British Diabetic Association 20120201

• Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.

  Diabetologia 20120201

• Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study.

  Diabetes technology & therapeutics 20120201

• Unlicensed use of metformin in children and adolescents in Germany and France.

  British journal of clinical pharmacology 20120201

• Gestational diabetes: implications for cardiovascular health.

  Current diabetes reports 20120201

• Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120201

• Metformin causes nitric oxide-mediated dilatation in a shorter time than insulin in the iliac artery of the anesthetized pig.

  Journal of cardiovascular pharmacology 20120201

• Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.

  The Journal of pharmacology and experimental therapeutics 20120201

• Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression.

  Medical hypotheses 20120201

• Chemoprevention in colorectal cancer--where we stand and what we have learned from twenty year's experience.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20120201

• Introduction of metformin for gestational diabetes mellitus in clinical practice: Has it had an impact?

  European journal of obstetrics, gynecology, and reproductive biology 20120201

• Management of diabetes in pregnancy.

  Current diabetes reports 20120201

• Medical therapy for nonalcoholic fatty liver disease in children and adolescents.

  Expert review of gastroenterology & hepatology 20120201

• Androgens and antimüllerian hormone in mothers with polycystic ovary syndrome and their newborns.

  Fertility and sterility 20120201

• Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.

  Biochimica et biophysica acta 20120201

• Use of metformin is not associated with a decreased risk of colorectal cancer: a case-control analysis.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120201

• Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

  Diabetes care 20120201

• Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006.

  Diabetes care 20120201

• Acute renal failure after intragastric balloon in morbidly-obese metformin-treated diabetic patients. Report of two cases.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201

• Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study.

  Diabetes care 20120201

• Pharmacokinetics of a fixed-dose glimepiride/sustained-release metformin combination.

  International journal of clinical pharmacology and therapeutics 20120201

• Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival.

  Diabetes care 20120201

• Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.

  The American journal of medicine 20120201

• Metformin: a potential novel endometrial cancer therapy.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120201

• Quantifying the effect of metformin treatment and dose on glycemic control.

  Diabetes care 20120201

• Highlights from the latest articles in diabetes pharmacogenomics.

  Pharmacogenomics 20120201

• Male partial hypogonadotrophic hypogonadism with gynaecomastia and metabolic syndrome.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201

• [Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: effects on body composition].

  Minerva ginecologica 20120201

• Fixed-dose glucose-lowering drug combinations: preventable lactic acidosis.

  Prescrire international 20120201

• Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats.

  European review for medical and pharmacological sciences 20120201

• Does use of metformin protect against cancer in Type 2 diabetes mellitus?

  Journal of endocrinological investigation 20120201

• [Metformin improves epididymal sperm quality and antioxidant function of the testis in diet-induced obesity rats].

  Zhonghua nan ke xue = National journal of andrology 20120201

• Glycaemic control and cost analysis when changing from gliclazide co-administered with metformin to pre-combined glibenclamide-metformin tablets in type 2 diabetes mellitus.

  The Medical journal of Malaysia 20120201

• Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.

  Life sciences 20120130

• Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia.

  Blood 20120126

• Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

  Cell cycle (Georgetown, Tex.) 20120115

• Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

  The Journal of biological chemistry 20120113

• Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.

  Journal of perinatal medicine 20120110

• Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway.

  Biochemical and biophysical research communications 20120106

• Cancer research. Cancer prevention with a diabetes pill?

  Science (New York, N.Y.) 20120106

• Evaluation of guideline recommendations on oral medications for type 2 diabetes mellitus: a systematic review.

  Annals of internal medicine 20120103

• Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.

  Life sciences 20120102

• The effect of oral metformin on insulin sensitivity in insulin-resistant ponies.

  Veterinary journal (London, England : 1997) 20120101

• Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography-electrospray tandem mass spectrometry.

  Biomedical chromatography : BMC 20120101

• Lupin seed γ-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of HepG2 cells.

  The British journal of nutrition 20120101

• Metformin and improvement of the hepatic insulin resistance index independent of anthropometric changes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• Caloric restriction and chronic inflammatory diseases.

  Oral diseases 20120101

• Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120101

• Unlicensed use of metformin in children and adolescents in the UK.

  British journal of clinical pharmacology 20120101

• Metformin induced expression of Hsp60 in human THP-1 monocyte cells.

  Cell stress & chaperones 20120101

• Predictive value of HbA1c for incident diabetes among subjects with impaired glucose tolerance--analysis of the Indian Diabetes Prevention Programmes.

  Diabetic medicine : a journal of the British Diabetic Association 20120101

• Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients.

  Diabetes, obesity & metabolism 20120101

• Discordant effects on central obesity, hepatic insulin resistance, and alanine aminotransferase of low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance.

  Diabetes, obesity & metabolism 20120101

• Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study.

  Archives of gerontology and geriatrics 20120101

• Metformin in equine metabolic syndrome: an enigma or a dead duck?

  Veterinary journal (London, England : 1997) 20120101

• Metformin and neoplasia: implications and indications.

  Pharmacology & therapeutics 20120101

• Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.

  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120101

• Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).

  Molecular and cellular biochemistry 20120101

• AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

  Leukemia 20120101

• Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study.

  Annals of clinical biochemistry 20120101

• Effects of pioglitazone add-on to gliclazide and metformin on glycemic control in patients with type 2 diabetes.

  Endocrine research 20120101

• Metformin effects revisited.

  Diabetes research and clinical practice 20120101

• Addition of metformin to sildenafil treatment for erectile dysfunction in eugonadal nondiabetic men with insulin resistance. A prospective, randomized, double-blind pilot study.

  Journal of andrology 20120101

• A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.

  European journal of endocrinology 20120101

• Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes.

  Diabetes care 20120101

• Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureas.

  Diabetes & vascular disease research 20120101

• Effect of initial combination therapy with sitagliptin and metformin on β-cell function in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20120101

• Can a protocol for glycaemic control improve type 2 diabetes outcomes after gastric bypass?

  Obesity surgery 20120101

• The safety, efficacy and predictors for HbA1c reduction of sitagliptin in the treatment of Japanese type 2 diabetes.

  Diabetes research and clinical practice 20120101

• The cost-effectiveness of saxagliptin versus NPH insulin when used in combination with other oral antidiabetes agents in the treatment of type 2 diabetes mellitus in Poland.

  Diabetes technology & therapeutics 20120101

• Successful treatment of prediabetes in clinical practice: targeting insulin resistance and β-cell dysfunction.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• Reversible severe deterioration of glycaemic control after withdrawal of metformin treatment.

  Diabetologia 20120101

• LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120101

• Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.

  Fertility and sterility 20120101

• Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study.

  Diabetes care 20120101

• Metformin and cancer therapy.

  Current opinion in oncology 20120101

• Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.

  Diabetes 20120101

• Metformin and heart failure: never say never again.

  Expert opinion on pharmacotherapy 20120101

• Metformin + saxagliptin for type 2 diabetes.

  Expert opinion on pharmacotherapy 20120101

• Spontaneous platelet aggregation evaluated by laser light scatter in patients with type 2 diabetes: effects of short-term improved glycemic control and adiponectin.

  Translational research : the journal of laboratory and clinical medicine 20120101

• Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea.

  Translational research : the journal of laboratory and clinical medicine 20120101

• Diabetes and pancreatic cancer.

  Molecular carcinogenesis 20120101

• Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

  Obstetrics and gynecology 20120101

• For what reasons should metformin be used in the management of polycystic ovary syndrome?

  Journal of endocrinological investigation 20120101

• Should all women with PCOS be treated for insulin resistance?

  Fertility and sterility 20120101

• Postmarketing pharmacovigilance of adverse drug reactions: the case of rosiglitazone in Mexico.

  International journal of clinical pharmacology and therapeutics 20120101

• Metabolic compartments in tumor tissue: implications for therapy.

  Cell cycle (Georgetown, Tex.) 20120101

• The role of metformin in the management of NAFLD.

  Experimental diabetes research 20120101

• Proton pump inhibitor therapy associated with lower glycosylated hemoglobin levels in type 2 diabetes.

  Journal of the American Board of Family Medicine : JABFM 20120101

• Fixed-dose combination antidiabetic therapy: real-world factors associated with prescribing choices and relationship with patient satisfaction and compliance.

  Advances in therapy 20120101

• Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons.

  BMC neuroscience 20120101

• Quantifying the impact of drug exposure misclassification due to restrictive drug coverage in administrative databases: a simulation cohort study.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120101

• Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas.

  Physiological research 20120101

• Persistence of initial oral antidiabetic treatment in patients with type 2 diabetes mellitus.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• Outcome of metformin treatment in polycystic ovary syndrome.

  Mymensingh medical journal : MMJ 20120101

• Bioequivalence and pharmacokinetic comparison of 3 metformin extended/sustained release tablets in healthy Indian male volunteers.

  Arzneimittel-Forschung 20120101

• Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

  Neuroendocrinology 20120101

• Treating polycystic ovary syndrome and infertility.

  MCN. The American journal of maternal child nursing 20120101

• AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells.

  PloS one 20120101

• Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach.

  La Clinica terapeutica 20120101

• Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).

  PloS one 20120101

• Swim training reduces metformin levels in fructose-induced insulin resistant rats.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

• Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells.

  Cardiovascular diabetology 20120101

• Podocyte as a potential target of inflammation: role of pioglitazone hydrochloride in patients with type 2 diabetes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial.

  BMC cancer 20120101

• Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.

  PloS one 20120101

• Effectiveness of metformin and lifestyle interventions as an initial treatment in Japanese patients with newly diagnosed type 2 diabetes: a prospective observational study.

  The journal of medical investigation : JMI 20120101

• Effect of metformin and pioglitazone treatment on cardiovascular risk profile in polycystic ovary syndrome.

  Acta medica Indonesiana 20120101

• Metformin plus PIAF combination chemotherapy for hepatocellular carcinoma.

  Experimental oncology 20120101

• Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells.

  Scientific reports 20120101

• Is metformin indicated as primary ovulation induction agent in women with PCOS? A systematic review and meta-analysis.

  Gynecologic and obstetric investigation 20120101

• Mechanisms involved in the protective effects of metformin against nonalcoholic fatty liver disease.

  Current medicinal chemistry 20120101

• Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway.

  Photochemistry and photobiology 20120101

• Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• [Molecular and genetic aspects of heart failure in diabetic patients].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20120101

• Hypoglycemics for the treatment of type 2 diabetes in patients with chronic kidney disease: a focus on new agents.

  CANNT journal = Journal ACITN 20120101

• Obesity and metformin.

  Journal of pediatric endocrinology & metabolism : JPEM 20120101

• Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.

  Journal of pediatric endocrinology & metabolism : JPEM 20120101

• The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial.

  Journal of pediatric endocrinology & metabolism : JPEM 20120101

• Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.

  PloS one 20120101

• [The influence of metformin and N-acetylcysteine on mammographic density in postmenopausal women].

  Voprosy onkologii 20120101

• [Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges].

  Akusherstvo i ginekologiia 20120101

• Ketosis-prone type 2 diabetes mellitus in a patient with Sheehan's syndrome: a rare convergence of two distinct endocrine entities.

  BMJ case reports 20120101

• Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats.

  Oxidative medicine and cellular longevity 20120101

• Effects of a vildagliptin/metformin combination on markers of atherosclerosis, thrombosis, and inflammation in diabetic patients with coronary artery disease.

  Cardiovascular diabetology 20120101

• Effect of metformin on hepatic glucose production in Japanese patients with type 2 diabetes mellitus.

  Endocrine journal 20120101

• Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering?

  Cardiovascular diabetology 20120101

• Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial.

  Cardiovascular diabetology 20120101

• The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus.

  Biological & pharmaceutical bulletin 20120101

• The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese.

  Experimental diabetes research 20120101

• Cost-effectiveness and budget impact of saxagliptine as additional therapy to metformin for the treatment of diabetes mellitus type 2 in the Brazilian private health system.

  Revista da Associacao Medica Brasileira (1992) 20120101

• Comparison of metformin and insulin in the control of hyperglycaemia in non-diabetic critically ill patients.

  Endokrynologia Polska 20120101

• [Metformin does not suppress the aromatase expression in breast cancer tissue of patients with concurrent type 2 diabetes].

  Voprosy onkologii 20120101

• The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration.

  Experimental diabetes research 20120101

• Long-term clinical and economic outcomes associated with liraglutide versus sitagliptin therapy when added to metformin in the treatment of type 2 diabetes: a CORE Diabetes Model analysis.

  Journal of medical economics 20120101

• Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus.

  Journal of clinical lipidology 20120101

• The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.

  International journal of molecular sciences 20120101

• [The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo].

  Biomeditsinskaia khimiia 20120101

• The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells.

  Molecular systems biology 20120101

• [Treatment of infertility].

  Duodecim; laaketieteellinen aikakauskirja 20120101

• Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.

  PloS one 20120101

• Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Fatal metformin intoxication with markedly elevated blood and liver concentrations.

  Journal of analytical toxicology 20120101

• Use of computer alerts to prevent the inappropriate use of metformin in an inpatient setting.

  Quality management in health care 20120101

• Genetics of type 2 diabetes mellitus and other specific types of diabetes; its role in treatment modalities.

  Diabetes & metabolic syndrome 20120101

• Glycemic control and weight changes in patients with type 2 diabetes intensified to three insulin regimens after therapeutic failure to exenatide.

  Acta clinica Belgica 20120101

• Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis.

  PloS one 20120101

• Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells.

  PloS one 20120101

• Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin.

  Experimental diabetes research 20120101

• Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.

  PloS one 20120101

• [Pharmacogenetic features of the effect of metformin in patients with coronary heart disease in the presence of metabolic syndrome and type 2 diabetes mellitus in terms of PPAR-gamma2 gene polymorphism].

  Terapevticheskii arkhiv 20120101

• [Role of metformin in diabetes treatment--is metformin falling from grace?].

  Nederlands tijdschrift voor geneeskunde 20120101

• Metformin stimulates FGF21 expression in primary hepatocytes.

  Experimental diabetes research 20120101

• Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

  PloS one 20120101

• 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells.

  Biochemical and biophysical research communications 20111209

• Antileukemic effects of AMPK activators on BCR-ABL-expressing cells.

  Blood 20111208

• Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens.

  European journal of pharmacology 20111205

• Controlling release of metformin HCl through incorporation into stomach specific floating alginate beads.

  Molecular pharmaceutics 20111205

• More favorable progesterone receptor phenotype of breast cancer in diabetics treated with metformin.

  Medical oncology (Northwood, London, England) 20111201

• Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.

  The pharmacogenomics journal 20111201

• Metformin-related lactic acidosis in patients with acute kidney injury.

  International urology and nephrology 20111201

• Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients.

  Annals of oncology : official journal of the European Society for Medical Oncology 20111201

• Metformin in prostate cancer: two for the price of one.

  Annals of oncology : official journal of the European Society for Medical Oncology 20111201

• The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus.

  Acta diabetologica 20111201

• Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.

  Human & experimental toxicology 20111201

• Metformin as an antitumor agent in cancer prevention and treatment.

  Journal of diabetes 20111201

• Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes.

  Obesity (Silver Spring, Md.) 20111201

• Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study.

  Diabetes, obesity & metabolism 20111201

• Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.

  Diabetes, obesity & metabolism 20111201

• Differences in insulin treatment satisfaction following randomized addition of biphasic, prandial or basal insulin to oral therapy in type 2 diabetes.

  Diabetes, obesity & metabolism 20111201

• The effects of metformin and letrozole on endometrium and ovary in a rat model.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111201

• Randomized study of repaglinide alone and in combination with metformin in Chinese subjects with type 2 diabetes naive to oral antidiabetes therapy.

  Expert opinion on pharmacotherapy 20111201

• Targeting the renin-angiotensin system: potential beneficial effects of the angiotensin II receptor blockers in patients with nonalcoholic steatohepatitis.

  Hepatology (Baltimore, Md.) 20111201

• Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism.

  American journal of reproductive immunology (New York, N.Y. : 1989) 20111201

• Reduced cell proliferation and neuroblast differentiation in the dentate gyrus of high fat diet-fed mice are ameliorated by metformin and glimepiride treatment.

  Neurochemical research 20111201

• Pioglitazone reduces urinary albumin excretion in renin-angiotensin system inhibitor-treated type 2 diabetic patients with hypertension and microalbuminuria: the APRIME study.

  Clinical and experimental nephrology 20111201

• Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

  American journal of physiology. Renal physiology 20111201

• Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation.

  Journal of medicinal food 20111201

• The cardioprotective effects of metformin.

  Current opinion in lipidology 20111201

• Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.

  Diabetologia 20111201

• Sulfonylureas or dipeptidyl peptidase (DPP-4) inhibitors in the management of type 2 diabetes: debate is not yet closed.

  Current diabetes reports 20111201

• Adiponectin levels in nonalcoholic fatty liver disease.

  Metabolism: clinical and experimental 20111201

• Pharmacokinetics of a fixed-dose combination of atorvastatin and metformin extended release versus concurrent administration of individual formulations: a randomized, open-label, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study.

  Clinical drug investigation 20111201

• Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

  Biochemical pharmacology 20111201

• Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2.

  Clinical and experimental pharmacology & physiology 20111201

• IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer.

  Endocrine-related cancer 20111201

• Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.

  Diabetologia 20111201

• Current perspectives of insulin resistance and polycystic ovary syndrome.

  Diabetic medicine : a journal of the British Diabetic Association 20111201

• Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.

  Diabetologia 20111201

• Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell.

  Endocrinology 20111201

• Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line.

  Hearing research 20111201

• Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial.

  Fertility and sterility 20111201

• The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

  Pharmacogenetics and genomics 20111201

• Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.

  Molecular cancer therapeutics 20111201

• Linagliptin for the treatment of type 2 diabetes (pharmacokinetic evaluation).

  Expert opinion on drug metabolism & toxicology 20111201

• Comparisons of persistence and durability among three oral antidiabetic therapies using electronic prescription-fill data: the impact of adherence requirements and stockpiling.

  Clinical pharmacology and therapeutics 20111201

• Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison.

  Clinical therapeutics 20111201

• Drug treatment of obesity.

  The Psychiatric clinics of North America 20111201

• Progression to insulin for patients with diabetes mellitus using the Texas Medicaid database.

  Clinical therapeutics 20111201

• Current world literature.

  Current opinion in lipidology 20111201

• Monitoring metformin in cardiac patients exposed to contrast media using ultra-high-performance liquid chromatography tandem mass-spectrometry.

  Therapeutic drug monitoring 20111201

• Pregnancy management of women with pregestational diabetes.

  Endocrinology and metabolism clinics of North America 20111201

• Beyond metformin: initiating combination therapy in patients with type 2 diabetes mellitus.

  Pharmacotherapy 20111201

• Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.

  Cell cycle (Georgetown, Tex.) 20111201

• [Metformin and insulin in chronic heart failure: contraindications not contraindicated and indications not indicated].

  Giornale italiano di cardiologia (2006) 20111201

• A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.

  The Yale journal of biology and medicine 20111201

• AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.

  The International journal of artificial organs 20111201

• Metformin: multi-faceted protection against cancer.

  Oncotarget 20111201

• Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.

  Annals of the New York Academy of Sciences 20111201

• Economic evaluation of outpatients with type 2 diabetes mellitus assisted by a pharmaceutical care service.

  Arquivos brasileiros de endocrinologia e metabologia 20111201

• AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.

  Oncotarget 20111201

• Metformin as an adjunct to insulin for glycemic control in patients with type 2 diabetes after CABG surgery: a randomized double blind clinical trial.

  Pakistan journal of biological sciences : PJBS 20111201

• [Incretin-based therapy for treating patients with type 2 diabetes].

  Orvosi hetilap 20111127

• Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes.

  Cancer 20111115

• Metformin protects against doxorubicin-induced cardiotoxicity: involvement of the adiponectin cardiac system.

  Free radical biology & medicine 20111115

• Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.

  Cancer biology & therapy 20111115

• Cost-effectiveness of second-line antihyperglycemic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20111108

• Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.

  Biochemical and biophysical research communications 20111104

• Insulin resistance and liver microcirculation in a rat model of early NAFLD.

  Journal of hepatology 20111101

• Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?

  British journal of pharmacology 20111101

• Fatty acid-binding protein-4 plasma levels are associated to metabolic abnormalities and response to therapy in girls and young women with androgen excess.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111101

• A randomized, parallel group, double-blind, multicentre study comparing the efficacy and safety of Avandamet (rosiglitazone/metformin) and metformin on long-term glycaemic control and bone mineral density after 80 weeks of treatment in drug-naïve type 2 diabetes mellitus patients.

  Diabetes, obesity & metabolism 20111101

• Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial.

  Hepatology (Baltimore, Md.) 20111101

• Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.

  American journal of physiology. Endocrinology and metabolism 20111101

• Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study.

  Diabetic medicine : a journal of the British Diabetic Association 20111101

• Use of metformin and the risk of ovarian cancer: a case-control analysis.

  Gynecologic oncology 20111101

• Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone.

  Cytokine 20111101

• Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20111101

• Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus.

  Diabetes research and clinical practice 20111101

• Associations between the use of metformin, sulphonylureas, or diet alone and cardiovascular outcomes in 6005 people with type 2 diabetes in the FIELD study.

  Diabetes research and clinical practice 20111101

• Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment.

  The Journal of clinical endocrinology and metabolism 20111101

• Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin.

  The Journal of clinical endocrinology and metabolism 20111101

• Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial.

  Diabetes research and clinical practice 20111101

• Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways.

  Microbiology and immunology 20111101

• Weight beneficial treatments for type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20111101

• Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.

  Molecular bioSystems 20111101

• Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial.

  Fertility and sterility 20111101

• Insulin sensitizers may attenuate lean mass loss in older men with diabetes.

  Diabetes care 20111101

• Should combination therapy be the paradigm for future nonalcoholic steatohepatitis clinical trials?

  Hepatology (Baltimore, Md.) 20111101

• A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.

  Clinical pharmacology and therapeutics 20111101

• [Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].

  Presse medicale (Paris, France : 1983) 20111101

• Pharmacokinetics of metformin in girls aged 9 years.

  Clinical pharmacokinetics 20111101

• Pharmacokinetic comparison of a new sustained-release formulation of glimepiride/metformin 1/500 mg combination tablet and a sustained-release formulation of glimepiride/metformin 2/500 mg combination tablet in healthy Korean male volunteers: a randomized, 2-sequence, 2-period, 2-treatment crossover study.

  Clinical therapeutics 20111101

• Characterizing the structure of pharmaceutical granules obtained by wet granulation with varying amounts of water via Raman chemical imaging.

  Applied spectroscopy 20111101

• Insulin sensitisers in the treatment of non-alcoholic fatty liver disease: a systematic review.

  Health technology assessment (Winchester, England) 20111101

• Pioglitazone may accelerate disease course of slowly progressive type 1 diabetes.

  Diabetes/metabolism research and reviews 20111101

• Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control.

  Current clinical pharmacology 20111101

• Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.

  Aging 20111101

• Prevalence of diabetic retinopathy in Peruvian patients with type 2 diabetes: results of a hospital-based retinal telescreening program.

  Revista panamericana de salud publica = Pan American journal of public health 20111101

• Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose.

  Current drug safety 20111101

• Therapeutic effect of metformin and vitamin E versus prescriptive diet in obese adolescents with fatty liver.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20111101

• Combination of TS-021 with metformin improves hyperglycemia and synergistically increases pancreatic β-cell mass in a mouse model of type 2 diabetes.

  Life sciences 20111024

• [Hypoglycemia].

  Praxis 20111019

• In vitro and in vivo anti-melanoma action of metformin.

  European journal of pharmacology 20111015

• Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats.

  European journal of pharmacology 20111015

• Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats.

  Journal of ethnopharmacology 20111011

• Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats.

  Journal of ethnopharmacology 20111011

• Statins for women with polycystic ovary syndrome not actively trying to conceive.

  The Cochrane database of systematic reviews 20111005

• Intensive glucose control and cardiovascular outcomes in type 2 diabetes.

  Heart, lung & circulation 20111001

• Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort.

  Metabolism: clinical and experimental 20111001

• Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111001

• Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.

  Archives of physiology and biochemistry 20111001

• A systematic review of metformin to limit weight-gain with atypical antipsychotics.

  Journal of clinical pharmacy and therapeutics 20111001

• Inlay osmotic pump tablets containing metformin and glipizide.

  Drug development and industrial pharmacy 20111001

• Metformin pharmacokinetics in nondiabetic pregnant women with polycystic ovary syndrome.

  European journal of clinical pharmacology 20111001

• Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats.

  Journal of medicinal food 20111001

• Long-term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome.

  Clinical endocrinology 20111001

• Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats.

  Journal of cellular biochemistry 20111001

• Does metformin influence the insulin-, IGF I- and IGF II-receptor gene expression and Akt phosphorylation in human decidualized endometrial stromal cells?

  European journal of obstetrics, gynecology, and reproductive biology 20111001

• Organic cation transporter 3: expression in failing and nonfailing human heart and functional characterization.

  Journal of cardiovascular pharmacology 20111001

• Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells.

  American journal of physiology. Gastrointestinal and liver physiology 20111001

• Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea.

  Chemosphere 20111001

• Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program.

  Diabetologia 20111001

• Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase.

  Fitoterapia 20111001

• The role of metformin and thiazolidinediones in the regulation of hepatic glucose metabolism and its clinical impact.

  Trends in pharmacological sciences 20111001

• Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20111001

• APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.

  Molecular endocrinology (Baltimore, Md.) 20111001

• GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.

  Diabetes 20111001

• mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.

  Medical hypotheses 20111001

• Metformin as a geroprotector.

  Rejuvenation research 20111001

• Retrospective chart review of children with type 2 diabetes mellitus evaluating the efficacy of metformin vs. insulin vs. combination insulin/metformin.

  Southern medical journal 20111001

• Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age.

  Diabetes care 20111001

• Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis.

  Diabetes care 20111001

• Metformin therapy during pregnancy: good for the goose and good for the gosling too?

  Diabetes care 20111001

• Metformin and colorectal cancer risk in diabetic patients.

  Diabetes care 20111001

• Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients.

  Pakistan journal of pharmaceutical sciences 20111001

• [Pancreatic diseases: update 2011].

  Deutsche medizinische Wochenschrift (1946) 20111001

• Bioequivalence assessment of metformin hydrochloride using a limited sampling strategy.

  International journal of clinical pharmacology and therapeutics 20111001

• Norepinephrine uptake mechanisms in cardiovascular disease deserve our attention.

  Journal of cardiovascular pharmacology 20111001

• Fixed dose combination diabetes medicines - usage in the Australian veteran population.

  Australian family physician 20111001

• [Rare cause of insufficient metabolic control of diabetes mellitus - Case 10/2011].

  Deutsche medizinische Wochenschrift (1946) 20111001

• Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin.

  Breast (Edinburgh, Scotland) 20111001

• Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

  Aging 20111001

• Metformin intoxication requiring dialysis.

  Hemodialysis international. International Symposium on Home Hemodialysis 20111001

• Metformin hydrochloride-loaded poly(vinyl alcohol) composites as drug delivery systems.

  Journal of nanoscience and nanotechnology 20111001

• Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.

  Journal of agricultural and food chemistry 20110928

• [Dipeptidyl-peptidase-4 inhibitors (gliptins): a new class of oral antidiabetic drugs].

  Orvosi hetilap 20110911

• Interventions for latent autoimmune diabetes (LADA) in adults.

  The Cochrane database of systematic reviews 20110907

• Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control.

  Acta physiologica (Oxford, England) 20110901

• Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110901

• Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells.

  The Journal of steroid biochemistry and molecular biology 20110901

• Use of metformin in pediatric age.

  Pediatric diabetes 20110901

• Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial.

  Metabolism: clinical and experimental 20110901

• Triple oral fixed-dose diabetes polypill versus insulin plus metformin efficacy demonstration study in the treatment of advanced type 2 diabetes (TrIED study-II).

  Diabetes, obesity & metabolism 20110901

• An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypoglycaemia.

  Diabetes, obesity & metabolism 20110901

• Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome.

  The journal of obstetrics and gynaecology research 20110901

• Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome.

  Clinical endocrinology 20110901

• Thyrotropin-lowering effect of metformin in a patient with resistance to thyroid hormone.

  Clinical endocrinology 20110901

• A treatment strategy implementing combination therapy with sitagliptin and metformin results in superior glycaemic control versus metformin monotherapy due to a low rate of addition of antihyperglycaemic agents.

  Diabetes, obesity & metabolism 20110901

• Prognostic value of total testosterone for pregnancy during treatment in patients with clomiphene-citrate-resistant polycystic ovary syndrome: a pilot study.

  Archives of gynecology and obstetrics 20110901

• Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: the Microalbuminuria Education and Medication Optimisation (MEMO) study.

  Diabetes research and clinical practice 20110901

• Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients.

  European journal of pharmacology 20110901

• Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.

  Drug metabolism and disposition: the biological fate of chemicals 20110901

• Metformin for gestational diabetes in routine clinical practice.

  Diabetic medicine : a journal of the British Diabetic Association 20110901

• Therapeutic effects of metformin in breast cancer: involvement of the immune system?

  Cancer immunology, immunotherapy : CII 20110901

• Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy.

  Journal of ethnopharmacology 20110901

• Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants.

  Chemosphere 20110901

• Could there be a role for metformin in type 1 and type 2 diabetic pregnancies?

  Diabetologia 20110901

• AMP-activated protein kinase: also regulated by ADP?

  Trends in biochemical sciences 20110901

• Vildagliptin improves endothelium-dependent vasodilatation in type 2 diabetes.

  Diabetes care 20110901

• A case of lactic acidosis (LA) after administration of tenofovir and metformin in a diabetic patient with recently diagnosed HIV infection.

  Journal of renal care 20110901

• Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial.

  Diabetes care 20110901

• Adherence to oral antidiabetic agents with pioglitazone and metformin: comparison of fixed-dose combination therapy with monotherapy and loose-dose combination therapy.

  Clinical therapeutics 20110901

• Efficacy and safety of sitagliptin and the fixed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naïve patients with type 2 diabetes.

  International journal of clinical practice 20110901

• Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

  Cell cycle (Georgetown, Tex.) 20110901

• Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes.

  Diabetes care 20110901

• Incretin-based therapy and the quest for sustained improvements in β-cell health.

  Diabetes care 20110901

• Liver uptake of biguanides in rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110901

• Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

  Cell death & disease 20110901

• Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome: a randomized controlled trial.

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110901

• Intensifying type 2 diabetes therapy: assessing the options. Introduction.

  The Journal of family practice 20110901

• Options for intensifying diabetes treatment.

  The Journal of family practice 20110901

• Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901

• Anti-Müllerian hormone in women with polycystic ovary syndrome before and after therapy with metformin.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901

• [Effect of metformin on apoptosis of renal cell carcinoma cells in vitro and its mechanisms].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110901

• Diabetes mellitus and the risk of cancer.

  Minerva endocrinologica 20110901

• Hypoglycemic effects and biochemical mechanisms of oat products on streptozotocin-induced diabetic mice.

  Journal of agricultural and food chemistry 20110824

• Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet.

  Cell cycle (Georgetown, Tex.) 20110815

• Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

  Circulation 20110809

• Glycated hemoglobin as a prognostic risk marker in nondiabetic patients after acute myocardial infarction: what now?

  Circulation 20110809

• Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

  Cell metabolism 20110803

• The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110801

• AMPK and vasculoprotection.

  Pharmacology & therapeutics 20110801

• Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.

  European journal of clinical pharmacology 20110801

• Treatment intensification in patients with type 2 diabetes who failed metformin monotherapy.

  Diabetes, obesity & metabolism 20110801

• Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study.

  European heart journal 20110801

• Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: more support for cardiovascular outcome assessments.

  European heart journal 20110801

• Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20110801

• The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy.

  Medical hypotheses 20110801

• Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.

  American journal of physiology. Heart and circulatory physiology 20110801

• Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomized trial.

  Human reproduction (Oxford, England) 20110801

• Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study.

  Human reproduction (Oxford, England) 20110801

• Metformin as adjuvant therapy to IVF in women with PCOS: when is intention-to-treat unintentional?

  Human reproduction (Oxford, England) 20110801

• Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.

  Molecular endocrinology (Baltimore, Md.) 20110801

• AMP-activated protein kinase: a potential player in Alzheimer's disease.

  Journal of neurochemistry 20110801

• Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence.

  The Journal of clinical endocrinology and metabolism 20110801

• Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma.

  Leukemia & lymphoma 20110801

• Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

  Breast cancer research and treatment 20110801

• Impact of rosiglitazone therapy on the lipid profile, glycemic control, and medication costs among type 2 diabetes patients.

  Current medical research and opinion 20110801

• Menopause and risk of diabetes in the Diabetes Prevention Program.

  Menopause (New York, N.Y.) 20110801

• Lifestyle intervention in postmenopausal women: winning the game against diabetes.

  Menopause (New York, N.Y.) 20110801

• Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells.

  Anatomical record (Hoboken, N.J. : 2007) 20110801

• Weight-reducing effects of metformin are sustained over 40 weeks for psychiatric inpatients receiving polypharmacy.

  Journal of clinical psychopharmacology 20110801

• Effect of combined metformin and oral contraceptive therapy on metabolic factors and endothelial function in overweight and obese women with polycystic ovary syndrome.

  Fertility and sterility 20110801

• Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients.

  The Journal of clinical endocrinology and metabolism 20110801

• Impact of insulin-sensitizing agents on risk for liver cancer and liver-related death in diabetic patients with compensated hepatitis C cirrhosis.

  The Journal of clinical endocrinology and metabolism 20110801

• Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy?

  Diabetes research and clinical practice 20110801

• Metabolic syndrome and mental illness. Weight gain and other unhealthy attributes increase risk of diabetes and heart disease.

  The Harvard mental health letter 20110801

• [Diabetes and cancer risk: oncologic considerations].

  Orvosi hetilap 20110717

• Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression.

  Chemico-biological interactions 20110715

• A convenient synthesis of novel pyranosyl homo-C-nucleosides and their antidiabetic activities.

  Carbohydrate research 20110715

• Liquid chromatographic determination of sitagliptin either alone or in ternary mixture with metformin and sitagliptin degradation product.

  Talanta 20110715

• Insulin management of type 2 diabetes mellitus.

  American family physician 20110715

• Nonalcoholic fatty liver disease: Targeted therapy in children--what is the right way?

  Nature reviews. Gastroenterology & hepatology 20110712

• Influence of therapy with metformin on the concentration of certain divalent cations in patients with non-insulin-dependent diabetes mellitus.

  Biological trace element research 20110701

• Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells.

  Breast cancer research and treatment 20110701

• Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.

  American journal of respiratory cell and molecular biology 20110701

• Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes.

  The Journal of nutritional biochemistry 20110701

• Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone.

  Metabolism: clinical and experimental 20110701

• Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients.

  Diabetes research and clinical practice 20110701

• Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

  Clinical science (London, England : 1979) 20110701

• Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects.

  Diabetes, obesity & metabolism 20110701

• The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20110701

• Promoter-specific effects of metformin on aromatase transcript expression.

  Steroids 20110701

• AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.

  Diabetologia 20110701

• A Dose-Ranging Study of the DPP-IV Inhibitor PF-734200 Added to Metformin in Subjects With Type 2 Diabetes*.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110701

• Sitagliptin more effectively achieves a composite endpoint for A1C reduction, lack of hypoglycemia and no body weight gain compared with glipizide.

  Diabetes research and clinical practice 20110701

• The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study.

  Journal of assisted reproduction and genetics 20110701

• Intensive glucose control and risk of cancer in patients with type 2 diabetes.

  Diabetologia 20110701

• The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.

  European journal of obstetrics, gynecology, and reproductive biology 20110701

• Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

  Cancer research 20110701

• Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation.

  Acta pharmacologica Sinica 20110701

• Should metformin be our antiglycemic agent of choice post-transplantation?

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110701

• Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.

  Biopharmaceutics & drug disposition 20110701

• Comparison of the dipeptidyl peptidase-4 inhibitor vildagliptin and the sulphonylurea gliclazide in combination with metformin, in Muslim patients with type 2 diabetes mellitus fasting during Ramadan: results of the VECTOR study.

  Current medical research and opinion 20110701

• LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

  Cell cycle (Georgetown, Tex.) 20110701

• Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms.

  Fertility and sterility 20110701

• Clinical practice and implications of recent diabetes trials.

  Current opinion in cardiology 20110701

• Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

  Diabetes care 20110701

• Suppression of FoxO1 activity by long-chain fatty acyl analogs.

  Diabetes 20110701

• Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: a large population-based study.

  Diabetes research and clinical practice 20110701

• Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes.

  Postgraduate medicine 20110701

• Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.

  Cancer 20110701

• Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance.

  Diabetes care 20110701

• What's next for diabetes prevention?

  Diabetes care 20110701

• Adherence to medication under mandatory and voluntary mail benefit designs.

  The American journal of managed care 20110701

• Metformin-induced hemolytic anemia.

  The Israel Medical Association journal : IMAJ 20110701

• More adverse neurological consequences of metformin-induced vitamin B12 deficiency.

  Southern medical journal 20110701

• Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.

  Bulletin of experimental biology and medicine 20110701

• Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.

  Fertility and sterility 20110630

• Insulin resistance influences central opioid activity in polycystic ovary syndrome.

  Fertility and sterility 20110630

• Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study.

  Fertility and sterility 20110630

• Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.

  Behavioural brain research 20110620

• AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells.

  Biochemical and biophysical research communications 20110617

• Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110615

• Levels of evidence needed for changing indications, contraindications, and Food and Drug Administration labeling: the case of metformin.

  Archives of internal medicine 20110613

• Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells.

  Biochemical and biophysical research communications 20110610

• Baicalin upregulates the genetic expression of antioxidant enzymes in Type-2 diabetic Goto-Kakizaki rats.

  Life sciences 20110606

• AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells.

  Molecular and cellular endocrinology 20110606

• Metformin-associated lactic acidosis treated with prolonged hemodialysis.

  The American journal of emergency medicine 20110601

• The anti-atherogenic aspect of metformin treatment in insulin resistant women with the polycystic ovary syndrome: role of the newly established pro-inflammatory adipokine Acute-phase Serum Amyloid A; evidence of an adipose tissue-monocyte axis.

  Atherosclerosis 20110601

• Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.

  British journal of pharmacology 20110601

• Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110601

• Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.

  BJOG : an international journal of obstetrics and gynaecology 20110601

• Metformin for obesity and glucose dysregulation in patients with schizophrenia receiving antipsychotic drugs.

  Journal of psychopharmacology (Oxford, England) 20110601

• Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks.

  Diabetes, obesity & metabolism 20110601

• Prognostic implications of glucose-lowering treatment in patients with acute myocardial infarction and diabetes: experiences from an extended follow-up of the Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) 2 Study.

  Diabetologia 20110601

• Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

  The Journal of pharmacology and experimental therapeutics 20110601

• Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110601

• Do placebo based validation standards mimic real batch products behaviour? Case studies.

  Journal of pharmaceutical and biomedical analysis 20110601

• Liraglutide therapy in Prader-Willi syndrome.

  Diabetic medicine : a journal of the British Diabetic Association 20110601

• Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins.

  Gynecologic oncology 20110601

• Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.

  Toxicological sciences : an official journal of the Society of Toxicology 20110601

• Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic.

  The American journal of the medical sciences 20110601

• Scintigraphic diagnosis of Erdheim-Chester disease.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110601

• DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide.

  Diabetic medicine : a journal of the British Diabetic Association 20110601

• Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20110601

• In search of the 'LINK': Acute Phase Serum Amyloid A.

  Atherosclerosis 20110601

• PIOfix-study: effects of pioglitazone/metformin fixed combination in comparison with a combination of metformin with glimepiride on diabetic dyslipidemia.

  Diabetes technology & therapeutics 20110601

• Acute kidney injury associated with metformin.

  The American journal of emergency medicine 20110601

• Investigation of the potential effects of metformin on atherothrombotic risk factors in hyperlipidemic rats.

  European journal of pharmacology 20110601

• Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110601

• Effect of gastric bypass surgery on the absorption and bioavailability of metformin.

  Diabetes care 20110601

• Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review.

  Reproductive biomedicine online 20110601

• Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects.

  Clinical pharmacology and therapeutics 20110601

• Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.

  Journal of clinical pharmacy and therapeutics 20110601

• Increased F-18 FDG intestinal uptake in diabetic patients on metformin: a matched case-control analysis.

  Clinical nuclear medicine 20110601

• Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

  Diabetes 20110601

• Management of metabolic syndrome in children and adolescents.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20110601

• Oral hypoglycemic agents in pregnancy.

  Obstetrics and gynecology clinics of North America 20110601

• Quiz page June 2011. Profound metabolic acidosis and abdominal pain in a diabetic patient on long-term hemodialysis.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20110601

• Use of metformin in the setting of mild-to-moderate renal insufficiency.

  Diabetes care 20110601

• What, how, and how much should patients with burns be fed?

  The Surgical clinics of North America 20110601

• Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial.

  The Australian & New Zealand journal of obstetrics & gynaecology 20110601

• How can primary care providers manage pediatric obesity in the real world?

  Journal of the American Academy of Nurse Practitioners 20110601

• Exenatide improves weight loss insulin sensitivity and β-cell function following administration to a type 2 diabetic HIV patient on antiretroviral therapy.

  Annales d'endocrinologie 20110601

• Effect of aspirin on the expression of hepatocyte NF-κB and serum TNF-α in streptozotocin-induced type 2 diabetic rats.

  Journal of Korean medical science 20110601

• Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer.

  Future oncology (London, England) 20110601

• Metformin: a new option in cancer treatment.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110601

• Metformin for cancer prevention.

  Frontiers of medicine 20110601

• Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase.

  Chinese medical journal 20110601

• Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats.

  Asian Pacific journal of tropical medicine 20110601

• Effectiveness of adding vildagliptin to the treatment of diabetic patients nonresponsive to the combination of metformin and a sulphonylurea.

  Arquivos brasileiros de endocrinologia e metabologia 20110601

• Recent diabetes issues affecting the primary care clinician.

  Southern medical journal 20110601

• Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus.

  Journal of the American College of Nutrition 20110601

• Therapeutic effects of biguanide vs. statin in polycystic ovary syndrome: a randomized clinical trial.

  Pakistan journal of biological sciences : PJBS 20110601

• Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus.

  International journal of cardiology 20110519

• Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis.

  Annals of internal medicine 20110517

• Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.

  European journal of pharmacology 20110511

• Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.

  Life sciences 20110509

• [Metformin - mechanisms of action and use for the treatment of type 2 diabetes mellitus].

  Postepy higieny i medycyny doswiadczalnej (Online) 20110506

• Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.

  Zygote (Cambridge, England) 20110501

• Effects of metabolic acidosis on expression levels of renal drug transporters.

  Pharmaceutical research 20110501

• Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome.

  Fertility and sterility 20110501

• Metformin restores endothelial function in aorta of diabetic rats.

  British journal of pharmacology 20110501

• Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation.

  Journal of gastroenterology and hepatology 20110501

• A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20110501

• Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial.

  Diabetes, obesity & metabolism 20110501

• Effect of dose escalation of metformin on clinical features, insulin sensitivity and androgen profile in polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20110501

• Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes.

  Neuropharmacology 20110501

• The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents.

  Clinical chemistry and laboratory medicine 20110501

• The metabolic status modulates the effect of metformin on the antimullerian hormone-androgens-insulin interplay in obese women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20110501

• Insulin therapy has a complex relationship with measure of oxidative stress in type 2 diabetes: a case for further study.

  Diabetes/metabolism research and reviews 20110501

• Predictors of response to dipeptidyl peptidase-4 inhibitors: evidence from randomized clinical trials.

  Diabetes/metabolism research and reviews 20110501

• Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects.

  Diabetes/metabolism research and reviews 20110501

• Diabetes mellitus type 2 through oncology lens.

  Medical hypotheses 20110501

• Effect of sitagliptin plus metformin on β-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats.

  Diabetes research and clinical practice 20110501

• Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.

  Cancer letters 20110501

• Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.

  Cancer research 20110501

• Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.

  Diabetes 20110501

• Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells.

  Molecular cancer research : MCR 20110501

• Preventive therapy for breast cancer: a consensus statement.

  The Lancet. Oncology 20110501

• Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy.

  Clinical journal of the American Society of Nephrology : CJASN 20110501

• Determination of rosiglitazone and metformin in human serum by CE-ESI-MS.

  Journal of separation science 20110501

• Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells.

  Journal of cellular biochemistry 20110501

• Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.

  Diabetes 20110501

• Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes.

  Diabetes care 20110501

• Comment on: Chen et al. Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack. Diabetes Care 2010;33:2552-2554.

  Diabetes care 20110501

• Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

  Neoplasia (New York, N.Y.) 20110501

• Insulin treatment for type 2 diabetes: when to start, which to use.

  Cleveland Clinic journal of medicine 20110501

• Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response.

  Cell cycle (Georgetown, Tex.) 20110501

• Liraglutide for the treatment of type 2 diabetes.

  Health technology assessment (Winchester, England) 20110501

• Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats.

  Indian journal of experimental biology 20110501

• Type 2 diabetes mellitus: practical approaches for primary care physicians.

  The Journal of the American Osteopathic Association 20110501

• [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].

  Nihon rinsho. Japanese journal of clinical medicine 20110501

• Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.

  JAMA 20110427

• [Metformin treatment with or without life style changes in patients with polycystic ovary syndrome].

  Orvosi hetilap 20110417

• Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.

  Archives of biochemistry and biophysics 20110415

• AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

  Science (New York, N.Y.) 20110408

• AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

  Cell metabolism 20110406

• Electrodeless, accurate pH determination in highly basic media using a new set of (1)H NMR pH indicators.

  Journal of pharmaceutical and biomedical analysis 20110405

• The effect of comprehensive lifestyle intervention or metformin on obesity in young women.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20110401

• The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth.

  Journal of cellular and molecular medicine 20110401

• The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells.

  Breast cancer research and treatment 20110401

• The effect of different hormone therapies on anti-müllerian hormone serum levels in anovulatory women of reproductive age.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110401

• Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.

  Journal of cellular physiology 20110401

• Metabolic syndrome in severe mental disorders.

  Metabolic syndrome and related disorders 20110401

• Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.

  British journal of pharmacology 20110401

• Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2.

  Bone 20110401

• Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.

  Biochimica et biophysica acta 20110401

• Self-reported experience of hypoglycemia among adults with type 2 diabetes mellitus (Exhype).

  Diabetes research and clinical practice 20110401

• Metformin and digestive disorders.

  Diabetes & metabolism 20110401

• Are sulfonylureas less desirable than DPP-4 inhibitors as add-on to metformin in the treatment of type 2 diabetes?

  Current diabetes reports 20110401

• Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia.

  The American journal of cardiology 20110401

• Metformin modulates IL-8, IL-1β, ICAM and IGFBP-1 expression in human endometrial stromal cells.

  Reproductive biomedicine online 20110401

• Pharmacotherapy: GLP-1 analogues and insulin: sound the wedding bells?

  Nature reviews. Endocrinology 20110401

• One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial.

  International journal of clinical practice 20110401

• Activation of AMP-kinase by policosanol requires peroxisomal metabolism.

  Lipids 20110401

• Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a.

  Cell cycle (Georgetown, Tex.) 20110401

• Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.

  Diabetes 20110401

• [Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

  Atencion primaria 20110401

• Lixisenatide for type 2 diabetes mellitus.

  Expert opinion on investigational drugs 20110401

• Efficacy and safety of the dipeptidyl peptidase-4 inhibitor PF-734200 added to metformin in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20110401

• Diabetes and pancreatic cancer: chicken or egg?

  Pancreas 20110401

• Antidiabetic treatments and risk of hospitalisation with myocardial infarction: a nationwide case-control study.

  Pharmacoepidemiology and drug safety 20110401

• Long term patterns of use after initiation of oral antidiabetic drug therapy.

  Pharmacoepidemiology and drug safety 20110401

• Improvement in metformin and insulin utilisation in the Australian veteran population associated with quality use of medicines intervention programs.

  Pharmacoepidemiology and drug safety 20110401

• Comment on: Chen et al. utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack. Diabetes Care 2010;33:2552–2554.

  Diabetes care 20110401

• [Efficacy and tolerability of sitagliptin in type 2 diabetic patients inadequately controlled with metformin. A prospective observational study in austrian primary care].

  Wiener klinische Wochenschrift 20110401

• Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials.

  The Australian & New Zealand journal of obstetrics & gynaecology 20110401

• [Effectiveness of metformin in prevention of development of hyperglycemia and neuronal damage caused by ischemic stress].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401

• The risks and benefits of implementing glycemic control guidelines in frail older adults with diabetes mellitus.

  Journal of the American Geriatrics Society 20110401

• Gerosuppressant metformin: less is more.

  Aging 20110401

• Effects of metformin on plasma concentrations of glucose and mannose, G6Pase and PEPCK activity, and mRNA expression in the liver and kidney of chickens.

  British poultry science 20110401

• Fecal incontinence resolved using metformin withdrawal.

  Journal of the American Geriatrics Society 20110401

• Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the estimation of miglitol in human plasma using metformin as the internal standard.

  Drug testing and analysis 20110401

• Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients.

  Gender medicine 20110401

• New therapeutic options: management strategies to optimize glycemic control.

  The Journal of the American Osteopathic Association 20110401

• [Colorectal cancer and diabetes].

  Vnitrni lekarstvi 20110401

• [Dyspeptic syndrome associated with antidiabetic therapy].

  Vnitrni lekarstvi 20110401

• [Therapeutic approaches to improve blood glucose control in a patient with type 2 diabetes on a metformin-sulfonylurea combination].

  Revue medicale de Liege 20110401

• [Effects of metformin therapy on markers of coagulation disorders in hyperinsulinemic women with polycystic ovary syndrome].

  Ginekologia polska 20110401

• Diagnosis and management of acromegaly: giant invasive adenoma.

  Acta medica Indonesiana 20110401

• Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.

  Journal of ethnopharmacology 20110324

• Saxagliptin/metformin (kombiglyze XR) for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20110321

• Effects of metformin on the reproductive system of androgenized female rats.

  Fertility and sterility 20110315

• Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.

  Oncogene 20110310

• Occult metformin toxicity in three patients with profound lactic acidosis.

  The Journal of emergency medicine 20110301

• Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis.

  Journal of psychopharmacology (Oxford, England) 20110301

• The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression.

  Metabolism: clinical and experimental 20110301

• Divergent effects of ethinylestradiol-drospirenone and flutamide-metformin on follistatin in adolescents and women with hyperinsulinemic androgen excess.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110301

• Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110301

• Thiazolidinediones plus metformin association on body weight in patients with type 2 diabetes.

  Diabetes research and clinical practice 20110301

• Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth.

  Journal of diabetes 20110301

• Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta-analysis.

  Clinical endocrinology 20110301

• Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation.

