115-96-8 | Ethanol, 2-chloro-, 1,1',1''-phosphate

Packsize	Purity	Availability	Price	Discounted Price
1g	95%(GC)	in stock	$24.00	$17.00
25g	>93.0%(GC)	in stock	$27.00	$19.00
100g	>93.0%(GC)	in stock	$84.00	$59.00

Description

• Catalog Number: AA20013
• Chemical Name: Ethanol, 2-chloro-, 1,1',1''-phosphate
• CAS Number: 115-96-8
• Molecular Formula: C6H12Cl3O4P
• Molecular Weight: 285.4898
• MDL Number: MFCD00000967
• SMILES: ClCCOP(=O)(OCCCl)OCCCl
• NSC Number: 3213

Computed Properties

• Complexity: 152
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• XLogP3: 1.3

Literature

• The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish.

  Chemosphere 20170201

• Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats.

  The Journal of toxicological sciences 20170101

• Developmental neurotoxicity of organophosphate flame retardants in early life stages of Japanese medaka (Oryzias latipes).

  Environmental toxicology and chemistry 20161201

• Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway.

  Journal of applied toxicology : JAT 20160701

• Differential modulation of neuro- and interrenal steroidogenesis of juvenile salmon by the organophosphates - tris(2-butoxyethyl)- and tris(2-cloroethyl) phosphate.

  Environmental research 20160701

• Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity.

  Neurotoxicology and teratology 20160101

• Lipid peroxidation and oxidative stress responses in juvenile salmon exposed to waterborne levels of the organophosphate compounds tris(2-butoxyethyl)- and tris(2-chloroethyl) phosphates.

  Journal of toxicology and environmental health. Part A 20160101

• TPP and TCEP induce oxidative stress and alter steroidogenesis in TM3 Leydig cells.

  Reproductive toxicology (Elmsford, N.Y.) 20151101

• Exposure of male mice to two kinds of organophosphate flame retardants (OPFRs) induced oxidative stress and endocrine disruption.

  Environmental toxicology and pharmacology 20150701

• Affinities of organophosphate flame retardants to tumor suppressor gene p53: an integrated in vitro and in silico study.

  Toxicology letters 20150122

• Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP).

  Neurotoxicology and teratology 20150101

• Determination and prediction of the binding interaction between organophosphate flame retardants and p53.

  Chemical research in toxicology 20141117

• The interaction between organic phosphate ester and p53: an integrated experimental and in silico approach.

  Marine pollution bulletin 20140830

• Potential estrogenic effects of phosphorus-containing flame retardants.

  Environmental science & technology 20140617

• Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels.

  Toxicology letters 20140616

• Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteosarcoma (U2OS) cell-based reporter gene assays.

  Environmental science & technology 20130319

• Development of surrogate correlation models to predict trace organic contaminant oxidation and microbial inactivation during ozonation.

  Water research 20121201

• Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure.

  Environmental health perspectives 20121101

• Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis.

  Archives of toxicology 20120901

• Occurrence of alternative flame retardants in indoor dust from New Zealand: indoor sources and human exposure assessment.

  Chemosphere 20120901

• Complete detoxification of tris(2-chloroethyl) phosphate by two bacterial strains: Sphingobium sp. strain TCM1 and Xanthobacter autotrophicus strain GJ10.

  Journal of bioscience and bioengineering 20120901

• Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis.

  Chemosphere 20120801

• Occurrence and behavior of emerging contaminants in surface water and a restored wetland.

  Chemosphere 20120801

• Levels and distributions of organophosphate flame retardants and plasticizers in sediment from Taihu Lake, China.

  Environmental toxicology and chemistry 20120701

• Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish.

  Aquatic toxicology (Amsterdam, Netherlands) 20120615

• Organophosphorus flame retardants and plasticizers in airborne particles over the Northern Pacific and Indian Ocean toward the Polar Regions: evidence for global occurrence.

  Environmental science & technology 20120320

• Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain).

