115-46-8 | Alpha,alpha-diphenyl-4-piperidinomethanol

Packsize	Purity	Availability	Price	Discounted Price
5g	99%	in stock	$12.00	$8.00
25g	98%	in stock	$54.00	$38.00
100g	98%	in stock	$169.00	$119.00

Description

• Catalog Number: AA19947
• Chemical Name: Alpha,alpha-diphenyl-4-piperidinomethanol
• CAS Number: 115-46-8
• Molecular Formula: C18H21NO
• Molecular Weight: 267.3654
• MDL Number: MFCD00066980
• SMILES: OC(c1ccccc1)(c1ccccc1)C1CCNCC1

Computed Properties

• Complexity: 268
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 2.9

Literature

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.

  Bioorganic & medicinal chemistry letters 20090901

• Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20060801

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.

  Clinical pharmacology and therapeutics 20060301

• The effect of rifampin administration on the disposition of fexofenadine.

  Clinical pharmacology and therapeutics 20010301

• Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

  Pharmaceutical research 19990501