  British journal of pharmacology 20110301

• Multiple outcomes associated with the use of metformin and sulphonylureas in type 2 diabetes: a population-based cohort study in Italy.

  European journal of clinical pharmacology 20110301

• Combined metformin and clomiphene citrate versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

  The journal of obstetrics and gynaecology research 20110301

• What to add in with metformin in type 2 diabetes?

  QJM : monthly journal of the Association of Physicians 20110301

• Metformin-associated lactic acidosis: is it really just an association?

  The American journal of emergency medicine 20110301

• Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells.

  The Journal of clinical endocrinology and metabolism 20110301

• The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study.

  Fertility and sterility 20110301

• Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin.

  Diabetes, obesity & metabolism 20110301

• Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials.

  Diabetes, obesity & metabolism 20110301

• Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial.

  Diabetes, obesity & metabolism 20110301

• Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.

  European journal of endocrinology 20110301

• Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin.

  Endocrinology 20110301

• Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20110301

• Action of metformin on the insulin-signaling pathway and on glucose transport in human granulosa cells.

  The Journal of clinical endocrinology and metabolism 20110301

• Oral hypoglycemic agents for gestational diabetes mellitus?

  Expert opinion on drug safety 20110301

• Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants.

  Clinical pharmacology and therapeutics 20110301

• Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism.

  Diabetes 20110301

• Metformin or thiazolidinedione therapy in PCOS?

  Nature reviews. Endocrinology 20110301

• Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis.

  British journal of clinical pharmacology 20110301

• Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia.

  Diabetes care 20110301

• Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.

  Journal of renal care 20110301

• Can modeling of health outcomes facilitate regulatory decision making? The benefit-risk tradeoff for rosiglitazone in 1999 vs. 2007.

  Clinical pharmacology and therapeutics 20110301

• Sitagliptin and metformin--novel combination therapy.

  Expert opinion on pharmacotherapy 20110301

• Liraglutide improves treatment satisfaction in people with Type 2 diabetes compared with sitagliptin, each as an add on to metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20110301

• Which oral agent to use when metformin is no longer effective?

  QJM : monthly journal of the Association of Physicians 20110301

• [Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110301

• [Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

  Revista clinica espanola 20110301

• [Effects of antidiabetic drug metformin on human breast carcinoma cells with different estrogen receptor expressing in vitro].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110301

• [Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110301

• Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

  Cell death & disease 20110301

• Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture.

  Oncotarget 20110301

• Metformin versus metformin plus rosiglitazone in women with polycystic ovary syndrome.

  Chinese medical journal 20110301

• Design of a decision support system to help clinicians manage glycemia in patients with type 2 diabetes mellitus.

  Journal of diabetes science and technology 20110301

• The fixed combination of pioglitazone and metformin improves biomarkers of platelet function and chronic inflammation in type 2 diabetes patients: results from the PIOfix study.

  Journal of diabetes science and technology 20110301

• [Clinical vignette. Which combination of oral glucose-lowering agents to use after failure of metformin monotherapy in type 2 diabetes?].

  Revue medicale de Liege 20110301

• When metformin fails in type 2 diabetes mellitus.

  Archives of internal medicine 20110227

• Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats.

  European journal of pharmacology 20110225

• [Expression of aquaporin 7 in perirenal adipose tissue of Otsuka Long-Evans Tokushima Fatty diabetic rats].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110218

• Genomics: Drugs, diabetes and cancer.

  Nature 20110217

• [Mini-review BMJ 'rational testing' Praxis 2011;100(2):99-103].

  Praxis 20110216

• Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

• Sitagliptin/metformin fixed-dose combination: in patients with type 2 diabetes mellitus.

  Drugs 20110212

• [Short-lasting lactic acidosis after heart arrest].

  Ugeskrift for laeger 20110207

• Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment.

  Metabolism: clinical and experimental 20110201

• Database evaluation of the effects of long-term rosiglitazone treatment on cardiovascular outcomes in patients with type 2 diabetes.

  Journal of clinical pharmacology 20110201

• Metformin plus oral contraceptive may decrease plasma sCD40 ligand in women with PCOS patients.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110201

• Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats.

  Phytotherapy research : PTR 20110201

• Early metformin therapy to delay menarche and augment height in girls with precocious pubarche.

  Fertility and sterility 20110201

• Aging and TOR: interwoven in the fabric of life.

  Cellular and molecular life sciences : CMLS 20110201

• Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.

  Diabetologia 20110201

• Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents.

  Breast cancer research and treatment 20110201

• Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry.

  Diabetes care 20110201

• Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA).

  Biology of reproduction 20110201

• Effects of rosiglitazone/metformin fixed-dose combination therapy and metformin monotherapy on serum vaspin, adiponectin and IL-6 levels in drug-naïve patients with type 2 diabetes.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110201

• Diabetes, metformin and lactic acidosis.

  Clinical endocrinology 20110201

• Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells.

  The Journal of endocrinology 20110201

• PRKA/AMPK: integrating energy status with fertility in pituitary gonadotrophs.

  Biology of reproduction 20110201

• New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser.

  Diabetologia 20110201

• When should an insulin sensitizing agent be used in the treatment of polycystic ovary syndrome?

  Clinical endocrinology 20110201

• AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.

  Neuro-oncology 20110201

• Metformin treatment for small benign thyroid nodules in patients with insulin resistance.

  Metabolic syndrome and related disorders 20110201

• Study comparing the effect of pioglitazone in combination with either metformin or sulphonylureas on lipid profile and glycaemic control in patients with type 2 diabetes (ECLA).

  Current medical research and opinion 20110201

• Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.

  Clinical and experimental pharmacology & physiology 20110201

• Metformin and the incidence of prostate cancer in patients with type 2 diabetes.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110201

• Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.

  Endocrinology 20110201

• Improved glycaemic control with reduced hypoglycaemic episodes and without weight gain using long-term modern premixed insulins in type 2 diabetes.

  International journal of clinical practice 20110201

• Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

  Nature genetics 20110201

• Pharmacological management of type 2 diabetes: the potential of incretin-based therapies.

  Diabetes, obesity & metabolism 20110201

• Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial.

  Diabetes, obesity & metabolism 20110201

• Phosphoprotein enriched in diabetes gene product (Ped/pea-15) is increased in omental adipose tissue of women with the polycystic ovary syndrome: ex vivo regulation of ped/pea-15 by glucose, insulin and metformin.

  Diabetes, obesity & metabolism 20110201

• Simultaneous determination and pharmacokinetic study of metformin and rosiglitazone in human plasma by HPLC-ESI-MS.

  Journal of chromatographic science 20110201

• Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.

  Diabetes 20110201

• Clinical pharmacokinetics of metformin.

  Clinical pharmacokinetics 20110201

• Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety.

  Best practice & research. Clinical obstetrics & gynaecology 20110201

• Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20110201

• Pharmacotherapy for obese adolescents.

  Pediatric clinics of North America 20110201

• [Perioperative management of chronic treatment and medical devices. Endocrine pathology].

  Annales francaises d'anesthesie et de reanimation 20110201

• If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

  Aging 20110201

• Optimizing outcomes for GLP-1 agonists.

  The Journal of the American Osteopathic Association 20110201

• [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20110201

• Diabetes drug could work against Alzheimer's, animal study suggests.

  Pakistan journal of biological sciences : PJBS 20110201

• AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells.

  Biochemical and biophysical research communications 20110128

• Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

  Science (New York, N.Y.) 20110128

• Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats.

  Journal of ethnopharmacology 20110127

• In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine.

  Journal of ethnopharmacology 20110127

• Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.

  European journal of pharmacology 20110125

• Summaries for patients: Does adding exenatide to insulin treatment benefit patients with type 2 diabetes?

  Annals of internal medicine 20110118

• Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial.

  Annals of internal medicine 20110118

• Metformin activates AMP kinase through inhibition of AMP deaminase.

  The Journal of biological chemistry 20110107

• Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner.

  Journal of cellular and molecular medicine 20110101

• Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20110101

• Does long-term metformin treatment increase cardiac lipoprotein lipase?

  Metabolism: clinical and experimental 20110101

• Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: a prospective randomized study.

  Fertility and sterility 20110101

• Efficacy and safety of metformin for treatment of type 2 diabetes in elderly Japanese patients.

  Geriatrics & gerontology international 20110101

• A comparison of twice-daily biphasic insulin aspart 70/30 and once-daily insulin glargine in persons with type 2 diabetes mellitus inadequately controlled on basal insulin and oral therapy: a randomized, open-label study.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

• Statin therapy improves sustained virologic response among diabetic patients with chronic hepatitis C.

  Gastroenterology 20110101

• Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis.

  Atherosclerosis 20110101

• Pharmacological treatment of the pathogenetic defects in type 2 diabetes: the randomized multicenter South Danish Diabetes Study.

  Diabetes care 20110101

• AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.

  Diabetologia 20110101

• Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110101

• Differential effects of rosiglitazone and metformin on postprandial lipemia in patients with HIV-lipodystrophy.

  Arteriosclerosis, thrombosis, and vascular biology 20110101

• Metformin use and mortality in ambulatory patients with diabetes and heart failure.

  Circulation. Heart failure 20110101

• OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.

  Diabetes 20110101

• Effect of pioglitazone on serum concentrations of osteoprotegerin in patients with type 2 diabetes mellitus.

  European journal of endocrinology 20110101

• Metformin and cancer occurrence in insulin-treated type 2 diabetic patients.

  Diabetes care 20110101

• Metformin in type 1 diabetes reduces insulin requirements without significantly improving glycaemic control. Reply to Schatz H [letter].

  Diabetologia 20110101

• Glucose homeostasis in rainbow trout fed a high-carbohydrate diet: metformin and insulin interact in a tissue-dependent manner.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110101

• Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats.

  Clinical and experimental pharmacology & physiology 20110101

• Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes.

  Clinical and experimental pharmacology & physiology 20110101

• The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells.

  Oncology reports 20110101

• Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects.

  Diabetes, obesity & metabolism 20110101

• Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study.

  Diabetes, obesity & metabolism 20110101

• Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a 16-week, randomized, double-blind, active control trial(*).

  Diabetes, obesity & metabolism 20110101

• Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20110101

• Metformin and incident breast cancer among diabetic women: a population-based case-control study in Denmark.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101

• Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes.

  Metabolism: clinical and experimental 20110101

• Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus.

  Current medical research and opinion 20110101

• Add-on therapies to metformin for type 2 diabetes.

  Expert opinion on pharmacotherapy 20110101

• Metformin may maintain weight loss in obese patients with dysglycaemia initially treated with rimonabant.

  Diabetic medicine : a journal of the British Diabetic Association 20110101

• Guideline-conformity of initiation with oral hypoglycemic treatment for patients with newly therapy-dependent type 2 diabetes mellitus in Austria.

  Pharmacoepidemiology and drug safety 20110101

• Clinical pearls in general internal medicine.

  Mayo Clinic proceedings 20110101

• [Fatty liver and its clinical management in obese adolescents].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

• Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.

  Diabetes/metabolism research and reviews 20110101

• Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals.

  BMC cancer 20110101

• Chemoprevention of hormone receptor-negative breast cancer: new approaches needed.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20110101

• Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism.

  Diabetes & vascular disease research 20110101

• Electroconvulsive therapy for the treatment of refractory mania.

  Journal of psychiatric practice 20110101

• Recommendations for the pharmacologic treatment of hyperglycemia in type 2 diabetes. Consensus document.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

• Advantages of extended-release metformin in patients with type 2 diabetes mellitus.

  Postgraduate medicine 20110101

• Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin.

  Journal of Alzheimer's disease : JAD 20110101

• Insulin resistance: pathophysiology and rationale for treatment.

  Annals of nutrition & metabolism 20110101

• Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans.

  PloS one 20110101

• Management of cardiovascular risk factors with pioglitazone combination therapies in type 2 diabetes: an observational cohort study.

  Cardiovascular diabetology 20110101

• The effect of weight loss and treatment with metformin on serum vaspin levels in women with polycystic ovary syndrome.

  Endocrine journal 20110101

• Metformin: the safest hypoglycaemic agent in chronic kidney disease?

  Nephron. Clinical practice 20110101

• Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats.

  International journal of molecular sciences 20110101

• Metformin-induced lactic acidosis: no one left behind.

  Critical care (London, England) 20110101

• Metformin: its emerging role in oncology.

  Hormones (Athens, Greece) 20110101

• [Metformin in type 2 diabetes. An extensive observational study confirms the agent as first choice--so far].

  Lakartidningen 20110101

• In vitro and in vivo effects of metformin on human adipose tissue adiponectin.

  Obesity facts 20110101

• Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence.

  Luminescence : the journal of biological and chemical luminescence 20110101

• Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil.

  Revista da Associacao Medica Brasileira (1992) 20110101

• The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS).

  Clinical laboratory 20110101

• Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situations.

  Clinical drug investigation 20110101

• Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats.

  International journal of biological sciences 20110101

• [Plasmapheresis as treatment for severe hypertriglyceridemia].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

• Total cholesterol, high density lipoprotein and triglyceride for cardiovascular disease in elderly patients treated with metformin.

  Archives of pharmacal research 20110101

• Understanding the benefit of metformin use in cancer treatment.

  BMC medicine 20110101

• Targeting type 2 diabetes.

  Handbook of experimental pharmacology 20110101

• Determinants of an optimal response to pioglitazone in terms of HDL-cholesterol.

  Internal medicine (Tokyo, Japan) 20110101

• [Metformin slows down ageing processes at the cellular level in SHR mice].

  Tsitologiia 20110101

• Prolonged hemodialysis for severe metformin intoxication.

  Renal failure 20110101

• [Metformin-induced lactic acidosis due to acute renal failure].

  Anales del sistema sanitario de Navarra 20110101

• Concomitant oral antihyperglycemic agent use and associated treatment outcomes after initiation of insulin therapy.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

• Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20110101

• Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations.

  Journal of translational medicine 20110101

• [Therapeutic approach to dyslipidemia and goal achievement in a Spanish population with type 2 diabetes without cardiovascular disease].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

• Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.

  International journal of biological sciences 20110101

• Effects of metformin and rosiglitazone on peripheral insulin resistance and β-cell function in obesity: a double-blind, randomized, controlled study.

  The Journal of international medical research 20110101

• Variation in KCNQ1 is associated with therapeutic response to sulphonylureas.

  Medical science monitor : international medical journal of experimental and clinical research 20110101

• Obesity and type 2 diabetes mellitus in South Dakota: focused insight into prevalence, physiology and treatment.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20110101

• The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II.

  Experimental diabetes research 20110101

• Double-blind, randomized, multicentre, and active comparator controlled investigation of the effect of pioglitazone, metformin, and the combination of both on cardiovascular risk in patients with type 2 diabetes receiving stable basal insulin therapy: the PIOCOMB study.

  Cardiovascular diabetology 20110101

• Pancreatogenic diabetes: special considerations for management.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20110101

• Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Latin American consensus: children born small for gestational age.

  BMC pediatrics 20110101

• Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling.

  Oncology research 20110101

• Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

  PloS one 20110101

• The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?

  BMC neuroscience 20110101

• Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate.

  Physiological research 20110101

• The beneficial effect of α-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data.

  Journal of diabetes and its complications 20110101

• Bioequivalence of saxagliptin/metformin extended-release (XR) fixed-dose combination tablets and single-component saxagliptin and metformin XR tablets in healthy adult subjects.

  Clinical drug investigation 20110101

• What your doctor is reading.

  Diabetes self-management 20110101

• Management of metformin-associated lactic acidosis by continuous renal replacement therapy.

  PloS one 20110101

• Colesevelam hydrochloride added to background metformin therapy in patients with type 2 diabetes mellitus: a pooled analysis from 3 clinical studies.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

• The Hirsute woman: challenges in evaluation and management.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

• Nutritional improvement of metabolic syndrome parameters in immature fructose-fed wild-type mice.

  Molecular medicine reports 20110101

• Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.

  Neoplasma 20110101

• Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice.

  PloS one 20110101

• Formulation and evaluation of metformin oro-dispersible tablets.

  Acta poloniae pharmaceutica 20110101

• RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.

  PloS one 20110101

• [Efficacy of metformin as initial therapy in patients with coronary artery disease and diabetes type 2].

  Likars'ka sprava 20110101

• The nephrologist's role in metformin-induced lactic acidosis.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

• Metformin-induced lactic acidosis: usefulness of measuring levels and therapy with high-flux haemodialysis.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

• [Metformin in adolescents and adults with type 1 diabetes mellitus: not evidence-based].

  Nederlands tijdschrift voor geneeskunde 20110101

• [Reactive-dystrophic processes in salivary glands (sialoadenoses) running on the background of metabolic syndrome].

  Stomatologiia 20110101

• Simultaneous spectrophotometric determination of metformin hydrochloride and glibenclamide in binary mixtures using combined discrete and continuous wavelet transforms.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101

• Metformin-associated lactic acidosis in Chinese patients with type II diabetes.

  Pharmacology 20110101

• Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients.

  Redox report : communications in free radical research 20110101

• Antidiabetic pharmacology: a link between metabolic syndrome and neuro-oncology?

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• [Guideline: type 2 diabetes mellitus therapy: metformin, a critical perspective].

  Acta medica portuguesa 20110101

• Changes in labelling for metformin use in patients with type 2 diabetes and heart failure: documented safety outweighs theoretical risks.

  Open medicine : a peer-reviewed, independent, open-access journal 20110101

• Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis.

  Open medicine : a peer-reviewed, independent, open-access journal 20110101

• Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats.

  Pharmacology 20110101

• Development and validation of new assay method for the simultaneous analysis of diltiazem, metformin, pioglitazone and rosiglitazone by RP-HPLC and its applications in pharmaceuticals and human serum.

  Journal of chromatographic science 20110101

• Combination therapy with metformin and fenofibrate for insulin resistance in obesity.

  The Journal of international medical research 20110101

• [Severe lactic acidosis due to metformin: report of 3 cases].

  Annales de biologie clinique 20110101

• Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression.

  PloS one 20110101

• Metformin and lactic acidosis.

  Acta clinica Belgica 20110101

• Metformin-associated lactic acidosis (MALA): case report.

  Acta clinica Belgica 20110101

• Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data.

  PloS one 20110101

• AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.

  PloS one 20110101

• Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy.

  PloS one 20110101

• [Breast cancer subtypes and their endocrine-metabolic basis; practical aspects].

  Voprosy onkologii 20110101

• [Antidiabetes drug metformin is a donor of nitric oxide: ESR measurement of efficiency].

  Biofizika 20110101

• Drug-drug interaction study between a novel oral ibandronate formulation and metformin.

  Arzneimittel-Forschung 20110101

• Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• [Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer].

  Voprosy onkologii 20110101

• Probable hepatotoxicity associated with the use of metformin in type 2 diabetes.

  BMJ case reports 20110101

• Metformin and insomnia: an interesting story.

  Diabetes & metabolic syndrome 20110101

• Development and validation of a stability indicating capillary electrophoresis method for the determination of metformin hydrochloride in tablets.

  Journal of pharmaceutical and biomedical analysis 20101215

• Holiday reading: Learning medicine through riddles.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20101214

• Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents.

  Molecules (Basel, Switzerland) 20101210

• [Metformin treatment causes persisting lactic acidosis after cardiac arrest].

  Ugeskrift for laeger 20101206

• [New clinical data with metformin therapy in patients with diabetes mellitus].

  Orvosi hetilap 20101205

• Failure to metformin and insulin secretagogue monotherapy: an observational cohort study.

  Acta diabetologica 20101201

• Baseline atherosclerosis parameter could assess the risk of bone loss during pioglitazone treatment in type 2 diabetes mellitus.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101201

• Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents.

  Fertility and sterility 20101201

• Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20101201

• Metformin 2,500 mg/day in the treatment of obese women with polycystic ovary syndrome and its effect on weight, hormones, and lipid profile.

  Archives of gynecology and obstetrics 20101201

• Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone-binding globulin and androgen receptor polymorphisms.

  Fertility and sterility 20101201

• Insulin-sensitizing agents in the treatment of polycystic ovary syndrome: an update.

  Current opinion in obstetrics & gynecology 20101201

• Diabetes and cancer.

  QJM : monthly journal of the Association of Physicians 20101201

• Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus.

  Current opinion in lipidology 20101201

• Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue.

  Experimental dermatology 20101201

• Mechanisms of metformin action on glucose transport and metabolism in human adipocytes.

  Biochemical pharmacology 20101201

• Investigation of Metformin HCl lot-to-lot variation on flowability differences exhibited during drug product processing.

  Journal of pharmaceutical sciences 20101201

• Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study.

  Diabetologia 20101201

• Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats.

  Pharmaceutical biology 20101201

• Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.

  American journal of physiology. Cell physiology 20101201

• Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome.

  Diabetes 20101201

• Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters.

  Xenobiotica; the fate of foreign compounds in biological systems 20101201

• Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells.

  Biological chemistry 20101201

• Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.

  The Journal of clinical endocrinology and metabolism 20101201

• AMPK as a therapeutic target in renal cell carcinoma.

  Cancer biology & therapy 20101201

• A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin.

  Diabetes, obesity & metabolism 20101201

• Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas.

  Diabetes, obesity & metabolism 20101201

• Limitations of metformin use in patients with kidney disease: are they warranted?

  Diabetes, obesity & metabolism 20101201

• Remission of diabetes mellitus type 2 with severe hyperglycemia after Exenatide treatment.

  Diabetes research and clinical practice 20101201

• Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1.

  Clinical pharmacology and therapeutics 20101201

• Serum sialic acid changes in type 2 diabetic patients on metformin or rosiglitazone treatment.

  Journal of clinical pharmacy and therapeutics 20101201

• AMPK signaling: a targetable tumor suppressor pathway?

  Cancer biology & therapy 20101201

• Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20101201

• Impact of medication discontinuation on increased intestinal FDG accumulation in diabetic patients treated with metformin.

  AJR. American journal of roentgenology 20101201

• Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues.

  Hepatology (Baltimore, Md.) 20101201

• Continuous glucose monitoring reveals different glycemic responses of moderate- vs high-carbohydrate lunch meals in people with type 2 diabetes.

  Journal of the American Dietetic Association 20101201

• Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.

  Diabetes care 20101201

• Considering options for attenuating postmeal glucose excursions.

  Diabetes care 20101201

• Effects of pioglitazone and metformin fixed-dose combination therapy on cardiovascular risk markers of inflammation and lipid profile compared with pioglitazone and metformin monotherapy in patients with type 2 diabetes.

  Journal of clinical hypertension (Greenwich, Conn.) 20101201

• Impact of treatment with metformin on adipokines in patients with polycystic ovary syndrome.

  European cytokine network 20101201

• Metformin during pregnancy in polycystic ovary syndrome: another vitamin bites the dust.

  The Journal of clinical endocrinology and metabolism 20101201

• Old age may not be a contraindication to the use of metformin.

  Journal of the Chinese Medical Association : JCMA 20101201

• Fasting plasma lactate concentrations in ambulatory elderly patients with type 2 diabetes receiving metformin therapy: a retrospective cross-sectional study.

  Journal of the Chinese Medical Association : JCMA 20101201

• [Antidiabetic therapy--a new possibility in the complex therapy of cancer?].

  Magyar onkologia 20101201

• Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.

  Aging 20101201

• [Induction of ovulation].

  Journal de gynecologie, obstetrique et biologie de la reproduction 20101201

• A new shine on an old med. The story of metformin's past, present, and possible future.

  Diabetes forecast 20101201

• Metformin and sex: Why suppression of aging may be harmful to young male mice.

  Aging 20101201

• [Metformin as the first line antidiabetic agent].

  Vnitrni lekarstvi 20101201

• [Limited sampling strategy to estimate pharmacokinetic parameters of orally administered metformin hydrochloride].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101201

• Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone.

  Chinese medical journal 20101201

• Metformin use and mortality among patients with diabetes and atherothrombosis.

  Archives of internal medicine 20101122

• The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.

  Blood 20101118

• Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

  Cell cycle (Georgetown, Tex.) 20101115

• Determination of metformin in mouse, rat, dog and human plasma samples by laser diode thermal desorption/atmospheric pressure chemical ionization tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20101102

• Effects of metformin plus simvastatin on polycystic ovary syndrome: a prospective, randomized, double-blind, placebo-controlled study.

  Fertility and sterility 20101101

• Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study.

  Fertility and sterility 20101101

• Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial.

  Fertility and sterility 20101101

• Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome.

  Fertility and sterility 20101101

• pH 6.68--surviving severe metformin intoxication.

  QJM : monthly journal of the Association of Physicians 20101101

• Transient vision loss in a patient with metformin-associated lactic acidosis.

  The American journal of emergency medicine 20101101

• Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin.

  Urology 20101101

• AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

  Diabetologia 20101101

• Safety and tolerability of vildagliptin vs. thiazolidinedione as add-on to metformin in type 2 diabetic patients with and without mild renal impairment: a retrospective analysis of the GALIANT study.

  Diabetes research and clinical practice 20101101

• AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.

  Bone 20101101

• Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.

  American journal of obstetrics and gynecology 20101101

• Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomised controlled trial.

  International journal of clinical practice 20101101

• Effects of metformin in experimental stroke.

  Stroke 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

  Pharmacogenetics and genomics 20101101

• Glycemic and weight changes after persistent use of incident oral diabetes therapy: a Veterans Administration retrospective cohort study.

  Pharmacoepidemiology and drug safety 20101101

• N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial.

  Journal of women's health (2002) 20101101

• Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

  Cancer prevention research (Philadelphia, Pa.) 20101101

• Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20101101

• Regression to normoglycaemia by fenofibrate in pre-diabetic subjects complicated with hypertriglyceridaemia: a prospective randomized controlled trial.

  Diabetic medicine : a journal of the British Diabetic Association 20101101

• Diabetes mellitus and increased risk of cancer: focus on metformin and the insulin analogs.

  Pharmacotherapy 20101101

• A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity.

  World journal of pediatrics : WJP 20101101

• Metformin for aging and cancer prevention.

  Aging 20101101

• Pronounced weight gain in insulin-treated patients with type 2 diabetes mellitus is associated with an unfavourable cardiometabolic risk profile.

  The Netherlands journal of medicine 20101101

• Does metformin increase the risk of fatal or nonfatal lactic acidosis?

  American family physician 20101101

• [Tough glucose reduction necessary in newly diagnosed diabetes].

  Lakartidningen 20101101

• [Medication of the month. Sitagliptin-metformin fixed combination (Janumet)].

  Revue medicale de Liege 20101101

• Successful strategy to improve glucose tolerance in Thai obese youth.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20101101

• Post-prandial carbohydrate modulation via gut--Indian perspective.

  The Journal of the Association of Physicians of India 20101101

• A prospective, parallel group, open-labeled, comparative, multi-centric, active controlled study to evaluate the safety, tolerability and benefits of fixed dose combination of acarbose and metformin versus metformin alone in type 2 diabetes.

  The Journal of the Association of Physicians of India 20101101

• Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

  Lancet (London, England) 20101023

• Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

  Lancet (London, England) 20101023

• Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

  Lancet (London, England) 20101023

• AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

  The Journal of biological chemistry 20101015

• Comparison of effects of 3 mg drospirenone plus 20 μg ethinyl estradiol alone or combined with metformin or cyproterone acetate on classic metabolic cardiovascular risk factors in nonobese women with polycystic ovary syndrome.

  Fertility and sterility 20101001

• The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20101001

• Treatment of clinical insulin resistance in children: a systematic review.

  Obesity reviews : an official journal of the International Association for the Study of Obesity 20101001

• [Metformin-associated hepatotoxicity].

  Medicina intensiva 20101001

• The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents: a meta-analysis.

  The Journal of clinical psychiatry 20101001

• Direct healthcare costs of patients with type 2 diabetes using long-acting insulin analogues or NPH insulin in a basal insulin-only regimen.

  Primary care diabetes 20101001

• Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome.

  Archives of gynecology and obstetrics 20101001

• Comparison of potential risks of lactic acidosis induction by biguanides in rats.

  Regulatory toxicology and pharmacology : RTP 20101001

• Efficacy of primary prevention interventions when fasting and postglucose dysglycemia coexist: analysis of the Indian Diabetes Prevention Programmes (IDPP-1 and IDPP-2).

  Diabetes care 20101001

• Metformin compared with glyburide for the management of gestational diabetes.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20101001

• Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients.

  Diabetes care 20101001

• Generation, validation and humanisation of a novel insulin resistant cell model.

  Biochemical pharmacology 20101001

• Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes.

  Diabetologia 20101001

• Metformin in type 1 diabetes reduces insulin requirements without significantly improving glycaemic control.

  Diabetologia 20101001

• Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.

  The Journal of pharmacology and experimental therapeutics 20101001

• Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study.

  European journal of endocrinology 20101001

• Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease.

  The Annals of pharmacotherapy 20101001

• Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20101001

• National survey on management of weight reduction in PCOS women in the United Kingdom.

  European journal of obstetrics, gynecology, and reproductive biology 20101001

• Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes.

  European journal of endocrinology 20101001

• Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

  Diabetes 20101001

• Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin.

  Expert opinion on drug metabolism & toxicology 20101001

• Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

  Current molecular medicine 20101001

• Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20101001

• Metabolic syndrome with the atypical antipsychotics.

  Current opinion in endocrinology, diabetes, and obesity 20101001

• Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101001

• Saxagliptin and metformin XR combination therapy provides glycemic control over 24 hours in patients with T2DM inadequately controlled with metformin.

  Current medical research and opinion 20101001

• Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus.

  Diabetes/metabolism research and reviews 20101001

• Effect of pioglitazone and acarbose on endothelial inflammation biomarkers during oral glucose tolerance test in diabetic patients treated with sulphonylureas and metformin.

  Journal of clinical pharmacy and therapeutics 20101001

• Ovulation induction in polycystic ovary syndrome: No. 242, May 2010.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20101001

• Pharmacotherapy of ovarian hyperstimulation syndrome.

  Expert opinion on pharmacotherapy 20101001

• Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target.

  Diabetic medicine : a journal of the British Diabetic Association 20101001

• Using a PCT-wide electronic system called the Deadly Trio database to provide safety alerts about prescribing of metformin in renal disease.

  Diabetic medicine : a journal of the British Diabetic Association 20101001

• Effect of Metformin on mortality in patients with heart failure and type 2 diabetes mellitus.

  The American journal of cardiology 20101001

• Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and intestinal CYP3A1/2.

  British journal of pharmacology 20101001

• BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus.

  Current opinion in investigational drugs (London, England : 2000) 20101001

• Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection.

  Journal of chromatographic science 20101001

• Early clinical studies with liraglutide.

  International journal of clinical practice. Supplement 20101001

• Can acute overdose of metformin lead to lactic acidosis?

  The American journal of emergency medicine 20101001

• Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies.

  American journal of veterinary research 20101001

• Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin.

  Diabetes, obesity & metabolism 20101001

• Continuation versus discontinuation of insulin secretagogues when initiating insulin in type 2 diabetes.

  Diabetes, obesity & metabolism 20101001

• The relationship between the drug concentration profiles in plasma and the drug doses in the colon.

  Chemical & pharmaceutical bulletin 20101001

• Effects of metformin plus gliclazide compared with metformin alone on circulating endothelial progenitor cell in type 2 diabetic patients.

  Endocrine 20101001

• What are these lesions that spread from the lips. Fixed drug eruption.

  JAAPA : official journal of the American Academy of Physician Assistants 20101001

• Successful management of high-dose metformin intoxication. Role of vasopressin in the management of severe lactic acidosis.

  Middle East journal of anaesthesiology 20101001

• AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

  Molecular cell 20100924

• Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats.

  Free radical biology & medicine 20100915

• Nickel oxide nanotubes-carbon microparticles/Nafion nanocomposite for the electrooxidation and sensitive detection of metformin.

  Talanta 20100915

• Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.

  Cell cycle (Georgetown, Tex.) 20100915

• The importance of regulation of blood glucose levels through activation of peripheral 5'-AMP-activated protein kinase on ischemic neuronal damage.

  Brain research 20100910

• Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial.

  Fertility and sterility 20100901

• Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

  Fertility and sterility 20100901

• Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women.

  Clinical and experimental medicine 20100901

• Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20100901

• Effects of metformin administration on plasma gonadotropin levels in women with infertility, with an in vitro study of the direct effects on the pituitary gonadotrophs.

  Pituitary 20100901

• Effects of metformin and weight loss on serum alanine aminotransferase activity in the diabetes prevention program.

  Obesity (Silver Spring, Md.) 20100901

• Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy.

  Breast cancer research and treatment 20100901

• Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase.

  Breast cancer research and treatment 20100901

• Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100901

• Glucose-lowering therapies and cancer risk: the trials and tribulations of trials and observations.

  Diabetologia 20100901

• Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials.

  Diabetologia 20100901

• Can postprandial blood glucose excursion be predicted in type 2 diabetes?

  Diabetes care 20100901

• Systematic care to reduce ethnic disparities in diabetes care.

  Diabetes research and clinical practice 20100901

• Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

  International journal of radiation oncology, biology, physics 20100901

• The role of serum lactate in the acute care setting.

  Journal of intensive care medicine 20100901

• Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100901

• Metformin versus acarbose therapy in patients with polycystic ovary syndrome (PCOS): a prospective randomised double-blind study.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100901

• Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.

  Endocrinology 20100901

• New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100901

• Sulphonylurea-metformin combination therapy, cardiovascular disease and all-cause mortality: the Fremantle Diabetes Study.

  Diabetes, obesity & metabolism 20100901

• Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study.

  Diabetes, obesity & metabolism 20100901

• Metformin: taking away the candy for cancer?

  European journal of cancer (Oxford, England : 1990) 20100901

• Initial nonadherence, primary failure and therapeutic success of metformin monotherapy in clinical practice.

  Current medical research and opinion 20100901

• Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20100901

• Lactic acidosis induced by metformin: incidence, management and prevention.

  Drug safety 20100901

• Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with Type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled trial.

  Diabetic medicine : a journal of the British Diabetic Association 20100901

• Impaired glucose tolerance and insulin resistance in heart failure: underrecognized and undertreated?

  Journal of cardiac failure 20100901

• Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial.

  Cancer prevention research (Philadelphia, Pa.) 20100901

• Metformin and other biguanides in oncology: advancing the research agenda.

  Cancer prevention research (Philadelphia, Pa.) 20100901

• Chemoprevention meets glucose control.

  Cancer prevention research (Philadelphia, Pa.) 20100901

• Metformin prevents tobacco carcinogen--induced lung tumorigenesis.

  Cancer prevention research (Philadelphia, Pa.) 20100901

• Metformin induced severe hypophosphatemia in a patient on hemodialysis.

  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20100901

• Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies.

  The Journal of family practice 20100901

• Distinguishing among incretin-based therapies. Safety, tolerability, and nonglycemic effects of incretin-based therapies.

  The Journal of family practice 20100901

• Distinguishing among incretin-based therapies. Patient education and self-management.

  The Journal of family practice 20100901

• Distinguishing among incretin-based therapies. Introduction.

  The Journal of family practice 20100901

• Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies.

  The Journal of family practice 20100901

• Metformin in polycystic ovary syndrome.

  Annals of the New York Academy of Sciences 20100901

• Effect of metformin taken in the 'fresh' in vitro fertilization/intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome.

  Human fertility (Cambridge, England) 20100901

• [Anti-cancer activity of metformin: new perspectives for an old drug].

  Revue medicale suisse 20100901

• Countering side effects.

  Journal of psychiatric practice 20100901

• The adjunctive use of metformin to treat or prevent atypical antipsychotic-induced weight gain: a review.

  Journal of psychiatric practice 20100901

• Benefits of self-monitoring blood glucose in the management of new-onset Type 2 diabetes mellitus: the St Carlos Study, a prospective randomized clinic-based interventional study with parallel groups.

  Journal of diabetes 20100901

• Top ways to reduce your risk of developing diabetes.

  Mayo Clinic health letter (English ed.) 20100901

• Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome.

  Minerva endocrinologica 20100901

• The RCPE UK Consensus Statement on Diabetes.

  The journal of the Royal College of Physicians of Edinburgh 20100901

• Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study.

  Clinical therapeutics 20100901

• Results of a model analysis of the cost-effectiveness of liraglutide versus exenatide added to metformin, glimepiride, or both for the treatment of type 2 diabetes in the United States.

  Clinical therapeutics 20100901

• Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit.

  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20100901

• [Clinical practice guidelines in type 2 diabetes mellitus: similarities and discrepancies].

  Medicina clinica 20100901

• [Reporting adverse reactions and events in randomised clinical trials].

  Ugeskrift for laeger 20100830

• Evaluation of consumer medication information dispensed in retail pharmacies.

  Archives of internal medicine 20100809

• Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial.

  Lancet (London, England) 20100807

• Individualised incretin-based treatment for type 2 diabetes.

  Lancet (London, England) 20100807

• Glucose metabolism in burn patients: the role of insulin and other endocrine hormones.

  Burns : journal of the International Society for Burn Injuries 20100801

• Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.

  Breast cancer research and treatment 20100801

• Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study.

  International journal of obesity (2005) 20100801

• Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway.

  Cardiovascular research 20100801

• AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

  Bone 20100801

• Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure.

  Diabetologia 20100801

• Effects of the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals.

  Diabetologia 20100801

• AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction.

  Aging cell 20100801

• Number of circulating endothelial progenitor cells as a marker of vascular endothelial function for type 2 diabetes.

  Vascular medicine (London, England) 20100801

• Hypoglycemic symptoms in patients with type 2 diabetes in Asia-Pacific-Real-life effectiveness and care patterns of diabetes management: the RECAP-DM study.

  Diabetes research and clinical practice 20100801

• Metformin and cancer: licence to heal?

  Expert opinion on investigational drugs 20100801

• Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100801

• Evaluation of the potential for pharmacokinetic and pharmacodynamic interactions between dutogliptin, a novel DPP4 inhibitor, and metformin, in type 2 diabetic patients.

  Current medical research and opinion 20100801

• Nearly fatal metabolic acidosis: septic or toxic?

  European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100801

• A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects.

  Diabetes, obesity & metabolism 20100801

• Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin.

  Schizophrenia research 20100801

• Evaluation of a focal lesion in the liver. answer to the clinical challenges and images in GI question: image 3: Focal fatty infiltration.

  Gastroenterology 20100801

• Relationship between cumulative dose of thiazolidinediones and clinical outcomes in type 2 diabetic patients with history of heart failure: a population-based cohort study in Taiwan.

  Pharmacoepidemiology and drug safety 20100801

• Insulin pump therapy in patients with type 2 diabetes safely improved glycemic control using a simple insulin dosing regimen.

  Diabetes technology & therapeutics 20100801

• Cimetidine-induced lactic acidosis and acute pancreatitis.

  Southern medical journal 20100801

• [Rapid blood pH recovery in comatose patients with lactic acidosis is life saving].

  Der Internist 20100801

• Metformin and contrast media.

  Radiology 20100801

• Self-monitoring of blood glucose in tablet-treated type 2 diabetic patients (ZODIAC).

  The Netherlands journal of medicine 20100801

• Frequent reoccurrence of hypoglycemia in a type 2 diabetic patient with insulin antibodies.

  Molecular diagnosis & therapy 20100801

• Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond.

  Future oncology (London, England) 20100801

• [Effects of metformin on proliferation of human colon carcinoma cell line SW-480].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

• Metformin treatment for Type 2 diabetes in pregnancy?

  Best practice & research. Clinical endocrinology & metabolism 20100801

• Adding noninsulin antidiabetic drugs to metformin therapy for type 2 diabetes.

  JAMA 20100728

• Adding noninsulin antidiabetic drugs to metformin therapy for type 2 diabetes.

  JAMA 20100728

• Approval of chronic medication - Discovery Health hits new lows.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20100727

• [Vitamin B12 deficiency secondary to metformin therapy].

  Medicina clinica 20100717

• [Metformin and vitamin B12 deficiency].

  Medicina clinica 20100717

• Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study.

  Lancet (London, England) 20100710

• Preventing type 2 diabetes with low-dose combinations.

  Lancet (London, England) 20100710

• Pioglitazone in addition to metformin improves erythrocyte deformability in patients with Type 2 diabetes mellitus.

  Clinical science (London, England : 1979) 20100709

• Protective effect of metformin in CD1 mice placed on a high carbohydrate-high fat diet.

  Biochemical and biophysical research communications 20100702

• Metformin overdose with a resultant serum pH of 6.59: survival without sequalae.

  The Journal of emergency medicine 20100701

• Three cases of severe metformin-related lactic acidosis.

  European journal of anaesthesiology 20100701

• Pioglitazone decreases plasma cholesteryl ester transfer protein mass, associated with a decrease in hepatic triglyceride content, in patients with type 2 diabetes.

  Diabetes care 20100701

• Effects of metformin on glucose metabolism of perfused rat livers.

  Molecular and cellular biochemistry 20100701

• Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice.

  Diabetologia 20100701

• A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.

  Diabetes care 20100701

• Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study.

  Diabetes care 20100701

• The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.

  Diabetes care 20100701

• Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains.

  European journal of medicinal chemistry 20100701

• Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.

  The Journal of pharmacology and experimental therapeutics 20100701

• Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action.

  Diabetes 20100701

• N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents.

  European journal of medicinal chemistry 20100701

• The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

  Diabetes care 20100701

• PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene.

  Human reproduction (Oxford, England) 20100701

• Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metformin.

  Primary care diabetes 20100701

• Metformin: a therapeutic option for treating nonalcoholic fatty liver disease.

  Digestive diseases and sciences 20100701

• Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.

  Molecular carcinogenesis 20100701

• Pioglitazone versus metformin in two rat models of glucose intolerance and diabetes.

  Pakistan journal of pharmaceutical sciences 20100701

• An energetic tale of AMPK-independent effects of metformin.

  The Journal of clinical investigation 20100701

• Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

  The Journal of clinical investigation 20100701

• Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model.

  Archives of physiology and biochemistry 20100701

• Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1.

  British journal of pharmacology 20100701

• Use of metformin in the treatment of polycystic ovary syndrome.

  Women's health (London, England) 20100701

• Analysis of metformin treatment for adolescent obesity at 48 rather than 24 weeks after treatment cessation.

  Archives of pediatrics & adolescent medicine 20100701

• Acute metformin overdose.

  Annals of emergency medicine 20100701

• Improving glycemic control and cardiometabolic risk through integrated treatment plans.

  The Journal of the American Osteopathic Association 20100701

• The increasing epidemiology of diabetes and review of current treatment algorithms.

  The Journal of the American Osteopathic Association 20100701

• Illustrative case and discussion: a 58-year-old man with diabetes.

  The Journal of the American Osteopathic Association 20100701

• Risks and benefits of attaining HbA(1c) goals: examining the evidence.

  The Journal of the American Osteopathic Association 20100701

• A single-center, open, comparative study of the effect of using self-monitoring of blood glucose to guide therapy on preclinical atherosclerotic markers in type 2 diabetic subjects.

  Journal of diabetes science and technology 20100701

• Influence of oral antidiabetic drugs on hyperglycemic response to foods in persons with type 2 diabetes mellitus as assessed by continuous glucose monitoring system: a pilot study.

  Journal of diabetes science and technology 20100701

• A retrospective cohort study of economic outcomes and adherence to monotherapy with metformin, pioglitazone, or a sulfonylurea among patients with type 2 diabetes mellitus in the United States from 2003 to 2005.

  Clinical therapeutics 20100701

• Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers.

  Clinical therapeutics 20100701

• Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20100626

• Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats.

  European journal of pharmacology 20100610

• Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

  Cell metabolism 20100609

• Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet.

  Clinical science (London, England : 1979) 20100608

• An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome.

  Fertility and sterility 20100601

• AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.

  American journal of respiratory cell and molecular biology 20100601

• Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients.

  Metabolism: clinical and experimental 20100601

• Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells.

  Immunopharmacology and immunotoxicology 20100601

• Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial.

  American journal of obstetrics and gynecology 20100601

• Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients.

  Clinical biochemistry 20100601

• Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.

  Diabetes care 20100601

• Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.

  Endocrine-related cancer 20100601

• Long-term metformin use is associated with decreased risk of breast cancer.

  Diabetes care 20100601

• Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database.

  Diabetes care 20100601

• Epidemiological aspects of neoplasms in diabetes.

  Acta diabetologica 20100601

• Adjunct therapy for type 1 diabetes mellitus.

  Nature reviews. Endocrinology 20100601

• LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

• Metformin provides weight reduction for hospitalized patients receiving polypharmacy.

  Journal of clinical psychopharmacology 20100601

• Metformin: safety in cardiac patients.

  Postgraduate medical journal 20100601

• Review: metformin: potential benefits and use in chronic kidney disease.

  Nephrology (Carlton, Vic.) 20100601

• Metformin-induced regulation of the intestinal D-glucose transporters.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601

• [Comparison on efficacy and safety of two regimens for treatment of type 2 diabetes mellitus: glargine plus metformin versus neutral protamine hagedorn plus metformin].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100601

• [Hypoglycemic therapy in heart disease patients with type 2 diabetes mellitus].

  Giornale italiano di cardiologia (2006) 20100601

• [Effect of metformin on the formation of hepatic fibrosis in type 2 diabetic rats].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100601

• RCPE UK consensus statement on diabetes.

  The journal of the Royal College of Physicians of Edinburgh 20100601

• Development of directly compressible metformin hydrochloride by the spray-drying technique.

  Acta pharmaceutica (Zagreb, Croatia) 20100601

• Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway.

  Biochemical and biophysical research communications 20100528

• Reduced serum vitamin B-12 in patients taking metformin.

  BMJ (Clinical research ed.) 20100520

• [Treatment guidelines for hyperglycaemia in type 2 diabetes patients with stable chronic heart failure or ischemic cardiomyopathy without heart failure].

  Medicina clinica 20100508

• Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

  Cell metabolism 20100505

• Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.

  Fertility and sterility 20100501

• Acidosis in the hospital setting: is metformin a common precipitant?

  Internal medicine journal 20100501

• Effects of testosterone and metformin on glucose metabolism in endometrium.

  Fertility and sterility 20100501

• The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus.

  Current vascular pharmacology 20100501

• The use of metformin in type 1 diabetes: a systematic review of efficacy.

  Diabetologia 20100501

• Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells.

  Domestic animal endocrinology 20100501

• Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin.

  Diabetes care 20100501

• Clearance of the high intestinal (18)F-FDG uptake associated with metformin after stopping the drug.

  European journal of nuclear medicine and molecular imaging 20100501

• Pharmacokinetics of metformin during pregnancy.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care.

  Diabetologia 20100501

• Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.

  Kidney international 20100501

• Diabetes therapy and cancer risk: causal effects and other plausible explanations.

  Diabetologia 20100501

• Clinical evaluation of combined therapy for type 2 diabetes.

  Current medical research and opinion 20100501

• Metformin supplementation and life span in Fischer-344 rats.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20100501

• Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease.

  Liver international : official journal of the International Association for the Study of the Liver 20100501

• [Revascularization in patients with type 2 diabetes and coronary artery disease: BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Study Group].

  Der Internist 20100501

• Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100501

• The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?

  Expert opinion on therapeutic targets 20100501

• Diabetes: preventing type 2 diabetes mellitus: is metformin the answer?

  Nature reviews. Endocrinology 20100501

• Understanding the inter-relationship between improved glycaemic control, hypoglycaemia and weight change within a long-term economic model.

  Diabetes, obesity & metabolism 20100501

• Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes.

  Diabetes, obesity & metabolism 20100501

• Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20100501

• [Sequential treatment with insulin glargine and metformin, and exenatide in a patient with newly diagnosed type-2 diabetes].

  Deutsche medizinische Wochenschrift (1946) 20100501

• Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria.

  Kidney international 20100501

• Metformin in cancer therapy: a new perspective for an old antidiabetic drug?

  Molecular cancer therapeutics 20100501

• Effective switch from premixed to basal-prandial insulin to achieve glycemic goals in type 2 diabetes.

  Postgraduate medicine 20100501

• Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin.

  Expert review of molecular diagnostics 20100501

• Everything old is new again: spironolactone and metformin in the treatment of acne.

  Journal of drugs in dermatology : JDD 20100501

• [Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases].

  La Tunisie medicale 20100501

• Calorie restriction: what recent results suggest for the future of ageing research.

  European journal of clinical investigation 20100501

• Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced?

  Diabetic medicine : a journal of the British Diabetic Association 20100501

• Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: a randomized double-blind placebo-controlled study.

  Diabetic medicine : a journal of the British Diabetic Association 20100501

• Incorporating practical lifestyle management for obesity.

  The Journal of family practice 20100501

• Diabetes drug interferes with vitamin B12.

  Harvard heart letter : from Harvard Medical School 20100501

• Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.

  Indian journal of experimental biology 20100501

• Addition of incretin therapy to metformin in type 2 diabetes.

  Lancet (London, England) 20100424

• Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial.

  Lancet (London, England) 20100424

• Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.

  Journal of ethnopharmacology 20100421

• Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma.

  Cancer 20100415

• Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes.

  JAMA 20100414

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20100414

• [Diagnosis and treatment of polycystic ovary syndrome].

  Orvosi hetilap 20100404

• Atorvastatin pretreatment augments the effect of metformin in patients with polycystic ovary syndrome (PCOS).

  Clinical endocrinology 20100401

• Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention.

  Journal of endocrinological investigation 20100401

• Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.

  American journal of obstetrics and gynecology 20100401

• Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control study.

  Pharmacoepidemiology and drug safety 20100401

• Sulphonyurea as a cause of severe hypoglycaemia in the community.

  Primary care diabetes 20100401

• Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine.

  The Journal of pharmacology and experimental therapeutics 20100401

• Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy.

  Diabetes care 20100401

• Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.

  Diabetes 20100401

• Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus.

  Neurochemical research 20100401

• Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.

  American journal of physiology. Endocrinology and metabolism 20100401

• Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

  The Journal of endocrinology 20100401

• Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.

  Diabetes 20100401

• Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response.

  Human reproduction (Oxford, England) 20100401

• [An approach to adopt in patients with metformin-associated vitamin B12 deficiency].

  Atencion primaria 20100401

• Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse.

  Archives of biochemistry and biophysics 20100401

• The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.

  Human reproduction (Oxford, England) 20100401

• Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome.

  The Journal of steroid biochemistry and molecular biology 20100401

• Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly.

  The Annals of pharmacotherapy 20100401

• Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100401

• Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain.

  The Annals of pharmacotherapy 20100401

• Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.

  American journal of obstetrics and gynecology 20100401

• Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20100401

• Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots.

  Diabetes, obesity & metabolism 20100401

• Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.

  Journal of child and adolescent psychopharmacology 20100401

• Insulin, insulin resistance, obesity, and cancer.

  Current diabetes reports 20100401

• Hirsutism: Diagnosis and management.

  Gender medicine 20100401

• The impact of publishing medical specialty society guidelines on subsequent adoption of best practices: a case study with type 2 diabetes.

