115-53-7 | Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9α,13α,14α)-

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$177.00	$124.00
5g	98%	in stock	$5,823.00	$4,077.00

Description

• Catalog Number: AA19987
• Chemical Name: Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9α,13α,14α)-
• CAS Number: 115-53-7
• Molecular Formula: C19H23NO4
• Molecular Weight: 329.3902
• MDL Number: MFCD00134303
• SMILES: COC1=C[C@@H]2[C@@H]3Cc4c([C@@]2(CC1=O)CCN3C)c(O)c(cc4)OC

Computed Properties

• Complexity: 562
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.2

Literature

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  PloS one 20130101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo.

  International journal of molecular medicine 20121101

• Design, synthesis and molecular docking studies of sinomenine derivatives.

  Bioorganic & medicinal chemistry letters 20120915

• Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells.

  European review for medical and pharmacological sciences 20120901

• Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use.

  Pharmaceutical biology 20120801

• Effects of alkaloid sinomenine on levels of IFN-γ, IL-1β, TNF-α and IL-6 in a rat renal allograft model.

  Immunotherapy 20120801

• Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.

  Journal of chromatography. A 20120727

• Sinomenine can prolong high-risk corneal graft survival in a rat model.

  Immunotherapy 20120601

• Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced lung cancer cell apoptosis.

  Molecular medicine reports 20120501

• Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents.

  European journal of medicinal chemistry 20120401

• Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120315

• Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.

  Immunological investigations 20120101

• Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.

  Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101

• Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase.

  Journal of neuroinflammation 20120101

• Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• A nonpolar blueberry fraction blunts NADPH oxidase activation in neuronal cells exposed to tumor necrosis factor-α.

  Oxidative medicine and cellular longevity 20120101

• Oxidative stress and microglial cells in Parkinson's disease.

  Mediators of inflammation 20120101

• Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

  Mediators of inflammation 20120101

• Protective effects of sinomenine against doxorubicin-induced nephrosis in rats.

  Journal of Asian natural products research 20120101

• Preparation and in vitro evaluation of tacrolimus-loaded ethosomes.

  TheScientificWorldJournal 20120101

• Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.

  Rheumatology international 20111101

• Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels.

  British journal of pharmacology 20111101

• (7R,8S,9S,12S)-1-Benz-yloxy-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane.

  Acta crystallographica. Section E, Structure reports online 20111001

• Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.

  Journal of ethnopharmacology 20110901

• (7R,8S,9S,12S)-1-(4-Chloro-benz-yloxy)-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane.

  Acta crystallographica. Section E, Structure reports online 20110901

• (9S,13R,14S)-7,8-Didehydro-4-(4-fluoro-benz-yloxy)-3,7-dimeth-oxy-17-methyl-morphinan-6-one sesquihydrate.

  Acta crystallographica. Section E, Structure reports online 20110801

• Anti-allergic effects of sinomenine by inhibition of prostaglandin D₂ and leukotriene C₄ in mouse bone marrow-derived mast cells.

  Immunopharmacology and immunotoxicology 20110601

• Two new morphinane alkaloids from Sinomenium acutum.

  Journal of Asian natural products research 20110601

• Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production.

  Bioorganic & medicinal chemistry 20110515

• (8S,9S,10R)-4-(4-Chloro-benz-yloxy)-7,8-didehydro-3,7-dimeth-oxy-17-methyl-morphinan-6-one monohydrate.

  Acta crystallographica. Section E, Structure reports online 20110501

• Immunosuppressive and anti-inflammatory activities of sinomenine.

  International immunopharmacology 20110301

• Immunomodulation of Autoimmune Arthritis by Herbal CAM.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Network target for screening synergistic drug combinations with application to traditional Chinese medicine.

  BMC systems biology 20110101

• Sinomenine inhibits microglial activation by Aβ and confers neuroprotection.

  Journal of neuroinflammation 20110101

• HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats.

  Acta pharmacologica Sinica 20101101

• (9S,13R,14S)-7,8-Didehydro-4-(4-iodo-benz-yloxy)-3,7-dimeth-oxy-17-methyl-morphinan-6-one monohydrate.

  Acta crystallographica. Section E, Structure reports online 20101101

• [Rat in vitro plasma-binding percentage determination of sinomenine hydrochloride by using microdialysis method and ultrafiltration].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

• [Study on the alkaloids in the stems and leaves of Stephania cepharantha (II)].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101001

• Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100801

• [Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

• Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii).

  Journal of natural medicines 20100701

• Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: the role of heme oxygenase-1.

  International immunopharmacology 20100601

• [The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

• Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride.

  Journal of pharmaceutical sciences 20100401

• Preparation and characterization of novel sinomenine microcapsules for oral controlled drug delivery.

  Drug development and industrial pharmacy 20100401

• Sinomenine, theophylline, cysteine, and levamisole: Comparisons of their kinetic effects on mineral formation induced by matrix vesicles.

  Journal of inorganic biochemistry 20100401

• [Preparation of sinomenine hydrochloride delayed-onset sustained-release tablets].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

• Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds.

