114798-36-6 | 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥95%	in stock	$74.00	$52.00
5mg	≥95%	in stock	$196.00	$137.00
10mg	≥95%	in stock	$321.00	$225.00
25mg	95%	in stock	$520.00	$364.00
50mg	95%	in stock	$780.00	$546.00

Description

• Catalog Number: AA19530
• Chemical Name: 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• CAS Number: 114798-36-6
• Molecular Formula: C22H21ClN6O
• Molecular Weight: 420.8947
• MDL Number: MFCD00870256
• SMILES: CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C=O)Cl

Computed Properties

• Complexity: 546
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 8
• XLogP3: 4.9

Literature

• CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.

  Drug metabolism and disposition: the biological fate of chemicals 20110501

• Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?

  Hypertension (Dallas, Tex. : 1979) 20091001

• Protein kinase C-inhibiting properties of the losartan metabolite EXP3179 make the difference.

  Hypertension (Dallas, Tex. : 1979) 20091001

• Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.

  Hypertension (Dallas, Tex. : 1979) 20091001

• Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.

  Hypertension (Dallas, Tex. : 1979) 20091001

• EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis.

  Arteriosclerosis, thrombosis, and vascular biology 20070501

• Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites.

  Hypertension (Dallas, Tex. : 1979) 20060301

• Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179.

  Circulation 20050920

• Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

  Journal of medicinal chemistry 20030605