  International journal of clinical practice 20100401

• Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study.

  International journal of clinical practice 20100401

• Biopharmaceutical evaluation of formulated metformin/rosiglitazone tablets.

  Drug discoveries & therapeutics 20100401

• Life threatening lactic acidosis.

  BMJ (Clinical research ed.) 20100324

• Toxicity and toxicokinetics of metformin in rats.

  Toxicology and applied pharmacology 20100315

• Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.

  Cancer research 20100315

• Metformin: a therapeutic opportunity in breast cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100315

• Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena.

  Cell cycle (Georgetown, Tex.) 20100315

• Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.

  The Journal of biological chemistry 20100312

• Insulin regimens in type 2 diabetes.

  The New England journal of medicine 20100311

• Insulin regimens in type 2 diabetes.

  The New England journal of medicine 20100311

• [Discharge letter with therapeutic recommendations: you have to sort out!].

  MMW Fortschritte der Medizin 20100311

• Metformin induces suppression of NAD(P)H oxidase activity in podocytes.

  Biochemical and biophysical research communications 20100305

• Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

  Cell metabolism 20100303

• Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome.

  Clinical endocrinology 20100301

• [Vitamin B12 deficiency in patients treated with metformin: an approach to adopt].

  Atencion primaria 20100301

• Effects of rosiglitazone and metformin treatment on apelin, visfatin, and ghrelin levels in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20100301

• Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto starch acetate fibers.

  Biotechnology and bioengineering 20100301

• Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis.

  Journal of gastroenterology and hepatology 20100301

• Acute rhabdomyolysis during treatment with amisulpride and metformin.

  European journal of clinical pharmacology 20100301

• Metformin influence on hormone levels at birth, in PCOS mothers and their newborns.

  Human reproduction (Oxford, England) 20100301

• Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20100301

• Secondary failure of metformin monotherapy in clinical practice.

  Diabetes care 20100301

• Variability and impact on design of bioequivalence studies.

  Basic & clinical pharmacology & toxicology 20100301

• Metformin inhibits inflammatory angiogenesis in a murine sponge model.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301

• Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20100301

• Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20100301

• Could oral hypoglycemics be the new therapeutic answer to chronic obstructive pulmonary disease?

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20100301

• Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.

  Southern medical journal 20100301

• Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100301

• Titration of inhaled human insulin (Exubera) in a treat-to-target regimen for patients with type 2 diabetes.

  Diabetes technology & therapeutics 20100301

• Exenatide versus glibenclamide in patients with diabetes.

  Diabetes technology & therapeutics 20100301

• Metformin for atypical antipsychotic-induced weight gain and glucose metabolism dysregulation: review of the literature and clinical suggestions.

  CNS drugs 20100301

• Association between vitamin B12 levels and mortality in hospitalized older adults.

  Journal of the American Geriatrics Society 20100301

• Diabetes: Strategies to prevent the type 2 diabetes mellitus epidemic.

  Nature reviews. Endocrinology 20100301

• The effect of metformin on alveolar bone in ligature-induced periodontitis in rats: a pilot study.

  Journal of periodontology 20100301

• Metformin improves sustained virologic response in difficult-to-cure hepatitis C: more questions than answers.

  Hepatology (Baltimore, Md.) 20100301

• Impact of metformin-induced gastrointestinal symptoms on quality of life and adherence in patients with type 2 diabetes.

  Postgraduate medicine 20100301

• Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes.

  Journal of cardiac failure 20100301

• Metformin use in patients with diabetes mellitus and heart failure: friend or foe?

  Journal of cardiac failure 20100301

• Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report.

  The American journal of emergency medicine 20100301

• Glucose supply and insulin demand dynamics of antidiabetic agents.

  Journal of diabetes science and technology 20100301

• [GLP-1: a new therapeutic principle for the treatment of type 2 diabetes mellitus].

  Medizinische Klinik (Munich, Germany : 1983) 20100301

• New therapeutic options: management strategies to optimize glycemic control.

  The Journal of the American Osteopathic Association 20100301

• [Sugar: results of a Belgian observational study on the use of sitagliptin in patients with type 2 diabetes].

  Revue medicale de Liege 20100301

• Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves.

  Natural product communications 20100301

• Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.

  Arquivos brasileiros de endocrinologia e metabologia 20100301

• A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study.

  Diabetic medicine : a journal of the British Diabetic Association 20100301

• Thailand Diabetic Registry cohort: predicting death in Thai diabetic patients and causes of death.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100301

• Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.

  Biochemical and biophysical research communications 20100226

• Metformin stinks, literally.

  Annals of internal medicine 20100216

• Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, metformin-like mechanism.

  Journal of ethnopharmacology 20100203

• Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome.

  Fertility and sterility 20100201

• Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit.

  Pediatric diabetes 20100201

• Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.

  Clinical and experimental pharmacology & physiology 20100201

• Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100201

• Intraperitoneal fat and insulin resistance in obese adolescents.

  Obesity (Silver Spring, Md.) 20100201

• Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin.

  Fertility and sterility 20100201

• Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.

  Metabolism: clinical and experimental 20100201

• Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.

  European journal of endocrinology 20100201

• AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

  American journal of physiology. Endocrinology and metabolism 20100201

• Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20100201

• Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.

  Reproduction (Cambridge, England) 20100201

• Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16.

  Diabetes care 20100201

• Metformin in chronic hepatitis C virus hepatitis: caution needed with sex-based subgroup analysis.

  Hepatology (Baltimore, Md.) 20100201

• Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome.

  Diabetes care 20100201

• Evaluation of a simple policy for pre- and post-prandial blood glucose self-monitoring in people with type 2 diabetes not on insulin.

  Diabetes research and clinical practice 20100201

• Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial.

  The Journal of clinical endocrinology and metabolism 20100201

• Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.

  Naunyn-Schmiedeberg's archives of pharmacology 20100201

• Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

  Pharmacogenetics and genomics 20100201

• Androgen excess in women: not just a cosmetic problem.

  Annales d'endocrinologie 20100201

• Should physicians prescribe metformin to women with polycystic ovary syndrome PCOS?

  Annales d'endocrinologie 20100201

• Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20100201

• Reproductive endocrinology: live birth prediction in polycystic ovary syndrome.

  Nature reviews. Endocrinology 20100201

• Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome.

  Journal of women's health (2002) 20100201

• Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up.

  Archives of pediatrics & adolescent medicine 20100201

• SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin.

  Acta pharmacologica Sinica 20100201

• Best methods for identification and treatment of PCOS.

  Minerva ginecologica 20100201

• Metformin's effect on exercise and postexercise substrate oxidation.

  International journal of sport nutrition and exercise metabolism 20100201

• Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid.

  Die Pharmazie 20100201

• Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.

  Cardiovascular drugs and therapy 20100201

• Efficacy of metformin in the treatment of diabetes mellitus complicating thalassemia major.

  La Tunisie medicale 20100201

• Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals.

  Archives of medical research 20100201

• Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.

  Indian journal of biochemistry & biophysics 20100201

• Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

• The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20100120

• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  The Cochrane database of systematic reviews 20100120

• Metformin, B(12), and enhanced breast cancer response to chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100110

• Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.

  Fertility and sterility 20100101

• Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations.

  Journal of diabetes and its complications 20100101

• Comparison of four different treatment regimens on coagulation parameters, hormonal and metabolic changes in women with polycystic ovary syndrome.

  Archives of gynecology and obstetrics 20100101

• The MALAdy of metformin poisoning: Is CVVH the cure?

  American journal of therapeutics 20100101

• Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical).

  Obesity (Silver Spring, Md.) 20100101

• The role of hyperglycemia in burned patients: evidence-based studies.

  Shock (Augusta, Ga.) 20100101

• Metformin: safety in cardiac patients.

  Heart (British Cardiac Society) 20100101

• Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes.

  Journal of diabetes and its complications 20100101

• Metformin reverses the deleterious effects of high glucose on osteoblast function.

  Journal of diabetes and its complications 20100101

• Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease.

  European journal of gastroenterology & hepatology 20100101

• Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.

  Contemporary clinical trials 20100101

• The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20100101

• Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity.

  The Journal of pediatrics 20100101

• Effects of colesevelam, rosiglitazone, or sitagliptin on glycemic control and lipid profile in patients with type 2 diabetes mellitus inadequately controlled by metformin monotherapy.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

• Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT).

  Diabetes care 20100101

• Many Americans have pre-diabetes and should be considered for metformin therapy.

  Diabetes care 20100101

• Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy.

  Gynecologic oncology 20100101

• High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

  Diabetes 20100101

• Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial.

  Diabetes care 20100101

• Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.

  Diabetes care 20100101

• Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20100101

• Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100101

• Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.

  Pharmacogenetics and genomics 20100101

• Pioglitazone compared with metformin increases pericardial fat volume in patients with type 2 diabetes mellitus.

  The Journal of clinical endocrinology and metabolism 20100101

• Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

  Cell cycle (Georgetown, Tex.) 20100101

• Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.

  Obstetrics and gynecology 20100101

• Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome.

  Gynecologic and obstetric investigation 20100101

• The art and science of medical guidelines: what we know and what we believe.

  Radiology 20100101

• Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin.

  Radiology 20100101

• Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.

  International journal of clinical pharmacology and therapeutics 20100101

• Nutrition-related vitamin B12 deficiency in patients in Pakistan with type 2 diabetes mellitus not taking metformin.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

• Quantitative spot-test analysis of metformin in pharmaceutical preparations using ultraviolet-visible diffuse reflectance spectroscopy.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

• Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus.

  Diabetes technology & therapeutics 20100101

• Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

  PloS one 20100101

• Evaluation of efficacy and tolerability of gliclazide and metformin combination: a multicentric study in patients with type 2 diabetes mellitus uncontrolled on monotherapy with sulfonylurea or metformin.

  American journal of therapeutics 20100101

• Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs.

  Postgraduate medicine 20100101

• Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

  Postgraduate medicine 20100101

• Metabolic regulation of neuronal plasticity by the energy sensor AMPK.

  PloS one 20100101

• Hemoglobin A1c for the diagnosis of diabetes: practical considerations.

  Polskie Archiwum Medycyny Wewnetrznej 20100101

• Effect of pioglitazone on various parameters of insulin resistance including lipoprotein subclass according to particle size by a gel-permeation high-performance liquid chromatography in newly diagnosed patients with type 2 diabetes.

  Endocrine journal 20100101

• Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication.

  Critical care (London, England) 20100101

• Epidemiology, assessment, and management of excess abdominal fat in persons with HIV infection.

  AIDS reviews 20100101

• Relationship between drug release and some physical parameters of drug sorption onto PLA fibers.

  Journal of biomaterials science. Polymer edition 20100101

• Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Determination of metformin hydrochloride and glyburide in an antihyperglycemic binary mixture using high-performance liquid chromatographic-UV and spectrometric methods.

  Journal of AOAC International 20100101

• Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type 2 diabetes mellitus.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

• [Antihypertensive effect of metformin in essential hypertensive patients with hyperinsulinemia.].

  Zhonghua nei ke za zhi 20100101

• The BARI 2D study: a randomised trial of therapies for type 2 diabetes and coronary artery disease.

  Diabetes & vascular disease research 20100101

• Pre-existing cardiovascular diseases and glycemic control in patients with type 2 diabetes mellitus in Europe: a matched cohort study.

  Cardiovascular diabetology 20100101

• Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin.

  Neoplasma 20100101

• Clarifying metformin's role and risks in liver dysfunction.

  Journal of the American Pharmacists Association : JAPhA 20100101

• FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature.

  Dermatology (Basel, Switzerland) 20100101

• Insulin resistance and response to antiviral therapy in chronic hepatitis C: mechanisms and management.

  Digestive diseases (Basel, Switzerland) 20100101

• Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study.

  Reproductive biology and endocrinology : RB&E 20100101

• Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.

  BMJ (Clinical research ed.) 20100101

• A new look at established therapies: practical tools for optimizing insulin use.

  The Diabetes educator 20100101

• Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus.

  The Annals of pharmacotherapy 20100101

• The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis.

  Arquivos de gastroenterologia 20100101

• Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice.

  Biological & pharmaceutical bulletin 20100101

• Links between granuloma annulare, necrobiosis lipoidica diabeticorum and childhood diabetes: a matter of time?

  Pediatric dermatology 20100101

• Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes.

  Cardiology in review 20100101

• [Lipid profile in obese and non-obese women with polycystic ovary syndrome treated with metformin].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100101

• Diabetes and cancer: a consensus report.

  CA: a cancer journal for clinicians 20100101

• Comparison of pioglitazone vs glyburide in early heart failure: insights from a randomized controlled study of patients with type 2 diabetes and mild cardiac disease.

  Congestive heart failure (Greenwich, Conn.) 20100101

• Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.

  International journal of molecular sciences 20100101

• The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials.

  BMC infectious diseases 20100101

• What your doctor is reading.

  Diabetes self-management 20100101

• Cost effectiveness of insulin glargine plus oral antidiabetes drugs compared with premixed insulin alone in patients with type 2 diabetes mellitus in Canada.

  Applied health economics and health policy 20100101

• Comment: Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain.

  The Annals of pharmacotherapy 20100101

• [Mechanism of inhibition of hepatic glucose production by metformin: a new concept for an old remedy].

  Medecine sciences : M/S 20100101

• Initial combination therapy with metformin and colesevelam for achievement of glycemic and lipid goals in early type 2 diabetes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

• Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome.

  Journal of endocrinological investigation 20100101

• Low-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic ovary syndrome: prediction of effectiveness by multiple parameters related to insulin resistance.

  Hormones (Athens, Greece) 20100101

• How much do you know about metformin?

  Diabetes self-management 20100101

• An economic evaluation of colesevelam when added to metformin-, insulin- or sulfonylurea-based therapies in patients with uncontrolled type 2 diabetes mellitus.

  PharmacoEconomics 20100101

• [Effect of previous diabetes therapy on tumor receptor phenotype in breast cancer: comparison of metformin and sulphonylurea derivatives].

  Voprosy onkologii 20100101

• Increased expression of hepatic organic cation transporter 1 and hepatic distribution of metformin in high-fat diet-induced obese mice.

  Drug metabolism and pharmacokinetics 20100101

• Effects of metformin on rosiglitazone-induced cardiac hypertrophy in mice.

  Biological & pharmaceutical bulletin 20100101

• Management of diabetes mellitus in Cushing's syndrome.

  Neuroendocrinology 20100101

• [Dynamics of structural-functional parameters of cardiovascular system during use of complex therapy of women with type 2 diabetes mellitus].

  Kardiologiia 20100101

• A systems biology approach to identify effective cocktail drugs.

  BMC systems biology 20100101

• Diabetes treatment patterns and goal achievement in primary diabetes care (DiaRegis) - study protocol and patient characteristics at baseline.

  Cardiovascular diabetology 20100101

• Metabolic engineering of resveratrol and other longevity boosting compounds.

  BioFactors (Oxford, England) 20100101

• Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

  BioFactors (Oxford, England) 20100101

• [Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus].

  Terapevticheskii arkhiv 20100101

• Bioequivalence of sitagliptin/metformin fixed-dose combination tablets and concomitant administration of sitagliptin and metformin in healthy adult subjects: a randomized, open-label, crossover study.

  Clinical drug investigation 20100101

• Clinical outcomes of ovulation induction with metformin, clomiphene citrate and human menopausal gonadotrophin in polycystic ovary syndrome.

  The Journal of international medical research 20100101

• [Sonographic ovarian vascularization and volume in women with polycystic ovary syndrome treated with clomiphene citrate and metformin].

  Ginecologia y obstetricia de Mexico 20100101

• Persistence patterns with oral antidiabetes drug treatment in newly treated patients--a population-based study.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101

• Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.

  Pharmacological reports : PR 20100101

• Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

  Pharmacological reports : PR 20100101

• Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.

  Islets 20100101

• Justification of metformin hydrochloride biowaiver criteria based on bioequivalence study.

  Arzneimittel-Forschung 20100101

• Metformin: 'Old warrior for a new battle'.

  Indian journal of cancer 20100101

• [Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice].

  Voprosy onkologii 20100101

• Teaching an old drug new tricks: metformin as a targeted therapy for lung cancer.

  Seminars in thoracic and cardiovascular surgery 20100101

• Outcome of severe lactic acidosis associated with metformin accumulation.

  Critical care (London, England) 20100101

• Determination of impurities in medical products containing metformin hydrochloride.

  Acta poloniae pharmaceutica 20100101

• Optimization and validation of an RP-HPLC method for direct determination of metformin hydrochloride in human urine and in a dosage form.

  Journal of AOAC International 20100101

• Part D coverage gap and adherence to diabetes medications.

  The American journal of managed care 20100101

• [Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients].

  Voprosy onkologii 20100101

• [The effects of metformin plus sulfonylurea therapy on clinical features of the metabolic syndrome].

  Medicinski pregled 20100101

• Perioperative use of metformin in cardiac surgery.

  Medicina (Kaunas, Lithuania) 20100101

• Determination of metformin in human plasma and urine by high-performance liquid chromatography using small sample volume and conventional octadecyl silane column.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

• [Formulation by design of experiments of immediate release tablets with metformin hydrochloride and glibenclamide].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

• [Efficacy of short-term metformin application in complex treatment of patients with coronary artery disease and concomitant metabolic syndrome].

  Likars'ka sprava 20100101

• [Efficacy of complex therapy with metformin and ramipril combination for patients with metabolic syndrome].

  Likars'ka sprava 20100101

• Metformin and lactic acidosis. NSAIDs and renin-angiotensin-aldosterone system.

  BMJ (Clinical research ed.) 20091223

• Metformin and lactic acidosis. Metformin: framed again?

  BMJ (Clinical research ed.) 20091223

• Metformin as an addition to conventional chemotherapy in breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

• Triple verses glimepiride plus metformin therapy on cardiovascular risk biomarkers and diabetic cardiomyopathy in insulin resistance type 2 diabetes mellitus rats.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208

• Sulphonylureas and cancer: a case-control study.

  Acta diabetologica 20091201

• Impact of acute kidney injury on metformin-associated lactic acidosis.

  International urology and nephrology 20091201

• Long-standing hidradenitis suppurativa treated effectively with metformin.

  Clinical and experimental dermatology 20091201

• Changes in health state utilities with changes in body mass in the Diabetes Prevention Program.

  Obesity (Silver Spring, Md.) 20091201

• The backbone of oral glucose-lowering therapy: time for a paradigm shift?

  Fundamental & clinical pharmacology 20091201

• Recovery of acanthosis nigricans under prolonged metformin treatment in an adolescent with normal weight.

  Journal of endocrinological investigation 20091201

• Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.

  Annals of emergency medicine 20091201

• Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.

  Medical hypotheses 20091201

• Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by high-fat diet in mice.

  Biology of reproduction 20091201

• Drug sorption onto and release from soy protein fibers.

  Journal of materials science. Materials in medicine 20091201

• Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

• Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

  Journal of cellular physiology 20091201

• Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20091201

• The European Exenatide study of long-term exenatide vs. glimepiride for type 2 diabetes: rationale and patient characteristics.

  Diabetes, obesity & metabolism 20091201

• Effects of pioglitazone and rosiglitazone combined with metformin on body weight in people with diabetes.

  Diabetes, obesity & metabolism 20091201

• Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations.

  European journal of medicinal chemistry 20091201

• Glucose homeostasis is impaired by a paradoxical interaction between metformin and insulin in carnivorous rainbow trout.

  American journal of physiology. Regulatory, integrative and comparative physiology 20091201

• Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.

  Current opinion in obstetrics & gynecology 20091201

• Efficacy and safety of pioglitazone/metformin fixed-dose combination therapy compared with pioglitazone and metformin monotherapy in treating patients with T2DM.

  Current medical research and opinion 20091201

• Development of Gelucire 43/01 beads of metformin hydrochloride for floating delivery.

  AAPS PharmSciTech 20091201

• Changes in weight and metabolic parameters during treatment with antipsychotics and metformin: do the data inform as to potential guideline development? A systematic review of clinical studies.

  International journal of clinical practice 20091201

• Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin.

  Hepatology (Baltimore, Md.) 20091201

• Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate.

  Diabetes & metabolism 20091201

• LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091201

• Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.

  The Journal of clinical endocrinology and metabolism 20091201

• Metformin toxicity.

  European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20091201

• Current understanding of the pharmacogenomics of metformin.

  Clinical pharmacology and therapeutics 20091201

• Can metformin or rosiglitazone reduce metabolic side effects associated with atypical antipsychotics?

  Issues in mental health nursing 20091201

• Effects of Escherichia coli lipopolysaccharide on the metformin pharmacokinetics in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20091201

• Metformin, hepatitis C, and insulin resistance: sufficient evidence?

  Hepatology (Baltimore, Md.) 20091201

• Drugs that suppress TSH or cause central hypothyroidism.

  Best practice & research. Clinical endocrinology & metabolism 20091201

• Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.

  IDrugs : the investigational drugs journal 20091201

• Pharmacokinetics and bioequivalence evaluation of gliclazide/metformin combination tablet and equivalent doses of gliclazide and metformin in healthy Korean subjects.

  International journal of clinical pharmacology and therapeutics 20091201

• Metformin increases plasma ghrelin in Type 2 diabetes.

  British journal of clinical pharmacology 20091201

• Long-term glycaemic effects of pioglitazone compared with placebo as add-on treatment to metformin or sulphonylurea monotherapy in PROactive (PROactive 18).

  Diabetic medicine : a journal of the British Diabetic Association 20091201

• Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients.

  Clinical and investigative medicine. Medecine clinique et experimentale 20091201

• Mysterious metformin.

  The oncologist 20091201

• Effects of metformin on serum levels of sex hormone, leptin and insulin in ovariectomized Sprague-Dawley rats.

  Die Pharmazie 20091201

• Type 2 diabetes mellitus with pancreatic beta cell dysfunction in 3 horses confirmed with minimal model analysis.

  Equine veterinary journal 20091201

• Serum bicarbonate: can it be a marker of metformin induced acidosis in geriatrics?

  Nepal Medical College journal : NMCJ 20091201

• Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats.

  European journal of pharmacology 20091125

• If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091120

• Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.

  FEBS letters 20091119

• AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor.

  Cell cycle (Georgetown, Tex.) 20091115

• Metformin use in renal dysfunction: is a serum creatinine threshold appropriate?

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091115

• 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.

  Lancet (London, England) 20091114

• Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.

  The Journal of biological chemistry 20091113

• Continuation of metformin after introduction of insulin in type 2 diabetes.

  BMJ (Clinical research ed.) 20091109

• Relationship of plasma creatinine and lactic acid in type 2 diabetic patients without renal dysfunction.

  Chinese medical journal 20091105

• Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

  Fertility and sterility 20091101

• Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study.

  Cancer causes & control : CCC 20091101

• Effects of 1-year treatment with metformin on metabolic and cardiovascular risk factors in non-diabetic upper-body obese subjects with mild glucose anomalies: a post-hoc analysis of the BIGPRO1 trial.

  Diabetes & metabolism 20091101

• Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101

• Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes.

  Diabetes research and clinical practice 20091101

• Interaction of beta-blockers with the renal uptake transporter OCT2.

  Diabetes, obesity & metabolism 20091101

• A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes.

  Biopharmaceutics & drug disposition 20091101

• Determination of metformin in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

• Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.

  Archives of biochemistry and biophysics 20091101

• Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension.

  British journal of pharmacology 20091101

• [Female patient with type 2 diabetes in coma with metabolic acidosis].

  Der Internist 20091101

• Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.

  Diabetes care 20091101

• Changing the treatment paradigm for type 2 diabetes.

  Diabetes care 20091101

• Beta-cell protection and therapy for latent autoimmune diabetes in adults.

  Diabetes care 20091101

• Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No.

  Diabetes care 20091101

• Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes.

  Diabetes care 20091101

• A summary of the ADVANCE Trial.

  Diabetes care 20091101

• Clinical practice in type 2 diabetes: After metformin and lifestyle, then what?

  The Journal of family practice 20091101

• Rationale, design, and baseline data of the insulin glargine (Lantus) versus insulin detemir (Levemir) Treat-To-Target (L2T3) study: A multinational, randomized noninferiority trial of basal insulin initiation in type 2 diabetes.

  Diabetes technology & therapeutics 20091101

• Comparative study of low-dose pioglitazone or metformin treatment in Japanese diabetic patients with metabolic syndrome.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20091101

• [Liraglutide: a human GLP-1 analogue for the treatment of diabetes mellitus type 2].

  Medizinische Monatsschrift fur Pharmazeuten 20091101

• Treating type 2 diabetes. A specialist's approach.

  Advance for nurse practitioners 20091101

• Metformin--a convenient alternative to insulin for Indian women with diabetes in pregnancy.

  Indian journal of medical sciences 20091101

• Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats.

  Methods and findings in experimental and clinical pharmacology 20091101

• Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits.

  Heart and vessels 20091101

• Pharmacokinetic comparison of a new glimepiride 1-mg + metformin 500-mg combination tablet formulation and a glimepiride 2-mg + metformin 500-mg combination tablet formulation: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy, fasting Korean male volunteers.

  Clinical therapeutics 20091101

• Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes: results from a pilot study.

  Journal of diabetes science and technology 20091101

• Effect of metformin on miscarriage in pregnant patients with polycystic ovary syndrome.

  The West Indian medical journal 20091101

• Metformin: fifty-two not out.

  Journal of the Indian Medical Association 20091101

• Three-year efficacy of complex insulin regimens in type 2 diabetes.

  The New England journal of medicine 20091029

• Saxagliptin.

  Drugs 20091022

• Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism.

  Biochemical and biophysical research communications 20091016

• Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20091015

• Development and validation of an analytical method for metformin hydrochloride and its related compound (1-cyanoguanidine) in tablet formulations by HPLC-UV.

  Talanta 20091015

• [Type 2 diabetes: interview with Prof. Stephan Matthaei. Reaching HbA1c target value while preventing hypoglycemia].

  MMW Fortschritte der Medizin 20091015

• [Combination antidiabetic therapy. Better control of blood glucose values].

  MMW Fortschritte der Medizin 20091015

• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  The Cochrane database of systematic reviews 20091007

• Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.

  Atherosclerosis 20091001

• Vertebral fractures in males with type 2 diabetes treated with rosiglitazone.

  Bone 20091001

• Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control.

  Diabetes, obesity & metabolism 20091001

• Short-term metformin treatment for clomiphene citrate-resistant women with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20091001

• Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes.

  Diabetes, obesity & metabolism 20091001

• Is it the time for metformin to take place in adjuvant treatment of Her-2 positive breast cancer? Teaching new tricks to old dogs.

  Medical hypotheses 20091001

• Metformin promotes induction of lipoprotein lipase in skeletal muscle through activation of adenosine monophosphate-activated protein kinase.

  Metabolism: clinical and experimental 20091001

• Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway.

  Endocrinology 20091001

• Regulation of glucose-6-phosphatase gene expression by insulin and metformin.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091001

• Changes in insulin secretion and insulin sensitivity in relation to the glycemic outcomes in subjects with impaired glucose tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1).

  Diabetes care 20091001

• Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

  Hepatology (Baltimore, Md.) 20091001

• Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better?

  Diabetes care 20091001

• Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial--a primary care, type 2 diabetes study.

  Diabetes, obesity & metabolism 20091001

• Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

• Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients.

  Diabetes research and clinical practice 20091001

• Metformin: diamonds are forever.

  Expert opinion on pharmacotherapy 20091001

• Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan.

  International journal of clinical practice 20091001

• Effects of bed-time insulin versus pioglitazone on abdominal fat accumulation, inflammation and gene expression in adipose tissue in patients with type 2 diabetes.

  Diabetes research and clinical practice 20091001

• Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

  Diabetologia 20091001

• Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats.

  Diabetes/metabolism research and reviews 20091001

• Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS).

  Reproductive sciences (Thousand Oaks, Calif.) 20091001

• The transmembrane transport of metformin by osteoblasts from rat mandible.

  Archives of oral biology 20091001

• Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

  Cancer research 20091001

• Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia-induced phosphatidylserine externalization and reversed by metformin.

  Molecular bioSystems 20091001

• Metformin in the treatment of clomiphene citrate-resistant women with polycystic ovary syndrome undergoing in vitro fertilisation treatment: a randomised controlled trial.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20091001

• Diabetic diarrhea.

  Current gastroenterology reports 20091001

• Oral glucose tolerance test (OGTT) in normal control and glucose induced hyperglycemic rats with Coccinia cordifolia l. and Catharanthus roseus L.

  Pakistan journal of pharmaceutical sciences 20091001

• Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance.

  Hepatology (Baltimore, Md.) 20091001

• Therapies for type 2 diabetes and coronary artery disease.

  The New England journal of medicine 20091001

• Hyperinsulinemia and risk for hepatocellular carcinoma in patients with chronic liver diseases and Type 2 diabetes mellitus.

  Expert review of gastroenterology & hepatology 20091001

• [Oral hypoglycaemic agents in 2009].

  Therapeutische Umschau. Revue therapeutique 20091001

• [Insulin and type 2 diabetes mellitus].

  Therapeutische Umschau. Revue therapeutique 20091001

• Gastroretentive drug delivery of metformin hydrochloride: formulation and in vitro evaluation using 3(2) full factorial design.

  Current drug delivery 20091001

• Long-term glycaemic control with metformin-sulphonylurea-pioglitazone triple therapy in PROactive (PROactive 17).

  Diabetic medicine : a journal of the British Diabetic Association 20091001

• Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment.

  Reproductive biomedicine online 20091001

• Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status.

  Advances in therapy 20091001

• [Glargine insulin and cancer risk].

  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20091001

• Polycystic ovary syndrome and metabolic comorbidities: therapeutic options.

  Drugs of today (Barcelona, Spain : 1998) 20091001

• [Photosensitivity induced by metformin: a report of 3 cases].

  La Tunisie medicale 20091001

• Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats.

  Journal of ethnopharmacology 20090925

• Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial.

  JAMA 20090916

• Metformin associated lactic acidosis.

  BMJ (Clinical research ed.) 20090916

• Attenuation of hepatic expression and secretion of selenoprotein P by metformin.

  Biochemical and biophysical research communications 20090911

• [Polycystic ovary syndrome. Diet helps control hormone chaos].

  MMW Fortschritte der Medizin 20090910

• Investigating infertility.

  BMJ (Clinical research ed.) 20090909

• Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months.

  Clinical endocrinology 20090901

• Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels.

  European journal of nutrition 20090901

• Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet.

  Diabetes, obesity & metabolism 20090901

• The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone.

  Diabetes care 20090901

• The effect of metformin in overweight patients with type 1 diabetes and poor metabolic control.

  Basic & clinical pharmacology & toxicology 20090901

• Insulin and metformin regulate circulating and adipose tissue chemerin.

  Diabetes 20090901

• Effect of DHEA and metformin on corpus luteum in mice.

  Reproduction (Cambridge, England) 20090901

• TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients.

  Diabetes care 20090901

• Metformin for obesity in children and adolescents: a systematic review.

  Diabetes care 20090901

• Effects of rosiglitazone on fasting plasma fibroblast growth factor-21 levels in patients with type 2 diabetes mellitus.

  European journal of endocrinology 20090901

• The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

  Clinical pharmacology and therapeutics 20090901

• Diabetes medications and body weight.

  Expert opinion on drug safety 20090901

• Metformin improves postprandial glucose homeostasis in rainbow trout fed dietary carbohydrates: a link with the induction of hepatic lipogenic capacities?

  American journal of physiology. Regulatory, integrative and comparative physiology 20090901

• New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.

  Diabetes care 20090901

• The influence of glucose-lowering therapies on cancer risk in type 2 diabetes.

  Diabetologia 20090901

• Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program.

  Diabetes care 20090901

• Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma.

  Hypertension research : official journal of the Japanese Society of Hypertension 20090901

• Earlier triple therapy with pioglitazone in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20090901

• Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as first-line therapy in type 2 diabetes and colesevelam HCl in prediabetes.

  Current medical research and opinion 20090901

• Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans.

  American journal of physiology. Endocrinology and metabolism 20090901

• Total and acylated ghrelin levels in type 2 diabetic patients: similar levels observed after treatment with metformin, pioglitazone or diet therapy.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090901

• Antidiabetic agents and cardiovascular risk in type 2 diabetes.

  Nature reviews. Endocrinology 20090901

• In situ forming formulation: development, evaluation, and optimization using 3(3) factorial design.

  AAPS PharmSciTech 20090901

• Rosiglitazone maleate + metformin hydrochloride extend: review of an emerging compound.

  Expert opinion on investigational drugs 20090901

• Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans.

  Arteriosclerosis, thrombosis, and vascular biology 20090901

• Pharmacotherapy in pediatric obesity: current agents and future directions.

  Reviews in endocrine & metabolic disorders 20090901

• Diabetes: HOME reveals new data on a cornerstone of treatment.

  Nature reviews. Endocrinology 20090901

• Metformin, cancer, alphabet soup, and the role of epidemiology in etiologic research.

  Diabetes care 20090901

• Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?

  Cell cycle (Georgetown, Tex.) 20090901

• [Usefulness of metformin in diabetes-related bone disease].

  Clinical calcium 20090901

• Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany.

  Journal of environmental monitoring : JEM 20090901

• Selecting among ADA/EASD tier 1 and tier 2 treatment options.

  The Journal of family practice 20090901

• Practical applications of therapy with a glucagon-like peptide-1 receptor agonist.

  The Journal of family practice 20090901

• Patient education and monitoring recommendations for the use of glucagon-like peptide-1 receptor agonists.

  The Journal of family practice 20090901

• Is it time to test metformin in breast cancer prevention trials? A reply to the authors.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090901

• Initiation of prandial insulin therapy with AIR inhaled insulin or insulin lispro in patients with type 2 diabetes: A randomized noninferiority trial.

  Diabetes technology & therapeutics 20090901

• A comparison between simplified and intensive dose-titration algorithms using AIR inhaled insulin for insulin-naive patients with type 2 diabetes in a randomized noninferiority trial.

  Diabetes technology & therapeutics 20090901

• Treating patients with type 2 diabetes: what is after lifestyle management and metformin? A focus on the glucagon-like peptide-1 receptor agonists.

  The Journal of family practice 20090901

• Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis.

  Anaesthesia and intensive care 20090901

• In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.

  Circulation. Cardiovascular imaging 20090901

• Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20090901

• Ultra-performance hydrophilic interaction LC-MS/MS for the determination of metformin in mouse plasma.

  Bioanalysis 20090901

• [Use of metformin in polycystic ovary syndrome].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090827

• Metformin, diet and breast cancer: an avenue for chemoprevention.

  Cell cycle (Georgetown, Tex.) 20090815

• Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.

  Cancer research 20090815

• [Primary preventive effect of metformin upon atherosclerosis in patients with type 2 diabetes mellitus].

  Zhonghua yi xue za zhi 20090811

• The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome.

  Archives of gynecology and obstetrics 20090801

• Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice.

  Phytotherapy research : PTR 20090801

• The effects of brain-derived neurotrophic factor and metformin on in vitro developmental competence of bovine oocytes.

  Zygote (Cambridge, England) 20090801

• Antidiabetic therapies affect risk of pancreatic cancer.

  Gastroenterology 20090801

• Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus.

  The pharmacogenomics journal 20090801

• Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance.

  Endocrine 20090801

• Direct comparison among oral hypoglycemic agents and their association with insulin resistance evaluated by euglycemic hyperinsulinemic clamp: the 60's study.

  Metabolism: clinical and experimental 20090801

• Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

  Endocrinology 20090801

• Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

  Cardiovascular research 20090801

• Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia.

  Diabetes care 20090801

• Prescribing metformin in type 2 diabetes with a contraindication: prevalence and outcome.

  Pharmacy world & science : PWS 20090801

• A cohort study of thiazolidinediones and fractures in older adults with diabetes.

  The Journal of clinical endocrinology and metabolism 20090801

• Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial.

  Diabetes, obesity & metabolism 20090801

• Antihyperglycaemic medication modifies factors of postprandial satiety in type 2 diabetes.

  Diabetes, obesity & metabolism 20090801

• Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.

  European journal of clinical investigation 20090801

• Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia.

  European journal of obstetrics, gynecology, and reproductive biology 20090801

• Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study.

  Schizophrenia research 20090801

• Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects.

  Current medical research and opinion 20090801

• Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients.

  American journal of hypertension 20090801

• Sustained hyperglycemia among patients with diabetes: what matters when action is needed?

  Diabetes care 20090801

• The use of oral antidiabetic medications in gestational diabetes mellitus.

  Current diabetes reports 20090801

• The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: the current evidence.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090801

• Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study.

  Diabetic medicine : a journal of the British Diabetic Association 20090801

• Type 2 diabetes: target HbA1c of about 7%.

  Prescrire international 20090801

• Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin--diabetes control and potential adverse events.

  Best practice & research. Clinical endocrinology & metabolism 20090801

• [Glycemic control in type 2 diabetic patients in public and private healthcare service].

  Arquivos brasileiros de endocrinologia e metabologia 20090801

• The role of insulin-sensitizing agents in the treatment of polycystic ovary syndrome.

  Drugs 20090730

• The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

  Journal of medicinal chemistry 20090723

• Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue.

  The Journal of physiology 20090715

• Assessment of genomic instability in normal and diabetic rats treated with metformin.

  Chemico-biological interactions 20090715

• Metformin in breast cancer: time for action.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090710

• Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090710

• WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome.

  The Cochrane database of systematic reviews 20090708

• Enhancing CD8 T-cell memory by modulating fatty acid metabolism.

  Nature 20090702

• Immunology: A metabolic switch to memory.

  Nature 20090702

• Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes.

  Atherosclerosis 20090701

• Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).

  Diabetes care 20090701

• Metformin usages in women with heart failure.

  American journal of obstetrics and gynecology 20090701

• Lysophosphatidylcholine--biomarker of Metformin action: studied using UPLC/MS/MS.

  Biomedical chromatography : BMC 20090701

• Anti-Müllerian hormone concentrations in androgen-suppressed women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20090701

• Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study.

  Diabetes care 20090701

• Metformin in renal failure--weigh the evidence.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701

• Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.

  Diabetes 20090701

• Independent anti-inflammatory effect of insulin in newly diagnosed type 2 diabetes.

  Diabetes/metabolism research and reviews 20090701

• Adjuncts for ovarian stimulation: when do we adopt 'orphan indications' for approved drugs?

  Fertility and sterility 20090701

• Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.

  Diabetes research and clinical practice 20090701

• Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

  Cell cycle (Georgetown, Tex.) 20090701

• Three different premixed combinations of biphasic insulin aspart - comparison of the efficacy and safety in a randomized controlled clinical trial in subjects with type 2 diabetes.

  Diabetes, obesity & metabolism 20090701

• The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice.

  Molecular human reproduction 20090701

• Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

  Pharmacogenetics and genomics 20090701

• Metformin-associated lactic acidosis: a prognostic and therapeutic study.

  Critical care medicine 20090701

• Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090701

• Why check metformin levels?

  Critical care medicine 20090701

• Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.

  Obesity (Silver Spring, Md.) 20090701

• Bone disease, gestational diabetes mellitus, and health care.

  Diabetes care 20090701

• Regulation of glyceraldehyde 3-phosphate dehydrogenase expression by metformin in HepG2 cells.

  Biological & pharmaceutical bulletin 20090701

• mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb).

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090701

• Change in glucometer settings as a cause of sudden deterioration of glycemic control in type 2 diabetes.

  Diabetes technology & therapeutics 20090701

• Addressing metformin.

  Canadian family physician Medecin de famille canadien 20090701

• [Advantages of Chinese medicine for treatment of blood sugar and lipid metabolic disorders in patients with polycystic ovarian syndrome].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090701

• Simultaneous determination of metformin hydrochloride and pioglitazone hydrochloride in binary mixture and in their ternary mixture with pioglitazone acid degradate using spectrophotometric and chemometric methods.

  Drug testing and analysis 20090701

• [HbA1c 8.5% in elderly people with diabetes: is it good enough?].

  MMW Fortschritte der Medizin 20090625

• Thiazolidinediones and clinical outcomes in type 2 diabetes.

  Lancet (London, England) 20090620

• Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial.

  Lancet (London, England) 20090620

• Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.

  Journal of immunology (Baltimore, Md. : 1950) 20090615

• A randomized trial of therapies for type 2 diabetes and coronary artery disease.

  The New England journal of medicine 20090611

• Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome.

  Fertility and sterility 20090601

• Effects of metformin versus ethinyl-estradiol plus cyproterone acetate on ambulatory blood pressure monitoring and carotid intima media thickness in women with the polycystic ovary syndrome.

  Fertility and sterility 20090601

• The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease.

  Acta diabetologica 20090601

• Colesevelam HCl effects on atherogenic lipoprotein subclasses in subjects with type 2 diabetes.

  Atherosclerosis 20090601

• Disturbed stress responses in women with polycystic ovary syndrome.

  Psychoneuroendocrinology 20090601

• The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis.

  Acta diabetologica 20090601

• Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents.

  Diabetes care 20090601

• Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes.

  Diabetes 20090601

• Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials.

  European journal of endocrinology 20090601

• Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.

  Molecular pharmacology 20090601

• Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

  Diabetes 20090601

• Concomitant reduction in low-density lipoprotein cholesterol and glycated hemoglobin with colesevelam hydrochloride in patients with type 2 diabetes: a pooled analysis.

  Metabolic syndrome and related disorders 20090601

• Autophagy in human type 2 diabetes pancreatic beta cells.

  Diabetologia 20090601

• A cost-effectiveness analysis of pioglitazone plus metformin compared with rosiglitazone plus metformin from a third-party payer perspective in the US.

  Current medical research and opinion 20090601

• Balancing risk and benefit with oral hypoglycemic drugs.

  The Mount Sinai journal of medicine, New York 20090601

• AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.

  Biochemical pharmacology 20090601

• Current therapeutic drugs for type 2 diabetes, still useful after 50 years?

  Anesthesia and analgesia 20090601

• Reduced daily risk of glycemic variability: comparison of exenatide with insulin glargine.

  Diabetes technology & therapeutics 20090601

• Competact, a fixed combination of pioglitazone and metformin, improves metabolic markers in type 2 diabetes patients with insufficient glycemic control by metformin alone--results from a post-marketing surveillance trial under daily routine conditions.

  Diabetes technology & therapeutics 20090601

• [Metformin also as first choice in patients with normal weight. Has its use increased?].

  Atencion primaria 20090601

• Management of atypical antipsychotic drug-induced weight gain: focus on metformin.

  Pharmacotherapy 20090601

• Metformin/Repaglinide (PrandiMet) for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20090601

• Metformin and insulin meet in a most atypical way.

  Cell metabolism 20090601

• Ethnic origin is unrelated to autoimmunity and residual pancreatic function in 471 youth with clinically diagnosed type 2 diabetes.

  Pediatric diabetes 20090601

• Metformin is a unique drug.

  Canadian family physician Medecin de famille canadien 20090601

• Taking the stress out of insulin initiation in type 2 diabetes mellitus.

  Canadian family physician Medecin de famille canadien 20090601

• Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin.

  Diabetes, obesity & metabolism 20090601

• Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial.

  Diabetes, obesity & metabolism 20090601

• Metformin for weight control in pediatric patients on atypical antipsychotic medication.

  Journal of child and adolescent psychopharmacology 20090601

• Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20090601

• The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study.

  Taiwanese journal of obstetrics & gynecology 20090601

• Sitagliptin + metformin: new combination. Do not use this combination. Sitagliptin provides a slight increase of glucose-lowering effects, but there is a disturbing potential for long-term adverse effects: infections, depression, and cancer.

  Prescrire international 20090601

• Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery.

  Head and neck pathology 20090601

• [Metformin effects upon blood pressure and glucose metabolism of monossodium glutamate induced-obese spontaneously hypertensive rats].

  Arquivos brasileiros de endocrinologia e metabologia 20090601

• Initial therapy for type 2 diabetes. Examination of a combination approach.

  Advance for nurse practitioners 20090601

• Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.

  Journal of agricultural and food chemistry 20090527

• Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.

  Circulation 20090519

• Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.

  International journal of cardiology 20090515

• Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells.

  Cell cycle (Georgetown, Tex.) 20090515

• Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

  Cell 20090515

• [Insulin secretion is increased depending on glucose.. Metabolism regulation in type 2 diabetes mellitus over five paths].

  MMW Fortschritte der Medizin 20090507

• [Anti-diabetic treatment, insulin resistance and cardiovascular disease in patients with type 2 diabetes].

  Ugeskrift for laeger 20090504

• Insulin resistance directly contributes to androgenic potential within ovarian theca cells.

  Fertility and sterility 20090501

• The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis.

  Clinical endocrinology 20090501

• One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.

  Diabetes care 20090501

• Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090501

• Treatment choice and effectiveness of adding sulphonylurea or glitazones to metformin for the treatment of type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20090501

• Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride.

  Journal of pharmaceutical and biomedical analysis 20090501

• Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.

  Journal of cardiovascular pharmacology 20090501

• Continuous subcutaneous insulin infusion versus multiple daily insulin injections in type 2 diabetes: a meta-analysis.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090501

• Effect of two starting insulin regimens in patients with type II diabetes not controlled on a combination of oral antihyperglycemic medications.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090501

• Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial.

  Current medical research and opinion 20090501

• Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20090501

• Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes.

  Current medical research and opinion 20090501

• Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin.

  Metabolism: clinical and experimental 20090501

• Islet enhancer vildagliptin: a powerful partner with metformin for the treatment of patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20090501

• Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?

  Diabetes, obesity & metabolism 20090501

• The scientific evidence: vildagliptin and the benefits of islet enhancement.

  Diabetes, obesity & metabolism 20090501

• Translating science into clinical practice: focus on vildagliptin in combination with metformin.

  Diabetes, obesity & metabolism 20090501

• Gestational diabetes mellitus: developments in diagnosis and treatment.

  Women's health (London, England) 20090501

• Role of metformin in the treatment of gestational diabetes.

  The Annals of pharmacotherapy 20090501

• Pharmacokinetics and bioavailability of metformin in horses.

  American journal of veterinary research 20090501

• Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review.

  Journal of pediatric gastroenterology and nutrition 20090501

• [Protective effects of metformin on low-density lipoprotein-induced endothelial dysfunction in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090501

• Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen.

  Clinics (Sao Paulo, Brazil) 20090501

• By the way, doctor. I've had type 2 diabetes for 12 years; I'm now 81. I take metformin plus Januvia. My doctor has never suggested that I monitor myself on a daily basis with a meter. My hemoglobin A1c has been creeping up and is now at 7. Should I be getting more aggressive in my treatment?

  Harvard health letter 20090501

• In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats.

  Pakistan journal of biological sciences : PJBS 20090501

• The renaissance of metformin in endocrine clinical practice.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090501

• Can technology improve adherence to long-term therapies?

  Journal of diabetes science and technology 20090501

• Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus.

  Circulation 20090421

• Lost in translation: modulation of the metabolic-functional relation in the diabetic human heart.

  Circulation 20090421

• Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.

  The Cochrane database of systematic reviews 20090415

• [Progress in therapy for diabetes mellitus--insulin-resistance ameliorating agents].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410

• Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).

  Naunyn-Schmiedeberg's archives of pharmacology 20090401

• [Metformine induces false-positive (18)F-FDG PET/CT uptake].

  Presse medicale (Paris, France : 1983) 20090401

• The effect of metformin on the incidence of type 2 diabetes mellitus and cardiovascular disease risk factors in overweight and obese subjects--the Carmos study.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090401

• An RCT of metformin versus orlistat for the management of obese anovulatory women.

  Human reproduction (Oxford, England) 20090401

• Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes.

  Diabetes care 20090401

• Changes in albumin excretion in the diabetes prevention program.

  Diabetes care 20090401

• Metabolic and endocrine effects of metformin and metformin plus cyclic medroxyprogesterone acetate in women with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20090401

• Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• Effect of progression from impaired glucose tolerance to diabetes on cardiovascular risk factors and its amelioration by lifestyle and metformin intervention: the Diabetes Prevention Program randomized trial by the Diabetes Prevention Program Research Group.

  Diabetes care 20090401

• Simulated physician learning intervention to improve safety and quality of diabetes care: a randomized trial.

  Diabetes care 20090401

• Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.

  The pharmacogenomics journal 20090401

• Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090401

• Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: a case report.

  Diabetes & metabolism 20090401

• Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial.

  Diabetes, obesity & metabolism 20090401

• Pioglitazone treatment in type 2 diabetes mellitus when combined with portion control diet modifies the metabolic syndrome.

  Diabetes, obesity & metabolism 20090401

• Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study.

  Diabetes, obesity & metabolism 20090401

• AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.

  Clinical science (London, England : 1979) 20090401

• Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide.

  Current medical research and opinion 20090401

• The case. A suicidal woman with delayed high anion gap metabolic acidosis.

  Kidney international 20090401

• Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes.

  Journal of internal medicine 20090401

• Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells.

  Metabolism: clinical and experimental 20090401

• Hyperinsulinaemia and iron perturbation in patients with type 2 diabetes.

  International journal of clinical practice 20090401

• Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects.

  International journal of clinical pharmacology and therapeutics 20090401

• Treating prediabetes with metformin: systematic review and meta-analysis.

  Canadian family physician Medecin de famille canadien 20090401

• Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20090401

• Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients.

  Journal of assisted reproduction and genetics 20090401

• Customised birthweight centiles are useful for identifying small-for-gestational-age babies in women with type 2 diabetes.

  The Australian & New Zealand journal of obstetrics & gynaecology 20090401

• Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin.

  Hemodialysis international. International Symposium on Home Hemodialysis 20090401

• Is metformin beneficial for the treatment of infertility in women with PCOS?

  JAAPA : official journal of the American Academy of Physician Assistants 20090401

• [Alarming increase of the number of metformin intoxications. Ten times doubled number of inquiries to the Swedish Poison Information Center since 2000].

  Lakartidningen 20090401

• Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model.

  The Indian journal of medical research 20090401

• Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome.

  The journal of obstetrics and gynaecology research 20090401

• Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.

  Journal of proteome research 20090401

• Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome.

  Diabetes & vascular disease research 20090401

• Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus.

  Archives of internal medicine 20090323

• Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.

  World journal of gastroenterology 20090321

• [Certain beginning of insulin therapy: yes, we can, but...].

  Praxis 20090318

• Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.

  Cell cycle (Georgetown, Tex.) 20090315

• Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

  Breast cancer research and treatment 20090301

• Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

  Breast cancer research and treatment 20090301

• Pioglitazone reduces monocyte activation in type 2 diabetes.

  Acta diabetologica 20090301

• Management and 1 year outcome for UK children with type 2 diabetes.

  Archives of disease in childhood 20090301

• Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.

  Pharmaceutical research 20090301

• Comparison of glycaemic control in patients with Type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study.

  Acta diabetologica 20090301

• Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking.

  European journal of endocrinology 20090301

• The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090301

• Relationship between HbA1c and hypoglycaemia in patients with type 2 diabetes treated with different insulin regimens in combination with metformin.