  Phytotherapy research : PTR 20100201

• [Research progress on immunosuppressive activity of monomers extracted from Chinese medicine].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

• Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis.

  Biochemical and biophysical research communications 20100101

• The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity.

  Nutrition & metabolism 20100101

• Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro.

  Molecular medicine reports 20100101

• [Study on the detoxification of alcohol extracts from orientvine and its effective component on withdrawal syndromes of morphine].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090901

• [Research advances of mechanism of sinomenine in treating rheumatoid arthritis].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090801

• Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis.

  International immunopharmacology 20090701

• [Effects of sinomenine on the cultured smooth muscle cell MAPK PKC activities and intracellular free Ca2+].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090501

• Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147.

  Acta pharmacologica Sinica 20090401

• [Effect of sinomenine on the expression of chemokines and chemokine receptors in dendritic cells from patients with rheumatoid arthritis].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090401

• (9S,13R,14R)-7,8-Didehydro-3,4,7-trimeth-oxy-17-methyl-morphinan-6-one.

  Acta crystallographica. Section E, Structure reports online 20090401

• Screening of bioactive compounds from moutan cortex and their anti-inflammatory activities in rat synoviocytes.

  Evidence-based complementary and alternative medicine : eCAM 20090301

• [Preparation of gastric retenting and chronopharmacologic drug delivery tablets of sinomenine hydrochloride].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

• Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods.

  Biochimie 20090201

• Separation and detection of isoquinoline alkaloids using MEEKC coupled with field-amplified sample injection induced by ACN.

  Electrophoresis 20090201

• [Study on optimization of formulation and preparation process of sinomenine liposomes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

• [Study on pharmacokinetics and absolute bioavailability of sinomenine in beagle dogs].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

• Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis.

  BMC cell biology 20090101

• Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.

  BMC complementary and alternative medicine 20090101

• [Effects of sinomenine on synovial fluid and serum content of interleukin-1beta in rabbits with osteoarthritis].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20081201

• Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats.

  Biochemical and biophysical research communications 20081114

• [Bioequivalence study of sinomenine patch by microdialysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• Activation of opioid mu-receptor by sinomenine in cell and mice.

  Neuroscience letters 20081010

• Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis.

  Planta medica 20081001

• Development and evaluation of the Sinomenine transdermal patch.

  Pakistan journal of pharmaceutical sciences 20081001

• pH-dependent, stereoselective dimerization of sinomenine.

  Organic letters 20080904

• [Dynamic determination of sinomenine in skin by microdialysis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

• [Inhibitory effect of sinomenine on H2O2-induced apoptosis in neonatal rat cardiomyocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

• Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina.

  Organic letters 20080320

• Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine.

  International immunopharmacology 20080301

• [Role of alkaloid sinomenine in chronic rejection in the rat heart transplantation model].

  Zhonghua xin xue guan bing za zhi 20080201

• Morphinane alkaloid dimers from Sinomenium acutum.

  Journal of natural products 20080101

• Chemical markers for the quality control of herbal medicines: an overview.

  Chinese medicine 20080101

• Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines.

  Chinese medicine 20080101

• Sinomenine inhibits activation of rat retinal microglia induced by advanced glycation end products.

  International immunopharmacology 20071205

• Sinomenine suppresses TNF-alpha-induced VCAM-1 expression in human umbilical vein endothelial cells.

  Journal of ethnopharmacology 20071101

• Effect of sinomenine on collagen-induced arthritis in mice.

  Autoimmunity 20071101

• Vasodilatation induced by sinomenine lowers blood pressure in spontaneously hypertensive rats.

  Clinical and experimental pharmacology & physiology 20071001

• [Preparation of sinomenine microemulsion and its transdermal absorption].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

• [Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

• Vascular pharmacology of mokuboito (mu-fang-yi-tang) and its constituents on the smooth muscle and the endothelium in rat aorta.

  Evidence-based complementary and alternative medicine : eCAM 20070901

• Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis.

  Cell biology international 20070801

• Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells.

  International immunopharmacology 20070801

• Assessment of in vitro and in vivo recovery of sinomenine using microdialysis.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20070801

• Preparative isolation and purification of sinomenine from Sinomenium acutum by centrifugal partition chromatography.

  Journal of separation science 20070801

• Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis.

  Biological & pharmaceutical bulletin 20070801

• Voltammetric determination of sinomenine in biological fluid using a glassy carbon electrode modified by a composite film of polycysteic acid and carbon nanotubes.

  Combinatorial chemistry & high throughput screening 20070801

• [The effect of sinomenine on nNOS activity of brain tissues in morphine dependent and withdrawal mice].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801

• Retraction: Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.

  Journal of pharmacological sciences 20070701

• [Effects of sinomenine on NO/nNOS system in cerebellum and spinal cord of morphine-dependent and withdrawal mice].

  Sheng li xue bao : [Acta physiologica Sinica] 20070625

• Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice.

  International immunopharmacology 20070501

• Sinomenine inhibits maturation of monocyte-derived dendritic cells through blocking activation of NF-kappa B.

