114873-00-6 | Boc-l-2-fluorophenylalanine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$6.00
5g	98%	in stock	$23.00	$17.00
10g	98%	in stock	$41.00	$29.00

Description

• Catalog Number: AA19745
• Chemical Name: Boc-l-2-fluorophenylalanine
• CAS Number: 114873-00-6
• Molecular Formula: C14H18FNO4
• Molecular Weight: 283.2954
• MDL Number: MFCD00672520
• SMILES: O=C(OC(C)(C)C)N[C@H](C(=O)O)Cc1ccccc1F

Upstream Synthesis Route

Boc-Phe(2-F)-OH, also known as N-(tert-butoxycarbonyl)-L-phenylalanine(2-fluoro)-1-hydroxyethylamide, serves as a versatile building block in chemical synthesis due to its unique properties and reactivity. This compound, with a tert-butoxycarbonyl (Boc) protecting group on the amino group and a 2-fluoro substitution on the phenylalanine side chain, finds widespread application in peptide and pharmaceutical synthesis.The Boc protecting group is commonly utilized to temporarily shield the amine functionality of the phenylalanine residue in peptide synthesis. Its easy removal under mild acidic conditions enables selective deprotection without affecting other functional groups present in the molecule. This property makes Boc-Phe(2-F)-OH a valuable tool for the controlled assembly of peptides and peptide derivatives.The presence of the 2-fluoro substitution in the phenylalanine side chain imparts unique properties to the molecule, influencing its interactions with other chemical species. This fluorine atom can enhance the binding affinity, metabolic stability, and pharmacokinetic profile of the resulting peptide or drug candidate. Additionally, the fluorine atom's electron-withdrawing nature can alter the reactivity and selectivity of chemical transformations involving the phenylalanine residue.Overall, the strategic incorporation of Boc-Phe(2-F)-OH in chemical synthesis enables precise control over peptide assembly, modification, and functionalization. Its versatility and compatibility with various synthetic methodologies make it a valuable building block for the development of novel peptides, peptidomimetics, and pharmaceutical compounds.