  Diabetes/metabolism research and reviews 20090301

• Mechanism of action of metformin in nonalcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20090301

• Self blood glucose monitoring in type 2 diabetes. A financial impact analysis based on UK primary care.

  International journal of clinical practice 20090301

• Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.

  Diabetes 20090301

• Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study.

  Current medical research and opinion 20090301

• Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial.

  Current medical research and opinion 20090301

• Is it time to test metformin in breast cancer clinical trials?

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090301

• Diabetes treatment.

  Diabetes care 20090301

• Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al.

  Diabetes care 20090301

• Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer.

  The Annals of pharmacotherapy 20090301

• Treatment with metformin is protective against limitations in instrumental activities of daily living in older subjects with type 2 diabetes mellitus.

  Journal of the American Geriatrics Society 20090301

• Metformin and atorvastatin reduce adhesion formation in a rat uterine horn model.

  Reproductive biomedicine online 20090301

• Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort.

  Journal of the peripheral nervous system : JPNS 20090301

• Development of novel mucoadhesive pellets of metformin hydrochloride.

  Archives of pharmacal research 20090301

• [Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatán, México].

  Investigacion clinica 20090301

• [Vildagliptin (Galvus) and fixed combination vildagliptine-metformin (Eucreas) in the treatment of type 2 diabetes].

  Revue medicale de Liege 20090301

• Validation of anti-aging drugs by treating age-related diseases.

  Aging 20090301

• Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat.

  European journal of pharmacology 20090214

• Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.

  Circulation research 20090213

• Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome.

  Fertility and sterility 20090201

• Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial.

  Fertility and sterility 20090201

• Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity.

  European journal of pediatrics 20090201

• Effect of metformin, orlistat and pioglitazone treatment on mean insulin resistance and its biological variability in polycystic ovary syndrome.

  Clinical endocrinology 20090201

• Controlled release metformin hydrochloride microspheres of ethyl cellulose prepared by different methods and study on the polymer affected parameters.

  Journal of microencapsulation 20090201

• Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis.

  Clinical endocrinology 20090201

• Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents.

  Pediatric diabetes 20090201

• Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange.

  European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20090201

• Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase.

  The Journal of clinical endocrinology and metabolism 20090201

• The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

  The Journal of clinical endocrinology and metabolism 20090201

• The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells.

  Molecular nutrition & food research 20090201

• Metformin for the prevention of androgen deprivation induced metabolic syndrome, obesity and type 2 diabetes.

  Medical hypotheses 20090201

• O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease.

  Journal of proteome research 20090201

• Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.

  Endocrine reviews 20090201

• Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy.

  Diabetes, obesity & metabolism 20090201

• Nateglinide and glibenclamide metabolic effects in naïve type 2 diabetic patients treated with metformin.

  Journal of clinical pharmacy and therapeutics 20090201

• Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes.

  Cytokine 20090201

• CE with direct sample injection for the determination of metformin in plasma for type 2 diabetic mellitus: An adequate alternative to HPLC.

  Journal of separation science 20090201

• Treatment of non-alcoholic fatty liver disease in children: swim at your own risk.

  Pediatric diabetes 20090201

• [Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090201

• Metabolic risks in older adults receiving second-generation antipsychotic medication.

  Current psychiatry reports 20090201

• Alogliptin: a new, highly selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.

  Expert opinion on pharmacotherapy 20090201

• db/+ Mice as an alternate model in antidiabetic drug discovery research.

  Archives of medical research 20090201

• Drug evaluation: vildagliptin-metformin single-tablet combination.

  Advances in therapy 20090201

• Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose.

  The Kaohsiung journal of medical sciences 20090201

• [Metformin in serum. Results of a study as basis for preliminary therapeutic recommendations].

  Lakartidningen 20090201

• [Optimisation of pharmacological therapy in a patient with a newly diagnosed type 2 diabetes].

  Revue medicale de Liege 20090201

• Adverse effect of pioglitazone in military personnel and their families: a preliminary report.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20090201

• Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats.

  Journal of ethnopharmacology 20090130

• Follow-up of intensive glucose control in type 2 diabetes.

  The New England journal of medicine 20090122

• Follow-up of intensive glucose control in type 2 diabetes.

  The New England journal of medicine 20090122

• Follow-up of intensive glucose control in type 2 diabetes.

  The New England journal of medicine 20090122

• Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents.

  The Cochrane database of systematic reviews 20090121

• Glucose control and vascular complications in veterans with type 2 diabetes.

  The New England journal of medicine 20090108

• Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).

  Diabetes, obesity & metabolism 20090101

• Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

  Breast cancer research and treatment 20090101

• Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin?

  British journal of clinical pharmacology 20090101

• Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus.

  Journal of diabetes and its complications 20090101

• Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis.

  Human reproduction update 20090101

• Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.

  Diabetes care 20090101

• Clinical and behavioral correlates of achieving and maintaining glycemic targets in an underserved population with type 2 diabetes.

  Diabetes care 20090101

• Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20090101

• Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes.

  Journal of molecular endocrinology 20090101

• Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

  Diabetologia 20090101

• Antiandrogenic contraceptives increase serum adiponectin in obese polycystic ovary syndrome patients.

  Obesity (Silver Spring, Md.) 20090101

• Efficacy and safety of exenatide in patients of Asian descent with type 2 diabetes inadequately controlled with metformin or metformin and a sulphonylurea.

  Diabetes research and clinical practice 20090101

• Treatment options for HIV-associated central fat accumulation.

  AIDS patient care and STDs 20090101

• Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management.

  Hepatology (Baltimore, Md.) 20090101

• Increased insulin sensitivity by metformin enhances intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome.

  Dermatology (Basel, Switzerland) 20090101

• Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss.

  Translational research : the journal of laboratory and clinical medicine 20090101

• Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review.

  Obstetrics and gynecology 20090101

• The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.

  Cell cycle (Georgetown, Tex.) 20090101

• Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study.

  International journal of clinical practice 20090101

• Metformin maintains the weight loss and metabolic benefits following rimonabant treatment in obese women with polycystic ovary syndrome (PCOS).

  Clinical endocrinology 20090101

• Assessing the appropriate use of metformin in an inpatient setting and the effectiveness of two pharmacy-based measures to improve guideline adherence.

  Quality management in health care 20090101

• Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.

  Journal of human genetics 20090101

• Determinants of interleukin-6 and C-reactive protein vary in polycystic ovary syndrome, as do effects of short- and long-term metformin therapy.

  Hormone research 20090101

• A combination of grape seed-derived procyanidins and gypenosides alleviates insulin resistance in mice and HepG2 cells.

  Journal of food science 20090101

• Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality.

  Trials 20090101

• Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea.

  Current medical research and opinion 20090101

• Hot flashes and fatigue relieved by metformin.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090101

• Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy.

  Kidney & blood pressure research 20090101

• Should dialysis be offered in all cases of metformin-associated lactic acidosis?

  Critical care (London, England) 20090101

• Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine.

  Internal medicine (Tokyo, Japan) 20090101

• Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization.

  Acta obstetricia et gynecologica Scandinavica 20090101

• Metformin in chemically-induced mammary carcinogenesis in rats.

  Neoplasma 20090101

• Metformin and lactic acidosis in patients with type 2 diabetes--from pride and prejudice to sense and sensibility.

  Acta clinica Belgica 20090101

• Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.

  Cardiovascular diabetology 20090101

• [Application of numerical convolution in in vivo/in vitro correlation research].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090101

• Column high-performance liquid chromatographic method for the simultaneous determination of rosiglitazone and metformin in a pharmaceutical preparation.

  Journal of AOAC International 20090101

• The ADDITION-Cambridge trial protocol: a cluster -- randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients.

  BMC public health 20090101

• The management of gestational diabetes.

  Vascular health and risk management 20090101

• PCOS.

  BMJ clinical evidence 20090101

• Impact of prandial plus basal vs basal insulin on glycemic variability in type 2 diabetic patients.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090101

• Soluble CD40 ligand, plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor-1-antigen in normotensive type 2 diabetic subjects without diabetic complications. Effects of metformin and rosiglitazone.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20090101

• beta cell protecting and immunomodulatory activities of Paecilomyces Hepiali Chen mycelium in STZ induced T1DM mice.

  The American journal of Chinese medicine 20090101

• [A clinical case of lactic acidosis development in a diabetic patient taking metformin].

  Anesteziologiia i reanimatologiia 20090101

• [Drug treatment of insulin resistance].

  Revue medicale de Bruxelles 20090101

• Metformin effects on clomifene-induced ovulation in the polycystic ovary syndrome.

  La Tunisie medicale 20090101

• Psychometric evaluation of the Diabetes Symptom Checklist-Revised (DSC-R)--a measure of symptom distress.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

• Rosiglitazone and myocardial infarction in patients previously prescribed metformin.

  PloS one 20090101

• Thiazolidinediones and cardiovascular events in patients with type 2 diabetes mellitus: a retrospective cohort study of over 473,000 patients using the National Health Insurance database in Taiwan.

  Drug safety 20090101

• The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS).

  Internal medicine (Tokyo, Japan) 20090101

• Evaluation of the repaglinide efficiency in comparison to the glimepiride in the type 2 diabetes patients poorly regulated by the metmorfine administration.

  Bratislavske lekarske listy 20090101

• Metformin plus pentoxifylline versus prescriptive diet in non-alcoholic steatohepatitis (NASH): a randomized controlled pilot trial.

  Gastroenterologie clinique et biologique 20090101

• [Effect of metformin on the clinical course of gout and insulin resistance].

  Klinicheskaia meditsina 20090101

• Mechanisms involved in metformin action in the treatment of polycystic ovary syndrome.

  Current pharmaceutical design 20090101

• Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering?

  Current pharmaceutical design 20090101

• An attempt at conservative treatment in selected cases of type I endometrial carcinoma (stage I a/G1) in young women.

  European journal of gynaecological oncology 20090101

• [Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].

  Nederlands tijdschrift voor geneeskunde 20090101

• Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial.

  Scandinavian journal of gastroenterology 20090101

• Beneficial effects of telmisartan in an HIV+ diabetic insulin-dependent patient.

  International journal of immunopathology and pharmacology 20090101

• Metformin, estrogen replacement therapy and gonadotropin inhibition fail to improve insulin sensitivity in a girl with aromatase deficiency.

  Hormone research 20090101

• What your doctor is reading.

  Diabetes self-management 20090101

• Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.

  BMJ (Clinical research ed.) 20090101

• Lifestyle modification and metformin as long-term treatment options for obese adolescents: study protocol.

  BMC public health 20090101

• Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

  BMJ (Clinical research ed.) 20090101

• Leptin concentrations in patients with polycystic ovary syndrome before and after met-formin treatment depending on insulin resistance, body mass index and androgen con-centrations--introductory report.

  Folia histochemica et cytobiologica 20090101

• [Adipose tissue inflammation and atherosclerosis].

  Kardiologiia 20090101

• [Could oral antidiabetic agents be useful in the management of different types of diabetes and syndromes of insulin resistance in children and adolescents?].

  Przeglad lekarski 20090101

• Treatment with sitagliptin or metformin does not increase body weight despite predicted reductions in urinary glucose excretion.

  Journal of diabetes science and technology 20090101

• Optimising the medical management of hyperglycaemia in type 2 diabetes in the Middle East: pivotal role of metformin.

  International journal of clinical practice 20090101

• [Effects of the combined treatment with Metformin/Glimepiride on endothelial function of patients with type 2 diabetes mellitus. A positron emission tomography (PET) evaluation study].

  Archivos de cardiologia de Mexico 20090101

• How to explain a PaO2 of 140 mmHg in a venous line?

  Acta bio-medica : Atenei Parmensis 20090101

• Metformin and troglitazone in the treatment of female infertility associated with polycystic ovarian syndrome.

  JNMA; journal of the Nepal Medical Association 20090101

• [Metformin--an inhibitor of early stages of protein glycation].

  Folia medica Cracoviensia 20090101

• Use of bar coding technology to flag ER patients on metformin-containing drugs.

  Radiology management 20090101

• Metformin induces apoptosis of pancreatic cancer cells.

  World journal of gastroenterology 20081221

• Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.

  Bioorganic & medicinal chemistry letters 20081215

• Changes in metformin pharmacokinetics after intravenous and oral administration to rats with short-term and long-term diabetes induced by streptozotocin.

  Journal of pharmaceutical sciences 20081201

• A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): a randomized open-label parallel study.

  Clinical endocrinology 20081201

• Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS).

  Clinical endocrinology 20081201

• Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach.

  Diabetes, obesity & metabolism 20081201

• Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes.

  Diabetes, obesity & metabolism 20081201

• Effect of FeSO4 treatment on glucose metabolism in diabetic rats.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20081201

• Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naïve patients with type 2 diabetes: comparison with metformin.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081201

• Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance.

  Pediatric diabetes 20081201

• Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib.

  Molecular pharmacology 20081201

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

  Toxicology and applied pharmacology 20081201

• Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.

  The Journal of clinical endocrinology and metabolism 20081201

• Metformine for psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome.

  Archives of women's mental health 20081201

• Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes: what to add--insulin glargine or pioglitazone?

  Diabetes research and clinical practice 20081201

• Risk of coronary artery disease associated with initial sulphonylurea treatment of patients with type 2 diabetes: a matched case-control study.

  Diabetes research and clinical practice 20081201

• Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells.

  The Journal of pharmacy and pharmacology 20081201

• Metformin and lactic acidosis.

  British journal of anaesthesia 20081201

• Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis.

  Gastroenterology 20081201

• Gestational diabetes: an opportunity for improvement.

  The Journal of clinical endocrinology and metabolism 20081201

• Insulin-lowering effects of metformin in women with early breast cancer.

  Clinical breast cancer 20081201

• PCOS and infertility.

  Panminerva medica 20081201

• Fast capillary electrophoresis coupled with time-of-flight mass spectrometry under separation conditions of high electrical field strengths.

  The Analyst 20081201

• Use of metformin in polycystic ovary syndrome.

  American journal of obstetrics and gynecology 20081201

• [Constitutional syndrome associated to metformin induced hepatotoxicity].

  Gastroenterologia y hepatologia 20081201

• Exenatide and acute pancreatitis.

  The Journal of the Association of Physicians of India 20081201

• Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes.

  Vascular health and risk management 20081201

• [Six-month effectiveness and tolerability of pioglitazone in combination with sulfonylureas or metformin for the treatment of type 2 diabetes mellitus].

  Medicina clinica 20081129

• Insulin resistance and fertility in polycystic ovary syndrome.

  Journal of medicine and life 20081115

• Metformin, but not pioglitazone, decreases postchallenge plasma ghrelin levels in type 2 diabetic patients: a possible role in weight stability?

  Diabetes, obesity & metabolism 20081101

• Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

  Clinical pharmacology and therapeutics 20081101

• Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness.

  The Journal of clinical endocrinology and metabolism 20081101

• [New therapies for type 2 diabetes: what place for incretin-based agents and rimonabant compared to the previous ones?].

  La Revue de medecine interne 20081101

• AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials.

  The Journal of clinical endocrinology and metabolism 20081101

• Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes.

  Diabetologia 20081101

• The effects of pioglitazone and metformin on plasma visfatin levels in patients with treatment naive type 2 diabetes mellitus.

  Diabetes research and clinical practice 20081101

• Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

  Diabetes care 20081101

• Metformin suppresses intestinal polyp growth in ApcMin/+ mice.

  Cancer science 20081101

• Hyperglycaemia secondary to mirtazapine therapy in a 37-year-old man.

  The Australian and New Zealand journal of psychiatry 20081101

• Current and emerging therapies in nonalcoholic fatty liver disease.

  Seminars in liver disease 20081101

• Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease.

  Diabetes & vascular disease research 20081101

• Impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women: do we need a new drug?

  The Journal of clinical endocrinology and metabolism 20081101

• Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

  Mini reviews in medicinal chemistry 20081101

• Use of insulin-sensitizing agents in the treatment of polycystic ovary syndrome.

  Fertility and sterility 20081101

• Treatment of white coat hypertension with metformin.

  International heart journal 20081101

• [Safety of metformin in the treatment of elderly type 2 diabetes mellitus].

  Zhonghua nei ke za zhi 20081101

• Effectiveness and long-term safety of thiazolidinediones and metformin in renal transplant recipients.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081101

• Effects of basal insulin analog and metformin on glycaemia control and weight as risk factors for endothelial dysfunction.

  Bosnian journal of basic medical sciences 20081101

• Severe acanthosis nigricans in a 17 year-old female with partial lipodystrophic syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20081101

• Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.

  Biochemical and biophysical research communications 20081024

• Summaries for patients. Comparison of two types of insulin added to diabetes pills in poorly controlled type 2 diabetes.

  Annals of internal medicine 20081021

• Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial.

  Annals of internal medicine 20081021

• [Toxic metformin-associated acute pancreatitis without kidney failure].

  Medicina clinica 20081018

• [Initial therapy of diabetes mellitus in the family practice. Give yourself time!].

  MMW Fortschritte der Medizin 20081016

• Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects.

  Archives of internal medicine 20081013

• 10-year follow-up of intensive glucose control in type 2 diabetes.

  The New England journal of medicine 20081009

• Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin.

  World journal of gastroenterology 20081007

• Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome.

  Fertility and sterility 20081001

• Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.

  Fertility and sterility 20081001

• Therapeutic response to metformin in an underweight patient with polycystic ovarian syndrome.

  Fertility and sterility 20081001

• Alteration of ghrelin-neuropeptide Y network in obese patients with polycystic ovary syndrome: role of hyperinsulinism.

  Clinical endocrinology 20081001

• Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).

  Atherosclerosis 20081001

• Homeostasis model assessment-insulin resistance (HOMA-IR), a key role for assessing the ovulation function in polycystic ovary syndrome (PCOS) patients with insulin resistance.

  Endocrine journal 20081001

• Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome.

  European journal of endocrinology 20081001

• Cimetidine does not appear to influence the distribution of metformin into human milk.

  British journal of clinical pharmacology 20081001

• Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.

  Biochemical pharmacology 20081001

• Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels.

  The Journal of endocrinology 20081001

• Thiazolidinediones in type 2 diabetes: a cardiology perspective.

  The Annals of pharmacotherapy 20081001

• No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.

  Journal of applied physiology (Bethesda, Md. : 1985) 20081001

• First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.

  International journal of obesity (2005) 20081001

• Metformin increases HDL3-cholesterol and decreases subcutaneous truncal fat in nondiabetic patients with HIV-associated lipodystrophy.

  AIDS patient care and STDs 20081001

• Janumet: a combination product suitable for use in patients with Type 2 diabetes.

  Expert opinion on investigational drugs 20081001

• Managing hyperglycaemia.

  The British journal of general practice : the journal of the Royal College of General Practitioners 20081001

• Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?

  The journal of obstetrics and gynaecology research 20081001

• A randomized, controlled trial of the effects of rosiglitazone on adipokines, and inflammatory and fibrinolytic markers in diabetic patients: study design and protocol.

  The Canadian journal of cardiology 20081001

• [Current evidence-based medicine for early intervention in diabetes].

  Nihon rinsho. Japanese journal of clinical medicine 20081001

• Metformin-responsive classic salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a case report.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081001

• [United Kingdom Prospective Diabetes Study (UKPDS): 10 years later].

  Revue medicale de Liege 20081001

• The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20081001

• The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.

  Cancer prevention research (Philadelphia, Pa.) 20081001

• Vildagliptin and vildagliptin/metformin: new drug. Same limited efficacy as sitagliptin in type 2 diabetes.

  Prescrire international 20081001

• Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?

  Journal of the Indian Medical Association 20081001

• A 39-year-old man with HIV-associated lipodystrophy.

  JAMA 20080903

• Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects.

  Diabetes, obesity & metabolism 20080901

• Weight changes in type 2 diabetes and the impact of gender.

  Diabetes, obesity & metabolism 20080901

• Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats.

  Diabetes, obesity & metabolism 20080901

• Acute effect of metformin on exercise capacity in active males.

  Diabetes, obesity & metabolism 20080901

• Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.

  Fertility and sterility 20080901

• Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications.

  Diabetes, obesity & metabolism 20080901

• Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20080901

• Potential benefits of early addition of rosiglitazone in combination with glimepiride in the treatment of type 2 diabetes.

  Diabetes, obesity & metabolism 20080901

• Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver.

  Acta diabetologica 20080901

• Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth.

  Endocrine-related cancer 20080901

• The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome.

  International journal of clinical practice 20080901

• Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective.

  Human reproduction (Oxford, England) 20080901

• Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice.

  The Journal of steroid biochemistry and molecular biology 20080901

• Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes.

  American journal of physiology. Heart and circulatory physiology 20080901

• Strategies to control antipsychotic-induced weight gain.

  Psychoneuroendocrinology 20080901

• Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions.

  Xenobiotica; the fate of foreign compounds in biological systems 20080901

• Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20080901

• Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes.

  The Journal of pharmacy and pharmacology 20080901

• Cancer and aging: more puzzles, more promises?

  Cell cycle (Georgetown, Tex.) 20080901

• Clinical development of metformin extended-release tablets for type 2 diabetes: an overview.

  Expert opinion on drug metabolism & toxicology 20080901

• Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin.

  European journal of endocrinology 20080901

• Metformin slows down aging and extends life span of female SHR mice.

  Cell cycle (Georgetown, Tex.) 20080901

• Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes.

  Xenobiotica; the fate of foreign compounds in biological systems 20080901

• Physicochemical interactions of metformin hydrochloride and glibenclamide with several health foods.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080901

• Considerations regarding the use of metformin with olanzapine.

  The American journal of psychiatry 20080901

• Olanzapine treatment and weight gain: considering the lipid side effects of antipsychotics.

  The American journal of psychiatry 20080901

• Pupillary autonomic neuropathy simulating partial Horner syndrome in diabetes mellitus and its reversal with control of blood glucose.

  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20080901

• Approach to the patient with prediabetes.

  The Journal of clinical endocrinology and metabolism 20080901

• Metformin: a multitasking medication.

  Diabetes & vascular disease research 20080901

• Metformin therapy and clinical uses.

  Diabetes & vascular disease research 20080901

• Improvement of glycaemic and lipid profiles with muraglitazar plus metformin in patients with type 2 diabetes: an active-control trial with glimepiride.

  Diabetes & vascular disease research 20080901

• Effect of metformin-containing antidiabetic regimens on all-cause mortality in veterans with type 2 diabetes mellitus.

  The American journal of the medical sciences 20080901

• [Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Addressing insulin resistance in Type 1 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20080901

• [When oral therapy of type 2 diabetes fails--basal insulin is more effective than change in life style (interview by Dr. Thomas Meissner)].

  MMW Fortschritte der Medizin 20080828

• Association between oral antidiabetic use, adverse events and outcomes in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20080801

• Nateglinide, alone or in combination with metformin, is effective and well tolerated in treatment-naïve elderly patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20080801

• Effect of homocysteine-lowering therapy on arterial elasticity and metabolic parameters in metformin-treated diabetic patients.

  Atherosclerosis 20080801

• Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.

  Clinical and experimental pharmacology & physiology 20080801

• Coronary heart disease outcomes in patients receiving antidiabetic agents in the PharMetrics database 2000-2007.

  Pharmacoepidemiology and drug safety 20080801

• Auto-immune neutropenia associated with metformin in a patient with splenic marginal zone lymphoma.

  Pharmacy world & science : PWS 20080801

• Mechanisms underlying saturable intestinal absorption of metformin.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies.

  Diabetes care 20080801

• Metformin inhibits intracellular lipid accumulation in the murine pre-adipocyte cell line, 3T3-L1.

  Diabetes, obesity & metabolism 20080801

• Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?

  Human reproduction (Oxford, England) 20080801

• In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.

  Gynecologic oncology 20080801

• Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20080801

• Metformin and the intestine.

  Diabetologia 20080801

• Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes.

  Clinical and experimental immunology 20080801

• Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test.

  Obesity (Silver Spring, Md.) 20080801

• Heeding clues to metformin-associated lactic acidosis: prompt response can save life.

  Emergency medicine journal : EMJ 20080801

• Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients.

  Current opinion in obstetrics & gynecology 20080801

• Reverse of progestin-resistant atypical endometrial hyperplasia by metformin and oral contraceptives.

  Obstetrics and gynecology 20080801

• Comparison of gene expression changes induced by biguanides in db/db mice liver.

  The Journal of toxicological sciences 20080801

• Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome.

  Pharmacogenomics 20080801

• A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents.

  Saudi medical journal 20080801

• Metformin use in polycystic ovary syndrome: metabolic benefits and diabetes prevention.

  The American journal of medicine 20080801

• A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects.

  Current medical research and opinion 20080801

• Insulin, insulin-like growth factors and neoplasia.

  Best practice & research. Clinical endocrinology & metabolism 20080801

• New combination treatments in the management of diabetes: focus on sitagliptin-metformin.

  Vascular health and risk management 20080801

• Metformin dispersible tablets: line extension. A welcome formulation of an essential drug.

  Prescrire international 20080801

• Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury.

  American journal of respiratory and critical care medicine 20080715

• Targeting AMPK: a new therapeutic opportunity in breast cancer.

  Critical reviews in oncology/hematology 20080701

• Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program.

  Diabetes care 20080701

• The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.

  Diabetes research and clinical practice 20080701

• Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine.

  Diabetes care 20080701

• Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin.

  Human reproduction (Oxford, England) 20080701

• Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080701

• Retinol-binding protein 4 and insulin resistance in polycystic ovary syndrome.

  Diabetes care 20080701

• Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080701

• Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20080701

• Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20080701

• The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.

  Equine veterinary journal 20080701

• Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration.

  Basic & clinical pharmacology & toxicology 20080701

• Treatment options in insulin resistance obesity-related acanthosis nigricans.

  The Annals of pharmacotherapy 20080701

• Pharmacologic treatment options for prediabetes.

  Nature clinical practice. Endocrinology & metabolism 20080701

• Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective.

  Fertility and sterility 20080701

• OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.

  Pharmacogenetics and genomics 20080701

• Effects of swimming on the pharmacokinetics and glucose tolerance of metformin in insulin-resistant rats.

  Biopharmaceutics & drug disposition 20080701

• Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin.

  Metabolism: clinical and experimental 20080701

• An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet.

  Metabolism: clinical and experimental 20080701

• The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy.

  European journal of heart failure 20080701

• Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080701

• A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage.

  Reproductive biomedicine online 20080701

• How does blood glucose control with metformin influence intensive insulin protocols? Evidence for involvement of oxidative stress and inflammatory cytokines.

  Advances in therapy 20080701

• Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080701

• Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation.

  Journal of chromatographic science 20080701

• Organic cation transporters.

  Xenobiotica; the fate of foreign compounds in biological systems 20080701

• Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Adult metformin ingestions reported to Texas poison control centers, 2000-2006.

  Human & experimental toxicology 20080701

• Assessment of the efficacy and tolerability of a fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg in diabetic dyslipidaemia in adult Indian patients.

  Journal of the Indian Medical Association 20080701

• Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.

  Experimental cell research 20080610

• The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

  Oncogene 20080605

• A 40-year-old woman with diabetes contemplating pregnancy after gastric bypass surgery.

  JAMA 20080604

• [Metformin role in the treatment of type 2 diabetes in 2008].

  Revue medicale suisse 20080604

• Rosiglitazone is more effective than metformin in improving fasting indexes of glucose metabolism in severely obese, non-diabetic patients.

  Diabetes, obesity & metabolism 20080601

• Antiretroviral therapy and the human immunodeficiency virus--improved survival but at what cost?

  Diabetes, obesity & metabolism 20080601

• The effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20080601

• AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080601

• Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080601

• Metformin: effects on micro and macrovascular complications in type 2 diabetes.

  Cardiovascular drugs and therapy 20080601

• Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

  Diabetes 20080601

• Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.

  European journal of endocrinology 20080601

• Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus.

  Journal of clinical pharmacology 20080601

• Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.

  Diabetes 20080601

• Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

  American journal of physiology. Heart and circulatory physiology 20080601

• Treatment of impaired glucose tolerance in childhood.

  Nature clinical practice. Endocrinology & metabolism 20080601

• Weight loss of black, white, and Hispanic men and women in the Diabetes Prevention Program.

  Obesity (Silver Spring, Md.) 20080601

• Glycaemic control and adverse events in patients with type 2 diabetes treated with metformin + sulphonylurea: a meta-analysis.

  Diabetes, obesity & metabolism 20080601

• Glycaemic control among patients with type 2 diabetes mellitus in seven European countries: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study.

  Diabetes, obesity & metabolism 20080601

• Hypoglycaemia in patients with type 2 diabetes treated with a combination of metformin and sulphonylurea therapy in France.

  Diabetes, obesity & metabolism 20080601

• Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study.

  Diabetes, obesity & metabolism 20080601

• Development of a diabetes treatment simulation model: with application to assessing alternative treatment intensification strategies on survival and diabetes-related complications.

  Diabetes, obesity & metabolism 20080601

• Cost-effectiveness of sitagliptin-based treatment regimens in European patients with type 2 diabetes and haemoglobin A1c above target on metformin monotherapy.

  Diabetes, obesity & metabolism 20080601

• Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.

  Diabetologia 20080601

• Acarbose for polycystic ovary syndrome.

  The Annals of pharmacotherapy 20080601

• Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers.

  Current medical research and opinion 20080601

• Role of metformin for weight management in patients without type 2 diabetes.

  The Annals of pharmacotherapy 20080601

• Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.

  Fundamental & clinical pharmacology 20080601

• Mecobalamin.

  Expert opinion on investigational drugs 20080601

• Metformin as a weight-loss tool in 'at-risk' obese adolescents: a magic bullet?

  The Journal of pediatrics 20080601

• Addition of metformin to a lifestyle modification program in adolescents with insulin resistance.

  The Journal of pediatrics 20080601

• Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model.

  Prenatal diagnosis 20080601

• Type 2 diabetes: a well-characterised but suboptimally controlled disease. Can we bridge the divide?

  Diabetes & metabolism 20080601

• Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea.

  Translational research : the journal of laboratory and clinical medicine 20080601

• Drugs in infertility and fetal safety.

  Fertility and sterility 20080601

• Pharmacotherapy for obesity in menopausal women.

  Menopause international 20080601

• Metformin, B12 and homocysteine levels: the plausible cause or effect?

  Journal of the Formosan Medical Association = Taiwan yi zhi 20080601

• Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study.

  Clinical therapeutics 20080601

• [Effect of insulin plus rosiglitazone or metformin on serum N-terminal pro-brain natriuretic peptide in type 2 diabetes mellitus: a randomized-controlled study].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20080601

• [Incretin-mimetic drugs, an insulin alternative in type 2 diabetes].

  Soins; la revue de reference infirmiere 20080601

• [Non-alcoholic fatty liver disease--new view].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080601

• Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet.

  Vascular health and risk management 20080601

• Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease.

  Vascular health and risk management 20080601

• Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study.

  Psychiatry research 20080530

• Capillary liquid chromatography and capillary electrochromatography using silica hydride stationary phases.

  Journal of chromatography. A 20080516

• Metformin for metabolic dysregulation in schizophrenic patients treated with olanzapine.

  Progress in neuro-psychopharmacology & biological psychiatry 20080515

• The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozocin-induced diabetic rats.

  Chemico-biological interactions 20080509

• Metformin versus insulin for the treatment of gestational diabetes.

  The New England journal of medicine 20080508

• Gestational diabetes--setting limits, exploring treatments.

  The New England journal of medicine 20080508

• Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20080501

• Economic evaluation of the treatment of type 2 diabetes with insulin glargine based on the LAPTOP trial.

  The European journal of health economics : HEPAC : health economics in prevention and care 20080501

• Response to Pokharna and Kanna: initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

  Diabetes, obesity & metabolism 20080501

• Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.

  Fertility and sterility 20080501

• Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome.

  Fertility and sterility 20080501

• A systematic review of commonly used medical treatments for hirsutism in women.

  Clinical endocrinology 20080501

• Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.

  Basic research in cardiology 20080501

• Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT).

  Diabetes care 20080501

• Impact of fixed-dose combination drugs on adherence to prescription medications.

  Journal of general internal medicine 20080501

• Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche.

  The Journal of clinical endocrinology and metabolism 20080501

• Establishing pragmatic estimated glomerular filtration rate thresholds to guide metformin prescribing: careful assessment of risks and benefits is required.

  Diabetic medicine : a journal of the British Diabetic Association 20080501

• Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.

  Nature clinical practice. Endocrinology & metabolism 20080501

• Rosiglitazone therapy improves insulin resistance parameters in overweight and obese diabetic patients intolerant to metformin.

  Archives of medical research 20080501

• Extended-release metformin in Asian patients.

  International journal of clinical practice 20080501

• The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study.

  International journal of clinical practice 20080501

• CB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant.

  Journal of neuroendocrinology 20080501

• Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes.

  European journal of endocrinology 20080501

• Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach.

  Metabolism: clinical and experimental 20080501

• Efficacy of berberine in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20080501

• Psoriatic exacerbation associated with insulin therapy.

  Diabetes care 20080501

• Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment.

  The Netherlands journal of medicine 20080501

• Bioequivalence of vildagliptin/metformin fixed-dose combination tablets and a free combination of vildagliptin and metformin in healthy subjects.

  International journal of clinical pharmacology and therapeutics 20080501

• [Metformin and kidneys].

  Vnitrni lekarstvi 20080501

• Metformin in polycystic ovary syndrome.

  The New England journal of medicine 20080424

• Metformin in polycystic ovary syndrome.

  The New England journal of medicine 20080424

• Metformin in polycystic ovary syndrome.

  The New England journal of medicine 20080424

• Metformin in polycystic ovary syndrome.

  The New England journal of medicine 20080424

• Antipsychotic-induced weight gain in patients with schizophrenia.

  JAMA 20080423

• Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study.

  The Medical journal of Australia 20080421

• [Metformin should not be used by patients with reduced renal function].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080417

• Doctors seek to prevent breast cancer recurrence by lowering insulin levels.

  Journal of the National Cancer Institute 20080416

• Polycystic ovary syndrome.

  Best practice & research. Clinical obstetrics & gynaecology 20080401

• 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.

  Endocrinology 20080401

• Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program.

  Diabetes 20080401

• Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2.

  British journal of pharmacology 20080401

• Clinical review: Antiandrogens for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials.

  The Journal of clinical endocrinology and metabolism 20080401

• Clinical review: Insulin sensitizers for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials.

  The Journal of clinical endocrinology and metabolism 20080401

• Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

  Journal of hypertension 20080401

• The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20080401

• Glycaemic control in critically ill patients with myotonic dystrophy.

  Anaesthesia 20080401

• Use of metformin in polycystic ovary syndrome: a meta-analysis.

  Obstetrics and gynecology 20080401

• Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovarian syndrome.

  Saudi medical journal 20080401

• Polymorphism in human organic cation transporters and metformin action.

  Pharmacogenomics 20080401

• Cellulose acetate microspheres as floating depot systems to increase gastric retention of antidiabetic drug: formulation, characterization and in vitro-in vivo evaluation.

  Drug development and industrial pharmacy 20080401

• Pretreatments before the induction of ovulation in assisted reproduction technologies: evidence-based medicine in 2007.

  Annals of the New York Academy of Sciences 20080401

• Resistin is expressed in human hepatocytes and induces insulin resistance.

  Endocrine 20080401

• [Metformin. Contraindications in heart failure reconsidered].

  Medizinische Monatsschrift fur Pharmazeuten 20080401

• Effects of metformin on QT and QTc interval dispersion of diabetic rats.

  Arquivos brasileiros de cardiologia 20080401

• Metformin: a review.

  Drugs of today (Barcelona, Spain : 1998) 20080401

• Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial.

  Journal of pediatric endocrinology & metabolism : JPEM 20080401

• Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin.

  Vascular health and risk management 20080401

• Metformin and lifestyle changes help people taking antipsychotics lose weight.

  The Harvard mental health letter 20080401

• Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.

  Molecular and cellular endocrinology 20080326

• Diabetes specialists keep ACCORD data in perspective.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

• Sitagliptin: a novel agent for the management of type 2 diabetes mellitus.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

• [The effectiveness in type 2 diabetes prevention: a forced landing to reality].

  Medicina clinica 20080308

• AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase.

  The Journal of biological chemistry 20080307

• Examination of metformin hydrochloride in a continuous dissolution/HDM system.

  International journal of pharmaceutics 20080303

• C-reactive protein levels are unaffected by metformin during pretreatment and an IVF cycle in women with polycystic ovary syndrome.

  Fertility and sterility 20080301

• Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome.

  Fertility and sterility 20080301

• Effect of pioglitazone on heart function and N-terminal pro-brain natriuretic peptide levels of patients with type 2 diabetes.

  Acta diabetologica 20080301

• Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

  The Journal of clinical endocrinology and metabolism 20080301

• Erythromelalgia in a diabetic patient managed with gabapentin.

  Diabetes research and clinical practice 20080301

• Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program.

  Diabetes care 20080301

• Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

  Diabetes 20080301

• Clinical predictors of disease progression and medication initiation in untreated patients with type 2 diabetes and A1C less than 7%.

  Diabetes care 20080301

• 2-year effects of pioglitazone add-on to sulfonylurea or metformin on oral glucose tolerance in patients with type 2 diabetes.

  Diabetes research and clinical practice 20080301

• Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.

  Acta diabetologica 20080301

• The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats.

  Journal of neuroendocrinology 20080301

• Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study.

  Journal of the American Academy of Dermatology 20080301

• Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080301

• Effects of exenatide versus insulin analogues on weight change in subjects with type 2 diabetes: a pooled post-hoc analysis.

  Current medical research and opinion 20080301

• Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study.

  The American journal of psychiatry 20080301

• Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide.

  Diabetes, obesity & metabolism 20080301

• Does metformin improve polycystic ovary syndrome symptoms through reduction in body iron stores?

  European journal of endocrinology 20080301

• Consensus on infertility treatment related to polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20080301

• Metformin does not suppress thyrotropin.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080301

• Artificially low HbA1c associated with treatment with ribavirin.

  BMJ (Clinical research ed.) 20080301

• [AMPK: a link between metabolism and reproduction?].

  Medecine sciences : M/S 20080301

• Outlook: metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview.

  Reproductive biomedicine online 20080301

• Formulation and in vitro studies of a fixed-dose combination of a bilayer matrix tablet containing metformin HCl as sustained release and glipizide as immediate release.

  Drug development and industrial pharmacy 20080301

• [Metformin and type-2 diabetes mellitus].

  Atencion primaria 20080301

• Cost-utility analysis of intensive blood glucose control with metformin versus usual care in overweight type 2 diabetes mellitus patients in Beijing, P.R. China.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080301

• Cost-effectiveness analysis of thiazolidinediones in uncontrolled type 2 diabetic patients receiving sulfonylureas and metformin in Thailand.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080301

• Beneficial effects of strategies for primary prevention of diabetes on cardiovascular risk factors: results of the Indian Diabetes Prevention Programme.

  Diabetes & vascular disease research 20080301

• Achieving glycosylated hemoglobin targets using the combination of repaglinide and metformin in type 2 diabetes: a reanalysis of earlier data in terms of current targets.

  Clinical therapeutics 20080301

• [Adjunctive therapies to glycaemic control of type 1 diabetes mellitus].

  Arquivos brasileiros de endocrinologia e metabologia 20080301

• [Lactic acidosis caused by metformin].

  Anales de medicina interna (Madrid, Spain : 1984) 20080301

• AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.

  The Journal of biological chemistry 20080222

• Insulin in the adjuvant breast cancer setting: a novel therapeutic target for lifestyle and pharmacologic interventions?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080220

• Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

  Circulation 20080219

• Efficient delivery of siRNA using dendritic poly(L-lysine) for loss-of-function analysis.

  Journal of controlled release : official journal of the Controlled Release Society 20080218

• Clinical decisions. Management of type 2 diabetes--polling results.

  The New England journal of medicine 20080214

• [Insulin-using woman with type 2 diabetes and weight problems].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080214

• An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

  Regulatory peptides 20080207

• Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.

  Clinical pharmacology and therapeutics 20080201

• Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-cyclodextrin.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080201

• Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.

  Biology of reproduction 20080201

• Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

  Diabetes 20080201

• Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin.

  Clinical science (London, England : 1979) 20080201

• Comparison of different drugs as add-on treatments to metformin in type 2 diabetes: a meta-analysis.

  Diabetes research and clinical practice 20080201

• Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin.

  Clinical endocrinology 20080201

• Management of type 2 diabetes in the obese patient: current concerns and emerging therapies.

  Current medical research and opinion 20080201

• Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trials.

  Current medical research and opinion 20080201

• The ratio of leptin to adiponectin can be used as an index of insulin resistance.

  Metabolism: clinical and experimental 20080201

• Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes.

  Current medical research and opinion 20080201

• The investigation and management of severe hyperandrogenism pre- and postmenopause: non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080201

• STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.

  International journal of clinical pharmacology and therapeutics 20080201

• High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.

  Hepatology (Baltimore, Md.) 20080201

• Type 2 diabetes mellitus and heart failure.

  Pharmacotherapy 20080201

• Optimizing antidiabetic treatment options for patients with type 2 diabetes mellitus and cardiovascular comorbidities.

  Pharmacotherapy 20080201

• Combined therapy with insulin plus oral agents: is there any advantage? An argument in favor.

  Diabetes care 20080201

• Treatment of type 2 diabetes with combined therapy: what are the pros and cons?

  Diabetes care 20080201

• Insulin as a first-line therapy in type 2 diabetes: should the use of sulfonylureas be halted?

  Diabetes care 20080201

• The nuts and bolts of achieving end points with real-time continuous glucose monitoring.

  Diabetes care 20080201

• Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels.

  The Journal of pharmacy and pharmacology 20080201

• Optimization of metformin HCl 500 mg sustained release matrix tablets using Artificial Neural Network (ANN) based on Multilayer Perceptrons (MLP) model.

  Chemical & pharmaceutical bulletin 20080201

• Metformin-associated lactic acidosis following contrast media-induced nephrotoxicity.

  European journal of anaesthesiology 20080201

• Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction.

  Clinical toxicology (Philadelphia, Pa.) 20080201

• Meta-analysis: metformin treatment in persons at risk for diabetes mellitus.

  The American journal of medicine 20080201

• Oral antidiabetic medication adherence and glycemic control in managed care.

  The American journal of managed care 20080201

• Ovulation induction in polycystic ovary syndrome.

  Minerva ginecologica 20080201

• Medical therapy in women with polycystic ovarian syndrome before and during pregnancy and lactation.

  Minerva ginecologica 20080201

• Role of metformin in patients with polycystic ovary syndrome: the state of the art.

  Minerva ginecologica 20080201

• A retrospective analysis of the fasting plasma glucose and glycosylated hemoglobin and pharmacotherapy change patterns among type 2 diabetes mellitus patients.

  Clinical therapeutics 20080201

• [Metformin and AMPK: an old drug and a new enzyme in the context of metabolic syndrome].

  Arquivos brasileiros de endocrinologia e metabologia 20080201

• Impact of metformin on peak aerobic capacity.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20080201

• Sitagliptin: new drug. Type 2 diabetes: limited efficacy, too many unknown risks.

  Prescrire international 20080201

• The use of metformin as first line treatment in polycystic ovary syndrome.

  Irish medical journal 20080201

• Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

  Diabetes & metabolism 20080201

• DPP-4 inhibitors and GLP-1 analogues: for whom? Which place for incretins in the management of type 2 diabetic patients?

  Diabetes & metabolism 20080201

• Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS.

  The Cochrane database of systematic reviews 20080123

• Clinical decisions. Management of type 2 diabetes.

  The New England journal of medicine 20080117

• Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial.

  JAMA 20080109

• HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies.

  Journal of pharmaceutical and biomedical analysis 20080107

• Metformin for the treatment of the polycystic ovary syndrome.

  The New England journal of medicine 20080103

• Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.

  European journal of obstetrics, gynecology, and reproductive biology 20080101

• Medication use and disease management of type 2 diabetes in Belgium.

  Pharmacy world & science : PWS 20080101

• Metformin and body weight.

  International journal of obesity (2005) 20080101

• Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes.

  Diabetes research and clinical practice 20080101

• High and typical 18F-FDG bowel uptake in patients treated with metformin.

  European journal of nuclear medicine and molecular imaging 20080101

• Metformin promotes isolated rat liver mitochondria impairment.

  Molecular and cellular biochemistry 20080101

• Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes.

  Diabetes 20080101

• Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects.

  Diabetes/metabolism research and reviews 20080101

• Why insulin sensitizers but not secretagogues should be retained when initiating insulin in type 2 diabetes.

  Diabetes/metabolism research and reviews 20080101

• Efficacy and treatment satisfaction of once-daily insulin glargine plus one or two oral antidiabetic agents versus continuing premixed human insulin in patients with Type 2 diabetes previously on long-term conventional insulin therapy: the SWITCH Pilot Study.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

• Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.

  The Journal of clinical endocrinology and metabolism 20080101

• Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study.

  Diabetes, obesity & metabolism 20080101

• Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.

  Journal of molecular neuroscience : MN 20080101

• Lowering the threshold for defining microalbuminuria: effects of a lifestyle-metformin intervention in obese 'normoalbuminuric' non-diabetic subjects.

  American journal of hypertension 20080101

• Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.

  Clinical hemorheology and microcirculation 20080101

• Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

• Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation?

  Diabetes, obesity & metabolism 20080101

• Glucose lowering treatment in patients with coronary artery disease is prognostically important not only in established but also in newly detected diabetes mellitus: a report from the Euro Heart Survey on Diabetes and the Heart.

  European heart journal 20080101

• The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial.

  European heart journal 20080101

• Pioglitazone and metformin for increased small low-density lipoprotein in polycystic ovary syndrome: counterpoint.

  American journal of obstetrics and gynecology 20080101

• Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes.

  European journal of endocrinology 20080101

• Polycystic ovarian syndrome, biomarkers, and metformin: research, risk, and reality.

  The Journal of clinical endocrinology and metabolism 20080101

• Functional involvement of the organic cation transporter 2 (rOct2) in the renal uptake of organic cations in rats.

  The Journal of international medical research 20080101

• Metformin in therapy naive patients with polycystic ovary syndrome.

  Human reproduction update 20080101

• Emerging concepts in the medical and surgical treatment of obesity.

  Frontiers of hormone research 20080101

• Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects.

  Advances in cardiology 20080101

• Choosing first-line therapy for management of type 2 diabetes.

  American family physician 20080101

• Estimating the long-term cost-effectiveness of exenatide in the United States: an adjunctive treatment for type 2 diabetes mellitus.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

• Acne in adult women.

  Skinmed 20080101

• [The possibility of prevention of type 2 diabetes].

  Endokrynologia Polska 20080101

• Serum transforming growth factor-beta 1 levels in normoalbuminuric and normotensive patients with type 2 diabetes. Effect of metformin and rosiglitazone.

  Hormones (Athens, Greece) 20080101

• Metformin: effective and safe in renal disease?

  International urology and nephrology 20080101

• Effects of Persea americana Mill (Lauraceae) ['Avocado'] ethanolic leaf extract on blood glucose and kidney function in streptozotocin-induced diabetic rats and on kidney cell lines of the proximal (LLCPK1) and distal tubules (MDBK).

  Methods and findings in experimental and clinical pharmacology 20080101

• Re: 'Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome', Sinha SK et al., JPEM 2007; 20: 1045-1052.

  Journal of pediatric endocrinology & metabolism : JPEM 20080101

• An overview of obesity in children with psychiatric disorders taking atypical antipsychotics.

  Harvard review of psychiatry 20080101

• Pediatric obesity: parallels with addiction and treatment recommendations.

  Harvard review of psychiatry 20080101

• Metformin and parameters of physical health.

  Internal medicine (Tokyo, Japan) 20080101

• [Efficacy and safety of the use of metformin in patients with chronic heart failure and type 2 diabetes mellitus. results of the study 'rational effective mulicomponent therapy in the battle against diabetes mellitus in patients with chronic heart failure'].

  Kardiologiia 20080101

• Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study).

  Cardiovascular diabetology 20080101

• Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: restoration of pharmacokinetic parameters to the control state by insulin treatment.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

• Metformin-induced lactic acidosis in a type 2 diabetic patient with acute renal failure.

  La Clinica terapeutica 20080101

• Metformin-associated lactic acidosis in a pregnant patient.

  Gynecologic and obstetric investigation 20080101

• A comparison of select cardiovascular outcomes by antidiabetic prescription drug classes used to treat type 2 diabetes among Military Health System beneficiaries, fiscal year 2003-2006.

  American journal of therapeutics 20080101

• Metformin reduces cellular lysophosphatidylcholine and thereby may lower apolipoprotein B secretion in primary human hepatocytes.

  Biochimica et biophysica acta 20080101

• [Metformin therapy in polycystic ovary syndrome].

  Ginekologia polska 20080101

• Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.

  The American journal of Chinese medicine 20080101

• [Multiple risk factors and drug interactions leading to severe lactic acidosis].

  Therapie 20080101

• Improvement of autoimmune hypoglycemia by decreasing circulating free insulin concentrations with metformin.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080101

• Intensification of oxidative stress and inflammation in type 2 diabetes despite antihyperglycemic treatment.

  Cardiovascular diabetology 20080101

• Evaluation of adverse events of oral antihyperglycemic monotherapy experienced by a geriatric population in a real-world setting: a retrospective cohort analysis.

  Drugs & aging 20080101

• Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes.

  Internal medicine (Tokyo, Japan) 20080101

• Haemoglobin A1c goal attainment in relation to dose in patients with diabetes mellitus taking metformin: a nested, case-control study.

  Clinical drug investigation 20080101

• [Metformin in the clinical practice. Polish Society of Endocrinology consensus based on the European and American medical societies].

  Endokrynologia Polska 20080101

• Homeostasis model assessment (HOMA) as surrogate insulinization criteria in patients with type 2 diabetes.

  American journal of therapeutics 20080101

• Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study.

  Scandinavian journal of clinical and laboratory investigation 20080101

• Fixed-dose combination tablet of repaglinide and metformin is bioequivalent to concomitantly administered individual tablets of repaglinide and metformin : randomized, single-blind, three-period crossover study in healthy subjects.

  Clinical drug investigation 20080101

• Metformin in the treatment of polycystic ovary syndrome.

  Current pharmaceutical design 20080101

• Insulin resistance postburn: underlying mechanisms and current therapeutic strategies.

  Journal of burn care & research : official publication of the American Burn Association 20080101

• Performing meta-analysis with incomplete statistical information in clinical trials.

  BMC medical research methodology 20080101

• Metformin use in decompensated heart failure.

  Cardiology in review 20080101

• Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.

  Drug metabolism and pharmacokinetics 20080101

• Metformin Trumps insulin in the treatment of gestational diabetes.