  International immunopharmacology 20070501

• [Effects of sinomenine on intracellular free calcium concentration and the activity of protein kinase in cultured rabbit aortic smooth muscle cells].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070501

• Effect of sinomenine on human cytochrome P450 activity.

  Clinica chimica acta; international journal of clinical chemistry 20070401

• In vivo analysis and spatial profiling of phytochemicals in herbal tissue by matrix-assisted laser desorption/ionization mass spectrometry.

  Analytical chemistry 20070401

• Determination of sinomenine in Sinomenium acutum by capillary electrophoresis with electrochemiluminescence detection.

  Analytica chimica acta 20070321

• A spectroscopic and molecular modeling study of sinomenine binding to transferrin.

  Bioorganic & medicinal chemistry letters 20070315

• [The effects of sinomenine on the expresssion of ICAM-1 and IL-2 during the rejection of rat cardiac allograft].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070301

• Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal medicinal preparation.

  Journal of pharmaceutical and biomedical analysis 20070104

• Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry.

  Biomedical chromatography : BMC 20070101

• Three major urinary metabolites of sinomenine in rats.

  Journal of Asian natural products research 20070101

• Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.

  Journal of neuroinflammation 20070101

• Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions.

  Drug target insights 20070101

• Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine.

  Pharmaceutical research 20061201

• Suppression of Th1 and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the chinese medicinal plant Sinomenium acutum.

  Planta medica 20061201

• [Effects of Caulis Sinomenii and sinomenine on morphine-induced place preference and brain histamine level in mice].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061201

• Synthesis and anti-inflammatory activities investigation of sinomenine derivatives on ring C.

  Natural product research 20060901

• [Determination in vitro of rat plasma protein binding rate of sinomenine by using microdialysis method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060901

• In vitro pharmacological actions of sinomenine on the smooth muscle and the endothelial cell activity in rat aorta.

  Life sciences 20060815

• Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum.

  Archives of pharmacal research 20060801

• Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.

  Life sciences 20060710

• [Study on determination of entrapment efficiency of sinomenine liposomes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

• [Effects of the alkaloid sinomenine on COX-2 activity and acute rejection in heart allografts: an experiment with rats].

  Zhonghua yi xue za zhi 20060404

• The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.

  Journal of ethnopharmacology 20060220

• Behavioral effects of sinomenine in murine models of anxiety.

  Life sciences 20051205

• Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.

  Journal of pharmacological sciences 20051201

• [Study of the relative recovery of sinomenine microdialysis system and it's influential factor].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051201

• The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro.

  Life sciences 20051104

• [New study progress of sinomenine].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001

• [Changes in cAMP and cGMP levels in neonatal rat histaminergic neurons of tuberomammillary nucleus following 48-hour morphine exposure and effects of sinomenine intervention].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050901

• [Effect of sinomenine on adjuvant arthritis and its mechanisms].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

• Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs.

  World journal of gastroenterology 20050807

• Sinomenine inhibits B7-H1 and B7-DC expression on human renal tubular epithelial cells.

  International immunopharmacology 20050801

• Morphinane alkaloids with cell protective effects from Sinomenium acutum.

  Journal of natural products 20050701

• [Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701

• Determination of sinomenine in human plasma by HPLC/ESI/ion trap mass spectrum.

  Clinica chimica acta; international journal of clinical chemistry 20050601

• [Research on extracting process for Fengshitongbi capsules].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050601

• Supercritical fluid extraction of sinomenine from Sinomenium acutum (Thumb) Rehd et Wils.

  Journal of chromatography. A 20050520

• Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats.

  Journal of ethnopharmacology 20050513

• Requirement for ERK activation in sinomenine-induced apoptosis of macrophages.

  Immunology letters 20050415

• Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats.

  Journal of ethnopharmacology 20050408

• [Immunopharmacological action of sinomenine, an alkaloid isolated from Sinomenium acutum, and its mechanism of action in treating rheumatoid arthritis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050201

• Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method.

  Biological & pharmaceutical bulletin 20050101

• The anti-angiogenic effect of sinomenine.

  Angiogenesis 20050101

• Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart.

  The American journal of Chinese medicine 20050101

• N-inversion-associated conformational dynamics is unusually rapid in morphine alkaloids.

  Journal of natural products 20041101

• [Inhibitory effect of sinomenine on expression of cyclooxygenase-2 in lipopolysaccharide-induced PC-12 cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901

• Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

  Journal of ethnopharmacology 20040401

• [Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040301

• Sinomenine blocks tissue remodeling in a rat model of chronic cardiac allograft rejection.

  Transplantation 20030415

• Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein in Sprague-Dawley rats.

  Life sciences 20030411

• Effect of sinomenine on morphine dependence in isolated guinea pig ileum.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401

• [The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

• [Study on the permeability of 125I-sinomenine via the transdermal delivery way in rats].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020601

• [Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020501

• [Study progress in Sinomenium acutum (Thunb.) Rehd. et Wils].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301

• [Advances in the study on transdermal permeation of active elements of natural drugs in vitro].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

• The alkaloid sinomenine in rat transplant models: and yet it does move.

  Transplant international : official journal of the European Society for Organ Transplantation 20010101