  Medscape journal of medicine 20080101

• Desaturase activities and metabolic control in type 2 diabetes.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Quality of diabetes care among patients managed by teleconsultation.

  Journal of telemedicine and telecare 20080101

• Insulin resistance: a potential new target for therapy in patients with heart failure.

  Cardiovascular therapeutics 20080101

• Undiagnosed type 2 diabetes mellitus presenting with orbital cellulitis.

  Orbit (Amsterdam, Netherlands) 20080101

• Metformin: effective in the prevention of new-onset type 2 diabetes?

  Progress in cardiovascular nursing 20080101

• Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study.

  PloS one 20080101

• Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary.

  Health and quality of life outcomes 20080101

• [Used of oral antidiabetic agents in pediatric patients - own observations].

  Endokrynologia Polska 20080101

• Metformin-associated lactic acidosis in an intensive care unit.

  Critical care (London, England) 20080101

• Antidiabetic and antioxidant activities of major flavonoids of Cynanchum acutum L. (Asclepiadaceae) growing in Egypt.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

• Estradiol-to-testosterone ratio is associated with response to metformin treatment in women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS).

  Chang Gung medical journal 20080101

• [Avandia and avandamet in the treatment of patients with diabetes mellitus type 2: effects on secretion of some fat tissue hormones].

  Terapevticheskii arkhiv 20080101

• Alterations of coagulation in metformin intoxication.

  Hormones (Athens, Greece) 20080101

• [Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].

  Rontgenpraxis; Zeitschrift fur radiologische Technik 20080101

• Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus.

  Cell transplantation 20080101

• Identification and treatment of prediabetes to prevent progression to type 2 diabetes.

  Clinical cornerstone 20080101

• Diabetes: glycaemic control in type 2.

  BMJ clinical evidence 20080101

• Contraindications to metformin therapy among patients with type 2 diabetes mellitus.

  Pharmacy world & science : PWS 20071201

• Pioglitazone: an anti-diabetic compound with anti-aging properties.

  Biogerontology 20071201

• The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome.

  Clinical endocrinology 20071201

• Effect of metformin on clastogenic and biochemical changes induced by adriamycin in Swiss albino mice.

  Mutation research 20071201

• Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and rosiglitazone or insulin and acarbose in type 2 diabetes.

  Acta diabetologica 20071201

• Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus.

  European journal of clinical pharmacology 20071201

• Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin.

  Biopharmaceutics & drug disposition 20071201

• The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.

  Diabetologia 20071201

• Use of insulin sensitizers in NASH.

  Endocrinology and metabolism clinics of North America 20071201

• Polycystic ovarian syndrome--prognosis and treatment outcomes.

  Current opinion in obstetrics & gynecology 20071201

• Metformin therapy in patients with type 2 diabetes complicated by heart failure.

  American heart journal 20071201

• [Overdose of metformin secondary to acute renal insufficiency: a report of six cases].

  Medicina intensiva 20071201

• Use of metformin according to estimated glomerular filtration rate: the threshold and the equation are important.

  Diabetic medicine : a journal of the British Diabetic Association 20071201

• Estimated glomerular filtration rate (eGFR) and metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20071201

• Metformin in heart failure.

  Diabetes care 20071201

• Non-surgical interventions for threatened and recurrent miscarriages.

  Singapore medical journal 20071201

• DPP-4 inhibitors.

  Best practice & research. Clinical endocrinology & metabolism 20071201

• Metformin discontinuation rate among patients with type-2 diabetes mellitus in Basrah, Iraq.

  Saudi medical journal 20071201

• Effect of rosiglitazone and metformin on insulin resistance in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy containing protease inhibitor: randomized prospective controlled clinical trial.

  Croatian medical journal 20071201

• Metformin decreases circulating acylation-stimulating protein levels in polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20071201

• Blurred vision.

  The Netherlands journal of medicine 20071201

• [Inflammation, atherosclerosis, classic cardiovascular risk factors, biostatistics, clinical significance. Where are we?].

  Revista espanola de cardiologia 20071201

• [Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia].

  Revista espanola de cardiologia 20071201

• Exenatide: new drug. Type 2 diabetes for some overweight patients.

  Prescrire international 20071201

• Cardiovascular risk in women with polycystic ovary syndrome.

  Minerva endocrinologica 20071201

• Insulin glargine added to therapy with oral antidiabetic agents improves glycemic control and reduces long-term complications in patients with type 2 diabetes - a simulation with the Diabetes Mellitus Model (DMM).

  International journal of clinical pharmacology and therapeutics 20071201

• A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications.

  Vascular health and risk management 20071201

• Clinical management strategies for type 2 diabetes.

  JAAPA : official journal of the American Academy of Physician Assistants 20071201

• The nurse's role in discouraging clinical inertia in diabetes management: optimizing cardiovascular health among African-Americans.

  Journal of National Black Nurses' Association : JNBNA 20071201

• Pharmacotherapy for obesity.

  Current atherosclerosis reports 20071201

• Incretin enhancers and the evolution of antihyperglycemic therapy in type 2 diabetes.

  Endocrinology and metabolism clinics of North America 20071201

• Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

  Cancer research 20071115

• Physical-chemical characterization of binary systems of metformin hydrochloride with triacetyl-beta-cyclodextrin.

  Journal of pharmaceutical and biomedical analysis 20071105

• Letter to the editor in reference to article titled: Initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

  Diabetes, obesity & metabolism 20071101

• When a friend can become an enemy! Recognition and management of metformin-associated lactic acidosis.

  Kidney international 20071101

• Medical therapy for diabetes is associated with increased use of lower endoscopy.

  Pharmacoepidemiology and drug safety 20071101

• Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.

  American journal of physiology. Endocrinology and metabolism 20071101

• A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.

  Endocrinology 20071101

• Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial.

  Human reproduction (Oxford, England) 20071101

• Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.

  International journal of clinical practice 20071101

• Normalization of metabolic syndrome using fenofibrate, metformin or their combination.

  Diabetes, obesity & metabolism 20071101

• Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study.

  Saudi medical journal 20071101

• Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice.

  Biological & pharmaceutical bulletin 20071101

• Flutamide metformin for post-menarcheal girls with preclinical ovarian androgen excess: evidence for differential response by androgen receptor genotype.

  European journal of endocrinology 20071101

• Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance.

  European journal of endocrinology 20071101

• Glycemic response to newly initiated diabetes therapies.

  The American journal of managed care 20071101

• Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20071101

• FPIN's clinical inquiries. Metformin therapy and diabetes prevention in adolescents who are obese.

  American family physician 20071101

• Effect of biphasic insulin aspart 30 combined with metformin on glycaemic control in obese people with type 2 diabetes.

  Bosnian journal of basic medical sciences 20071101

• Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.

  Vascular medicine (London, England) 20071101

• Efficacy and treatment satisfaction of once-daily insulin glargine plus one or two oral antidiabetic agents versus continuing premixed human insulin in patients with type 2 diabetes previously on long-term conventional insulin therapy: the Switch pilot study.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20071101

• Effect of glyburide-metformin combination tablet in patients with type 2 diabetes.

  Journal of the Chinese Medical Association : JCMA 20071101

• [New data on hypoglycemia risk and beta cell function].

  MMW Fortschritte der Medizin 20071101

• Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial.

  Clinical therapeutics 20071101

• Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, randomized, open-label, parallel-group comparison.

  Clinical therapeutics 20071101

• Comparison of biphasic insulin aspart 30 given three times daily or twice daily in combination with metformin versus oral antidiabetic drugs alone in patients with poorly controlled type 2 diabetes: a 16-week, randomized, open-label, parallel-group trial conducted in russia.

  Clinical therapeutics 20071101

• Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison.

  The Journal of reproductive medicine 20071101

• [Blood pressure and type 2 diabetes mellitus: impact of the insulin therapy].

  La Tunisie medicale 20071101

• Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.

  The New England journal of medicine 20071025

• Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry.

  Journal of pharmaceutical and biomedical analysis 20071018

• Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

  Biochemical and biophysical research communications 20071012

• Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients.

  Diabetes research and clinical practice 20071001

• Evaluation of endothelial function in women with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20071001

• A comparison of mealtime insulin aspart and human insulin in combination with metformin in type 2 diabetes patients.

  Diabetes research and clinical practice 20071001

• Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• Effects of water deprivation on the pharmacokinetics of metformin in rats.

  Biopharmaceutics & drug disposition 20071001

• Establishing pragmatic estimated GFR thresholds to guide metformin prescribing.

  Diabetic medicine : a journal of the British Diabetic Association 20071001

• A randomized placebo-controlled trial of metformin for the treatment of HIV lipodystrophy.

  HIV medicine 20071001

• beta-cell function and anti-diabetic pharmacotherapy.

  Diabetes/metabolism research and reviews 20071001

• Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20071001

• A comment on 'the risk of coronary heart disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and sulfonylurea therapy'.

  Pharmacoepidemiology and drug safety 20071001

• Adipose tissue and diabetes therapy: do we hit the target?

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20071001

• Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20071001

• Risk of multiple gestation after ovulation induction in polycystic ovary syndrome.

  The Journal of reproductive medicine 20071001

• Sitagliptin with metformin: profile of a combination for the treatment of type 2 diabetes.

  Drugs of today (Barcelona, Spain : 1998) 20071001

• [Clinical study on effect of Bushen Huayu Qutan Recipe in treating polycystic ovarian syndrome].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071001

• [Relation of serum uric acid levels with basic metabolic parameters in patients with metabolic syndrome during insulin-sensitizing therapy].

  Georgian medical news 20071001

• Polycystic ovary syndrome and female reproduction.

  British journal of nursing (Mark Allen Publishing) 20071001

• Who should benefit from the use of alpha-glucosidase inhibitors?

  Current diabetes reports 20071001

• [Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• Pattern of potential drug-drug interactions in diabetic out-patients in a tertiary care teaching hospital in Nepal.

  The Medical journal of Malaysia 20071001

• Managing anovulatory infertility and polycystic ovary syndrome.

  BMJ (Clinical research ed.) 20070929

• Liquid chromatography tandem mass spectrometry method for simultaneous determination of antidiabetic drugs metformin and glyburide in human plasma.

  Journal of pharmaceutical and biomedical analysis 20070921

• Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

  BMJ (Clinical research ed.) 20070908

• Catalytic action of copper (II) ion on electrochemical oxidation of metformine and voltammetric determination of metformine in pharmaceuticals.

  Journal of pharmaceutical and biomedical analysis 20070903

• The effects of rosiglitazone, metformin, and diet with exercise in nonalcoholic fatty liver disease.

  Digestive diseases and sciences 20070901

• Long-term treatment combining continuous subcutaneous insulin infusion with oral hypoglycaemic agents is effective in type 2 diabetes.

  Diabetes & metabolism 20070901

• Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20070901

• Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses.

  Diabetes care 20070901

• Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation.

  Biology of reproduction 20070901

• AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations.

  Diabetes 20070901

• Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin.

  Diabetes, obesity & metabolism 20070901

• Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20070901

• Persisting benefits 12-18 months after discontinuation of pubertal metformin therapy in low birthweight girls.

  Clinical endocrinology 20070901

• Pharmacotherapeutic options for overweight adolescents.

  The Annals of pharmacotherapy 20070901

• [Pharmacological recommendations in the daily metabolic control of diabetes mellitus type 2. The role of the new insulins].

  Revista clinica espanola 20070901

• The management of insulin resistance in polycystic ovary syndrome.

  Trends in endocrinology and metabolism: TEM 20070901

• Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin.

  Acta paediatrica (Oslo, Norway : 1992) 20070901

• Drug-induced vitamin B12 deficiency.

  The Nurse practitioner 20070901

• Rosiglitazone and myocardial infarction: cause for concern or misleading meta-analysis?

  Diabetic medicine : a journal of the British Diabetic Association 20070901

• Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is ...

  The Journal of clinical endocrinology and metabolism 20070901

• [Alternative approaches to ovarian stimulation].

  Gynecologie, obstetrique & fertilite 20070901

• The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes.

  Diabetes & vascular disease research 20070901

• Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20070901

• Obesity and the polycystic ovary syndrome.

  Minerva endocrinologica 20070901

• [The effect of metformin on insulin receptor protein tyrosine kinase activity of HIT-T15 cell exposed to high concentration glucose and free fatty acid].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

• [Fat cells becoming ever more prolific--editorial].

  Vnitrni lekarstvi 20070901

• [Serum level of retinol-binding protein 4 in obese patients with insulin resistance and in patients with type 2 diabetes treated with metformin].

  Vnitrni lekarstvi 20070901

• Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20070901

• Metabolic syndrome: are we at risk?

  Nepal Medical College journal : NMCJ 20070901

• Economic effect of augmentation strategies in patients with type 2 diabetes initiated on sulfonylureas.

  Managed care interface 20070901

• [Pioglitazone protects the type-2-diabetes patient from myocardial infarction and stroke].

  MMW Fortschritte der Medizin 20070802

• Continuous glucose monitoring versus self-monitoring of blood glucose in the treatment of gestational diabetes mellitus.

  Diabetes research and clinical practice 20070801

• Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels.

  Diabetes research and clinical practice 20070801

• Formulation and development of hydrodynamically balanced system for metformin: in vitro and in vivo evaluation.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070801

• Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.

  Molecular reproduction and development 20070801

• N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study.

  Fertility and sterility 20070801

• Comparison of two doses of metformin (2.5 and 1.5 g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference.

  Fertility and sterility 20070801

• Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes.

  Diabetes care 20070801

• Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.

  The Journal of clinical endocrinology and metabolism 20070801

• Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20070801

• Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

  British journal of pharmacology 20070801

• Both slow-release and regular-form metformin improve glycemic control without altering plasma visfatin level in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20070801

• Polycystic ovary syndrome update in adolescence.

  Current opinion in pediatrics 20070801

• Metformin prevents an adaptive increase in GSH and induces apoptosis under the conditions of GSH deficiency in H4IIE cells.

  Journal of toxicology and environmental health. Part A 20070801

• Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy.

  Pharmacotherapy 20070801

• Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070801

• Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen.

  The American journal of managed care 20070801

• Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20070801

• The incretin mimetic exenatide as a monotherapy in patients with type 2 diabetes.

  Diabetes technology & therapeutics 20070801

• Effects of pioglitazone in combination with metformin or a sulfonylurea compared to a fixed-dose combination of metformin and glibenclamide in patients with type 2 diabetes.

  Diabetes technology & therapeutics 20070801

• Effects of early use of pioglitazone in combination with metformin in patients with newly diagnosed type 2 diabetes.

  Current medical research and opinion 20070801

• Type 2 diabetes: the end of clinical inertia.

  Southern medical journal 20070801

• Pioglitazone + metformin: new drug. A combination product to avoid.

  Prescrire international 20070801

• Changing incident diabetes regimens: a Veterans Administration cohort study from 2000 to 2005.

  Diabetes care 20070801

• Acromegaly symptoms without pituitary adenoma in an adolescent.

  Journal of pediatric endocrinology & metabolism : JPEM 20070801

• Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes.

  Vascular health and risk management 20070801

• Analysis of metformin dosage formulations by capillary electrophoresis at nano scale detection.

  Combinatorial chemistry & high throughput screening 20070801

• Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy.

  Endocrine 20070801

• Initiating insulin in patients with type 2 diabetes.

  The Journal of family practice 20070801

• [Metformin-related lactic acidosis in an 85-year-old woman].

  Nederlands tijdschrift voor geneeskunde 20070728

• [Metformin-related lactic acidosis in an 85-year-old woman].

  Nederlands tijdschrift voor geneeskunde 20070728

• [Metformin-related lactic acidosis in an 85-year-old woman].

  Nederlands tijdschrift voor geneeskunde 20070728

• Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

  The Journal of biological chemistry 20070720

• Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.

  Cancer research 20070715

• Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis.

  The New England journal of medicine 20070705

• Rosiglitazone and cardiotoxicity--weighing the evidence.

  The New England journal of medicine 20070705

• Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: a prospective, randomized crossover study.

  Diabetes/metabolism research and reviews 20070701

• Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome.

  Fertility and sterility 20070701

• Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

  American journal of physiology. Heart and circulatory physiology 20070701

• Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia.

  American journal of physiology. Endocrinology and metabolism 20070701

• Comment on: Nauck MA, Duran S, Kim D et al (2007) A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia 50:259-267.

  Diabetologia 20070701

• A randomized controlled trial examining combinations of repaglinide, metformin and NPH insulin.

  Diabetic medicine : a journal of the British Diabetic Association 20070701

• Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20070701

• Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration.

  Diabetes care 20070701

• Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI.

  Diabetic medicine : a journal of the British Diabetic Association 20070701

• Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

• Effects of lifestyle changes and metformin on salt sensitivity and nitric oxide metabolism in obese salt-sensitive Hispanics.

  Journal of human hypertension 20070701

• Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric, double-blind, placebo-controlled trial.

  Schizophrenia research 20070701

• Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

• A case of fatal intoxication from metformin.

  Journal of forensic sciences 20070701

• Oral antidiabetic agents in pregnancy and lactation: a paradigm shift?

  The Annals of pharmacotherapy 20070701

• The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats.

  Diabetes/metabolism research and reviews 20070701

• Coronary heart disease outcomes in patients receiving antidiabetic agents.

  Pharmacoepidemiology and drug safety 20070701

• Prevention of contrast-induced nephropathy: a critical review.

  Current opinion in nephrology and hypertension 20070701

• [Status of glitazones in treatment of type 2 diabetes mellitus].

  Der Internist 20070701

• Short-term effects of metformin in type 2 diabetes.

  Diabetes, obesity & metabolism 20070701

• Nateglinide or gliclazide in combination with metformin for treatment of patients with type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone: 1-year trial results.

  Diabetes, obesity & metabolism 20070701

• Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone.

  The Journal of clinical endocrinology and metabolism 20070701

• Pharmacological management of gestational diabetes: an overview.

  Diabetes care 20070701

• A trial in progress: gestational diabetes. Treatment with metformin compared with insulin (the Metformin in Gestational Diabetes [MiG] trial).

  Diabetes care 20070701

• Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a 6-month prospective study.

  European journal of endocrinology 20070701

• Sodium alginate microspheres of metformin HCl: formulation and in vitro evaluation.

  Current drug delivery 20070701

• Effects of lifestyle intervention and metformin on weight management and markers of metabolic syndrome in obese adolescents.

  Journal of the American Academy of Nurse Practitioners 20070701

• Preventing diabetes, Part II: an action plan.

  Harvard men's health watch 20070701

• New medications help those with diabetes avoid heart trouble. Drugs mimic the body's natural insulin and glucose controls, but diet and exercise are still keys to controlling the disease.

  Heart advisor 20070701

• Pioglitazone and metformin.

  Drugs of today (Barcelona, Spain : 1998) 20070701

• Effects of bacterial lipopolysaccharide on the pharmacokinetics of metformin in rats.

  International journal of pharmaceutics 20070607

• Sitagliptin/metformin (Janumet) for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20070604

• Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.

  Fertility and sterility 20070601

• AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

  American journal of physiology. Endocrinology and metabolism 20070601

• Simple and rapid method determination for metformin in human plasma using high performance liquid chromatography tandem mass spectrometry: application to pharmacokinetic studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• Body size and shape changes and the risk of diabetes in the diabetes prevention program.

  Diabetes 20070601

• A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients.

  Diabetes care 20070601

• The effects of metformin and glibenclamide on glucose metabolism, counter-regulatory hormones and cardiovascular responses in women with Type 2 diabetes during exercise of moderate intensity.

  Diabetic medicine : a journal of the British Diabetic Association 20070601

• Polycystic ovary syndrome: androgens and hypertension.

  Hypertension (Dallas, Tex. : 1979) 20070601

• A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20070601

• Is metformin the treatment of choice for anovulation in polycystic ovary syndrome?

  Nature clinical practice. Endocrinology & metabolism 20070601

• Rosiglitazone RECORD study: glucose control outcomes at 18 months.

  Diabetic medicine : a journal of the British Diabetic Association 20070601

• Metformin and glitazones: do they really help PCOS patients?

  The Journal of family practice 20070601

• Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats.

  Obesity (Silver Spring, Md.) 20070601

• Metformin/rosiglitazone combination pill (Avandamet) for the treatment of patients with Type 2 diabetes.

  Expert opinion on pharmacotherapy 20070601

• The use of oral antidiabetic agents in primary care.

  Australian family physician 20070601

• Janumet.

  JAAPA : official journal of the American Academy of Physician Assistants 20070601

• Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.

  Xenobiotica; the fate of foreign compounds in biological systems 20070601

• Severe hypoglycemia in a patient with type 2 diabetes mellitus on metformin monotherapy.

  The Journal of the Association of Physicians of India 20070601

• Effect of chronic co-administration of metformin and vitamin C on plasma glucose and lipid concentrations in normal rats.

  African journal of medicine and medical sciences 20070601

• [Classic drug in diabetes therapy. Revise contraindications?].

  MMW Fortschritte der Medizin 20070531

• Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants.

  Life sciences 20070530

• CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.

  The Journal of biological chemistry 20070525

• Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells.

  Biochemical and biophysical research communications 20070525

• New treatments for diabetes.

  The New England journal of medicine 20070524

• [Polycystic ovary syndrome (PCOS)].

  MMW Fortschritte der Medizin 20070524

• Hospital admission associated with Medicare Part D 'doughnut hole'.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070515

• [Efficacy and safety of extended-release metformin in treatment of type 2 diabetes mellitus].

  Zhonghua yi xue za zhi 20070515

• Treatment of infertility in the polycystic ovary syndrome.

  The New England journal of medicine 20070510

• Treatment of infertility in the polycystic ovary syndrome.

  The New England journal of medicine 20070510

• Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats.

  Journal of ethnopharmacology 20070504

• Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes.

  Diabetes/metabolism research and reviews 20070501

• Metabolic syndrome does not increase the risk of conversion of impaired glucose tolerance to diabetes in Asian Indians--Result of Indian diabetes prevention programme.

  Diabetes research and clinical practice 20070501

• The risk of coronary heart disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and sulfonylurea therapy.

  Pharmacoepidemiology and drug safety 20070501

• Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review.

  Human reproduction (Oxford, England) 20070501

• Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess.

  The Journal of clinical endocrinology and metabolism 20070501

• Lowering effect on postprandial glycemic response of nopales added to Mexican breakfasts.

  Diabetes care 20070501

• Comment on: Evans JMM, Ogston SA, Emslie-Smith A, Morris AD (2006) Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

  Diabetologia 20070501

• Introducing estimated glomerular filtration rate (eGFR) into clinical practice in the UK: implications for the use of metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20070501

• Diabetes care for patients with peripheral arterial disease.

  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20070501

• Short-term effects of metformin in type 2 diabetes.

  Diabetes, obesity & metabolism 20070501

• Weight gain in type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20070501

• Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial.

  Diabetes, obesity & metabolism 20070501

• Metformin and fetal malformations.

  Fertility and sterility 20070501

• Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

  Cellular and molecular life sciences : CMLS 20070501

• Pharmacogenetics of metformin response: a step in the path toward personalized medicine.

  The Journal of clinical investigation 20070501

• Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

  The Journal of clinical investigation 20070501

• Controlled natural cycle IVF: a novel approach for a dominant follicle during an in-vitro maturation cycle.

  Reproductive biomedicine online 20070501

• Do we need new drugs for the treatment of type 2 diabetes mellitus?

  The Netherlands journal of medicine 20070501

• What is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unanswered.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501

• Metformin in normal-weight hirsute women with polycystic ovary syndrome with normal insulin sensitivity.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501

• Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin.

  Hypertension research : official journal of the Japanese Society of Hypertension 20070501

• [Effect of lifestyle adjustment, metformin and rosiglitazone in polycystic ovary syndrome].

  Zhonghua fu chan ke za zhi 20070501

• Treatment of type 2 diabetes mellitus and the incretin system.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20070501

• Comparison of extended-release metformin in combination with a sulfonylurea (glyburide) to sulfonylurea monotherapy in adult patients with type 2 diabetes: a multicenter, double-blind, randomized, controlled, phase III study.

  Clinical therapeutics 20070501

• Induction of long-term glycemic control in type 2 diabetic patients using pioglitazone and metformin combination.

  The Journal of the Association of Physicians of India 20070501

• [Metformin-related lactic acidosis in an 85-year-old woman].

  Nederlands tijdschrift voor geneeskunde 20070428

• [Fatal autointoxication with metformin].

  Nederlands tijdschrift voor geneeskunde 20070428

• Meglitinide analogues for type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20070418

• [Diabetes type 2 in pediatrics: diagnosis and management].

  Revue medicale suisse 20070418

• [ADOPT study: Reevaluation of antidiabetic drugs. Control of diabetes].

  MMW Fortschritte der Medizin 20070412

• [Consulting Prof. Dr. Stephan Matthaei. Quakenbrück diabetes center. Prescription relevant conclusions].

  MMW Fortschritte der Medizin 20070412

• The long and short of metformin-related vitamin B12 deficiency.

  Archives of internal medicine 20070409

• Vitamin B12 deficiency in patients receiving metformin: clinical data.

  Archives of internal medicine 20070409

• Metformin and vitamin B12 deficiency: association and not causation may play a major role in cohort studies.

  Archives of internal medicine 20070409

• Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats.

  Journal of ethnopharmacology 20070404

• Summaries for patients. Exenatide therapy for type 2 diabetes.

  Annals of internal medicine 20070403

• The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial.

  Annals of internal medicine 20070403

• Exenatide in combination therapy: small study, big market, and many unanswered questions.

  Annals of internal medicine 20070403

• An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction.

  International journal of obesity (2005) 20070401

• Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

  The Journal of clinical endocrinology and metabolism 20070401

• Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology.

  Fertility and sterility 20070401

• Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin.

  Diabetes care 20070401

• Insulin glargine in combination with nateglinide in people with Type 2 diabetes: a randomized placebo-controlled trial.

  Diabetic medicine : a journal of the British Diabetic Association 20070401

• Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas.

  Endocrine journal 20070401

• Metformin treatment in pregnant women with polycystic ovary syndrome--is reduced complication rate mediated by changes in the uteroplacental circulation?

  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20070401

• Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care.

  Diabetic medicine : a journal of the British Diabetic Association 20070401

• Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

  British journal of pharmacology 20070401

• Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial.

  Archives of Iranian medicine 20070401

• The safety of metformin in heart failure.

  The Annals of pharmacotherapy 20070401

• Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: a randomized, single-blind comparative study.

  Diabetes care 20070401

• Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program.

  Diabetes 20070401

• The effects of metformin and rosiglitazone, alone and in combination, on the ovary and endometrium in polycystic ovary syndrome.

  American journal of obstetrics and gynecology 20070401

• FPIN's clinical inquiries. Glycemic control in patients with type 2 diabetes.

  American family physician 20070401

• Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds.

  Journal of molecular endocrinology 20070401

• Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes.

  Pediatric diabetes 20070401

• Metformin: new indication. Useful for some children with type 2 diabetes.

  Prescrire international 20070401

• Effects of metformin treatment in women with polycystic ovary syndrome depends on insulin resistance.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070401

• Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.

  Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 20070401

• Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes.

  Georgian medical news 20070401

• [Clinical effects of metformin in patients with polcystic ovarian syndrome].

  Ginecologia y obstetricia de Mexico 20070401

• Metformin and polycystic ovary syndrome.

  Current opinion in endocrinology, diabetes, and obesity 20070401

• Glycemic durability of monotherapy for diabetes.

  The New England journal of medicine 20070329

• Glycemic durability of monotherapy for diabetes.

  The New England journal of medicine 20070329

• [Exenatide--an incretin-mimetic agent for the treatment of type 2 diabetes mellitus].

  Deutsche medizinische Wochenschrift (1946) 20070316

• [Metformin and vitamin B 12 deficiency].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070315

• An investigation into keratinolytic enzymes to enhance ungual drug delivery.

  International journal of pharmaceutics 20070306

• Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome.

  The Medical journal of Australia 20070305

• Role of metformin in the initiation of pharmacotherapy for type 2 diabetes: an Asian-Pacific perspective.

  Diabetes research and clinical practice 20070301

• Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes.

  Heart (British Cardiac Society) 20070301

• Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes.

  American journal of physiology. Endocrinology and metabolism 20070301

• Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).

  Biology of reproduction 20070301

• Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome.

  Diabetic medicine : a journal of the British Diabetic Association 20070301

• Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1.

  Metabolism: clinical and experimental 20070301

• Insulin counter-regulatory factors, fibrinogen and C-reactive protein during olanzapine administration: effects of the antidiabetic metformin.

  International clinical psychopharmacology 20070301

• Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20070301

• Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial.

  Diabetes, obesity & metabolism 20070301

• Pharmacologic therapy of polycystic ovary syndrome.

  Clinical obstetrics and gynecology 20070301

• Ovulation induction management of PCOS.

  Clinical obstetrics and gynecology 20070301

• Pregnancy considerations in women with polycystic ovary syndrome.

  Clinical obstetrics and gynecology 20070301

• A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes.

  American heart journal 20070301

• Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome.

  Diabetes care 20070301

• An anti-aging drug today: from senescence-promoting genes to anti-aging pill.

  Drug discovery today 20070301

• Treatment of fibrosis in nonalcoholic fatty liver disease.

  Current gastroenterology reports 20070301

• Race, ethnicity, and use of thiazolidinediones among US adults with diabetes.

  Current medical research and opinion 20070301

• Insulin as initial therapy in type 2 diabetes: effective, safe, and well accepted.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20070301

• Metformin before and during pregnancy and lactation in polycystic ovary syndrome.

  Expert opinion on drug safety 20070301

• [Detection of LADA-type diabetes in overweight diabetic patients. Is treatment with metformin suitable?].

  Atencion primaria 20070301

• Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070301

• [Vascular dysfunction in metabolic disorders: evaluation of some therapeutic interventions].

  Bulletin de l'Academie nationale de medecine 20070301

• AMP-activated protein kinase in metabolic control and insulin signaling.

  Circulation research 20070216

• Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.

  The New England journal of medicine 20070208

• Treating the polycystic ovary syndrome the old-fashioned way.

  The New England journal of medicine 20070208

• Succinic acid monoethyl ester, a novel insulinotropic agent: effect on lipid composition and lipid peroxidation in streptozotocin-nicotin-amide induced type 2 diabetic rats.

  Molecular and cellular biochemistry 20070201

• A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.

  American journal of physiology. Renal physiology 20070201

• Polycystic ovary-related miscarriage: should metformin be proposed to such frustrated women?

  Human reproduction (Oxford, England) 20070201

• Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation.

  The Journal of clinical endocrinology and metabolism 20070201

• Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons.

  Endocrinology 20070201

• Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20070201

• A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study.

  Diabetologia 20070201

• Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20070201

• Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus.

  Clinical endocrinology 20070201

• Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome treated with metformin.

  Internal medicine journal 20070201

• Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.

  British journal of anaesthesia 20070201

• Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion.

  Diabetic medicine : a journal of the British Diabetic Association 20070201

• Antidiabetic agents in subjects with mild dysglycaemia: prevention or early treatment of type 2 diabetes?

  Diabetes & metabolism 20070201

• [Drug treatment of type 2 diabetes].

  Presse medicale (Paris, France : 1983) 20070201

• Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

  Diabetes 20070201

• Is metformin safe in patients with mild renal insufficiency?

  Diabetes care 20070201

• An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin: response to Barnett et al.

  Diabetes care 20070201

• Don't throw the baby out with the bath water: mortality with combination metformin and sulfonylurea.

  Diabetes/metabolism research and reviews 20070201

• Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity?

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070201

• Combination of oral antidiabetic agents with basal insulin versus premixed insulin alone in randomized elderly patients with type 2 diabetes mellitus.

  Journal of the American Geriatrics Society 20070201

• Metformin: preventable lactic acidosis.

  Prescrire international 20070201

• Formulation and evaluation of ethyl cellulose microspheres prepared by the multiple emulsion technique.

  Die Pharmazie 20070201

• Design and in vitro testing of a floatable gastroretentive tablet of metformin hydrochloride.

  Die Pharmazie 20070201

• Sitagliptin.

  Nature reviews. Drug discovery 20070201

• Antidiabetic prescriptions and glycemic control in German patients with type 2 diabetes mellitus: a retrospective database study.

  Clinical therapeutics 20070201

• C-reactive protein in obese PCOS women and the effect of metformin therapy.

  Bosnian journal of basic medical sciences 20070201

• Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis.

  The Cochrane database of systematic reviews 20070124

• Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome.

  The Cochrane database of systematic reviews 20070124

• Metformin therapy in a transgenic mouse model of Huntington's disease.

  Neuroscience letters 20070110

• [Metformin can cause vitamin B 12 deficiency in diabetes].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070104

• Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet.

  Journal of ethnopharmacology 20070103

• Effects of metformin and rosiglitazone in HIV-infected patients with hyperinsulinemia and elevated waist/hip ratio.

  AIDS (London, England) 20070102

• Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study.

  International journal of obesity (2005) 20070101

• Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention.

  International journal of obesity (2005) 20070101

• Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes.

  American journal of physiology. Endocrinology and metabolism 20070101

• Phentermine, sibutramine and metformin could be used for the prevention and treatment of steroid-induced weight gain.

  Medical hypotheses 20070101

• Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome.

  Fertility and sterility 20070101

• Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

  Journal of human genetics 20070101

• Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome.

  Metabolism: clinical and experimental 20070101

• The perioperative management of metformin for the oral and maxillofacial surgery patient: risks and recommendations.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070101

• Thinking like a pancreas: perioperative glycemic control.

  Anesthesia and analgesia 20070101

• Recent metformin ingestion does not increase in-hospital morbidity or mortality after cardiac surgery.

  Anesthesia and analgesia 20070101

• A lifetime modelled economic evaluation comparing pioglitazone and rosiglitazone for the treatment of type 2 diabetes mellitus in the UK.

  PharmacoEconomics 20070101

• Oral antidiabetic drugs: bioavailability assessment of fixed-dose combination tablets of pioglitazone and metformin. Effect of body weight, gender, and race on systemic exposures of each drug.

  Journal of clinical pharmacology 20070101

• Oral antidiabetic drugs: effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet.

  Journal of clinical pharmacology 20070101

• Weight changes following the initiation of new anti-hyperglycaemic therapies.

  Diabetes, obesity & metabolism 20070101

• The addition of metformin in type 1 diabetes improves insulin sensitivity, diabetic control, body composition and patient well-being.

  Diabetes, obesity & metabolism 20070101

• [Severe lactic acidosis associated to metformin intoxication].

  Nutricion hospitalaria 20070101

• Metformin and vitamin B12 deficiency: the role of H2 receptor antagonists and proton pump inhibitors.

  Age and ageing 20070101

• The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.

  Journal of alternative and complementary medicine (New York, N.Y.) 20070101

• Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats.

  Journal of andrology 20070101

• Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.

  Journal of diabetes and its complications 20070101

• Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus.

  Journal of diabetes and its complications 20070101

• An optimized in vitro assay for screening compounds that stimulate liver cell glucose utilization with low cytotoxicity.

  Journal of pharmacological and toxicological methods 20070101

• A comparative study of the effects of hypoglycemic agents on serum electrolytes in the diabetic patients.

  Pakistan journal of pharmaceutical sciences 20070101

• [ADOPT study: which first-line glucose-lowering oral medication in type 2 diabetes?].

  Revue medicale de Liege 20070101

• Metformin-associated lactic acidosis in a burn patient.

  Journal of burn care & research : official publication of the American Burn Association 20070101

• Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome.

  Acta obstetricia et gynecologica Scandinavica 20070101

• Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials.

  Clinical therapeutics 20070101

• Hypoglycaemic and hypotensive effects of Globimetula cupulata (DC) Van Tieghem (Loranthaceae) aqueous leaf extract in rats.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20070101

• Metformin plus low-dose glimeperide significantly improves Homeostasis Model Assessment for insulin resistance (HOMA(IR)) and beta-cell function (HOMA(beta-cell)) without hyperinsulinemia in patients with type 2 diabetes mellitus.

  American journal of therapeutics 20070101

• Exenatide: a review of its use in patients with type 2 diabetes mellitus (as an adjunct to metformin and/or a sulfonylurea).

  Drugs 20070101

• [Metformin-induced acute lactic acidosis].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

• Increased prothrombin time and lactic acidosis: rofecoxib drug interaction with acenocoumarin and metformin.

  Annals of cardiac anaesthesia 20070101

• Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes.

  Hypertension research : official journal of the Japanese Society of Hypertension 20070101

• Thiazolidinedione induced thyroid associated orbitopathy.

  BMC ophthalmology 20070101

• Relative bioavailability and bioequivalence of metforphin hydrochloride extended-released and immediate-released tablets in healthy Chinese volunteers.

  European journal of drug metabolism and pharmacokinetics 20070101

• Progress in the treatment of diabetes type 1 and 2.

  Pediatric endocrinology, diabetes, and metabolism 20070101

• Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetes.

  Journal of diabetes and its complications 20070101

• Comparison of the effects of zinc alone and zinc associated with selenium and vitamin E on insulin sensitivity and oxidative stress in high-fructose-fed rats.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20070101

• [Medical treatment of type 2 diabetes. Recommendations for good practice].

  Diabetes & metabolism 20070101

• Bioequivalence study of two metformin formulations.

  Arzneimittel-Forschung 20070101

• Effects of simvastatin and metformin on inflammation and insulin resistance in individuals with mild metabolic syndrome.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

• [ADOPT study. Glitazone controls diabetes progression].

  MMW Fortschritte der Medizin 20070101

• [New class of oral antidiabetic drugs. Effective in combination with metformin].

  MMW Fortschritte der Medizin 20070101

• Ovulation disorders: Part II. Anovulation associated with normal estrogen.

  Clinical and experimental obstetrics & gynecology 20070101

• Management of type 2 diabetes mellitus associated with pituitary gigantism.

  Pituitary 20070101

• [New rank order of antidiabetic drugs. Using glitazone before sulfonylurea drugs? (interview by Dr. Dirk Einecke)].

  MMW Fortschritte der Medizin 20070101

• Metformin-associated lactic acidosis precipitated by diarrhea.

  American journal of therapeutics 20070101

• Changes in glucose tolerance with metformin treatment in polycystic ovary syndrome: a retrospective analysis.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101

• Nutritional approach to metabolic changes arising out of schizophrenia therapy: case report.

  Internal medicine (Tokyo, Japan) 20070101

• Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes.

  Cardiovascular diabetology 20070101

• Sitagliptin: a novel drug for the treatment of type 2 diabetes.

  Cardiology in review 20070101

• Does metformin prevent short-term oxidant-induced dna damage? In vitro study on lymphocytes from aged subjects.

  Journal of basic and clinical physiology and pharmacology 20070101

• [Insulin resistance in type 2 diabetes patients].

  Przeglad lekarski 20070101

• [No influence of imatinib on type 2 diabetes].

  Przeglad lekarski 20070101

• [Metformin-associated lactic acidosis and acute renal failure secondary to cardiac catheterism].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101

• The role of metformin in polycystic ovary syndrome: a systematic review.

  Human reproduction update 20070101

• Recognition of fasting or overall hyperglycaemia when starting insulin treatment in patients with type 2 diabetes in general practice.

  Scandinavian journal of primary health care 20070101

• [Pathogenetic treatment of non-alcoholic steatohepatitis: arguments, efficacy, safety].

  Terapevticheskii arkhiv 20070101

• [The effect of metformin on fasting and postprandial insulin secretion in obese patients with diabetes mellitus type 2].

  Srpski arhiv za celokupno lekarstvo 20070101

• Unmet needs in controlling metabolic disease.

  Reviews in cardiovascular medicine 20070101

• [Angioedema associated with enalapril].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

• Focus on metformin - a major cardiovascular medication. 'Diabesity - the biggest epidemic in human history'.

  Cardiovascular journal of Africa 20070101

• Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions.

  Annals of hepatology 20070101

• Effects of nateglinide and glibenclamide on prothrombotic factors in naïve type 2 diabetic patients treated with metformin: a 1-year, double-blind, randomized clinical trial.

  Internal medicine (Tokyo, Japan) 20070101

• Rosiglitazone : a review of its use in type 2 diabetes mellitus.

  Drugs 20070101

• [Metabolic and hemodynamic effects of combined treatment with metformine and rosiglitasone (avandium) in patients with diabetes mellitus type 2 and high cardiovascular risk].

  Terapevticheskii arkhiv 20070101

• Metabolic effects of rosiglitazone and metformin in Greek patients with recently diagnosed type 2 diabetes.

  In vivo (Athens, Greece) 20070101

• Metformin.

  Endocrine research 20070101

• Oral metformin-ascorbic acid co-administration ameliorates alcohol-induced hepatotoxicity in rats.

  Nigerian quarterly journal of hospital medicine 20070101

• Identification and treatment of prediabetes to prevent progression to type 2 diabetes.

  Clinical cornerstone 20070101

• Is exenatide improving the treatment of type 2 diabetes? Analysis of the individual clinical trials with exenatide.

  Reviews on recent clinical trials 20070101

• [Metformin and type 2 diabetes: the UKPDS experience].

  Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

• [Metformin, fifty years since the arrival of this molecule!].

  Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

• Metformin as first choice in oral diabetes treatment: the UKPDS experience.

  Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

• Oral hypoglycemic agents and heart.

  Indian heart journal 20070101

• Insulin sensitizers in treatment of nonalcoholic fatty liver disease: Systematic review.

  World journal of gastroenterology 20061228

• [Biguanides].

  Nihon rinsho. Japanese journal of clinical medicine 20061228

• [Change in ghrelin level with the amelioration of glucose and lipid metabolic disorder in OLETF rats].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218

• Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

  Biochemical pharmacology 20061215

• Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress.

  Mutation research 20061210

• [Metformine hydrochloride reduces both acanthosis nigricans and insulin resistance in Japanese young female].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20061210

• Management of hyperglycaemia in type 2 diabetes: the end of recurrent failure?

  BMJ (Clinical research ed.) 20061209

• Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

  The New England journal of medicine 20061207

• Thiazolidinediones for initial treatment of type 2 diabetes?

  The New England journal of medicine 20061207

• Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.

  Journal of applied physiology (Bethesda, Md. : 1985) 20061201

• Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

  Molecular pharmacology 20061201

• Contemporary medical therapy for polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20061201

• Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome.

  Fertility and sterility 20061201

• Determination of metformin based on amplification of its voltammetric response by a combination of molecular wire and carbon nanotubes.

  Analytical and bioanalytical chemistry 20061201

• A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe.

  Diabetic medicine : a journal of the British Diabetic Association 20061201

• Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus.

  Clinical endocrinology 20061201

• Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone.

  Diabetes care 20061201

• [Development of body weight during antidiabetic treatment].

  Deutsche medizinische Wochenschrift (1946) 20061201

• [Oral antidiabetic therapy].

  Deutsche medizinische Wochenschrift (1946) 20061201

• Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome.

  Metabolism: clinical and experimental 20061201

• Gaining: pediatric patients and use of atypical antipsychotics.

  The American journal of psychiatry 20061201

• A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents.

  The American journal of psychiatry 20061201

• Metformin reduces abortion in pregnant women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20061201

• Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061201

• What can the clinician do to improve implantation?

  Reproductive biomedicine online 20061201

• Tolerability and effectiveness of fluoxetine, metformin and sibutramine in reducing anthropometric and metabolic parameters in obese patients.

  Arquivos brasileiros de endocrinologia e metabologia 20061201

• Metformin: 50 years old, fit as a fiddle, and indispensable for its pivotal role in type 2 diabetes management.

  Diabetes & metabolism 20061201

• A proof of concept, preliminary study to determine the effect of Yogasnas in controlling type 2 diabetes mellitus in newly detected subjects (when compared to metformin monotherapy).

  The Journal of the Association of Physicians of India 20061201

• Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death.

  Neuroscience 20061117

• [Human insulin vs. analogs. What is the cost of supplementary insulin therapy?].

  MMW Fortschritte der Medizin 20061109

• Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.

  American journal of physiology. Endocrinology and metabolism 20061101

• Comment on: Evans JM, Ogston SA, Emslie-Smith A, Morris A (2006) risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

  Diabetologia 20061101

• Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column.

  Biomedical chromatography : BMC 20061101

• Metformin and early pregnancy?

  Fertility and sterility 20061101

• Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects.

  Journal of pharmaceutical sciences 20061101

• Comment on: Evans JMM, Ogston SA, Emslie-Smith A, Morris AD (2006) risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

  Diabetologia 20061101

• Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.

  Fertility and sterility 20061101

• Improvement in glycaemic control with rosiglitazone/metformin fixed-dose combination therapy in patients with type 2 diabetes with very poor glycaemic control.

  Diabetes, obesity & metabolism 20061101

• Initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

  Diabetes, obesity & metabolism 20061101

• Weight gain and insulin requirement in type 2 diabetic patients during the first year after initiating insulin therapy dependent on baseline BMI.

  Diabetes, obesity & metabolism 20061101

• Use of insulin sensitizing agents in the treatment of polycystic ovary syndrome.

  Fertility and sterility 20061101

• Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.

  Cancer research 20061101

• The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome.

  European journal of endocrinology 20061101

• Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes.

  Diabetes care 20061101

• Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

  Diabetes care 20061101

• [Prevention and treatment for development and progression of diabetic macroangiopathy with pioglitazone and metformin].

  Nihon rinsho. Japanese journal of clinical medicine 20061101

• Clinical inquiries. What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?

  The Journal of family practice 20061101

• Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061101

• [Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].

  Medicina intensiva 20061101

• Relationship of body size and shape to the development of diabetes in the diabetes prevention program.

  Obesity (Silver Spring, Md.) 20061101

• Metformin and antihypertensive therapy with drugs blocking the renin angiotensin system, a cause of concern?

  Clinical nephrology 20061101

• Changes in weight, papilledema, headache, visual field, and life status in response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia.

  Translational research : the journal of laboratory and clinical medicine 20061101

• Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20061101

• Metformin: now or later?

  Harvard health letter 20061101

• Prevention of diabetes: lifestyle and metformin are the way forward.

  BMJ (Clinical research ed.) 20061028

• [The practice guideline 'Diabetes mellitus type 2' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice].

  Nederlands tijdschrift voor geneeskunde 20061021

• [The practice guideline 'Diabetes mellitus type 2' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice].

  Nederlands tijdschrift voor geneeskunde 20061021

• Solid phase extraction--non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020

• Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose.

  The Cochrane database of systematic reviews 20061018

• Case records of the Massachusetts General Hospital. Case 31-2006. A 15-year-old girl with severe obesity.

  The New England journal of medicine 20061012

• Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.

  European journal of pharmacology 20061010

• Risk factors of vitamin B(12) deficiency in patients receiving metformin.

  Archives of internal medicine 20061009

• Polycystic ovarian syndrome--prognosis and outcomes.

  Best practice & research. Clinical obstetrics & gynaecology 20061001

• Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

• Transfer of metformin across the dually perfused human placental lobule.

  American journal of obstetrics and gynecology 20061001

• Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study.

  The Journal of clinical endocrinology and metabolism 20061001

• Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.

  British journal of pharmacology 20061001

• Incretin mimetics as a novel therapeutic option for hepatic steatosis.

  Liver international : official journal of the International Association for the Study of the Liver 20061001

• Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria.

  Journal of hypertension 20061001

• The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.

  Fertility and sterility 20061001

• Effect of metformin plus roziglitazone compared with metformin alone on glycaemic control in well-controlled Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20061001

• The effect of metformin on blood glucose control in overweight patients with Type 1 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20061001

• Ovarian stockpiling in polycystic ovary syndrome, infertility, and the combined use of rosiglitazone and metformin.

  Diabetes care 20061001

• Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naïve patients: response to Rosenstock et al.

  Diabetes care 20061001

• An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with meformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea: response to Barnett et al.

  Diabetes care 20061001

• [Metformin-associated lactic acidosis].

  Annales francaises d'anesthesie et de reanimation 20061001

• Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin.

  Saudi medical journal 20061001

• Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes.

  Current medical research and opinion 20061001

• Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study.

  Journal of drugs in dermatology : JDD 20061001

• The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20061001

• Metformin-associated lactic acidosis in a patient with vertebral artery dissection.

  Southern medical journal 20061001

• Starting insulin therapy in type 2 diabetes: twice-daily biphasic insulin Aspart 30 plus metformin versus once-daily insulin glargine plus glimepiride.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20061001

• Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes.

  Annals of the New York Academy of Sciences 20061001

• Some effect of metformin on insulin resistance in an infant with leprechaunism.

  Journal of pediatric endocrinology & metabolism : JPEM 20061001

• Acute renal failure from contrast medium: beware patients taking metformin..

  BMJ (Clinical research ed.) 20060923

• [The metabolic syndrome and sports].

  MMW Fortschritte der Medizin 20060921

• Strategies to reduce the risk of contrast-induced nephropathy.

  The American journal of cardiology 20060918

• [Intensified insulin therapy. Is there an alternative to BE count?].

  MMW Fortschritte der Medizin 20060914

• Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study.

  Journal of the American College of Cardiology 20060905

• Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells.

  Biology of reproduction 20060901

• Metformin treatment is effective in obese teenage girls with PCOS.

  Human reproduction (Oxford, England) 20060901

• The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.

  The Journal of clinical endocrinology and metabolism 20060901

• Changes in patient weight and the impact of antidiabetic therapy during the first 5 years after diagnosis of diabetes mellitus.

  Diabetologia 20060901

• Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels.

  Diabetologia 20060901

• Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.

  Diabetologia 20060901

• Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin.

  Journal of pineal research 20060901

• Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis.

  Fertility and sterility 20060901

• Rare case of metformin-induced leukocytoclastic vasculitis.

  The Annals of pharmacotherapy 20060901

• Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.

  European journal of endocrinology 20060901

• Glycaemic control without weight gain in insulin requiring type 2 diabetes: 1-year results of the GAME regimen.

  Diabetes, obesity & metabolism 20060901

• Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial.

  Diabetes, obesity & metabolism 20060901

• Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione.

  Diabetes, obesity & metabolism 20060901

• Inhaled insulin as adjunctive therapy in subjects with type 2 diabetes failing oral agents: a controlled proof-of-concept study.

  Diabetes, obesity & metabolism 20060901

• Should metformin be prescribed to overweight adolescents in whom dietary/behavioural modifications have not helped?

  Archives of disease in childhood 20060901

• Adherence to preventive medications: predictors and outcomes in the Diabetes Prevention Program.

  Diabetes care 20060901

• Neither LKB1 nor AMPK are the direct targets of metformin.

  Gastroenterology 20060901

• Reductions in biomarkers of cardiovascular risk in type 2 diabetes with rosiglitazone added to metformin compared with dose escalation of metformin: an EMPIRE trial sub-study.

  Current medical research and opinion 20060901

• [Four cases of lactic acidosis following metformin treatment].

  Lakartidningen 20060901

• Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20060901

• Predictors of metabolic control at one year in a population of pediatric patients with type 2 diabetes mellitus: a retrospective study.

  Journal of pediatric endocrinology & metabolism : JPEM 20060901

• Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy.

  European journal of pharmacology 20060821

• [Improved blood sugar control plus weight loss].

  MMW Fortschritte der Medizin 20060817

• Metformin treatment to prevent early puberty in girls with precocious pubarche.

  The Journal of clinical endocrinology and metabolism 20060801

• The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.

  Clinical nutrition (Edinburgh, Scotland) 20060801

• The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice.

  Molecular human reproduction 20060801

• Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin.

  Metabolism: clinical and experimental 20060801

• Total cellular calcium and magnesium content of cultured human peripheral blood mononuclear cells following exposure to antidiabetic drugs.

  Acta diabetologica 20060801

• An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin.

  Diabetes care 20060801

• Metformin-pioglitazone and metformin-rosiglitazone effects on non-conventional cardiovascular risk factors plasma level in type 2 diabetic patients with metabolic syndrome.

  Journal of clinical pharmacy and therapeutics 20060801

• Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes.

  Journal of internal medicine 20060801

• Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.

  Reproductive biomedicine online 20060801

• Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol.

  Journal of molecular endocrinology 20060801

• Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?

  The British journal of nutrition 20060801

• Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060801

• Acute alopecia due to metformin treatment for polycystic ovarian syndrome.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060801

• Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment.

  Endocrine 20060801

• Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.

  Endocrine 20060801

• Thailand diabetes registry project: glycemic control in Thai type 2 diabetes and its relation to hypoglycemic agent usage.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

• Metformin beyond diabetes: new life for an old drug.

  Current diabetes reviews 20060801

• Diagnosis and new approaches in the therapy of gestational diabetes mellitus.

  Current diabetes reviews 20060801

• Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease.

  World journal of gastroenterology 20060721

• Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C.

  Biochemical pharmacology 20060714

• Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

  Biochemical pharmacology 20060714

• Intestinal permeability of metformin using single-pass intestinal perfusion in rats.

  World journal of gastroenterology 20060707

• Combined renal replacement therapy for severe metformin-induced lactic acidosis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701

• Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20060701

• Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality.

  Human reproduction (Oxford, England) 20060701

• Adverse reactions to intravenous iodinated contrast media: a primer for radiologists.

  Emergency radiology 20060701

• Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome.

  Fertility and sterility 20060701

• Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin.

  Diabetologia 20060701

• Dominant Western health care: type 2 diabetes mellitus.

  Journal of transcultural nursing : official journal of the Transcultural Nursing Society 20060701

• Expanding role of AMPK in endocrinology.

  Trends in endocrinology and metabolism: TEM 20060701

• Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus.

  Diabetes, obesity & metabolism 20060701

• Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20060701

• Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin.

  Diabetes, obesity & metabolism 20060701

• Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model.

  Metabolism: clinical and experimental 20060701

• Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases.

  Drug discovery today 20060701

• Toxicology case of the month: oral hypoglycaemic overdose.

  Emergency medicine journal : EMJ 20060701

• Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women.

  Fertility and sterility 20060701

• Ovulation induction in women with polycystic ovary syndrome.

  Fertility and sterility 20060701

• Insulin-sensitizing agents in women with polycystic ovary syndrome.

  Fertility and sterility 20060701

• Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.

  Fertility and sterility 20060701

• Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.

  Clinical endocrinology 20060701

• Metformin therapy improves coronary microvascular function in patients with polycystic ovary syndrome and insulin resistance.

  Clinical endocrinology 20060701

• Case studies in swelling polymeric gastric retentive tablets.

  Expert opinion on drug delivery 20060701

• The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome--a randomised, double-blind, placebo-controlled trial.

  BJOG : an international journal of obstetrics and gynaecology 20060701

• Cheilitis - the only presentation of photosensitivity.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20060701

• A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study.

  Diabetic medicine : a journal of the British Diabetic Association 20060701

• Comparison of insulin lispro mixture 25/75 with insulin glargine during a 24-h standardized test-meal period in patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20060701

• Comparison of nateglinide and gliclazide in combination with metformin, for treatment of patients with Type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone.

  Diabetic medicine : a journal of the British Diabetic Association 20060701

• Beta-cell response to metformin-glibenclamide combination tablets (Glucovance) in patients with type 2 diabetes.

  International journal of clinical practice 20060701

• Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome.

  Prilozi 20060701

• Race and medication adherence in Medicaid enrollees with type-2 diabetes.

  Journal of the National Medical Association 20060701

• Use of metformin for ovulation induction in women who have polycystic ovary syndrome with or without evidence of insulin resistance.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20060701

• Pioglitazone: an antidiabetic drug with cardiovascular therapeutic effects.

  Expert review of cardiovascular therapy 20060701

• Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20060701

• Development and validation of RP-HPLC method for the analysis of metformin.

  Pakistan journal of pharmaceutical sciences 20060701

• Effect of N-benzoyl-D-phenylalanine and metformin on insulin receptors in neonatal streptozotocin-induced diabetic rats: studies on insulin binding to erythrocytes.

  Archives of physiology and biochemistry 20060701

• Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial.

  BMJ (Clinical research ed.) 20060624

• Drugs for anovulatory infertility in polycystic ovary syndrome.

  BMJ (Clinical research ed.) 20060624

• Patient characteristics not described.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060620

• Gerontology: eat your cake and have it.

  Nature 20060615

• Comparative efficacy of glimepiride and/or metformin with insulin in type 2 diabetes.

  Diabetes research and clinical practice 20060601

• A systematic review and meta-analysis of randomized controlled trials on metformin co-administration during gonadotrophin ovulation induction or IVF in women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20060601

• Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease.

  Human reproduction (Oxford, England) 20060601

• Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty.

  The Journal of clinical endocrinology and metabolism 20060601

• Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin.

  Human reproduction (Oxford, England) 20060601

• The use of metformin for women with PCOS undergoing IVF treatment.

  Human reproduction (Oxford, England) 20060601

• Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.

  Endocrinology 20060601

• A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus.

  Journal of pharmacokinetics and pharmacodynamics 20060601

• Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin.

  The Journal of clinical endocrinology and metabolism 20060601

• Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20060601

• Insulin-sensitizing agents in polycystic ovary syndrome.

  European journal of endocrinology 20060601

• An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.

  Diabetes care 20060601

• Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

  Cell metabolism 20060601

• Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.

  Gastroenterology 20060601

• Metformin and the fate of fat.

  Gastroenterology 20060601

• Effects of metformin on insulin resistance, androgen concentration, ovulation and pregnancy rates in women with polycystic ovary syndrome following laparoscopic ovarian drilling.

  The journal of obstetrics and gynaecology research 20060601

• [Insulin sensitizer--anti-diabetic drugs, metformin and pioglitazone that can improve insulin resistance].

  Nihon rinsho. Japanese journal of clinical medicine 20060601

• Metformin, vitamin E, and diet for patients with nonalcoholic fatty liver disease.

  The American journal of gastroenterology 20060601

• Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers.

  Best practice & research. Clinical endocrinology & metabolism 20060601

• Pregnancy complications in PCOS.

  Best practice & research. Clinical endocrinology & metabolism 20060601

• Thiazolidinedione derivatives in type 2 diabetes mellitus.

  The Netherlands journal of medicine 20060601

• Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance.

  Reproductive biomedicine online 20060601

• Incretin mimetics and dipeptidyl peptidase-IV inhibitors: a review of emerging therapies for type 2 diabetes.

  Diabetes technology & therapeutics 20060601

• Symptoms and treatments of polycystic ovary syndrome.

  British journal of nursing (Mark Allen Publishing) 20060601

• Glycemic control and treatment failure with pioglitazone versus glibenclamide in type 2 diabetes mellitus: a 42-month, open-label, observational, primary care study.

  Current medical research and opinion 20060601

• [Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060601

• Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20060601

• Female infertility.

  Clinical evidence 20060601

• [Therapeutic effects of insulin-sensitizing drugs on nonalcoholic fatty liver disease: experiment with rats].

  Zhonghua yi xue za zhi 20060516

• Apparent resolution of type 2 diabetes mellitus after initiation of potent antiretroviral therapy in a man from Africa with HIV infection.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060515

• Metformin versus rosiglitazone in the treatment of polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20060501

• Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin.

  Diabetologia 20060501

• To: Holstein A, Stumvoll M (2005) Contraindications can damage your health--is metformin a case in point? Diabetologia 48:2454-2459.

  Diabetologia 20060501

• Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome.

  Fertility and sterility 20060501

• Chemiluminescence determination of metformin based on hydroxyl radical reaction and molecularly imprinted polymer on-line enrichment.

  Analytical and bioanalytical chemistry 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective.

  Metabolism: clinical and experimental 20060501

• Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.

  Diabetes care 20060501

• Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance.

  Diabetes care 20060501

• Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure.

  Diabetes care 20060501

• Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.

  Fertility and sterility 20060501

• Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin.

  American journal of obstetrics and gynecology 20060501

• Effects of growth hormone treatment on neutrophil count in children born small for gestational age.

  Pediatrics 20060501

• Glumetza: once-a-day dosing for management of type 2 diabetes.

  The Nurse practitioner 20060501

• [Nephrotoxicity after the use of intravenous X-ray contrast media in a type 2 diabetic being treated with metformin].

  Ugeskrift for laeger 20060501

• Expanding applications for metformin in polycystic ovarian syndrome.

  The Journal of pediatrics 20060501

• Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome.

  The Journal of pediatrics 20060501

• Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060501

• Exenatide: an incretin mimetic for the treatment of type 2 diabetes mellitus.

  Clinical therapeutics 20060501

• The effects of combined insulin and metformin therapy in obese patients with diabetes mellitus type 2 in the early stage of the disease.

  Bosnian journal of basic medical sciences 20060501

• [Factors influencing homocysteineamia in type 2 diabetic patients].

  La Tunisie medicale 20060501

• Preventing nephropathy induced by contrast medium.

  The New England journal of medicine 20060427

• Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats.

  Life sciences 20060425

• Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture.

  European journal of pharmacology 20060424

• [Effect of fenofibrate and metformin on lipotoxicity in OLETF rat kidney].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060418

• Treatment of nonalcoholic fatty liver disease.

  World journal of gastroenterology 20060414

• Metformin and type 2 diabetes mellitus.

  Canadian family physician Medecin de famille canadien 20060410

• Hirsutism.

  The New England journal of medicine 20060406

• Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases.

  The Biochemical journal 20060401

• Transporters as a determinant of drug clearance and tissue distribution.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Effects of rosiglitazone and metformin on pancreatic beta cell gene expression.

  Diabetologia 20060401

• LKB1: a sweet side to Peutz-Jeghers syndrome?

  Trends in molecular medicine 20060401

• Use of an electronic medical record to detect patients at high risk of metformin-induced lactic acidosis.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060401

• Metformin extended release for the treatment of type 2 diabetes mellitus.

  Expert opinion on pharmacotherapy 20060401

• Optimal treatments for the metabolic syndrome.

  Arteriosclerosis, thrombosis, and vascular biology 20060401

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

  Diabetes 20060401

• Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes.

  Diabetes care 20060401

• The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program.

  Diabetes care 20060401

• Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin.

  Fertility and sterility 20060401

• Ovulation induction in infertile patients with polycystic ovary syndrome.

  Minerva ginecologica 20060401

• [From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target].

  Medecine sciences : M/S 20060401

• [Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].

  Medecine sciences : M/S 20060401

• Effects of metformin on the glycemic control, lipid profile, and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060401

• Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.

  Diabetic medicine : a journal of the British Diabetic Association 20060401

• Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease.

  Diabetic medicine : a journal of the British Diabetic Association 20060401

• Insulin secretion and sensitivity as determinants of HbA1c in type 2 diabetes.

  European journal of clinical investigation 20060401

• Study on a new precolumn derivatization method in the determination of metformin hydrochloride.

  Journal of chromatographic science 20060401

• No more surrogate end-points in randomised trials: the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene.

  The Australian & New Zealand journal of obstetrics & gynaecology 20060401

• Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial.

  Current medical research and opinion 20060401

• Outcome of clinical pregnancies after ovulation induction using metformin.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060401

• A simple method to evaluate the risk of heart failure during glitazone therapy.

  Diabetes technology & therapeutics 20060401

• Effect of metformin on survival rate in experimental sepsis.

  Diabetes & metabolism 20060401

• Ovulatory disorders and infertility.

  The Journal of reproductive medicine 20060401

• Elimination of metformin-croscarmellose sodium interaction by competition.

  International journal of pharmaceutics 20060327

• Dried blood spot liquid chromatography assay for therapeutic drug monitoring of metformin.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

• Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products.

  The international journal of biochemistry & cell biology 20060301

• Metformin prevents endotoxin-induced liver injury after partial hepatectomy.

  The Journal of pharmacology and experimental therapeutics 20060301

• Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial.

  The Journal of clinical endocrinology and metabolism 20060301

• Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

  Arteriosclerosis, thrombosis, and vascular biology 20060301

• Metformin-glibenclamide versus metformin plus rosiglitazone in patients with type 2 diabetes inadequately controlled on metformin monotherapy.

  Diabetes, obesity & metabolism 20060301

• Tissue-specific regulation of malonyl-CoA decarboxylase activity in OLETF rats.

  Diabetes, obesity & metabolism 20060301

• Differential effect of glimepiride and rosiglitazone on metabolic control of type 2 diabetic patients treated with metformin: a randomized, double-blind, clinical trial.

  Diabetes, obesity & metabolism 20060301

• Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.

  Diabetologia 20060301

• Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.

  Diabetologia 20060301

• Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome.

  Metabolism: clinical and experimental 20060301

• Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.

  The American journal of cardiology 20060301

• Metformin use and diabetic pregnancy-has its time come?

  Diabetic medicine : a journal of the British Diabetic Association 20060301

• Pregnancy in women with Type 2 diabetes: who takes metformin and what is the outcome?

  Diabetic medicine : a journal of the British Diabetic Association 20060301

• Effect of pregnancy on the pharmacokinetics of metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20060301

• Metformin-related vitamin B12 deficiency.

  Age and ageing 20060301

• Beneficial effect of metformin on pregnancy outcome in women with polycystic ovary syndrome is not associated with major changes in C-reactive protein levels or indices of coagulation.

  Fertility and sterility 20060301

• Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.

  Diabetes 20060301

• Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats.

  Diabetes 20060301

• Stability of body weight in type 2 diabetes.

  Diabetes care 20060301

• Treatment escalation and rise in HbA1c following successful initial metformin therapy.

  Diabetes care 20060301

• Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients.

  Diabetes care 20060301

• Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone.

  Reproduction (Cambridge, England) 20060301

• Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome.

  Archives of pediatrics & adolescent medicine 20060301

• Metformin and heart failure: innocent until proven guilty.

  Diabetes care 20060301

• Therapy of NAFLD: insulin sensitizing agents.

  Journal of clinical gastroenterology 20060301

• Metformin for prevention of weight gain and insulin resistance with olanzapine: a double-blind placebo-controlled trial.

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20060301

• Metformin-associated lactic acidosis treated with continuous renal replacement therapy.

  Clinical therapeutics 20060301

• Is metformin or clomiphene citrate more effective for ovulation induction in polycystic ovary syndrome?

  Nature clinical practice. Endocrinology & metabolism 20060301

• [Diagnosis of vitamin B12 deficiency revised].

  Nederlands tijdschrift voor geneeskunde 20060225

• Metformin use during the first trimester of pregnancy. Is it safe?

  Canadian family physician Medecin de famille canadien 20060210

• [Prevention of contrast nephropathy; guidelines from the Department Nephrology of the University Medical Centre Groningen].

  Nederlands tijdschrift voor geneeskunde 20060204

• Effect of ecdysterone on glucose metabolism in vitro.

  Life sciences 20060202

• Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio.

  Human reproduction (Oxford, England) 20060201

• Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20060201

• Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.

  Cardiovascular research 20060201

• The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1).

  Diabetologia 20060201

• Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

  Diabetologia 20060201

• Population pharmacokinetics of metformin in late pregnancy.

  Therapeutic drug monitoring 20060201

• Variability in renal clearance of substrates for renal transporters in chinese subjects.

  Journal of clinical pharmacology 20060201

• The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20060201

• Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes.

  The American journal of medicine 20060201

• Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

  Diabetes 20060201

• Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.

  Diabetes care 20060201

• Improving metabolic control leads to better working memory in adults with type 2 diabetes.

  Diabetes care 20060201

• Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program.

  Diabetes care 20060201

• Metformin in pregnancy: its time has not yet come.

  Diabetes care 20060201

• Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children.

  Journal of pediatric gastroenterology and nutrition 20060201

• Fulfilling our assignment to improve the health of all: good science just isn't enough.

  Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20060201

• Comparison of lipid profiles and lipoprotein a levels in patients with type 2 diabetes mellitus during oral hypoglycemic or insulin therapy.

  Saudi medical journal 20060201

• Understanding the causes and management of hirsutism.

  Nursing times 20060201

• Metformin increases insulin sensitivity and plasma beta-endorphin in human subjects.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060201

• Medication costs as a primary cause of nonadherence in the elderly.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060201

• A randomized controlled trial of the efficacy of rosiglitazone and clomiphene citrate versus metformin and clomiphene citrate in women with clomiphene citrate-resistant polycystic ovary syndrome.

  Fertility and sterility 20060201

• Insulin resistance and improvements in signal transduction.

  Endocrine 20060201

• [Metformin hydrochloride ameliorates adiponectin levels and insulin sensitivity in adolescents with metabolic syndrome].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20060201

• The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

  Journal of bioenergetics and biomembranes 20060201

• Pioglitazone/metformin (Actoplus met).

  The Medical letter on drugs and therapeutics 20060130

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20060125

• Effect of high-fat diet and metformin treatment on ventilation and sleep apnea in non-obese rats.

  Respiratory physiology & neurobiology 20060125

• [Traditional contraindications to the use of metformin -- more harmful than beneficial?].

  Deutsche medizinische Wochenschrift (1946) 20060120

• Review article: Drug therapy for non-alcoholic fatty liver disease.

  Alimentary pharmacology & therapeutics 20060115

• Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.

  American journal of physiology. Endocrinology and metabolism 20060101

• Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study.

  Human reproduction (Oxford, England) 20060101

• Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats.

  Pharmacological research 20060101

• Thyrotropin suppression by metformin.

  The Journal of clinical endocrinology and metabolism 20060101

• Biphasic insulin aspart 30 plus metformin: an effective combination in type 2 diabetes.

  Diabetes, obesity & metabolism 20060101

• Effects of metformin and oleic acid on adipocyte expression of resistin.

  Diabetes, obesity & metabolism 20060101

• Long-term glycaemic efficacy and weight changes associated with thiazolidinediones when added at an advanced stage of type 2 diabetes.

  Diabetes, obesity & metabolism 20060101

• Retrospective review of metformin in inpatients and outpatients at the University of Michigan.

  Diabetes care 20060101

• Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

  Diabetes 20060101

• Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein.

  Diabetes 20060101

• Diabetes treatments have differential effects on nontraditional cardiovascular risk factors.

  Journal of diabetes and its complications 20060101

• Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women.

  Human reproduction update 20060101

• Higher-order multiple pregnancy associated with metformin in women with polycystic ovary syndrome: two cases and review of the literature.

  Fertility and sterility 20060101

• Metformin-associated lactic acidosis precipitated by acute renal failure.

  The American journal of the medical sciences 20060101

• Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin.

  Seminars in dialysis 20060101

• Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children.

  The Journal of pediatrics 20060101

• Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.

  Diabetes/metabolism research and reviews 20060101

• Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats.

  Gynecologic and obstetric investigation 20060101

• Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060101

• Anti-diabetic drug use and the risk of motor vehicle crash in the elderly.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20060101

• [Glucose control in cardiac disease].

  Clinical research in cardiology : official journal of the German Cardiac Society 20060101

• An update on the Diabetes Prevention Program.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

• Can glycemic targets be achieved-- in particular with two daily injections of a mix of intermediate- and short-acting insulin?

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

• In vitro availability of metformin in presence of h(2) receptor antagonists.

  Pakistan journal of pharmaceutical sciences 20060101

• Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin.

  Diabetes/metabolism research and reviews 20060101

• Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin.

  Diabetes/metabolism research and reviews 20060101

• Combined n-benzoyl-d-phenylalanine and metformin treatment reverses changes in the fatty acid composition of streptozotocin diabetic rats.

  Journal of basic and clinical physiology and pharmacology 20060101

• The case for combination therapy as first-line treatment for the type 2 diabetic patient.

  Treatments in endocrinology 20060101

• Spotlight on pioglitazone in type 2 diabetes mellitus.

  Treatments in endocrinology 20060101

• [A clinical case of development of lactic acid acidosis in a diabetic patient taking metformin].

  Anesteziologiia i reanimatologiia 20060101

• AMPK or ZMPK?

  Medical hypotheses 20060101

• Cost-effectiveness of rosiglitazone combination therapy for the treatment of type 2 diabetes mellitus in the UK.

  PharmacoEconomics 20060101

• Cost-effectiveness of rosiglitazone oral combination for the treatment of type 2 diabetes in Germany.

  PharmacoEconomics 20060101

• Lifetime health consequences and cost-effectiveness of rosiglitazone in combination with metformin for the treatment of type 2 diabetes in Spain.

  PharmacoEconomics 20060101

• Polycystic ovary syndrome and metformin in pregnancy.

  Acta obstetricia et gynecologica Scandinavica 20060101

• Pharmacological and surgical intervention for the prevention of diabetes.

  Nestle Nutrition workshop series. Clinical & performance programme 20060101

• Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice.

  Reproduction, fertility, and development 20060101

• Assessment of prescribing information for generic drugs manufactured in the Middle East and marketed in Saudi Arabia.

  Annals of Saudi medicine 20060101

• The treatment of type 2 diabetes mellitus in youth : which therapies?

  Treatments in endocrinology 20060101

• Spontaneous singleton and twin pregnancy in two patients with polycystic ovary syndrome and type 2 diabetes following treatment with metformin combined with rosiglitazone.

  Annals of Saudi medicine 20060101

• Lack of pharmacokinetic interaction for ISIS 113715, a 2'-0-methoxyethyl modified antisense oligonucleotide targeting protein tyrosine phosphatase 1B messenger RNA, with oral antidiabetic compounds metformin, glipizide or rosiglitazone.

  Clinical pharmacokinetics 20060101

• Glycoprotein changes in non-insulin dependent diabetic rats: effect of N-benzoyl-D-phenylalanine and metformin.

  Therapie 20060101

• [Probability of control of the patient with diabetes exclusively treated with pharmacological therapy].

  Revista medica del Instituto Mexicano del Seguro Social 20060101

• Metformin and pioglitazone: Effectively treating insulin resistance.

  Current medical research and opinion 20060101

• A fixed-dose combination of pioglitazone and metformin: A promising alternative in metabolic control.

  Current medical research and opinion 20060101

• Relationship of oral antihyperglycemic (sulfonylurea or metformin) medication adherence and hemoglobin A1c goal attainment for HMO patients enrolled in a diabetes disease management program.

  Journal of managed care pharmacy : JMCP 20060101

• Effects of glibornuride versus metformin on eye lenses and skin in experimental diabetes.

  Arzneimittel-Forschung 20060101

• Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity.

  Reproduction, fertility, and development 20060101

• Course of glycaemia in poorly controlled type 2 diabetes patients 2.5 years after optimizing oral treatment in general practice.

  The European journal of general practice 20060101

• The use of insulin sensitising agents in ovulation induction in women with polycystic ovary syndrome.

  Hormones (Athens, Greece) 20060101

• Treatment of type 2 diabetes. Use of fixed-dose oral combinations.

  Postgraduate medicine 20060101

• The role of continuous renal replacement therapy in the treatment of poisoning.

  Seminars in dialysis 20060101

• Association of diet alone, insulin, sulfonylureas, metformin, and thiazolidinediones with the severity of coronary artery disease in patients with diabetes mellitus.

  American journal of therapeutics 20060101

• [Quality of ambulatory care of non-insulin dependent diabetic patients].

  Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20060101

• Polycystic ovary syndrome in adolescents: current and future treatment options.

  Paediatric drugs 20060101

• Pioglitazone/metformin.

  Drugs 20060101

• 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.

  Nucleosides, nucleotides & nucleic acids 20060101

• Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73.

  Journal of diabetes and its complications 20060101

• Update on the management of polycystic ovary syndrome.

  Pharmacological reports : PR 20060101

• Type 2 diabetes mellitus: a review of pharmacological treatment.

  Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20060101

• From the World Congress of Cardiology, Barcelona, 2006--Support for wider metformin usage in type 2 diabetes.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101

• Effects of rosiglitazone and pioglitazone combined with metformin on the prothrombotic state of patients with type 2 diabetes mellitus and metabolic syndrome.

  The Journal of international medical research 20060101

• Utilization of diabetes medication and cost of testing supplies in Saskatchewan, 2001.

  BMC health services research 20060101

• [Clinical, hormonal and biochemical changes after treatment with metformin and weight reduction in women with polycystic ovary syndrome].

  Akusherstvo i ginekologiia 20060101

• The role of metformin in the treatment of polycystic ovary syndrome (PCOS).

  Chang Gung medical journal 20060101

• Ovarian stimulation in polycystic ovarian syndrome.

  International surgery 20060101

• [Effect of 6-month treatment with oral antiandrogen alone and in combination with insulin sensitizers on body composition, hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS) in order to determine therapeutic strategy].

  Akusherstvo i ginekologiia 20060101

• Sudden reversible osmotic lens damage ('sugar cracks') after initiation of metformin.

  The New England journal of medicine 20051215

• The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

  Science (New York, N.Y.) 20051209

• The beneficial effects of insulin and metformin on in vitro developmental potential of porcine oocytes and embryos.

  Biology of reproduction 20051201

• The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20051201

• Rosiglitazone treatment increases subcutaneous adipose tissue glucose uptake in parallel with perfusion in patients with type 2 diabetes: a double-blind, randomized study with metformin.

  The Journal of clinical endocrinology and metabolism 20051201

• [Therapeutic options for nonalcoholic fatty liver disease and steatohepatitis].

  Der Internist 20051201

• Long-term effects on lipids and lipoproteins of pioglitazone versus gliclazide addition to metformin and pioglitazone versus metformin addition to sulphonylurea in the treatment of type 2 diabetes.

  Diabetologia 20051201

• Contraindications can damage your health--is metformin a case in point?

  Diabetologia 20051201

• Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

  Diabetologia 20051201

• Type 2 diabetes mellitus in youth: the complete picture to date.

  Pediatric clinics of North America 20051201

• Insulin analogues in children and teens with type 1 diabetes: advantages and caveats.

  Pediatric clinics of North America 20051201

• Oral agents in managing diabetes mellitus in children and adolescents.

  Pediatric clinics of North America 20051201

• Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic?

  European journal of obstetrics, gynecology, and reproductive biology 20051201

• Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndrome.

  Clinical endocrinology 20051201

• Effects of rosiglitazone added to submaximal doses of metformin compared with dose escalation of metformin in type 2 diabetes: the EMPIRE Study.

  Current medical research and opinion 20051201

• [Effects of metformin on fatty liver in insulin-resistant rats].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20051201

• Description and preliminary evaluation of a Multiagent Intelligent Dosing System (MAIDS) to manage combination insulin-oral agent therapy in type 2 diabetes.

  Diabetes technology & therapeutics 20051201

• [Metformin in the treatment of type 2 diabetes in overweighted or obese patients].

  Anales de medicina interna (Madrid, Spain : 1984) 20051201

• The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome.

  Journal of endocrinological investigation 20051201

• Management of the metabolic syndrome.

  Panminerva medica 20051201

• Possible metformin-induced hepatotoxicity.

  The American journal of geriatric pharmacotherapy 20051201

• [Advance in treatment of polycystic ovary syndrome].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20051201

• [Effects of metformin on endothelial dysfunction of the renal circulation resulting from acute hyperglycemia in non-diabetic rabbits].

  Arquivos brasileiros de endocrinologia e metabologia 20051201

• Glycaemic control in type 2 diabetes.

  Clinical evidence 20051201

• Polycystic ovary syndrome.

  Clinical evidence 20051201

• Medicine. Cancer-suppressing enzyme adds a link to type 2 diabetes.

  Science (New York, N.Y.) 20051125

• Identification of potential caloric restriction mimetics by microarray profiling.

  Physiological genomics 20051117

• New drugs.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051115

• Inflammatory markers and the metabolic syndrome.

  Atherosclerosis 20051101

• Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study.

  The Journal of clinical endocrinology and metabolism 20051101

• Combination therapy using metformin or thiazolidinediones and insulin in the treatment of diabetes mellitus.

  Diabetes, obesity & metabolism 20051101

• Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents.

  Diabetes, obesity & metabolism 20051101

• Treating insulin resistance in type 2 diabetes with metformin and thiazolidinediones.

  Diabetes, obesity & metabolism 20051101

• Review article: the treatment of fatty liver disease associated with the metabolic syndrome.

  Alimentary pharmacology & therapeutics 20051101

• Autosampler programming for improved sample throughput in liquid chromatography/mass spectrometry.

  Clinical chemistry 20051101

• Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.

  Journal of mass spectrometry : JMS 20051101

• Insulin-sensitisers in the treatment of polycystic ovary syndrome.

  Expert opinion on pharmacotherapy 20051101

• Effect of metformin on the growth hormone response to growth hormone-releasing hormone in obese women with polycystic ovary syndrome.

  Fertility and sterility 20051101

• Glumetza offers once-a-day dosing for type 2 diabetes patients.

  The Nurse practitioner 20051101

• Lactic acidosis. Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus.

  Geriatrics 20051101

• Impact of metformin therapy in patients with polycystic ovarian syndrome.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051101

• Simultaneous determination of metformin and glimepride in pharmaceutical dosage form by reverse-phase liquid chromatography.

  Journal of separation science 20051101

• Drug treatment of type 2 diabetes in adults.

  Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20051101

• The 'worried-well', insulin resistance and metformin therapy.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20051101

• Metformin: old wine in new bottle--evolving technology and therapy in diabetes.

  The Journal of the Association of Physicians of India 20051101

• Drug therapy in prediabetes.

  Journal of the Indian Medical Association 20051101

• Prevention of type 2 diabetes in the prediabetic population.

  Journal of the Indian Medical Association 20051101

• Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression.

  Life sciences 20051007

• The Diabetes Prevention Program and the metabolic syndrome.

  Annals of internal medicine 20051004

• The Diabetes Prevention Program and the metabolic syndrome.

  Annals of internal medicine 20051004

• Antidiabetic therapy and the risk of heart failure in type 2 diabetic patients: an independent effect or confounding by indication.

  Pharmacoepidemiology and drug safety 20051001

• A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.

  Human reproduction (Oxford, England) 20051001

• Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetes.

  Diabetes research and clinical practice 20051001

• Rosiglitazone effects on blood pressure and metabolic parameters in nondipper diabetic patients.

  Diabetes research and clinical practice 20051001

• Patient-tailored conventional ovulation induction algorithms in anovulatory infertility.

  Trends in endocrinology and metabolism: TEM 20051001

• Acute myopathy in a type 2 diabetic patient on combination therapy with metformin, fenofibrate and rosiglitazone.

  Diabetologia 20051001

• Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20051001

• Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.

  Fundamental & clinical pharmacology 20051001

• Rosiglitazone plus metformin is effective and well tolerated in clinical practice: results from large observational studies in people with type 2 diabetes.

  International journal of clinical practice 20051001

• Improved clinical outcomes associated with metformin in patients with diabetes and heart failure.

  Diabetes care 20051001

• Metformin and heart failure: innocent until proven guilty.

  Diabetes care 20051001

• Metformin alters insulin signaling and viability of human granulosa cells.

  Fertility and sterility 20051001

• Metformin.

  Nursing times 20051001

• Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

  Drug metabolism and pharmacokinetics 20051001

• Cancer protection.

  Harvard health letter 20051001

• Insulin in type 2 diabetes: a useful alternative despite limited assessment based on surrogate endpoints.

  Prescrire international 20051001

• Effects of insulin sensitizers on islet transplantation.

  Transplantation proceedings 20051001

• Triple therapy with glimepiride in patients with type 2 diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study.

  Clinical therapeutics 20051001

• Rosiglitazone/metformin fixed-dose combination compared with uptitrated metformin alone in type 2 diabetes mellitus: a 24-week, multicenter, randomized, double-blind, parallel-group study.

  Clinical therapeutics 20051001

• Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study.

  Clinical therapeutics 20051001

• Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection.

  The journal of the Royal College of Physicians of Edinburgh 20051001

• Determination of metformin in human plasma by high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• [Metformin for type-2 diabetes mellitus. Systematic review and meta-analysis].

  Atencion primaria 20050915

• [The rehabilitation of metformin].

  Atencion primaria 20050915

• Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.

  Journal of ethnopharmacology 20050914

• [Metformin-associated lactic acidosis in a patient with pre-existing risk factors].

  Praxis 20050907

• Summaries for patients. HIV lipodystrophy: rosiglitazone or metformin?

  Annals of internal medicine 20050906

• Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial.

  Annals of internal medicine 20050906

• Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.

  European journal of pharmacology 20050905

• High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception.

  Human reproduction (Oxford, England) 20050901

• Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF.

  Human reproduction (Oxford, England) 20050901

• Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD): study design and protocol.

  Diabetologia 20050901

• Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20050901

• Insulin initiation in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20050901

• Management of diabetes during Ramadan.

  Diabetic medicine : a journal of the British Diabetic Association 20050901

• Metformin improves endothelial function in patients with metabolic syndrome.

  Journal of internal medicine 20050901

• Stockpiling of ovarian follicles and the response to rosiglitazone.

  Diabetes care 20050901

• Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050901

• Bioequivalence studies with metformin: comparability of reference tablets from different origins.

  International journal of clinical pharmacology and therapeutics 20050901

• Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.

  Fertility and sterility 20050901

• Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial.

  Fertility and sterility 20050901

• The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.

  Molecular cancer therapeutics 20050901

• Metformin as treatment for overweight and obese adults: a systematic review.

  Annals of family medicine 20050901

• Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART.

  Acta dermatovenerologica Alpina, Pannonica, et Adriatica 20050901

• Insulin resistance in polycystic ovarian disease.

  Southern medical journal 20050901

• Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.

  Obesity research 20050901

• Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial.

  Clinical therapeutics 20050901

• The effects of rosiglitazone and metformin on menstrual cyclicity and hirsutism in polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050901

• Metformin's contraindications should be contraindicated.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050830

• Metformin's contraindications: needed for now.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050830

• [Triple oral therapy in type 2 diabetes].

  Revue medicale suisse 20050824

• Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.

  European journal of pharmacology 20050822

• [Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences].

  Ugeskrift for laeger 20050822

• Summaries for patients. The outcomes and costs of diabetes prevention with a diet and exercise program or metformin: a computer model.

  Annals of internal medicine 20050816

• Clinical outcomes and cost-effectiveness of strategies for managing people at high risk for diabetes.

  Annals of internal medicine 20050816

• Safety of metformin use during the first trimester.

  Canadian family physician Medecin de famille canadien 20050810

• [Type 2 diabetic patient with reduced beta-cell function. New substance class: incretin-mimetics].

  MMW Fortschritte der Medizin 20050804

• Metformin and weight loss in obese women with polycystic ovary syndrome: comparison of doses.

  The Journal of clinical endocrinology and metabolism 20050801

• Effect of buformin and metformin on formation of advanced glycation end products by methylglyoxal.

  Clinica chimica acta; international journal of clinical chemistry 20050801

• Drugs for diabetes.

  Treatment guidelines from the Medical Letter 20050801

• Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide.

  Diabetic medicine : a journal of the British Diabetic Association 20050801

• Comparison of metabolic effects of pioglitazone, metformin, and glimepiride over 1 year in Japanese patients with newly diagnosed Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20050801

• Insulin pump therapy vs. multiple daily injections in obese Type 2 diabetic patients.

  Diabetic medicine : a journal of the British Diabetic Association 20050801

• Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20050801

• Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year.

  Diabetes care 20050801

• Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone.

  Diabetes 20050801

• Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin.

  Diabetes 20050801

• Usefulness of the addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus.

  Pediatrics international : official journal of the Japan Pediatric Society 20050801

• Pioglitazone, rosiglitazone, and rosiglitazone + metformin: new drugs. Glitazone + oral antidiabetic combination: inadequately evaluated.

  Prescrire international 20050801

• The patient with polycystic ovary syndrome.

  The Practitioner 20050801

• Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice.

  Endocrine journal 20050801

• Markedly improved glycemic control and enhanced insulin sensitivity in a patient with type 2 diabetes complicated by a suprasellar tumor treated with pioglitazone and metformin.

  Internal medicine (Tokyo, Japan) 20050801

• Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20050801

• In vitro and in vivo evaluation of two extended release preparations of combination metformin and glipizide.

  Drug development and industrial pharmacy 20050801

• Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury.

  The Journal of trauma 20050801

• Evaluation of efficacy and safety of fixed dose combination of glimepiride 2 mg pluspioglitazone 15 mg plus metformin SR 500 mg in the management of patients with type-2 diabetes mellitus.

  Journal of the Indian Medical Association 20050801

• Metformin monotherapy for type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20050720

• Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20050701

• Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20050701

• Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

  The Journal of biological chemistry 20050701

• Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20050701

• Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050701

• Metformin treatment of PCOS during adolescence and the reproductive period.

  European journal of obstetrics, gynecology, and reproductive biology 20050701

• The effect of metformin and rosiglitazone on postprandial lipid metabolism in obese insulin-resistant subjects.

  Diabetes, obesity & metabolism 20050701

• Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets.

  The Journal of pharmacy and pharmacology 20050701

• Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin?

  Diabetic medicine : a journal of the British Diabetic Association 20050701

• Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.

  Diabetes 20050701

• Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.

  Diabetes 20050701

• Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

  Diabetes 20050701

• Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project.

  Diabetes care 20050701

• Felodipine-influenced gingival enlargement in an uncontrolled type 2 diabetic patient.

  Journal of periodontology 20050701

• [HPLC determination of metformin hydrochloride-related substances].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050701

• Metformin prevents the impairment of endothelium-dependent vascular relaxation induced by high glucose challenge in rabbit isolated perfused kidneys.

  Naunyn-Schmiedeberg's archives of pharmacology 20050701

• Regulation of SNARK activity in response to cellular stresses.

  Biochimica et biophysica acta 20050620

• [Medical management of primary nonalcoholic fatty liver disease].

  Medicina clinica 20050618

• Metformin and reduced risk of cancer in diabetic patients.

  BMJ (Clinical research ed.) 20050604

• [What dosage of antidiabetics?].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050602

• Severe metformin intoxication with lactic acidosis in an adolescent.

  European journal of pediatrics 20050601

• Neutrophil count in small-for-gestational age children: contrasting effects of metformin and growth hormone therapy.

  The Journal of clinical endocrinology and metabolism 20050601

• Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.

  Human reproduction (Oxford, England) 20050601

• Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

  Diabetologia 20050601

• Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes.

  Diabetologia 20050601

• Is metformin therapy for polycystic ovary syndrome safe during pregnancy?

  Basic & clinical pharmacology & toxicology 20050601

• Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial.

  Contemporary clinical trials 20050601

• Efficacy and safety of hypoglycemic drugs in children with type 2 diabetes mellitus.

  Pharmacotherapy 20050601

• Secondary failure rates associated with metformin and sulfonylurea therapy for type 2 diabetes mellitus.

  Pharmacotherapy 20050601

• Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells.

  Metabolism: clinical and experimental 20050601

• Excretion of metformin into breast milk and the effect on nursing infants.

  Obstetrics and gynecology 20050601

• The 'worried-well', insulin resistance and metformin therapy.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050601

• Insulin-sensitizers may protect against CHF.

  Health news (Waltham, Mass.) 20050601

• Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice.

  Bulletin of experimental biology and medicine 20050601

• [Insulin sensitizers in the treatment of polycystic ovary].

  Ginecologia y obstetricia de Mexico 20050601

• [Treatment experience with metformin in polycystic ovary syndrome].

  Orvosi hetilap 20050522

• Effectiveness and side effects of thiazolidinediones for type 2 diabetes.

  The Medical journal of Australia 20050502

• Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue.

  American journal of physiology. Endocrinology and metabolism 20050501

• The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20050501

• Role of insulin secretagogues and insulin sensitizing agents in the prevention of cardiovascular disease in patients who have diabetes.

  Cardiology clinics 20050501

• A catalytic multi-pumping flow system for the chemiluminometric determination of metformin.

  Analytical and bioanalytical chemistry 20050501

• Therapeutic approaches to combating lipoatrophy: do they work?

  The Journal of antimicrobial chemotherapy 20050501

• Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study.

  Heart (British Cardiac Society) 20050501

• A randomized study of orlistat in combination with a weight management programme in obese patients with Type 2 diabetes treated with metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20050501

• Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial.

  Diabetic medicine : a journal of the British Diabetic Association 20050501

• Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20050501

• Patients with Type 2 diabetes treated with metformin: prevalence of contraindications and their correlation with discontinuation.

  Diabetic medicine : a journal of the British Diabetic Association 20050501

• A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease.

  The American journal of gastroenterology 20050501

• Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

  Diabetes 20050501

• Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance.

  Diabetes 20050501

• Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes.

  Diabetes care 20050501

• Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea.

  Diabetes care 20050501

• Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.

  Diabetes care 20050501

• Effect on glycemic control of the addition of 2.5 mg glipizide GITS to metformin in patients with T2DM.

  Diabetes research and clinical practice 20050501

• Placental passage of metformin in women with polycystic ovary syndrome.

  Fertility and sterility 20050501

• Metformin administration improves endothelial function in women with polycystic ovary syndrome.

  European journal of endocrinology 20050501

• The fatty liver and insulin resistance.

  Current molecular medicine 20050501

• Antithrombotic effects of rosiglitazone-metformin versus glimepiride-metformin combination therapy in patients with type 2 diabetes mellitus and metabolic syndrome.

  Pharmacotherapy 20050501

• A site-specific controlled-release system for metformin.

  The Journal of pharmacy and pharmacology 20050501

• [Study on the effect of qinggan jiangtang tablet in improving the insulin resistance in patients with multiple metabolic syndrome].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501

• Metformin: an advance in ovulation induction.

  Irish medical journal 20050501

• Efficacy of once- or twice-daily extended release metformin compared with thrice-daily immediate release metformin in type 2 diabetes mellitus.

  The Journal of the Association of Physicians of India 20050501

• [Use of oral lipid-lowering drugs in patients with type-2 diabetes mellitus].

  Atencion primaria 20050430

• [Therapy with oral antidiabetic agents -- special considerations in the case of coronary heart disease].

  Deutsche medizinische Wochenschrift (1946) 20050429

• [Controversial therapeutic strategies in the treatment of type 2 diabetes mellitus].

  MMW Fortschritte der Medizin 20050428

• Summaries for patients. The effect of diet and exercise or metformin on the metabolic syndrome.

  Annals of internal medicine 20050419

• The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial.

  Annals of internal medicine 20050419

• Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study.

  Human reproduction (Oxford, England) 20050401

• Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.

  The Journal of clinical endocrinology and metabolism 20050401

• What mediates the benefits associated with dipeptidyl peptidase-IV inhibition?

  Diabetologia 20050401

• Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20050401

• Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20050401

• Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.

  Diabetes care 20050401

• Renal status among patients using metformin in a primary care setting.

  Diabetes care 20050401

• Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism.

  Diabetes 20050401

• Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.

  Diabetes 20050401

• A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20050401

• [Metformin-induced cholestatic hepatitis].

  Gastroenterologia y hepatologia 20050401

• Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats.

  Diabetes research and clinical practice 20050401

• Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment.

  European journal of endocrinology 20050401

• [Perioperative treatment of patients with Diabetes mellitus].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20050401

• Research profile. Treating prediabetes. Exercise, metformin, or both? Barry Braun, PhD.

  Diabetes forecast 20050401

• Medicaid managed care: disparities in the use of thiazolidinediones compared with metformin.

  Journal of the National Medical Association 20050401

• Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20050401

• The management of type II diabetes.

  SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20050401

• The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

• Polycystic ovary syndrome.

  The New England journal of medicine 20050324

• [Cardiovascular risk to be considered. Proinsulin test for stage-adjusted therapy].

  MMW Fortschritte der Medizin 20050310

• Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20050301

• Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin?

  Intensive care medicine 20050301

• Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels.

  European heart journal 20050301

• Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells.

  International journal of molecular medicine 20050301

• Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone.

  Diabetes, obesity & metabolism 20050301

• Effects of metformin on the body composition in subjects with risk factors for type 2 diabetes.

  Diabetes, obesity & metabolism 20050301

• Improvement of glycaemic control with rebound following orlistat initiation and cessation associated with minimal weight change.

  Diabetic medicine : a journal of the British Diabetic Association 20050301

• Low-dose metformin improves hyperglycaemia related to myotonic dystrophy.

  Diabetic medicine : a journal of the British Diabetic Association 20050301

• Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study.

  Diabetes care 20050301

• The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20050301

• Summaries for patients. The cost-effectiveness of strategies to prevent type 2 diabetes.

  Annals of internal medicine 20050301

• The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance.

  Annals of internal medicine 20050301

• Antihyperglycemics during the perioperative period.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050301

• Intensive care treatment of severe mixed metabolic acidosis.

  Acta anaesthesiologica Scandinavica 20050301

• Glycemic management of type 2 diabetes: an emerging strategy with oral agents, insulins, and combinations.

  Endocrinology and metabolism clinics of North America 20050301

• Insulin monotherapy vs. combination therapy.

  American family physician 20050301

• Polycystic ovary syndrome--a management update.

  Australian family physician 20050301

• Effect of N-benzoyl-D-phenylalanine on streptozotocin-induced changes in the lipid and lipoprotein profile in rats.

  The Journal of pharmacy and pharmacology 20050301

• Diabetes in the new General Medical Services contract: targets and adherence to metformin therapy.

  International journal of clinical practice 20050301

• Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats.

  Human & experimental toxicology 20050301

• [Specific aspects of diabetes management in the elderly].

  MMW Fortschritte der Medizin 20050217

• Diabetes mellitus in a domesticated Spanish mustang.

  Journal of the American Veterinary Medical Association 20050215

• Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study.

  Circulation 20050208

• [Nothing here follows protocol F. Elderly diabetic patients are not 'DMP qualified'].

  MMW Fortschritte der Medizin 20050203

• Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome.

  The Journal of clinical endocrinology and metabolism 20050201

• Determinants of subclinical diabetic heart disease.

  Diabetologia 20050201

• Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury.

  Annals of surgery 20050201

• Combined use of metformin and ethinyl estradiol-cyproterone acetate in polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20050201

• Regarding the use of HOMA to aid drug selection.

  Diabetic medicine : a journal of the British Diabetic Association 20050201

• Educational intervention: a tool for decreasing medication errors.

  International journal for quality in health care : journal of the International Society for Quality in Health Care 20050201

• Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes.

  Diabetes care 20050201

• Initiating insulin therapy in type 2 Diabetes: a comparison of biphasic and basal insulin analogs.

  Diabetes care 20050201

• Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes.

  Diabetes care 20050201

• Clinical inquiries. Do insulin-sensitizing drugs increase ovulation rates for women with PCOS?

  The Journal of family practice 20050201

• Differential regulation of insulin action and tumor necrosis factor alpha system activity by metformin.

  Metabolism: clinical and experimental 20050201

• [Study on therapeutic effects of metformin on rat fatty livers induced by high fat feeding].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

• [Drug therapy for nonalcoholic fatty liver disease].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

• Which oral drug is right for your type 2 diabetes? New thinking on oral drug combinations that can provide better glycemic control.

  Health news (Waltham, Mass.) 20050201

• Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome.

  European journal of endocrinology 20050201

• Thiazolidinediones for treatment of polycystic ovary syndrome.

  Pharmacotherapy 20050201

• The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050201

• [Pathophysiological conditions progressing from impaired glucose tolerance: type 2 diabetes mellitus].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• [Characteristic of metformin for treatment of impaired glucose tolerance].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• [Diabetes prevention program (metformin)].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• [Diet therapy for impaired glucose tolerance].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• [Therapies for newly-onset diabetic patients].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• [Treatment for coronary artery disease patients with impaired glucose tolerance].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• Metformin transport by renal basolateral organic cation transporter hOCT2.

  Pharmaceutical research 20050201

• Use of metformin in pregnancies with diabetes: a case series from India.

  The Journal of the Association of Physicians of India 20050201

• Pioglitazone in a subgroup of patients with type 2 diabetes meeting the criteria for metabolic syndrome.

  International journal of clinical practice 20050201

• [DIGAMI 2: breaking the spell of insulin for heart infarct. Re the article in DMW 45/2004].

  Deutsche medizinische Wochenschrift (1946) 20050128

• Development and validation for high selective quantitative determination of metformin in human plasma by cation exchanging with normal-phase LC/MS/MS.

  Journal of pharmaceutical and biomedical analysis 20050104

• Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study.

  Diabetes/metabolism research and reviews 20050101

• Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy.

  The Journal of clinical endocrinology and metabolism 20050101

• Comparison of the effects of acarbose and metformin use on ovulation rates in clomiphene citrate-resistant polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20050101

• Pharmacologic prevention or delay of type 2 diabetes mellitus.

  The Annals of pharmacotherapy 20050101

• Metformin-diet benefits in women with polycystic ovary syndrome in the bottom and top quintiles for insulin resistance.

  Metabolism: clinical and experimental 20050101

• Effect of N-benzoyl-D-phenylalanine and metformin on carbohydrate metabolic enzymes in neonatal streptozotocin diabetic rats.

  Clinica chimica acta; international journal of clinical chemistry 20050101

• The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients.

  Human reproduction (Oxford, England) 20050101

• Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial.

  Journal of internal medicine 20050101

• Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting.

  Diabetes care 20050101

• Islet adaptation to insulin resistance: mechanisms and implications for intervention.

  Diabetes, obesity & metabolism 20050101

• Efficacy, dose-response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic control despite prior treatment with diet and exercise: results from two double-blind, placebo-controlled studies.

  Diabetes, obesity & metabolism 20050101

• Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome.

  The Journal of endocrinology 20050101

• Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment.

  Fertility and sterility 20050101

• Metabolic syndrome: evaluation of pathological and therapeutic outcomes.

  American heart journal 20050101

• Insulin sensitizers: past, present and future.

  Mymensingh medical journal : MMJ 20050101

• Effects of a combination of rhGH and metformin on adiponectin levels in patients with metabolic syndrome.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050101

• Metformin monotherapy in lean women with polycystic ovary syndrome.

  Reproductive biomedicine online 20050101

• [Clinicogenetic aspects of carbohydrate metabolism disorders and efficacy of their correction with moxonidine and metformine in patients with arterial hypertension].

  Terapevticheskii arkhiv 20050101

• Trends in the prevalence and management of diagnosed type 2 diabetes 1994-2001 in England and Wales.

  BMC family practice 20050101

• AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome.

  Medical hypotheses 20050101

• Effect of pioglitazone on metabolic syndrome risk factors: results of double-blind, multicenter, randomized clinical trials.

  Current medical research and opinion 20050101

• Long-term effect of glimepiride and rosiglitazone on non-conventional cardiovascular risk factors in metformin-treated patients affected by metabolic syndrome: a randomized, double-blind clinical trial.

  The Journal of international medical research 20050101

• Steady-state pharmacokinetics of a novel extended-release metformin formulation.

  Clinical pharmacokinetics 20050101

• [Metformin for the treatment of polycystic ovary syndrome].

  Akusherstvo i ginekologiia 20050101

• Rosiglitazone/Metformin.

  Drugs 20050101

• [Insulin sensitizers].

  Revue medicale de Liege 20050101

• [Towards a tripple oral therapy in the pharmacological treatment of type 2 diabetes?].

  Revue medicale de Liege 20050101

• Exenatide.

  Drugs 20050101

• Presentation of polycystic ovary syndrome and its management with clomiphene alone and in combination with metformin.

  Journal of Ayub Medical College, Abbottabad : JAMC 20050101

• Effects of metformin combined with cyproterone acetate on clinical features, endocrine and metabolism of non-obese women with polycystic ovarian syndrome.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

  Experimental gerontology 20050101

• Metformin extended release: metformin gastric retention, metformin GR, metformin XR.

  Drugs in R&D 20050101

• Effect of N-benzoyl-D-phenylalanine, a new potential oral antidiabetic agent, in neonatal streptozotocin-induced diabetes in rats.

  Pharmacological reports : PR 20050101

• Manufacturing violations prompt seizure of Paxil CR, Avandamet.

  FDA consumer 20050101

• Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20050101

• Estimation of pioglitazone hydrochloride and metformin hydrochloride in tablets by derivative spectrophotometry and liquid chromatographic methods.

  Journal of AOAC International 20050101

• Metformin lactic acidosis and anaesthesia: myth or reality?

  Acta anaesthesiologica Belgica 20050101

• Polycystic ovary syndrome (PCOS) in the adolescent patient: recommendations for practice.

  Pediatric nursing 20050101

• Willingness to pay for inhaled insulin: a contingent valuation approach.

  PharmacoEconomics 20050101

• [Molecular action of insulin-sensitizing agents].

  Endokrynologia Polska 20050101

• [Follow-up of the use of metformin among the high risk population].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

• Diabetes associated with atypical antipsychotic treatment may be severe but reversible: case report.

  International journal of psychiatry in medicine 20050101

• [Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].

  Terapevticheskii arkhiv 20050101

• Role of metformin in correcting hyperinsulinemia, menstrual irregularity and anovulation in polycystic ovary syndrome.

  Journal of Ayub Medical College, Abbottabad : JAMC 20050101

• Response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia.

  MedGenMed : Medscape general medicine 20050101

• Case 25-2004: a woman with severe obesity, diabetes, and hypertension.

  The New England journal of medicine 20041223

• [Rosiglitazone-metformin fixed dose combination for treatment of type 2 diabetes].

  Presse medicale (Paris, France : 1983) 20041218

• Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements?

  Human reproduction (Oxford, England) 20041201

• Effect of metformin vs. placebo treatment on serum fatty acids in non-diabetic obese insulin resistant individuals.

  Prostaglandins, leukotrienes, and essential fatty acids 20041201

• Metformin in polycystic ovary syndrome.

  Current opinion in obstetrics & gynecology 20041201

• [Oral diabetes treatment. Which substance is indicated at which time?].

  Der Internist 20041201

• Augmented metabolic control improves myocardial diastolic function and perfusion in patients with non-insulin dependent diabetes.

  Heart (British Cardiac Society) 20041201

• Metformin therapy in women with polycystic ovary syndrome.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20041201

• Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): treatment.

  Best practice & research. Clinical gastroenterology 20041201

• Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

  Diabetes 20041201

• Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes.

  Diabetes care 20041201

• Real world effectiveness of rosiglitazone added to maximal (tolerated) doses of metformin and a sulphonylurea agent: response to Roy et al.

  Diabetes care 20041201

• Alpha-lipoic acid, an anti-obesity agent?

  Expert opinion on investigational drugs 20041201

• Enhancement of insulin-stimulated myocardial glucose uptake in patients with Type 2 diabetes treated with rosiglitazone.

  Diabetic medicine : a journal of the British Diabetic Association 20041201

• Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trial.

  The Journal of clinical endocrinology and metabolism 20041201

• Retrobulbar injection of methylprednisolone in diffuse diabetic macular edema.

  Retina (Philadelphia, Pa.) 20041201

• Link between metformin and lactic acidosis?

  American family physician 20041201

• Radical-induced oxidation of metformin.

  European journal of biochemistry 20041201

• Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes.

  American heart journal 20041201

• Addition of rosiglitazone to glimepirid and metformin combination therapy in type 2 diabetes.

  Endocrine journal 20041201

• Initiating oral glucose-lowering therapy with metformin in type 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications.

  Diabetes & metabolism 20041201

• Combined therapy with insulin lispro Mix 75/25 plus metformin or insulin glargine plus metformin: a 16-week, randomized, open-label, crossover study in patients with type 2 diabetes beginning insulin therapy.

  Clinical therapeutics 20041201

• Adherence to a fixed-dose combination of rosiglitazone maleate/metformin hydrochloride in subjects with type 2 diabetes mellitus: a retrospective database analysis.

  Clinical therapeutics 20041201

• Test and teach. Number Fifty-three. Diagnosis: Diabetes-related dyslipidaemia.

  Pathology 20041201

• Polycystic ovary syndrome.

  Clinical evidence 20041201

• Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without Type 2 diabetes.

  Diabetes, nutrition & metabolism 20041201

• Effects of two different glibenclamide dose-strengths in the fixed combination with metformin in patients with poorly controlled T2DM: a double blind, prospective, randomised, cross-over clinical trial.

  Diabetes, nutrition & metabolism 20041201

• [Effects of glimepiride and metformin on free fatty acid in patients with Type 2 diabetes mellitus].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041201

• AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

  The Journal of biological chemistry 20041112

• Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.

  Biochemical and biophysical research communications 20041105

• Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome.

  Human reproduction (Oxford, England) 20041101

• Are laparoscopic ovarian diathermy and gonadotropin administration the only therapeutic second-steps in clomiphene-citrate resistant women with polycystic ovary syndrome?

  Human reproduction (Oxford, England) 20041101

• Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial.

  Diabetic medicine : a journal of the British Diabetic Association 20041101

• Economic evaluation of therapeutic interventions to prevent Type 2 diabetes in Canada.

  Diabetic medicine : a journal of the British Diabetic Association 20041101

• Impact of metformin on glucose metabolism in nondiabetic, obese African Americans: a placebo-controlled, 24-month randomized study.

  Diabetes care 20041101

• Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20041101

• Metformin in type 2 diabetes.

  The Journal of family practice 20041101

• Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

  The Journal of clinical endocrinology and metabolism 20041101

• Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes.

  The Journal of endocrinology 20041101

• Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy.

  Metabolism: clinical and experimental 20041101

• Does metformin induce ovulation in normoandrogenic anovulatory women?

  American journal of obstetrics and gynecology 20041101

• Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.

  Diabetologia 20041101

• Dysregulation of growth hormone in acquired generalized lipodystrophy.

  Saudi medical journal 20041101

• Dietary intake in the diabetes prevention program cohort: baseline and 1-year post randomization.

  Annals of epidemiology 20041101

• Hepatotoxicity of drugs used for treatment of obesity and its comorbidities.

  Seminars in liver disease 20041101

• A lesson in early morning hyperglycemia.

  The Nurse practitioner 20041101

• Redefining insulin therapy in type 2 diabetes mellitus.

  Postgraduate medicine 20041101

• Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

  The Journal of biological chemistry 20041015

• Dupuytren's disease risk factors.

  Journal of hand surgery (Edinburgh, Scotland) 20041001

• Metformin--current restrictions should be alleviated.

  Journal of internal medicine 20041001

• The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results.

  Diabetic medicine : a journal of the British Diabetic Association 20041001

• Two N,N-dimethylbiguanidium salts displaying double hydrogen bonds to the counter-ions.

  Acta crystallographica. Section C, Crystal structure communications 20041001

• Editorial: Metformin--comparison with other therapies in ovulation induction in polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20041001

• Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial.

  The Journal of clinical endocrinology and metabolism 20041001

• Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin.

  The Journal of clinical endocrinology and metabolism 20041001

• Do risk factors for lactic acidosis influence dosing of metformin?

  Journal of clinical pharmacy and therapeutics 20041001

• Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity.

  Fertility and sterility 20041001

• Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20041001

• Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.

  International journal of clinical practice 20041001

• Efficacy of metformin on ovulation induction in Asian women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20041001

• [Therapy objectives and daily practice--to which extent are blood sugar target values accessible in daily practice?].

  Praxis 20040929

• [Assessment of the management of type 2 diabetes].

  Presse medicale (Paris, France : 1983) 20040925

• Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.

  The Biochemical journal 20040915

• Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

• Erythema multiforme from metformin.

  The Annals of pharmacotherapy 20040901

• Nateglinide alone or with metformin safely improves glycaemia to target in patients up to an age of 84.

  Diabetes, obesity & metabolism 20040901

• Outcomes of initiation of therapy with once-daily combination of a thiazolidinedione and a biguanide at an early stage of type 2 diabetes.

  Diabetes, obesity & metabolism 20040901

• Effect of Pancreas Tonic (an ayurvedic herbal supplement) in type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20040901

• Pharmacokinetics and dose proportionality of extended-release metformin following administration of 1000, 1500, 2000 and 2500 mg in healthy volunteers.

  Biopharmaceutics & drug disposition 20040901

• Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin treatment.

  The Journal of clinical endocrinology and metabolism 20040901

• Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide.

  The Journal of clinical endocrinology and metabolism 20040901

• Nonadherence as a predictor of antidiabetic drug therapy intensification (augmentation).

  Pharmacoepidemiology and drug safety 20040901

• Metformin ameliorates treatment of obese type 2 diabetic patients with mental retardation; its effects on eating behavior and serum leptin levels.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040901

• [Current concept of polycystic ovary syndrome].

  Zhonghua fu chan ke za zhi 20040901

• [Clinical study on treating insulin resistance and promoting ovulation in polycystic ovary syndrome].

  Zhonghua fu chan ke za zhi 20040901

• Glycemic control with metformin or insulin therapy in adolescents with type 2 diabetes mellitus.

  Journal of pediatric endocrinology & metabolism : JPEM 20040901

• Durable efficacy of metformin/glibenclamide combination tablets (Glucovance) during 52 weeks of open-label treatment in type 2 diabetic patients with hyperglycaemia despite previous sulphonylurea monotherapy.

  International journal of clinical practice 20040901

• Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide.

  International journal of clinical practice 20040901

• Avandamet: combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes.

  International journal of clinical practice 20040901

• Is ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?

  Journal of endocrinological investigation 20040901

• Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040901

• Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040901

• Fatty acid composition of erythrocyte phospholipids is related to insulin levels, secretion and resistance in obese type 2 diabetics on Metformin.

  Clinica chimica acta; international journal of clinical chemistry 20040816

• Insulin resistance and metformin in polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20040810

• [Progress in diagnosis of and therapy for diabetic lactic acidosis].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040810

• Metformin therapy and diabetes in pregnancy.

  The Medical journal of Australia 20040802

• Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats.

  The Journal of pharmacology and experimental therapeutics 20040801

• Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study.

  Human reproduction (Oxford, England) 20040801

• Endothelial dysfunction, inflammation and diabetes.

  Reviews in endocrine & metabolic disorders 20040801

• Comparison of the effect of orlistat vs orlistat plus metformin on weight loss and insulin resistance in obese women.

  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20040801

• Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.

  Human reproduction (Oxford, England) 20040801

• Laparoscopic treatment of polycystic ovaries: is its place diminishing?

  Current opinion in obstetrics & gynecology 20040801

• Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

  Biochemical pharmacology 20040801

• Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040801

• Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome.

  Diabetic medicine : a journal of the British Diabetic Association 20040801

• Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes.

  Diabetes 20040801

• The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial.

  The Journal of clinical endocrinology and metabolism 20040801

• A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study.

  Fertility and sterility 20040801

• Treatment of polycystic ovary syndrome in adolescents.

  American family physician 20040801

• Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes.

  Current medical research and opinion 20040801

• Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions.

  Journal of mass spectrometry : JMS 20040801

• Nonalcoholic fatty liver disease in the pediatric population.

  Clinics in liver disease 20040801

• Metformin monitoring and change in serum creatinine levels in patients undergoing radiologic procedures involving administration of intravenous contrast media.

  Pharmacotherapy 20040801

• Monitoring safety and effectiveness in patients receiving metformin.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

• Effect of metformin on the clinical and metabolic assessment of women with polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040801

• Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.

  The Journal of biological chemistry 20040730

• [2-year data of large clinical comparative studies. Type 2 diabetes: lasting metabolic control with pioglitazone].

  MMW Fortschritte der Medizin 20040722

• Metformin and serious adverse effects.

  The Medical journal of Australia 20040705

• Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models.

  Biomaterials 20040701

• The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review.

  Journal of internal medicine 20040701

• Biowaiver extension potential to BCS Class III high solubility-low permeability drugs: bridging evidence for metformin immediate-release tablet.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040701

• Improved glycemic control without weight gain using triple therapy in type 2 diabetes.

  Diabetes care 20040701

• Real world effectiveness of rosiglitazone added to maximal (tolerated) doses of metformin and a sulfonylurea agent: a systematic evaluation of triple oral therapy in a minority population.

  Diabetes care 20040701

• The phantom of lactic acidosis due to metformin in patients with diabetes.

  Diabetes care 20040701

• The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients: response to Poulsen et al.

  Diabetes care 20040701

• Twice-Daily NPH or mixture insulins versus triple therapy: apples versus oranges: response to Poulsen et al.

  Diabetes care 20040701

• Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial.

  Alimentary pharmacology & therapeutics 20040701

• Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome.

  Acta obstetricia et gynecologica Scandinavica 20040701

• Evidence based medicine, guidelines and common sense.

  Age and ageing 20040701

• Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

  Diabetologia 20040701

• Enhancement of early- and late-phase insulin secretion and insulin sensitivity by the combination of repaglinide and metformin in type 2 diabetes mellitus.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040701

• Why hold the metformin?

  Nursing 20040701

• Surgical treatment of polycystic ovary syndrome associated with infertility.

  Reproductive biomedicine online 20040701

• Pharmacokinetic-pharmacodynamic modeling for the relationship between glucose-lowering effect and plasma concentration of metformin in volunteers.

  Archives of pharmacal research 20040701

• Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes.

  Drugs of today (Barcelona, Spain : 1998) 20040701

• Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040701

• Revisit of metformin treatment in polycystic ovarian syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040701

• Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

  American journal of physiology. Endocrinology and metabolism 20040601

• Increased adipose tissue expression of Grb14 in several models of insulin resistance.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601

• Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy.

  Human reproduction (Oxford, England) 20040601

• Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study.

  Human reproduction (Oxford, England) 20040601

• Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency.

  Diabetes research and clinical practice 20040601

• Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes.

  Diabetes research and clinical practice 20040601

• Should we continue or stop insulin sensitizing drugs during pregnancy?

  Current opinion in obstetrics & gynecology 20040601

• Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase.

  Biochemical pharmacology 20040601

• Hyperandrogenism and the skin.

  Journal of the American Academy of Dermatology 20040601

• Understanding the rising incidence of type 2 diabetes in adolescence.

  Archives of disease in childhood 20040601

• Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes.

  Diabetes care 20040601

• Rosiglitazone plus metformin: combination therapy for Type 2 diabetes.

  Expert opinion on pharmacotherapy 20040601

• Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention.

  The American journal of cardiology 20040601

• Comparison of efficacy of spironolactone with metformin in the management of polycystic ovary syndrome: an open-labeled study.

  The Journal of clinical endocrinology and metabolism 20040601

• Efficacy and tolerability of initial combination therapy with nateglinide and metformin in treatment-naïve patients with type 2 diabetes.

  Current medical research and opinion 20040601

• [Primary prevention of diabetes mellitus type 2].

  Der Internist 20040601

• Development of calorie restriction mimetics as a prolongevity strategy.

  Annals of the New York Academy of Sciences 20040601

• Splanchnic haemodynamics in non-alcoholic fatty liver disease: effect of a dietary/pharmacological treatment. A pilot study.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20040601

• Lipoatrophic diabetes in an elderly woman: clinical course and serum adipocytokine concentrations.

  Endocrine journal 20040601

• A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus.

  Clinical therapeutics 20040601

• [Lactic acidosis in diabetic patient treated with metformin].

  Anales de medicina interna (Madrid, Spain : 1984) 20040601

• Metabolic variations with oral antidiabetic drugs in patients with Type 2 diabetes: comparison between glimepiride and metformin.

  Diabetes, nutrition & metabolism 20040601

• Use of glimepiride and insulin sensitizers in the treatment of type 2 diabetes--a study in Indians.

  The Journal of the Association of Physicians of India 20040601

• Effect of potassium chloride and cationic drug on swelling, erosion and release from kappa-carrageenan matrices.

  AAPS PharmSciTech 20040601

• [Metformin, an efficacious drug in the treatment of polycystic ovary syndrome].

  Deutsche medizinische Wochenschrift (1946) 20040507

• Metformin therapy and diabetes in pregnancy.

  The Medical journal of Australia 20040503

• Polycystic ovary syndrome in adolescence--a therapeutic conundrum.

  Human reproduction (Oxford, England) 20040501

• Toxic effects from metformin exposure.

  The Annals of pharmacotherapy 20040501

• Screening for and treatment of polycystic ovary syndrome in teenagers.

  Experimental biology and medicine (Maywood, N.J.) 20040501

• Glycemic treatment: Control of glycemia.

  Diabetes care 20040501

• Starting insulin in type 2 diabetes: continue oral hypoglycemic agents? A randomized trial in primary care.

  The Journal of family practice 20040501

• Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients.

  The Journal of clinical endocrinology and metabolism 20040501

• Pioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI) in patients with type 2 diabetes.

  Current medical research and opinion 20040501

• Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement.

  Health technology assessment (Winchester, England) 20040501

• Medical treatment regimens of hirsutism.

  Reproductive biomedicine online 20040501

• By the way, doctor. I'm a 63-year-old woman with impaired fasting glucose, and I'd like to take Glucophage or Avandia to prevent or delay the onset of diabetes. My weight was well controlled until my 50s, when it started to rise. I think impaired fasting glucose caused the weight gain.

  Harvard health letter 20040501

• A validated HPLC method with ultraviolet detection for the determination of buformin in plasma.

  Biomedical chromatography : BMC 20040501

• Effects of metformin on clinical and biochemical parameters in polycystic ovary syndrome.

  The Journal of reproductive medicine 20040501

• [Cost-effective analysis of preventive treatment on diabetes].

  Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20040501

• Which treatment options should be used in adolescents with polycystic ovary syndrome?

  Journal of pediatric endocrinology & metabolism : JPEM 20040501

• [Diabetes mellitus, oxidative stress and advanced glycation endproducts].

  Annales pharmaceutiques francaises 20040501

• Assessment of quality control parameters and interchangeability of multisourced metformin HCl tablets marketed in Nigeria.

  Bollettino chimico farmaceutico 20040501

• Pioglitazone plus a sulphonylurea or metformin is associated with increased lipoprotein particle size in patients with type 2 diabetes.

  Diabetes & vascular disease research 20040501

• [Diabetes update: preventing type 2 diabetes. Individualized stepwise therapy (oral antidiabetic agents). Multifactorial intervention].

  Praxis 20040428

• Treatment of insulin resistance in diabetes mellitus.

  European journal of pharmacology 20040419

• Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20040415

• The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20040415

• Impaired glucose tolerance and impaired fasting glucose.

  American family physician 20040415

• Rapid determination of metformin in human plasma by liquid chromatography-tandem mass spectrometry method.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405

• Electronic monitoring and counseling to improve medication adherence.

  Behaviour research and therapy 20040401

• Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

  Diabetes 20040401

• Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity.

  The Journal of clinical endocrinology and metabolism 20040401

• Metformin induced acute pancreatitis precipitated by renal failure.

  Postgraduate medical journal 20040401

• Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients.

  Obesity research 20040401

• Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study.

  Current medical research and opinion 20040401

• Experiences of a poison center with metformin-associated lactic acidosis.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040401

• [Effects of rosiglitazone and metformin on insulin resistance in high-fat diet rats].

  Zhonghua nei ke za zhi 20040401

• Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?

  Reproductive biomedicine online 20040401

• The effect of oral folic acid on glutathione, glycaemia and lipids in Type 2 diabetes.

  Diabetes, nutrition & metabolism 20040401

• [Prevention by life style intervention and medication. To run away from type 2 diabetes].

  MMW Fortschritte der Medizin 20040401

• Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.

  The Journal of biological chemistry 20040326

• [Long-term HbA1c stable. Insulin sensitizer keeps diabetes in check].

  MMW Fortschritte der Medizin 20040325

• The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight.

  European journal of pharmacology 20040319

• Metformin-stimulated mannose transport in dermal fibroblasts.

  The Journal of biological chemistry 20040312

• Fast liquid chromatographic-tandem mass spectrometric (LC-MS-MS) determination of metformin in plasma samples.

  Journal of pharmaceutical and biomedical analysis 20040310

• [Etiology of and therapy for type-2 diabetes mellitus].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310

• Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context.

  Archives of internal medicine 20040308

• Type 2 diabetes mellitus: what is the optimal treatment regimen?

  The American journal of medicine 20040308

• Metformin hepatotoxicity.

  Annals of internal medicine 20040302

• Effects of insulin-sensitising agents in mice with hepatic insulin resistance.

  Diabetologia 20040301

• Prevention of weight gain in type 2 diabetes requiring insulin treatment.

  Diabetes, obesity & metabolism 20040301

• Pharmacologic therapy for HIV-associated lipodystrophy.

  The Annals of pharmacotherapy 20040301

• Metformin in the treatment of patients with non-alcoholic steatohepatitis.

  Alimentary pharmacology & therapeutics 20040301

• Diabetic ketoacidosis in a patient with chronic calcific pancreatitis after minor papilla stent insertion.

  Gastrointestinal endoscopy 20040301

• Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy.

  Human reproduction (Oxford, England) 20040301

• Six-month treatment with low-dose dexamethasone further reduces androgen levels in PCOS women treated with diet and lifestyle advice, and metformin.

  Human reproduction (Oxford, England) 20040301

• Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration.

  American journal of hypertension 20040301

• Insulin resistance as a therapeutic target for improved endothelial function: metformin.

  Current drug targets. Cardiovascular & haematological disorders 20040301

• Pioglitazone reduces blood pressure in non-dipping diabetic patients.

  Minerva endocrinologica 20040301

• Combination of metformin and thiazolidindiones restore insulin signalling in insulin-resistant cultured myotubes.

  Life sciences 20040227

• Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients.

  AIDS (London, England) 20040220

• Glycemic control with glyburide/metformin tablets in combination with rosiglitazone in patients with type 2 diabetes: a randomized, double-blind trial.

  The American journal of medicine 20040215

• Addition of pioglitazone or bedtime insulin to maximal doses of sulfonylurea and metformin in type 2 diabetes patients with poor glucose control: a prospective, randomized trial.

  The American journal of medicine 20040215

• The continuing legacy of the United Kingdom Prospective Diabetes Study.

  The Medical journal of Australia 20040202

• 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome.

  Clinical endocrinology 20040201

• Metformin and lactic acidosis: cause or coincidence? A review of case reports.

  Journal of internal medicine 20040201

• Mild cobalamin deficiency associated with long-term metformin intake--reply.

  Journal of internal medicine 20040201

• Diabetes in a nonpancreatectomized child with nesidioblastosis.

  Diabetes care 20040201

• Metformin in obstetric and gynecologic practice: a review.

  Obstetrical & gynecological survey 20040201

• Treatment of PCOS with metformin and other insulin-sensitizing agents.

  Current diabetes reports 20040201

• Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20040201

• Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin.

  Fertility and sterility 20040201

• Dexamethasone reduces androgen levels in metformin-treated patients with polycystic ovary syndrome.

  Fertility and sterility 20040201

• The treatment of polycystic ovary syndrome.

  Minerva ginecologica 20040201

• Metformin for the treatment of the polycystic ovary syndrome.

  Minerva ginecologica 20040201

• Comparison of pioglitazone and metformin efficacy using homeostasis model assessment.

  Diabetic medicine : a journal of the British Diabetic Association 20040201

• Metformin-induced encephalopathy without lactic acidosis.

  Diabetic medicine : a journal of the British Diabetic Association 20040201

• [Lactic acidosis and acute abdomen from biguanide intoxication].

  Der Anaesthesist 20040201

• Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents.

  Diabetes technology & therapeutics 20040201

• Simultaneous determination of metformin in combination with rosiglitazone by reversed-phase liquid chromatography.

  Journal of chromatographic science 20040201

• Intensive lifestyle changes or metformin in patients with impaired glucose tolerance: modeling the long-term health economic implications of the diabetes prevention program in Australia, France, Germany, Switzerland, and the United Kingdom.

  Clinical therapeutics 20040201

• Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.

  International journal of clinical practice 20040201

• Survival after myocardial infarction in patients with type 2 diabetes.

  JPMA. The Journal of the Pakistan Medical Association 20040201

• Metformin and serious adverse effects.

  The Medical journal of Australia 20040119

• Use of metformin is a cause of vitamin B12 deficiency.

  American family physician 20040115

• The effect of metformin treatment to ovarian response in cases with PCOS.

  Archives of gynecology and obstetrics 20040101

• Effects of short-term metformin treatment on insulin sensitivity of blood glucose and free fatty acids.

  Diabetes, obesity & metabolism 20040101

• Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.

  Diabetes research and clinical practice 20040101

• Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.

  Diabetes care 20040101

• One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes.

  Diabetes care 20040101

• Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20040101

• Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.

  Fertility and sterility 20040101

• Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20040101

• Modeling the efficiency of reaching a target intermediate end point: a case study in type 2 diabetes in the United States.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20040101

• Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome.

  The Journal of pediatrics 20040101

• Effects of short term metformin administration on androgens in diabetic men.

  Saudi medical journal 20040101

• Evaluation of the oral antihyperglycemic drug metformin in normal and diabetic cats.

  Journal of veterinary internal medicine 20040101

• Simultaneous high-performance liquid chromatographic determination of pioglitazone and metformin in pharmaceutical-dosage form.

  Journal of chromatographic science 20040101

• Complementary mode of action of rosiglitazone and metformin in a single tablet for the treatment of diabetes mellitus type 2.

  Arzneimittel-Forschung 20040101

• Should the insulin resistance syndrome be treated in the elderly?

  Drugs & aging 20040101

• Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040101

• Impact of adjunctive thiazolidinedione therapy on blood lipid levels and glycemic control in patients with type 2 diabetes.

  Current medical research and opinion 20040101

• Pioglitazone is effective therapy for elderly patients with type 2 diabetes mellitus.

  Drugs & aging 20040101

• Longitudinal metabolic observation of metformin effects during pregnancy in hyperinsulinemic women with polycystic ovary syndrome: a case report.

  Journal of endocrinological investigation 20040101

• [Acute kidney failure and severe lactic acidosis caused by metformin successfully treated with hemodialysis].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101

• [Treatment of adolescents with type 2 diabetes].

  Klinische Padiatrie 20040101

• Assessment of insulin resistance and effect of metformin in nonalcoholic steatohepatitis--a preliminary report.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20040101

• Metformin-associated respiratory alkalosis.

  American journal of therapeutics 20040101

• Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study.

  Diabetes/metabolism research and reviews 20040101

• Metformin for prevention of type 2 diabetes.

  The Annals of pharmacotherapy 20040101

• Using metformin safely. X-ray with caution.

  Diabetes self-management 20040101

• Metformin extended release--DepoMed: metformin, metformin gastric retention, metformin GR.

  Drugs in R&D 20040101

• AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase.

  Medical hypotheses 20040101

• Chronic activation of AMP-activated kinase as a strategy for slowing aging.

  Medical hypotheses 20040101

• Does bitter melon contain an activator of AMP-activated kinase?

  Medical hypotheses 20040101

• Severe diarrhoea complicating metformin therapy: an unusual presentation.

  Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20040101

• Insulin as initial therapy for type 2 diabetes is not in the patient's best interest.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

• Insulin: thoroughly modern therapy.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

• Towards single-tablet therapy for type 2 diabetes mellitus. Rationale and recent developments.

  Treatments in endocrinology 20040101

• Extended-release metformin hydrochloride. Single-composition osmotic tablet formulation.

  Treatments in endocrinology 20040101

• Single-composition extended-release metformin hydrochloride. A viewpoint by David Bell.

  Treatments in endocrinology 20040101

• Single-composition extended-release metformin hydrochloride. A viewpoint by Vivian Fonseca.

  Treatments in endocrinology 20040101

• [Combined use of metformin and Diane35 in polycystic ovary syndrome].

  Akusherstvo i ginekologiia 20040101

• Transfer of metformin into human milk.

  Advances in experimental medicine and biology 20040101

• [Assessment of efficacy of combined therapy with antihypertensive agents and biguanides in patients with metabolic syndrome].

  Kardiologiia 20040101

• Community pharmacists' counseling about metformin-associated lactic acidosis.

  Journal of the American Pharmacists Association : JAPhA 20040101

• Metformin versus sibutramine in the treatment of hyperinsulinemia in chronically anovulating women.

  Bratislavske lekarske listy 20040101

• The efficacy of repaglinide monotherapy and in combination with metformin in Indonesian type 2 diabetes mellitus patients.

  Acta medica Indonesiana 20040101

• Tolerability profile of metformin/glibenclamide combination tablets (Glucovance): a new treatment for the management of type 2 diabetes mellitus.

  Drug safety 20040101

• [Efficacy and safety of glimepiride plus metformin in a single presentation, as combined therapy, in patients with type 2 diabetes mellitus and secondary failure to glibenclamide, as monotherapy].

  Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20040101

• Effects of KST48 [(2R,5SR)3-(2-chlorobenzoyl)-5-(4-chlorophenoxymethyl)-2(3,4-dichlorophenyl) oxazolidine] on glucose transport in L6 myocytes.

  Arzneimittel-Forschung 20040101

• Reversible renal insufficiency attributable to thyroid hormone withdrawal in a patient with type 2 diabetes mellitus.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

• Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

• [Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].

  MMW Fortschritte der Medizin 20031218

• [Insulin resistance in polycystic ovary syndrome].

  Wiener klinische Wochenschrift 20031215

• [Blood sugar inspite of maximal metformin dosage. New fixed combination forces HbA1c down].

  MMW Fortschritte der Medizin 20031211

• Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

  Circulation 20031209

• Peroxisome proliferator-activated receptor-gamma agonists in atherosclerosis: current evidence and future directions.

  Current opinion in lipidology 20031201

• The role of metformin in the management of polycystic ovary syndrome.

  Current opinion in obstetrics & gynecology 20031201

• Therapy after single oral agent failure: adding a second oral agent or an insulin mixture?

  Diabetes research and clinical practice 20031201

• Metformin lactic acidosis, acute renal failure and rofecoxib.

  British journal of anaesthesia 20031201

• The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients.

  Diabetes care 20031201

• Safety issues on metformin use.

  Diabetes care 20031201

• Comparison of repaglinide and nateglinide in combination with metformin: response to Raskin et al.

  Diabetes care 20031201

• Metabolic and psychosocial effects of minimal invasive gastric banding for morbid obesity.

  Metabolism: clinical and experimental 20031201

• Acarbose for the prevention of diabetes.

  Cleveland Clinic journal of medicine 20031201

• Acarbose for the prevention of diabetes.

  Cleveland Clinic journal of medicine 20031201

• Improvement of acanthosis nigricans on isotretinoin and metformin.

  Journal of drugs in dermatology : JDD 20031201

• [Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome].

  Zhonghua fu chan ke za zhi 20031201

• Metformin protects against carbon tetrachloride hepatotoxicity in mice.

  Journal of pharmacological sciences 20031201

• Metformin hydrochloride in the treatment of type 2 diabetes mellitus: a clinical review with a focus on dual therapy.

  Clinical therapeutics 20031201

• [The use of oral antidiabetic drugs in the treatment of polycystic ovary syndrome].

  Zentralblatt fur Gynakologie 20031201

• Role of oral anti-diabetic agents in modifying cardiovascular risk factors.

  Minerva medica 20031201

• [Progress in the prevention of type 2 diabetes].

  Wiener klinische Wochenschrift 20031128

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.

  Archives of internal medicine 20031124

• [Physical activity in hyperglycemia and type 2 diabetes. Effective but still underutilized].

  MMW Fortschritte der Medizin 20031120

• [Metformin and lactic acidosis--fact or fiction? A review of current data].

  Praxis 20031119

• Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.

  Journal of internal medicine 20031101

• Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.

  Diabetologia 20031101

• Obese patients with polycystic ovary syndrome: evidence that metformin does not restore sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by ovarian steroids.

  The Journal of clinical endocrinology and metabolism 20031101

• Comparison of additional metformin or NPH insulin to mealtime insulin lispro therapy with mealtime human insulin therapy in secondary OAD failure.

  Diabetes, obesity & metabolism 20031101

• Greater reductions in A1C in type 2 diabetic patients new to therapy with glyburide/metformin tablets as compared to glyburide co-administered with metformin.

  Diabetes, obesity & metabolism 20031101

• Effect of metformin on fibrinolytic parameters in insulin-treated, type 2 diabetic patients.

  Diabetes & metabolism 20031101

• Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.

  Diabetic medicine : a journal of the British Diabetic Association 20031101

• Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy.

  The Journal of the Association of Physicians of India 20031101

• Metformin in polycystic ovary syndrome: systematic review and meta-analysis.

  BMJ (Clinical research ed.) 20031025

• Genetic cause of hyperglycaemia and response to treatment in diabetes.

  Lancet (London, England) 20031018

• Metformin as additional therapy in adolescents with poorly controlled type 1 diabetes: randomised placebo-controlled trial with aspects on insulin sensitivity.

  European journal of endocrinology 20031001

• New drugs and dosage forms.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031001

• Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20031001

• Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception.

  The Journal of clinical endocrinology and metabolism 20031001

• Insulin-lowering agents in the management of polycystic ovary syndrome.

  Endocrine reviews 20031001

• Nonalcoholic steatohepatitis: role of leptin in pathogenesis and benefits of metformin in treatment.

  The American journal of gastroenterology 20031001

• Inadequacy of therapeutic education: a risk factor of hypoglycaemia.

  Diabetes research and clinical practice 20031001

• Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20031001

• Effects of metformin or gemfibrozil on the lipodystrophy of HIV-infected patients receiving protease inhibitors.

  Antiviral therapy 20031001

• Unexpected survival from severe metformin-associated lactic acidosis.

  The Netherlands journal of medicine 20031001

• Treatment of atypical endometrial hyperplasia with an insulin-sensitizing agent.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20031001

• [Is type-2 diabetes mellitus preventable?].

  Orvosi hetilap 20030928

• [Lactic acidosis as adverse effect of metformin].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20030925

• [Optimized diabetes therapy in type 2 diabetics].

  Medizinische Klinik (Munich, Germany : 1983) 20030915

• Heart failure: treatment and ethnic origin.

  Lancet (London, England) 20030913

• Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

  Endocrinology 20030901

• Management of the overweight patient with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20030901

• Lipoprotein risk factors for cardiovascular disease in patients with type 2 diabetes mellitus treated with oral antihyperglycaemic agents.

  Diabetes, obesity & metabolism 20030901

• Within-trial cost-effectiveness of lifestyle intervention or metformin for the primary prevention of type 2 diabetes.

  Diabetes care 20030901

• Preventing, delaying, or masking type 2 diabetes with metformin in the diabetes prevention program?

  Diabetes care 20030901

• Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20030901

• Estimating the contribution of genes and environment to variation in renal drug clearance.

  Pharmacogenetics 20030901

• Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.

  The American journal of gastroenterology 20030901

• Is metformin more than an oral hypoglycaemic agent?

  Diabetes & metabolism 20030901

• Reducing insulin resistance with metformin: the evidence today.

  Diabetes & metabolism 20030901

• Improving survival with metformin: the evidence base today.

  Diabetes & metabolism 20030901

• Beneficial effects of metformin on haemostasis and vascular function in man.

  Diabetes & metabolism 20030901

• Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes.

  Diabetes & metabolism 20030901

• Do effects on blood pressure contribute to improved clinical outcomes with metformin?

  Diabetes & metabolism 20030901

• Antiatherogenic properties of metformin: the experimental evidence.

  Diabetes & metabolism 20030901

• Microcirculation in insulin resistance and diabetes: more than just a complication.

  Diabetes & metabolism 20030901

• Mitochondrial metabolism and type-2 diabetes: a specific target of metformin.

  Diabetes & metabolism 20030901

• Metformin inhibition of glycation processes.

  Diabetes & metabolism 20030901

• The potential of metformin for diabetes prevention.

  Diabetes & metabolism 20030901

• Metformin and vascular protection: a diabetologist's view.

  Diabetes & metabolism 20030901

• Metformin and vascular protection: a cardiologist's view.

  Diabetes & metabolism 20030901

• Metformin: drug of choice for the prevention of type 2 diabetes and cardiovascular complications in high-risk subjects.

  Diabetes & metabolism 20030901

• Diabetes drugs a problem in heart failure.

  Harvard heart letter : from Harvard Medical School 20030901

• Hyperglycaemic hyperosmolar syndrome in young obese Afro-Caribbean adults--a diagnostic dilemma. Report of two cases.

  The West Indian medical journal 20030901

• [Effects of metformin on gonadotropin-induced ovulation in patients with polycystic ovary syndrome].

  Zhonghua fu chan ke za zhi 20030901

• [Fasting hyperglycemia and postprandial glucose peaks. Diabetes therapy mustact on 2 sides].

  MMW Fortschritte der Medizin 20030821

• Management of diabetes mellitus and insulin resistance in patients with cardiovascular disease.

  The American journal of cardiology 20030818

• Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents.

  Biochemical pharmacology 20030815

• Patients with both diabetes and heart failure often treated with medications government considers unsafe.

  Report on medical guidelines & outcomes research 20030808

• [Hirsutism].

  MMW Fortschritte der Medizin 20030807

• AMP-activated protein kinase and muscle glucose uptake.

  Acta physiologica Scandinavica 20030801

• Metformin and gestational diabetes.

  Current diabetes reports 20030801

• Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin.

  Human reproduction (Oxford, England) 20030801

• Glyburide/metformin tablets: a new therapeutic option for the management of Type 2 diabetes.

  Expert opinion on pharmacotherapy 20030801

• Type 2 diabetes mellitus in youth.

  The Journal of school nursing : the official publication of the National Association of School Nurses 20030801

• Insulin 70/30 mix plus metformin versus triple oral therapy in the treatment of type 2 diabetes after failure of two oral drugs: efficacy, safety, and cost analysis.

  Diabetes care 20030801

• Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes.

  Diabetes care 20030801

• Case study: metformin-associated lactic acidosis: could orlistat be relevant?

  Diabetes care 20030801

• Contrast media and the kidney: European Society of Urogenital Radiology (ESUR) guidelines.

  The British journal of radiology 20030801

• Survival following a metformin overdose of 63 g: a case report.

  Pharmacology & toxicology 20030801

• Laparoscopic treatment of polycystic ovaries: is it time to relinquish the procedure?

  Fertility and sterility 20030801

• The importance of insulin resistance in polycystic ovary syndrome.

  Fertility and sterility 20030801

• Early effects of metformin on glucose dynamics in women with oligoamenorrhea and regular menstrual cycles who were wearing a subcutaneous glucose sensor.

  Fertility and sterility 20030801

• Benefits of combination therapy of insulin and oral hypoglycemic agents.

  Archives of internal medicine 20030801

• Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20030801

• Neuropsychological correlates of suboptimal adherence to metformin.

  Journal of behavioral medicine 20030801

• Efficacy, tolerability and safety of nateglinide in combination with metformin. Results from a study under general practice conditions.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030801

• Psoriasiform drug eruption associated with metformin hydrochloride: a case report.

  Dermatology online journal 20030801

• Is there a role for metformin or acarbose as a weight-loss agent in the absence of diabetes?

  Cleveland Clinic journal of medicine 20030801

• Polycystic ovary syndrome.

  Journal of pediatric and adolescent gynecology 20030801

• A case of megaloblastic anemia due to vitamin B12 deficiency precipitated in a totally gastrectomized type II diabetic patient following the introduction of metformin therapy.

  Endocrine journal 20030801

• Metformin-associated lactic acidosis and acute renal failure in a type 2 diabetic patient.

  Journal of the Chinese Medical Association : JCMA 20030801

• Polycystic ovary syndrome--a complex disorder among women.

  JAAPA : official journal of the American Academy of Physician Assistants 20030801

• A cautionary tale: fatal lactic acidosis complicating nucleoside analogue and metformin therapy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030715

• Metformin and thiazolidinedione use in Medicare patients with heart failure.

  JAMA 20030702

• The diabetes prevention program and its global implications.

  Journal of the American Society of Nephrology : JASN 20030701

• GnRH antagonists for treatment of polycystic ovarian syndrome.

  Fertility and sterility 20030701

• Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin.

  Diabetes care 20030701

• Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes.

  Diabetes care 20030701

• Treatment of patients over 64 years of age with type 2 diabetes: experience from nateglinide pooled database retrospective analysis.

  Diabetes care 20030701

• Combination treatment with metformin and glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, double-blind, comparative study.

  Metabolism: clinical and experimental 20030701

• Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome.

  Metabolism: clinical and experimental 20030701

• [Insulin-sensitizing agents: metformin and thiazolidinedione derivatives].

  Nihon rinsho. Japanese journal of clinical medicine 20030701

• [Nateglinide and mitiglinide].

  Nihon rinsho. Japanese journal of clinical medicine 20030701

• Key developments in endocrinology.

  The Practitioner 20030701

• Reducing coronary heart disease associated with type 2 diabetes: lifestyle intervention and treatment of dyslipidaemia.

  Diabetes research and clinical practice 20030701

• A comparison of costs for four oral antidiabetic regimens within a managed care population.

  Managed care interface 20030701

• Endocrine characteristics of polycystic ovary syndrome (PCOS).

  Indian journal of experimental biology 20030701

• [Aggressive and early combined drug therapy. Antidiabetics for prevention of myocardial infarct].

  MMW Fortschritte der Medizin 20030619

• Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones.

  Circulation 20030603

• Tritiated thymidine incorporation does not enhance sensitivity of the popliteal lymph node assay.

  Toxicology 20030603

• Metformin use as an adjunct to insulin treatment.

  The Medical journal of Australia 20030602

• Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.

  American journal of physiology. Endocrinology and metabolism 20030601

• Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin.

  Diabetes research and clinical practice 20030601

• The Diabetes Prevention Program.

  Current diabetes reports 20030601

• The comparison of clinical and hormonal parameters in PCOS patients treated with metformin and GnRH analogue.

  Archives of gynecology and obstetrics 20030601

• Metformin and its liver targets in the treatment of type 2 diabetes.

  Current drug targets. Immune, endocrine and metabolic disorders 20030601

• Management of hyperglycaemia in the patient with acute myocardial infarction.

  Diabetic medicine : a journal of the British Diabetic Association 20030601

• Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism.

  The Journal of clinical endocrinology and metabolism 20030601

• Combination agents for diabetes.

  Advance for nurse practitioners 20030601

• Insulin sensitizers for polycystic ovary syndrome.

  Clinical obstetrics and gynecology 20030601

• Comparison of the micro- and macro-vascular effects of glimepiride and gliclazide in metformin-treated patients with Type 2 diabetes: a double-blind, crossover study.

  British journal of clinical pharmacology 20030601

• Long-term efficacy of steady-dose metformin in type 2 diabetes mellitus: a retrospective study.

  Medical science monitor : international medical journal of experimental and clinical research 20030601

• The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20030601

• Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects.

  Diabetes & metabolism 20030601

• [Is it possible to prevent type 2 diabetes?].

  Annales d'endocrinologie 20030601

• [Medication of the month. Glucovance in type 2 diabetes, a fixed combination of metformin-glibenclamide for the treatment of a bipolar metabolic disease].

  Revue medicale de Liege 20030601

• Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure.

  Collegium antropologicum 20030601

• Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome.

  Lancet (London, England) 20030531

• [Type 2 diabetes -- higher doses of metformin improve metabolic control].

  MMW Fortschritte der Medizin 20030522

• Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20030501

• Influence of initial hyperglycaemia, weight and age on the blood glucose lowering efficacy and incidence of hypoglycaemic symptoms with a single-tablet metformin-glibenclamide therapy (Glucovance) in type 2 diabetes.

  Diabetes, obesity & metabolism 20030501

• Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes.

  Diabetes, obesity & metabolism 20030501

• Metformin and insulin in type 1 diabetes: the first step.

  Diabetes care 20030501

• Metformin in type 1 diabetes: is this a good or bad idea?

  Diabetes care 20030501

• Beta2-adrenergic receptor polymorphism and obesity in type 2 diabetes: response to van Tilburg et al.

  Diabetes care 20030501

• Bioadhesive delivery of metformin using prosopis gum with antidiabetic potential.

  Biological & pharmaceutical bulletin 20030501

• Type 2 diabetes presenting as diabetic ketoacidosis in adolescence.

  Diabetic medicine : a journal of the British Diabetic Association 20030501

• Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal.

  Metabolism: clinical and experimental 20030501

• An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress.

  Metabolism: clinical and experimental 20030501

• Urinary PC-1 and N-acetyl-beta-D-glucosaminidase activity in patients with type 2 diabetes treated with metformin, gliclazide or glibenclamide.

  Annals of clinical biochemistry 20030501

• Metformin induced anorexia and weight loss.

  Hawaii medical journal 20030501

• [Lactic acidosis and biguanides: coincidence or negligence of prescribing guidelines].

  Annales francaises d'anesthesie et de reanimation 20030501

• [Metformin-associated lactic acidosis precipitated by acute renal failure].

  Annales francaises d'anesthesie et de reanimation 20030501

• [Metformin-associated lactic acidosis remains a serious complication of metformin therapy].

  Annales francaises d'anesthesie et de reanimation 20030501

• Medical vs. surgical treatment for clomiphene citrate-resistant women with polycystic ovary syndrome.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20030501

• Efffect of addition of low-dose rosiglitazone to sulphonylurea therapy on glycemic control in type 2 diabetic patients.

  Chinese medical journal 20030501

• [Importance of sensitization of insulin receptors in the prevention of ovarian hyperstimulation syndrome].

  Ceska gynekologie 20030501

• Insulin in the early management of diabetic complications.

  The Journal of the Association of Physicians of India 20030501

• Does metformin interfere with thiamine?

  Archives of internal medicine 20030428

• Insulin-sensitizing drugs for polycystic ovary syndrome.

  The Medical letter on drugs and therapeutics 20030428

• Contraindications to use of metformin. Age and creatinine clearance need to be taken into consideration.

  BMJ (Clinical research ed.) 20030405

• Contraindications to use of metformin. Metformin may be useful in gestational diabetes.

  BMJ (Clinical research ed.) 20030405

• Contraindications to use of metformin. Blanket banning of metformin two days before surgery may not be a good idea.

  BMJ (Clinical research ed.) 20030405

• Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.

  Molecular pharmacology 20030401

• Metformin-associated lactic acidosis in a patient with liver disease.

  QJM : monthly journal of the Association of Physicians 20030401

• Body habitus changes related to lipodystrophy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030401

• Effects of withdrawal from metformin on the development of diabetes in the diabetes prevention program.

  Diabetes care 20030401

• Leptin and body fat in type 2 diabetes and monodrug therapy.

  The Journal of clinical endocrinology and metabolism 20030401

• Effect of pioglitazone compared with metformin on glycemic control and indicators of insulin sensitivity in recently diagnosed patients with type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20030401

• Metformin for the treatment of polycystic ovary syndrome.

  Obstetrics and gynecology 20030401

• Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome.

  Endocrine 20030401

• Metformin use in adolescent with PCOS--an invited editorial from the pediatric endocrinology perspective.

  Journal of pediatric and adolescent gynecology 20030401

• [Metabolic syndrome: to observe or to act?].

  Diabetes & metabolism 20030401

• [Drug compliance in type 2 diabetes: role of drug treatment regimens and consequences on their benefits].

  Diabetes & metabolism 20030401

• Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance.

  Diabetes & metabolism 20030401

• Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function.

  Diabetes & metabolism 20030401

• Metformin has direct effects on human ovarian steroidogenesis.

  Fertility and sterility 20030401

• Pharmacological regulation of hepatic glucose production.

  Current opinion in investigational drugs (London, England : 2000) 20030401

• A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.

  Archives of internal medicine 20030324

• [When HbA1c cannot be pushed down under 7. Don't hesitate to use a 2d antidiabetic agent].

  MMW Fortschritte der Medizin 20030306

• Insulin sensitisation in the treatment of Type 2 diabetes.

  Expert opinion on investigational drugs 20030301

• Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy.

  Diabetes 20030301

• Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy.

  Diabetes 20030301

• Metformin-induced hemolytic anemia in a patient with glucose-6- phosphate dehydrogenase deficiency.

  Diabetes care 20030301

• Effects of metformin on body mass index, menstrual cyclicity, and ovulation induction in women with polycystic ovary syndrome.

  Fertility and sterility 20030301

• Modulation of hunger by plasma glucose and metformin.

  The Journal of clinical endocrinology and metabolism 20030301

• Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

  The Journal of clinical endocrinology and metabolism 20030301

• Measurement of metformin concentration in erythrocytes: clinical implications.

  Diabetes, obesity & metabolism 20030301

• Differential effects of metformin on bile salt absorption from the jejunum and ileum.

  Diabetes, obesity & metabolism 20030301

• Metformin blunts stress-induced hyperglycemia after thermal injury.

  The Journal of trauma 20030301

• Slow response to loss of glycemic control in type 2 diabetes mellitus.

  The American journal of managed care 20030301

• Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients.

  Acta diabetologica 20030301

• [Should infertile women with polycystic ovarian syndrome be treated with metformine?].

  Gynecologie, obstetrique & fertilite 20030301

• Elevated concentrations of C-reactive protein in subjects with type 2 diabetes mellitus are moderately influenced by glycemic control.

  Journal of endocrinological investigation 20030301

• Multicenter, randomized, double-masked, parallel-group assessment of simultaneous glipizide/metformin as second-line pharmacologic treatment for patients with type 2 diabetes mellitus that is inadequately controlled by a sulfonylurea.

  Clinical therapeutics 20030301

• [Therapy decision based on the glucose triad. Drug treatment of type 2 diabetes].

  MMW Fortschritte der Medizin 20030227

• Rapid determination of metformin in human plasma using ion-pair HPLC.

  Journal of pharmaceutical and biomedical analysis 20030205

• Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects.

  Diabetes 20030201

• Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.

  Biochemical Society transactions 20030201

• Acarbose improves glycemic control in overweight type 2 diabetic patients insufficiently treated with metformin.

  Diabetes care 20030201

• Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial.

  Human reproduction (Oxford, England) 20030201

• Beneficial effects of a glyburide/metformin combination preparation in type 2 diabetes mellitus.

  The American journal of the medical sciences 20030201

• Current biochemical studies of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) suggest a new therapeutic approach.

  The American journal of gastroenterology 20030201

• Treatment of type 2 diabetes: inadequate assessment of oral antidiabetic combinations.

  Prescrire international 20030201

• [Insulin resistance and polycystic ovary syndrome].

  Gynecologie, obstetrique & fertilite 20030201

• Prevention of type 2 diabetes: are we ready?

  Minerva medica 20030201

• Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20030201

• Clinical, metabolic and endocrine parameters in response to metformin in obese women with polycystic ovary syndrome: a randomized, double-blind and placebo-controlled trial.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030201

• Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation.

  Clinical therapeutics 20030201

• Efficacy and safety of a combination of metformin and rosiglitaone in patients with type 2 diabetes mellitus--a postmarketing study.

  Journal of the Indian Medical Association 20030201

• Contraindications to the use of metformin.

  BMJ (Clinical research ed.) 20030104

• Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention program.

  Diabetes care 20030101

• A randomized trial of sibutramine in the management of obese type 2 diabetic patients treated with metformin.

  Diabetes care 20030101

• Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial.

  Diabetes care 20030101

• Is metformin cardioprotective?

  Diabetes care 20030101

• Lactic acidemia associated with metformin.

  The Annals of pharmacotherapy 20030101

• Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells.

  Acta pharmacologica Sinica 20030101

• Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study.

  The Journal of clinical endocrinology and metabolism 20030101

• A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome.

  Fertility and sterility 20030101

• Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20030101

• Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?

  European journal of endocrinology 20030101

• Evaluation of dosage adjustment in patients with renal impairment.

  Internal medicine journal 20030101

• Transfer of metformin into human milk.

  Clinical pharmacology and therapeutics 20030101

• Hypoglycemia and reduced feed intake in broiler chickens treated with metformin.

  Poultry science 20030101

• Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity.

  Journal of pediatric endocrinology & metabolism : JPEM 20030101

• European Society of Urogenital Radiology guidelines on administering contrast media.

  Abdominal imaging 20030101

• [Coma in type 2 diabete mellitus on metformin treatment].

  Annales de biologie clinique 20030101

• Diabetes medicine update. Old dogs, new tricks.

  Diabetes self-management 20030101

• [Current methods of glucose metabolism control in diabetes mellitus].

  Recenti progressi in medicina 20030101

• Triple oral anti-diabetic therapy in type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20030101

• Cardioprotection by metformin is abolished by a nitric oxide synthase inhibitor in ischemic rabbit hearts.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030101

• Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030101

• Insulin resistance syndrome in children : pathophysiology and potential management strategies.

  Paediatric drugs 20030101

• [Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].

  Journal de gynecologie, obstetrique et biologie de la reproduction 20030101

• The development of an oral antidiabetic combination tablet: design, evaluation and clinical benefits for patients with type 2 diabetes.

  Current medical research and opinion 20030101

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20030101

• Combination therapy with pioglitazone plus metformin or sulfonylurea in patients with Type 2 diabetes: influence of prior antidiabetic drug regimen.

  Journal of diabetes and its complications 20030101

• Metformin-induced acidosis due to a warfarin adverse drug event.

  The Annals of pharmacotherapy 20030101

• Economic model of first-line drug strategies to achieve recommended glycaemic control in newly diagnosed type 2 diabetes mellitus.

  PharmacoEconomics 20030101

• [Lipodystrophies: what treatment?].

  Journees annuelles de diabetologie de l'Hotel-Dieu 20030101

• Cardioprotection with pioglitazone is abolished by nitric oxide synthase inhibitor in ischemic rabbit hearts--comparison of the effects of pioglitazone and metformin.

  Diabetes/metabolism research and reviews 20030101

• Why I initiate therapy with two insulin sensitizers in patients with type 2 diabetes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20030101

• Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.

  The Cochrane database of systematic reviews 20030101

• Metformin: new understandings, new uses.

  Drugs 20030101

• Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents.

  Hormone research 20030101

• [Stroke is not equal to stroke. Keep track of the causes].

  MMW Fortschritte der Medizin 20030101

• Insulin resistance: from predisposing factor to therapeutic target in type 2 diabetes.

  Clinical therapeutics 20030101

• Metformin-induced cholestatic hepatitis.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20030101

• Starting patients with type 2 diabetes on insulin therapy using once-daily injections of biphasic insulin aspart 70/30, biphasic human insulin 70/30, or NPH insulin in combination with metformin.

  Journal of diabetes and its complications 20030101

• Improvements in glycemic control in type 2 diabetes patients switched from sulfonylurea coadministered with metformin to glyburide-metformin tablets.

  Journal of managed care pharmacy : JMCP 20030101

• Ondansetron and metformin-induced gastrointestinal side effects.

  American journal of therapeutics 20030101

• Long-term (2-4 year) weight reduction with metformin plus carbohydrate-modified diet in euglycemic, hyperinsulinemic, midlife women (Syndrome W).

  Heart disease (Hagerstown, Md.) 20030101

• [Kidney hypoperfusion and overdose of metformin as cause of severe lactic acidosis].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20030101

• Unsurpassed glycaemic control made simple.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20030101

• Analysis of metformin in antemortem serum and postmortem specimens by a novel HPLC method and application to an intoxication case.

  Journal of analytical toxicology 20030101

• Minireview: Up-date management of non responder to clomiphene citrate in polycystic ovary syndrome.

  The Kobe journal of medical sciences 20030101

• [Drug treatment of type 2 diabetes].

  Wiener medizinische Wochenschrift (1946) 20030101

• Comparative bioavailability of two oral formulations manufactured in Mexico containing glyburide and metformin in diabetic patients.

  Proceedings of the Western Pharmacology Society 20030101

• Crossover and double blind study with metformin and rosiglitazone in impaired glucose tolerance subjects.

  Proceedings of the Western Pharmacology Society 20030101

• A fatal case of metformin poisoning.

  Journal of toxicology. Clinical toxicology 20030101

• Therapy for type 2 diabetes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20030101

• The combination metformin/glyburide exerts its hypoglycemic effect mainly by increasing insulin secretion: a controlled, randomized, double-blind, crossover study.

  Diabetes, nutrition & metabolism 20030101

• Current indications for metformin therapy.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20030101

• Metformin in the treatment of obesity in subjects with normal glucose tolerance.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20030101

• [Effects of metformin on endocrine parameters and reproductive function in women with polycystic ovary syndrome].

  Biomeditsinskaia khimiia 20030101

• Metformin use in an obese diabetic patient from weeks 1 to 21 of pregnancy.

  Journal of medicine 20030101

• Metaglip and Avandamet for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20021223

• Dutasteride (Avodart) for benign prostatic hyperplasia.

  The Medical letter on drugs and therapeutics 20021223

• Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes.

  Diabetes 20021201

• Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects.

  Diabetes care 20021201

• Combination of insulin and metformin in the treatment of type 2 diabetes.

  Diabetes care 20021201

• The benefits of metformin therapy during continuous subcutaneous insulin infusion treatment of type 1 diabetic patients.

  Diabetes care 20021201

• Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes.

  Diabetes care 20021201

• Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome--beyond ovulation induction.

  Human reproduction (Oxford, England) 20021201

• [Hemodyalisis as therapy of choice in lactic acidosis associated with metformin].

  Revista clinica espanola 20021201

• Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine.

  Acta pharmacologica Sinica 20021201

• Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels.

  The Journal of clinical endocrinology and metabolism 20021201

• Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism.

  The Journal of clinical endocrinology and metabolism 20021201

• Rosiglitazone and pioglitazone: new preparations. Two new oral antidiabetics both poorly assessed.

  Prescrire international 20021201

• Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome.

  Fertility and sterility 20021201

• [Severe hypoglycemia caused by sulfonylureas and biguanides in a patient with obstructive anuria: resolution with ureteral stent].

  Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20021201

• Detection of insulin resistance and its treatment in adolescents with polycystic ovary syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20021201

• A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.

  Cleveland Clinic journal of medicine 20021201

• Hirsutism and adnexal masses in a teenager.

  Journal of pediatric and adolescent gynecology 20021201

• Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes.

  Chinese medical journal 20021201

• Repaglinide in combination therapy.

  Diabetes, nutrition & metabolism 20021201

• Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats.

  Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) 20021201

• [News on diabetes and public health perspectives].

  Presse medicale (Paris, France : 1983) 20021123

• [Does a reduced kidney function (creatinine clearance 10-15 ml/min), without acidosis, increase the risk for the rise of lactic acidosis caused by metformin?].

  Nederlands tijdschrift voor geneeskunde 20021116

• [Does the vitamin B12 deficiency caused by metformin disappear again after stopping this drug?].

  Nederlands tijdschrift voor geneeskunde 20021116

• Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.

  Biochemical and biophysical research communications 20021115

• Differential effect of glyburide (glibenclamide) and metformin on QT dispersion: a potential adenosine triphosphate sensitive K+ channel effect.

  The American journal of cardiology 20021115

• Metformin-associated lactic acidosis after elective cervical spine fusion: a case report.

  Spine 20021115

• Effects of berberine on glucose metabolism in vitro.

  Metabolism: clinical and experimental 20021101

• Glyburide/metformin combination product is safe and efficacious in patients with type 2 diabetes failing sulphonylurea therapy.

  Diabetes, obesity & metabolism 20021101

• Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells.

  Diabetes, obesity & metabolism 20021101

• Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin.

  Human reproduction (Oxford, England) 20021101

• Metformin and FSH for induction of ovulation in women with polycystic ovary syndrome.

  Human reproduction (Oxford, England) 20021101

• Effect of metformin on adipose tissue resistin expression in db/db mice.

  Biochemical and biophysical research communications 20021101

• Eudragit NE30D based metformin/gliclazide extended release tablets: formulation, characterisation and in vitro release studies.

  Chemical & pharmaceutical bulletin 20021101

• Transfer of metformin into human milk.

  Diabetologia 20021101

• Therapeutic options for the management of type 2 diabetes mellitus.

  The American journal of managed care 20021101

• The contentious nature of gestational diabetes: diet, insulin, glyburide and metformin.

  Expert opinion on pharmacotherapy 20021101

• Oral anti diabetic polychemotherapy in type 2 diabetes mellitus.

  Diabetes & metabolism 20021101

• [Medications for type-2 diabetes and high blood pressure].

  Medizinische Monatsschrift fur Pharmazeuten 20021101

• Metformin-associated vitamin B12 deficiency.

  Archives of internal medicine 20021028

• [Insulin resistance and its involvement in multiple risk factors associated with type 2 diabetes mellitus].

  Medicina clinica 20021012

• [In high risk for diabetes should drugs be used for prevention? (interview by Dr. Judith Neumaier)].

  MMW Fortschritte der Medizin 20021003

• Advances in polycystic ovary syndrome treatment: metformin and ovarian diathermy.

  Current women's health reports 20021001

• Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells.

  British journal of pharmacology 20021001

• Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy.

  Diabetes care 20021001

• Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes.

  Diabetes care 20021001

• A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes.

  Diabetes care 20021001

• Use of intravenous contrast agents in patients receiving metformin.

  Radiology 20021001

• Seeking sweet relief for diabetes.

  Nature biotechnology 20021001

• Bioequivalence evaluation of two brands of metformin 500 mg tablets (Dialon & Glucophage)--in healthy human volunteers.

  Biopharmaceutics & drug disposition 20021001

• Circulating ghrelin levels in patients with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20021001

• Sustained benefits of metformin therapy on markers of cardiovascular risk in human immunodeficiency virus-infected patients with fat redistribution and insulin resistance.

  The Journal of clinical endocrinology and metabolism 20021001

• Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans.

  Metabolism: clinical and experimental 20021001

• Metformin and BMI?

  Fertility and sterility 20021001

• Therapeutic approach in insulin resistance with acanthosis nigricans.

  International journal of clinical practice 20021001

• [Combination therapy with biguanides].

  Nihon rinsho. Japanese journal of clinical medicine 20021001

• Health and economic effects of adding nateglinide to metformin to achieve dual control of glycosylated hemoglobin and postprandial glucose levels in a model of type 2 diabetes mellitus.

  Clinical therapeutics 20021001

• [Effect of metformin on gene expression of phosphoenolpyruvate carboxykinase].

  Zhonghua nei ke za zhi 20021001

• [Perioperative metformin and lactacidosis].

  Der Anaesthesist 20021001

• Efficacy, effectiveness and safety of sulphonylurea-metformin combination therapy in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20020901

• Should patients with polycystic ovarian syndrome be treated with metformin?

  Human reproduction (Oxford, England) 20020901

• Metformin and FSH for induction of ovulation in women with polycystic ovarian syndrome.

  Human reproduction (Oxford, England) 20020901

• Clomid versus metformin for ovulation induction--let's not have any 'hanging chads'!

  Fertility and sterility 20020901

• Clomid versus metformin for ovulation induction--let's not have any 'hanging chads'!

  Fertility and sterility 20020901

• Effects of konjac extract on insulin sensitivity in high fat diet rats.

  Acta pharmacologica Sinica 20020901

• Can onset of diabetes be delayed?

  Postgraduate medicine 20020901

• Increased intraabdominal adipose tissue mass in fructose fed rats: correction by metformin.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020901

• Durability of efficacy and long-term safety profile of glyburide/metformin tablets in patients with type 2 diabetes mellitus: an open-label extension study.

  Clinical therapeutics 20020901

• Lipid effects of glyburide/metformin tablets in patients with type 2 diabetes mellitus with poor glycemic control and dyslipidemia in an open-label extension study.

  Clinical therapeutics 20020901

• High anion gap metabolic acidosis in suicide: don't forget metformin intoxication--two patients' experiences.

  Renal failure 20020901

• [Primary prevention of diabetes mellitus by pharmacological intervention].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Follow-up system for diabetic subjects screened in the place of work].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Structure and mechanisms of action of biguanides].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Metformin--its regimen and effects].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Adverse effect of biguanides].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Clinical usefulness of treatment with biguanide and insulin].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• [Management guideline for elderly diabetic patients].

  Nihon rinsho. Japanese journal of clinical medicine 20020901

• Rebuttal to Deacon and Holst: 'Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1' versus 'Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective'.

  Biochemical and biophysical research communications 20020816

• Inappropriate prescription for metformin.

  JAMA 20020814

• Inappropriate prescription for metformin.

  JAMA 20020814

• The contribution of metformin to glycaemic control in patients with Type 2 diabetes mellitus receiving combination therapy with insulin.

  Diabetes research and clinical practice 20020801

• Low-dose dexamethasone in the rat: a model to study insulin resistance.

  American journal of physiology. Endocrinology and metabolism 20020801

• Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect.

  Drug metabolism and disposition: the biological fate of chemicals 20020801

• Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.

  The Journal of pharmacology and experimental therapeutics 20020801

• The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

  Diabetes 20020801

• On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.

  Diabetes care 20020801

• Improved glycaemic control with metformin-glibenclamide combined tablet therapy (Glucovance) in Type 2 diabetic patients inadequately controlled on metformin.

  Diabetic medicine : a journal of the British Diabetic Association 20020801

• Adherence to oral hypoglycaemic agents prior to insulin therapy in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20020801

• Should patients with polycystic ovarian syndrome be treated with metformin?: an enthusiastic endorsement.

  Human reproduction (Oxford, England) 20020801

• The effect of metformin on hirsutism in polycystic ovary syndrome.

  European journal of endocrinology 20020801

• [Metformin--sensible or nonsensible change of treatment in the post-operative phase].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20020801

• Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes.

  NMR in biomedicine 20020801

• Effects of short term metformin administration on androgens in normal men.

  Saudi medical journal 20020801

• [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].

  Medizinische Klinik (Munich, Germany : 1983) 20020715

• [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]].

  Medizinische Klinik (Munich, Germany : 1983) 20020715

• The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

  The Journal of biological chemistry 20020712

• Metformin: an update.

  Annals of internal medicine 20020702

• Summaries for patients. Metformin for patients with type 2 diabetes mellitus.

  Annals of internal medicine 20020702

• Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes.

  Metabolism: clinical and experimental 20020701

• Metformin & lifestyle intervention prevent Type 2 diabetes: lifestyle intervention has the greater effect.

  Expert opinion on pharmacotherapy 20020701

• Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

  Diabetes 20020701

• Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin.

  Diabetes care 20020701

• Rosiglitazone in combination with glimepiride plus metformin in type 2 diabetic patients.

  Diabetes care 20020701

• Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study.

  Human reproduction (Oxford, England) 20020701

• Should intravenous contrast be used in patients receiving metformin.

  The American journal of emergency medicine 20020701

• Changes in treatment after the start of oral hypoglycaemic therapy in Type 2 diabetes: a population-based study.

  Diabetic medicine : a journal of the British Diabetic Association 20020701

• Options for pharmacological management of obesity in patients treated with atypical antipsychotics.

  International clinical psychopharmacology 20020701

• Oral hypoglycaemics. When not to use what.

  Australian family physician 20020701

• Can reducing peaks prevent type 2 diabetes: implication from recent diabetes prevention trials.

  International journal of clinical practice. Supplement 20020701

• Metformin: evidence-based versus rational pharmacotherapy.

  The Netherlands journal of medicine 20020701

• Discontinuation of metformin in type 2 diabetes patients treated with insulin.

  The Netherlands journal of medicine 20020701

• Combination of drugs in the management of diabetes mellitus.

  Journal of the Indian Medical Association 20020701

• Oral hypoglycaemic agent failure.

  Journal of the Indian Medical Association 20020701

• [Fatal lactic acidosis due to metformin in a male with type 2 diabetes mellitus and dehydration. Comments about a patient information leaflet].

  Medicina clinica 20020629

• [Islands cells are not activated quickly enough. Risk of obstruction of blood vessels].

  MMW Fortschritte der Medizin 20020627

• Glucose-tolerance testing in acute myocardial infarction.

  Lancet (London, England) 20020622

• [Blood glucose control with high dosage metformin. So that sweet hearts beat longer].

  MMW Fortschritte der Medizin 20020613

• Diabetes prevention.

  The New England journal of medicine 20020606

• Diabetes prevention.

  The New England journal of medicine 20020606

• Diabetes prevention.

  The New England journal of medicine 20020606

• Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).

  The American journal of cardiology 20020601

• Optimizing ovulation induction in women with polycystic ovary syndrome.

  Current opinion in obstetrics & gynecology 20020601

• Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation.

  The Journal of clinical endocrinology and metabolism 20020601

• Reversal of diabetes-induced rat graft transplant coronary artery disease by metformin.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020601

• The effect of metformin plus clomiphene citrate on ovulation and pregnancy rates in clomiphene-resistant women with polycystic ovary syndrome.

  Saudi medical journal 20020601

• Effect of BRX-220 against peripheral neuropathy and insulin resistance in diabetic rat models.

  Annals of the New York Academy of Sciences 20020601

• [The efficacy and safety of pioglitazone hydrochloride in combination with sulphonylureas and metfomin in the treatment of type 2 diabetes mellitus a 12-week randomized multi-centres placebo-controlled parallel study].

  Zhonghua nei ke za zhi 20020601

• Clinical and endocrinological effects of 6 months of metformin treatment in young hyperinsulinemic patients affected by polycystic ovary syndrome.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20020601

• [Metformin and anesthesia].

  Der Anaesthesist 20020601

• [Dangerous postprandial glucose peaks. Risk for heart and blood vessels].

  MMW Fortschritte der Medizin 20020523

• Frequency of inappropriate metformin prescriptions.

  JAMA 20020515

• [Simple corrections in therapy of type 2 diabetes. Lowering HbA1c below 7%].

  MMW Fortschritte der Medizin 20020509

• Metformin hydrochloride in patients undergoing myelography.

  AJR. American journal of roentgenology 20020501

• Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction.

  Diabetes care 20020501

• Striving for a more active community. Lessons from the diabetes prevention program and beyond.

  American journal of preventive medicine 20020501

• Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice.

  British journal of clinical pharmacology 20020501

• Diet and exercise. Preventing diabetes.

  Harvard health letter 20020501

• Current oral agents for type 2 diabetes. Many options, but which to choose when?

  Postgraduate medicine 20020501

• Nateglinide improves glycaemic control when added to metformin monotherapy: results of a randomized trial with type 2 diabetes patients.

  Diabetes, obesity & metabolism 20020501

• Simultaneous glyburide/metformin therapy is superior to component monotherapy as an initial pharmacological treatment for type 2 diabetes.

  Diabetes, obesity & metabolism 20020501

• Study makes strong case for early diabetes intervention.

  Disease management advisor 20020501

• [Pitfalls and precautions concerning the use of conventional oral antidiabetic drugs].

  Revue medicale de Liege 20020501

• Metformin and polycystic ovary syndrome: a literature review.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20020501

• [Metformin has a positive effect on disorders of carbohydrate metabolism in long-term care with low doses of prednisone].

  Casopis lekaru ceskych 20020426

• In vitro evaluation of a system for pH-controlled peroral delivery of metformin.

  Journal of controlled release : official journal of the Controlled Release Society 20020423

• [The effect of metformin on late diabetic complications and cardiovascular events in obese patients with type 2 diabetes].

  Ugeskrift for laeger 20020408

• [Metformin. Mode of action and effect of monotherapy and combination therapy on glucose metabolism in type 2 diabetes].

  Ugeskrift for laeger 20020408

• Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men.

  Metabolism: clinical and experimental 20020401

• A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone.

  Diabetes care 20020401

• Metformin for weight loss in pediatric patients taking psychotropic drugs.

  The American journal of psychiatry 20020401

• Should patients with polycystic ovarian syndrome be treated with metformin? A note of cautious optimism.

  Human reproduction (Oxford, England) 20020401

• Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020401

• Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance.

  The Journal of clinical endocrinology and metabolism 20020401

• Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome.

  Fertility and sterility 20020401

• Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort study.

  Diabetic medicine : a journal of the British Diabetic Association 20020401

• Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function.

  Biochemical pharmacology 20020401

• Inhibition of gluconeogenesis by vanadium and metformin in kidney-cortex tubules isolated from control and diabetic rabbits.

  Biochemical pharmacology 20020401

• In vivo kinetics of 123 iodine-labelled insulin in skeletal muscle of patients with type 2 diabetes. Effect of metformin.

  Diabetes & metabolism 20020401

• Effects of combined pioglitazone and metformin on diabetes and obesity in Wistar fatty rats.

  Clinical and experimental pharmacology & physiology 20020401

• Metformin improves cardiac functional recovery after ischemia in rats.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020401

• Preventing type 2 diabetes: lifestyle changes work better than drugs.

  Health news (Waltham, Mass.) 20020401

• Autoantibodies in children with type 2 diabetes mellitus.

  Journal of pediatric endocrinology & metabolism : JPEM 20020401

• Management of hyperglycemia in minority children with type 2 diabetes mellitus.

  Journal of pediatric endocrinology & metabolism : JPEM 20020401

• Treatment of type 2 diabetes mellitus in children and adolescents.

  Journal of pediatric endocrinology & metabolism : JPEM 20020401

• The role of the family in managing therapy in minority children with type 2 diabetes mellitus.

  Journal of pediatric endocrinology & metabolism : JPEM 20020401

• Polycystic ovary syndrome. Long term sequelae and management.

  Minerva ginecologica 20020401

• [Rosiglitazone: clinical data].

  Annales d'endocrinologie 20020401

• [Is a new therapeutic class justified in the treatment of type 2 diabetes?].

  Annales d'endocrinologie 20020401

• In support of metformin use in adolescent polycystic ovary syndrome.

  Journal of pediatric and adolescent gynecology 20020401

• Metformin in adolescents with polycystic ovary syndrome: opposed.

  Journal of pediatric and adolescent gynecology 20020401

• Common treatment of polycystic ovarian syndrome and major depressive disorder: case report and review.

  Current drug targets. Immune, endocrine and metabolic disorders 20020401

• [Effective reduction of the HbA1c level, fewer side effects. First fixed combination for type 2 diabetic patients].

  MMW Fortschritte der Medizin 20020328

• Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

  Biochemical and biophysical research communications 20020315

• The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas--a randomized trial.

  Diabetes research and clinical practice 20020301

• Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats.

  Biochemical and biophysical research communications 20020301

• Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization.

  Endocrinology 20020301

• Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome.

  Fertility and sterility 20020301

• Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes.

  Diabetes care 20020301

• Effects of glibenclamide, metformin and insulin on the incidence and latency of death by oubain-induced arrhythmias in mice.

  Pharmacological research 20020301

• Recovery from pH 6.38: lactic acidosis complicated by hypothermia.

  Emergency medicine journal : EMJ 20020301

• Severe hypoglycemia in an elderly patient treated with metformin.

  International journal of clinical pharmacology and therapeutics 20020301

• Adherence to oral antidiabetic therapy in a managed care organization: a comparison of monotherapy, combination therapy, and fixed-dose combination therapy.

  Clinical therapeutics 20020301

• Getting an extension.

  Diabetes, obesity & metabolism 20020301

• [Type 2 diabetes. How can the infarction risk be reduced?].

  MMW Fortschritte der Medizin 20020227

• Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy.

  Archives of internal medicine 20020225

• Metformin and vitamin B12 deficiency.

  Archives of internal medicine 20020225

• [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].

  Medizinische Klinik (Munich, Germany : 1983) 20020215

• [Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids].

  Casopis lekaru ceskych 20020215

• [Fatty liver and raised gamma-GT: it can happen to abstainers, too].

  MMW Fortschritte der Medizin 20020214

• Treatment of type 2 diabetes mellitus in children.

  JAMA 20020213

• Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

  The New England journal of medicine 20020207

• Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects.

  Diabetes 20020201

• Lipotoxicity in human pancreatic islets and the protective effect of metformin.

  Diabetes 20020201

• Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome.

  Fertility and sterility 20020201

• Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial.

  Human reproduction (Oxford, England) 20020201

• Metformin associated acute pancreatitis.

  Veterinary and human toxicology 20020201

• Effects of metformin on early pregnancy loss in the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20020201

• Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial.

  The Journal of clinical endocrinology and metabolism 20020201

• Polycystic ovary syndrome in adolescents.

  Adolescent medicine (Philadelphia, Pa.) 20020201

• Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.

  Diabetic medicine : a journal of the British Diabetic Association 20020201

• Polycystic ovary syndrome: not ovarian, not simple, unkind.

  Human fertility (Cambridge, England) 20020201

• Restoring post-prandial insulin release in type 2 diabetes.

  Hospital medicine (London, England : 1998) 20020201

• [Polycystic ovary syndrome: treatment with insulin-sensitizing agents].

  Annales d'endocrinologie 20020201

• [Effects of metformin on the plasminogen activator system, endocrine, metabolic profiles in patients with polycystic ovary syndrome and clomiphene resistant cases].

  Zhonghua fu chan ke za zhi 20020201

• Metformin in non-alcoholic steatohepatitis.

  Lancet (London, England) 20020126

• Oral antihyperglycemic therapy for type 2 diabetes: scientific review.

  JAMA 20020116

• Post-load hyperglycaemia-an inappropriate therapeutic target.

  Lancet (London, England) 20020112

• Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020105

• Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects.

  Diabetes 20020101

• Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet.

  Diabetes 20020101

• The effect of dimethylbiguanide on thrombin activity, FXIII activation, fibrin polymerization, and fibrin clot formation.

  Diabetes 20020101

• Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial.

  Diabetes care 20020101

• Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome.

  Fertility and sterility 20020101

• Insulin-metformin combination therapy in obese patients with type 2 diabetes.

  Journal of clinical pharmacology 20020101

• Beta-cell response to intravenous glucagon in African-American and Hispanic children with type 2 diabetes mellitus.

  Journal of pediatric endocrinology & metabolism : JPEM 20020101

• Type 2 diabetes management.

  British journal of community nursing 20020101

• Diabetes mellitus. Medication update.

  Southern medical journal 20020101

• Fowler's syndrome: cause or consequence of insulin resistance?

  BJU international 20020101

• Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats.

  Diabetes, obesity & metabolism 20020101

• Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity.

  Diabetes, obesity & metabolism 20020101

• Type 2 diabetes management: a comprehensive clinical review of oral medications.

  Comprehensive therapy 20020101

• The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System.

  Diabetes/metabolism research and reviews 20020101

• Patient compliance and persistence with anti-hyperglycemic therapy: evaluation of a population of type 2 diabetic patients.

  The Journal of international medical research 20020101

• United Kingdom prospective diabetes study: a different perspective.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• Effect of thiazolidinediones on high-density lipoprotein subfractions.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• Prediction of the effect of metformin treatment in patients with polycystic ovary syndrome.

  Gynecologic and obstetric investigation 20020101

• Children with type 2 diabetes: the risks of complications.

  Hormone research 20020101

• Efficacy and safety of rosiglitazone plus metformin in Mexicans with type 2 diabetes.

  Diabetes/metabolism research and reviews 20020101

• Metformin decreases platelet superoxide anion production in diabetic patients.

  Diabetes/metabolism research and reviews 20020101

• [Therapeutic renaissance. Biguanides in type-2 diabetes: metformin].

  Pharmazie in unserer Zeit 20020101

• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20020101

• Results of use of metformin and replacement of starch with saturated fat in diets of patients with type 2 diabetes.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• Clearance of metformin by hemofiltration in overdose.

  Journal of toxicology. Clinical toxicology 20020101

• [Changes in carbohydrate metabolism in the HIV/AIDS patient].

  Nutricion hospitalaria 20020101

• Long-term efficacy of triple oral therapy for type 2 diabetes mellitus.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers.

  Drug metabolism and drug interactions 20020101

• Diabetes prevention program: education is vital.

  The Diabetes educator 20020101

• Metformin-associated lactic acidosis: case reports and literature review.

  Journal of nephrology 20020101

• Metformin adjunctive therapy with insulin improves glycemic control in patients with type 1 diabetes mellitus: a pilot study.

  Journal of pediatric endocrinology & metabolism : JPEM 20020101

• Ovulation induction in perspective.

  Human reproduction update 20020101

• Preventing the progressive nature of type 2 diabetes.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20020101

• Impact of metformin therapy on ovarian stimulation and outcome in 'coasted' patients with polycystic ovary syndrome undergoing in-vitro fertilization.

  Reproductive biomedicine online 20020101

• Metformin plus glyburide combination as initial therapy in type 2 diabetes: one month follow-up.

  Proceedings of the Western Pharmacology Society 20020101

• Metformin plus glyburide combination as therapy in failure to monotherapy in type 2 diabetic patients: one month follow-up.

  Proceedings of the Western Pharmacology Society 20020101

• Influence of new evidence on prescription patterns.

  The Journal of the American Board of Family Practice 20020101

• Insulin and oral antidiabetic agents for treatment of polycystic ovary syndrome.

  Medscape women's health 20020101

• Resumption of fertility with diet in overweight women.

  Reproductive biomedicine online 20020101

• [Aspects of antihyperglycemic oral bitherapy in 76 cases of non insulindependent diabetes in Dakar].

  Sante (Montrouge, France) 20020101

• [Metabolic syndrome from the point of view of a cardiologist: diagnosis, non drug and drug treatment].

  Kardiologiia 20020101

• Metformin improves liver antioxidant potential in rats fed a high-fructose diet.

  Asia Pacific journal of clinical nutrition 20020101

• A 67-year-old female with a 4-year history of type 2 diabetes, treated with metformin, presented with unstable angina.

  Cardiovascular radiation medicine 20020101

• Clinical pharmacology physiology conference: metformin and lactic acidosis (LA).

  International urology and nephrology 20020101

• Inverse relationship between peripheral insulin removal and action: studies with metformin.

  American journal of physiology. Endocrinology and metabolism 20011201

• Ovarian steroidogenic response to human chorionic gonadotrophin in obese women with polycystic ovary syndrome: effect of metformin.

  Human reproduction (Oxford, England) 20011201

• Beneficial effects of metformin in normoglycemic morbidly obese adolescents.

  Metabolism: clinical and experimental 20011201

• Improved endothelial function with metformin in type 2 diabetes mellitus.

  Journal of the American College of Cardiology 20011201

• Metformin-like effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20011201

• Use of metformin in polycystic ovary syndrome.

  The Annals of pharmacotherapy 20011201

• Hypoglycaemia induced by disopyramide in a patient with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20011201

• Long-term glycaemic improvement after addition of metformin to insulin in insulin-treated obese type 2 diabetes patients.

  Diabetes, obesity & metabolism 20011201

• Panel discussion on achieving glycemic control.

  Postgraduate medicine 20011201

• [Some considerations on the Consensus of the Spanish Diabetes Society and the Spanish Society of Family and Community Medicine on the criteria and guidelines for combined therapy for type 2 diabetes].

  Atencion primaria 20011130

• [Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic ovary syndrome].

  Casopis lekaru ceskych 20011108

• Effects of sibutramine in obese female subjects with type 2 diabetes and poor blood glucose control.

  Diabetes care 20011101

• Effect of metformin on mouse embryo development.

  Fertility and sterility 20011101

• The effects of metformin and diet on plasma testosterone and leptin levels in obese men.

  Obesity research 20011101

• Metformin as a cause of late-onset chronic diarrhea.

  Pharmacotherapy 20011101

• Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

  American journal of hypertension 20011101

• [Metabolism control in overweight type 2 diabetics. High metformin dosage brings more].

  MMW Fortschritte der Medizin 20011101

• [Thus to avoid complications of diabetes. To combine early].

  MMW Fortschritte der Medizin 20011101

• [Recommendations for perioperative interruption of metformin medication].

  Deutsche medizinische Wochenschrift (1946) 20011026

• Effect of metformin on nitric oxide synthase in genetically obese (ob/ob) mice.

  Life sciences 20011026

• [Type 2 diabetes. Regulating insulin according to need].

  MMW Fortschritte der Medizin 20011018

• The blooming of the French lilac.

  The Journal of clinical investigation 20011015

• Role of AMP-activated protein kinase in mechanism of metformin action.

  The Journal of clinical investigation 20011015

• Determination of metformin in human plasma by high-performance liquid chromatography with spectrophotometric detection.

  Journal of chromatography. B, Biomedical sciences and applications 20011005

• Insulin resistance in clomiphene responders and non-responders with polycystic ovarian disease and therapeutic effects of metformin.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20011001

• Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy.

  The Journal of clinical endocrinology and metabolism 20011001

• Improved glycaemic control by addition of glimepiride to metformin monotherapy in type 2 diabetic patients.

  Diabetic medicine : a journal of the British Diabetic Association 20011001

• Metabolic and haemodynamic effects of metformin in patients with type 2 diabetes mellitus and hypertension.

  Diabetes, obesity & metabolism 20011001

• Miglitol combined with metformin improves glycaemic control in type 2 diabetes.

  Diabetes, obesity & metabolism 20011001

• Are adult drugs cool for kids?

  Diabetes, obesity & metabolism 20011001

• Metformin therapy in the management of polycystic ovary syndrome: endocrine, metabolic and reproductive effects.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20011001

• [Info-Meeting. Pharmacologic prevention of the progression from impaired glucose tolerance to type 2 diabetes: favorable effects of metformin and acarbose].

  Revue medicale de Liege 20011001

• [Metformin and anesthesia, how great is the risk of lactic acidosis?].

  Deutsche medizinische Wochenschrift (1946) 20010921

• [Better blood glucose control. Extending metformin dosage].

  MMW Fortschritte der Medizin 20010920

• Metformin in non-alcoholic steatohepatitis.

  Lancet (London, England) 20010915

• Modest lifestyle changes significantly reduce the risk of diabetes, study finds.

  Report on medical guidelines & outcomes research 20010906

• Pathophysiology and treatment of the dyslipidemia of insulin resistance.

  Current cardiology reports 20010901

• Incidence of new coronary events in older persons with diabetes mellitus and prior myocardial infarction treated with sulfonylureas, insulin, metformin, and diet alone.

  The American journal of cardiology 20010901

• Metformin to restore normal menses in oligo-amenorrheic teenage girls with polycystic ovary syndrome (PCOS).

  The Journal of adolescent health : official publication of the Society for Adolescent Medicine 20010901

• Metformin directly inhibits androgen production in human thecal cells.

  Fertility and sterility 20010901

• Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemia.

  The Journal of clinical endocrinology and metabolism 20010901

• Exercise adds to metformin and acarbose efficacy in db/db mice.

  Metabolism: clinical and experimental 20010901

• Monotherapy with metformin: does it improve hypoxia in type 2 diabetic patients?

  Clinical chemistry and laboratory medicine 20010901

• Exercise and diet reduce risk of diabetes, US study shows.

  BMJ (Clinical research ed.) 20010818

• Diet and exercise delay onset of type 2 diabetes, say US experts.

  Lancet (London, England) 20010818

• Metformin, but not exercise training, increases insulin responsiveness in skeletal muscle of Sprague-Dawley rats.

  Life sciences 20010817

• Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes.

  Biochemical pharmacology 20010815

• [Repaglinide, potentially a therapeutic improvement for diabetes mellitus type 2].

  Nederlands tijdschrift voor geneeskunde 20010811

• Depolarization of the liver cell membrane by metformin.

  Biochimica et biophysica acta 20010806

• [Effects of metformin on insulin resistance and on ovarian steroidogenesis in women with polycystic ovary syndrome].

  Minerva ginecologica 20010801

• Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin.

  American journal of physiology. Endocrinology and metabolism 20010801

• Utilization of oral hypoglycemic agents in a drug-insured U.S. population.

  Diabetes care 20010801

• Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial.

  Human reproduction (Oxford, England) 20010801

• The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: The Fremantle Diabetes Study.

  British journal of clinical pharmacology 20010801

• Intensive therapies for pediatric obesity.

  Pediatric clinics of North America 20010801

• Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism.

  The Journal of clinical endocrinology and metabolism 20010801

• Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes.

  Internal medicine journal 20010801

• In vitro-in vivo correlation (IVIVC) models for metformin after administration of modified-release (MR) oral dosage forms to healthy human volunteers.

  Journal of pharmaceutical sciences 20010801

• Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome.

  Archives of gynecology and obstetrics 20010801

• Metformin in obesity associated with antipsychotic drug administration: a pilot study.

  The Journal of clinical psychiatry 20010801

• Metabolic alterations in HIV lipodystrophy. IAPAC sessions 2001, July 18-19, 2001 - Chicago.

  IAPAC monthly 20010801

• A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats.

  Life sciences 20010720

• Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens.

  Steroids 20010701

• Relationship between ethnicity and glycemic control, lipid profiles, and blood pressure during the first 9 years of type 2 diabetes: U.K. Prospective Diabetes Study (UKPDS 55).

  Diabetes care 20010701

• Re: Contrast media-induced nephrotoxicity: identification of patients at risk and algorithms for prevention.

  Journal of vascular and interventional radiology : JVIR 20010701

• Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30.

  Metabolism: clinical and experimental 20010701

• Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.

  The Journal of the Arkansas Medical Society 20010701

• Cholestatic jaundice associated with the use of metformin.

  The American journal of gastroenterology 20010701

• A falling HbA1c is not necessarily an indicator of improving diabetes control.

  Annals of clinical biochemistry 20010701

• Metabolic effects of metformin in patients with impaired glucose tolerance.

  Diabetic medicine : a journal of the British Diabetic Association 20010701

• [Metformin and contrast media--increased risk of lactic acidosis?].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20010610

• Metformin and intervention in polycystic ovary syndrome. Endocrine Society of Australia, the Australian Diabetes Society and the Australian Paediatric Endocrine Group.

  The Medical journal of Australia 20010604

• Safety and efficacy of acarbose in the treatment of Type 2 diabetes: data from a 5-year surveillance study.

  Diabetes research and clinical practice 20010601

• The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes.

  Diabetes care 20010601

• The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome.

  European journal of endocrinology 20010601

• Use of urea containing dialysate to avoid disequilibrium syndrome, enabling intensive dialysis treatment of a diabetic patient with renal failure and severe metformin induced lactic acidosis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010601

• Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers.

  Journal of clinical pharmacology 20010601

• Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'.

  Diabetes, obesity & metabolism 20010601

• Management of type 2 diabetes. Evolving strategies for treatment.

  Obstetrics and gynecology clinics of North America 20010601

• Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?

  Pharmacy world & science : PWS 20010601

• Contraindications to metformin therapy in patients with Type 2 diabetes--a population-based study of adherence to prescribing guidelines.

  Diabetic medicine : a journal of the British Diabetic Association 20010601

• Nateglinide: a new rapid-acting insulinotropic agent.

  Expert opinion on pharmacotherapy 20010601

• [Metformin in the treatment of type 1 diabetics--a placebo controlled study].

  Casopis lekaru ceskych 20010524

• Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.

  The Journal of biological chemistry 20010518

• [Metformin and anesthesia--how great is the risk of lactic acidosis].

  Deutsche medizinische Wochenschrift (1946) 20010518

• The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial.

  Annals of internal medicine 20010501

• Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome.

  European journal of endocrinology 20010501

• The oral insulin sensitizer, thiazolidinedione, increases plasma vascular endothelial growth factor in type 2 diabetic patients.

  Diabetes care 20010501

• Critical appraisal of published research evidence: treatment of gestational diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20010501

• A comparison of glyburide and insulin in women with gestational diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20010501

• [Effects of metformin on hyperinsulinemic anovulation].

  Zhonghua fu chan ke za zhi 20010501

• Sulphonylureas and metformin overdose: clinical features and management.

  Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association 20010501

• [Metformin and intravascular contrast media. National guidelines 2001-03-16].

  Lakartidningen 20010418

• Nateglinide for type 2 diabetes.

  The Medical letter on drugs and therapeutics 20010402

• Prevention of pancreatic cancer induction in hamsters by metformin.

  Gastroenterology 20010401

• Metformin-associated lactic acidosis.

  The Journal of emergency medicine 20010401

• ION-pair liquid chromatography technique for the estimation of metformin in its multicomponent dosage forms.

  Journal of pharmaceutical and biomedical analysis 20010401

• Improved endothelial function with metformin in type 2 diabetes mellitus.

  Journal of the American College of Cardiology 20010401

• Additive glucose-lowering effects of glucagon-like peptide-1 and metformin in type 2 diabetes.

  Diabetes care 20010401

• Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia.

  Diabetes care 20010401

• The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes.

  Pediatrics 20010401

• Homocysteine and cardiovascular risk in patients with diabetes mellitus.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20010401

• [Type 2 diabetes mellitus: Which place for thiazolidinediones in the therapeutic strategy?].

  Diabetes & metabolism 20010401

• Caloric restriction in primates and relevance to humans.

  Annals of the New York Academy of Sciences 20010401

• Direct-to-consumer advertisements for Glucophage XR.

  The Medical letter on drugs and therapeutics 20010319

• Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation.

  Journal of controlled release : official journal of the Controlled Release Society 20010312

• Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles.

  Journal of controlled release : official journal of the Controlled Release Society 20010312

• Accumulation of triglyceride-rich lipoprotein in subjects with abdominal obesity: the biguanides and the prevention of the risk of obesity (BIGPRO) 1 study.

  Arteriosclerosis, thrombosis, and vascular biology 20010301

• Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20010301

• Metformin and the polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20010301

• Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors.

  Fertility and sterility 20010301

• Improved glycaemic control with miglitol in inadequately-controlled type 2 diabetics.

  Diabetes research and clinical practice 20010301

• Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects.

  Diabetes care 20010301

• Polycystic ovary syndrome and ovulation induction.

  Obstetrics and gynecology clinics of North America 20010301

• Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51).

  Diabetologia 20010301

• Rosiglitazone.

  Expert opinion on pharmacotherapy 20010301

• Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20010301

• 'Off-label' use of metformin warranted.

  Advance for nurse practitioners 20010301

• Increased PAI-1 and tPA antigen levels are reduced with metformin therapy in HIV-infected patients with fat redistribution and insulin resistance.

  The Journal of clinical endocrinology and metabolism 20010201

• Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone.

  Fertility and sterility 20010201

• Metformin retention independent of renal failure in intestinal occlusion.

  Diabetes & metabolism 20010201

• Oral antidiabetic treatment in patients with coronary disease: time-related increased mortality on combined glyburide/metformin therapy over a 7.7-year follow-up.

  Clinical cardiology 20010201

• Glyburide/metformin HCl clinical overview.

  Managed care (Langhorne, Pa.) 20010201

• Roundtable. Blueprint for conversion of patients on metformin and sulfonylurea to Glucovance.

  Managed care (Langhorne, Pa.) 20010201

• Be wary of recommending off-label use of meds.

  Advance for nurse practitioners 20010201

• [Short-term and long-term effect of metformin in type 1 diabetics].

  Vnitrni lekarstvi 20010201

• Combination therapy in type 2 diabetes: the role of repaglinide.

  The Journal of the Association of Physicians of India 20010125

• Do interventions to reduce coronary heart disease reduce the incidence of type 2 diabetes? A possible role for inflammatory factors.

  Circulation 20010123

• [Severe lactic acidosis due to metformin ingestion in a patient with contra-indication for metformin].

  Nederlands tijdschrift voor geneeskunde 20010113

• [Intensified conventional insulin therapy in patients with type 2 diabetes mellitus. Positive long-term effects of insulin lispro on metabolic control and microalbuminuria].

  Fortschritte der Medizin. Originalien 20010111

• Oral hypoglycaemic drugs and gastrointestinal symptoms in diabetes mellitus.

  Alimentary pharmacology & therapeutics 20010101

• Diabetes mellitus with left transverse sinus thrombosis and right transverse sinus aplasia.

  Diabetes research and clinical practice 20010101

• Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study.

  Fertility and sterility 20010101

• Diabetes in elderly adults.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20010101

• Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.

  Recent progress in hormone research 20010101

• Metformin, the rebirth of a biguanide: mechanism of action and place in the prevention and treatment of insulin resistance.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

• Adverse reactions to iodinated contrast media.

  European radiology 20010101

• Metformin in an HIV-infected patient with protease inhibitor-induced diabetic ketoacidosis.

  The Annals of pharmacotherapy 20010101

• Metformin-associated lactic acidosis in a low risk patient.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20010101

• Use of insulin-sensitizing agents in patients with polycystic ovary syndrome.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20010101

• [Current approaches to treatment of secondary sulfonylamide drug resistance in Type II diabetes mellitus].

  Likars'ka sprava 20010101

• Effect of hyperoxia and metformin on vascular responses to vasoactive compounds in rats.

  Journal of basic and clinical physiology and pharmacology 20010101

• Evidence of a threshold value of glycated hemoglobin to improve the course of renal function in type 2 diabetes with typical diabetic glomerulopathy.

  Journal of nephrology 20010101

• [Our experience in the treatment of polycystic ovary syndrome with Metformin].

  Akusherstvo i ginekologiia 20010101

• Cardiovascular risk reduction in diabetes: underemphasised and overdue. Messages from major trials.

  Clinical medicine (London, England) 20010101

• Metformin--long-term results.

  TreatmentUpdate 20010101

• [Effects of octreotide on serum and urine electrolytes in a patient with parathyroid carcinoma: clinical case].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20010101

• EMEA extends indications for metformin. A decision that relies on evidence-based medicine.

  Acta diabetologica 20010101

• Biochemical and body weight changes with metformin in polycystic ovary syndrome.

  Clinical and experimental obstetrics & gynecology 20010101

• [Antioxidant and anti-AGE therapeutics: evaluation and perspectives].

  Journal de la Societe de biologie 20010101

• Does metformin provide a new approach to the management of obesity?

  Heart disease (Hagerstown, Md.) 20010101

• Metformin and carbohydrate-modified diet: a novel obesity treatment protocol: preliminary findings from a case series of nondiabetic women with midlife weight gain and hyperinsulinemia.

  Heart disease (Hagerstown, Md.) 20010101

• Diet and exercise dramatically delay type 2 diabetes.

  AWHONN lifelines 20010101

• [When and how should polycystic ovary syndrome be treated?].

  Duodecim; laaketieteellinen aikakauskirja 20010101

• Patient perceptions of prandial oral therapy for type 2 diabetes.

  The Diabetes educator 20010101

• Type 2 diabetes mellitus: an evolving therapeutic approach.

  Papua and New Guinea medical journal 20010101

• Diet and exercise dramatically delay type 2 diabetes.

  Health care financing review 20010101

• [Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy].

  Nederlands tijdschrift voor geneeskunde 20000930

• Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin.

  Diabetes care 20000901

• [Metformin-induced lactic acidosis].

  Deutsche medizinische Wochenschrift (1946) 20000303

• Haemolytic anaemia due to metformin.

  Postgraduate medical journal 20000201

• [Hemodialysis cured severe lactic acidosis caused by metformin treatment].

  Lakartidningen 19991215

• Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism.

  Biochimica et biophysica acta 19990812

• [Hepatotoxic reaction associated with metformin and chlorpropamide treatment].

  Revista clinica espanola 19990201

• Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind study versus placebo.

  Journal of diabetes and its complications 19990101

• Folate administration reduces circulating homocysteine levels in NIDDM patients on long-term metformin treatment.

  Journal of internal medicine 19980801

• Metformin-induced acute hepatitis.

  The American journal of medicine 19980501

• [Treatment of hypertension associated with diabetes mellitus].

  Nihon rinsho. Japanese journal of clinical medicine 19970801

• Effects of adrenergic, cholinergic and ganglionic blockade on acute depressor responses to metformin in spontaneously hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 19970501

• Metformin-associated nonketotic metabolic acidosis.

  The Annals of pharmacotherapy 19970101

• Decreased vascular reactivity in metformin-treated fructose-hypertensive rats.

  Metabolism: clinical and experimental 19960901

• Metformin-induced lactic acidosis associated with acute renal failure.

  American journal of nephrology 19960101

• Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors.

  Journal of internal medicine 19910201

• Leucocytoclastic vasculitis and pneumonitis induced by metformin.

  British medical journal (Clinical research ed.) 19860823

• Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment.

  British medical journal 19800517

• The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases.

  Diabetologia 19741001

• [Reversible hyperlactatemia induced by phenformin with muscular asthenia and cardio-respiratory signs].

  La Presse medicale 19700103