  Chemosphere 20120301

• Determination of non-halogenated, chlorinated and brominated organophosphate flame retardants in herring gull eggs based on liquid chromatography-tandem quadrupole mass spectrometry.

  Journal of chromatography. A 20120113

• Organophosphate and phthalate esters in standard reference material 2585 organic contaminants in house dust.

  Analytical and bioanalytical chemistry 20120101

• Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.

  Toxicology and applied pharmacology 20111101

• [Simultaneous determination of six organophosphorous flame retardants in textiles by gas chromatography-tandem mass spectrometry combined with microwave assisted extraction].

  Se pu = Chinese journal of chromatography 20110801

• Identification of flame retardants in polyurethane foam collected from baby products.

  Environmental science & technology 20110615

• Reaction of tris(2-chloroethyl)phosphate with reduced sulfur species.

  Chemosphere 20110501

• Attenuation of contaminants of emerging concern during surface-spreading aquifer recharge.

  The Science of the total environment 20110215

• Occurrence and distribution of organophosphorus flame retardants and plasticizers in anthropogenically affected groundwater.

  Journal of environmental monitoring : JEM 20110201

• Organophosphate ester flame retardant-induced acute intoxications in dogs.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20101201

• Intra- and interspecific nuclear ribosomal gene variation in the two Japanese Eothenomys species, E. andersoni and E. smithii.

  Zoological science 20101201

• Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.

  International journal of environmental research and public health 20101101

• Occurrence and fate of organophosphorus flame retardants and plasticizers in urban and remote surface waters in Germany.

  Water research 20100701

• Seasonal fluctuations of organophosphate concentrations in precipitation and storm water runoff.

  Chemosphere 20100201

• Cellular effect evaluation of micropollutants using transporter functions of renal proximal tubule cells.

  Chemosphere 20091101

• Pressurized liquid extraction of organophosphate triesters from sediment samples using aqueous solutions.

  Journal of chromatography. A 20091016

• Waste-indicator and pharmaceutical compounds in landfill-leachate-affected ground water near Elkhart, Indiana, 2000-2002.

  Bulletin of environmental contamination and toxicology 20090601

• Advanced oxidation kinetics of aqueous trialkyl phosphate flame retardants and plasticizers.

  Environmental science & technology 20090415

• Indirect potable reuse: a sustainable water supply alternative.

  International journal of environmental research and public health 20090301

• Respiratory and dermal exposure to organophosphorus flame retardants and tetrabromobisphenol A at five work environments.

  Environmental science & technology 20090201

• Effect of tris-(2-chloroethyl)-phosphate (TCEP) at environmental concentration on the levels of cell cycle regulatory protein expression in primary cultured rabbit renal proximal tubule cells.

  Chemosphere 20081201

• Photooxidation and subsequent biodegradability of recalcitrant tri-alkyl phosphates TCEP and TBP in water.

  Water research 20081201

• Sources of endocrine-disrupting chemicals in urban wastewater, Oakland, CA.

  The Science of the total environment 20081101

• A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States--II) untreated drinking water sources.

  The Science of the total environment 20080901

• A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States--I) groundwater.

  The Science of the total environment 20080901

• Enrichment and characterization of chlorinated organophosphate ester-degrading mixed bacterial cultures.

  Journal of bioscience and bioengineering 20080701

• Differential response of Mono Mac 6, BEAS-2B, and Jurkat cells to indoor dust.

  Environmental health perspectives 20070901

• [Evaluation of indoor air contaminants by means of reference and guideline values].

  Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20070701

• [Determination of three organophosphorous flame retardants in textiles by gas chromatography].

  Se pu = Chinese journal of chromatography 20070501

• Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters.

  Water research 20070301

• Indoor organophosphate and polybrominated flame retardants in Tokyo.

  Indoor air 20070201

• Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast.

  Molecular systems biology 20070101

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Investigation of cytotoxic, genotoxic, mutagenic, and estrogenic effects of the flame retardants tris-(2-chloroethyl)-phosphate (TCEP) and tris-(2-chloropropyl)-phosphate (TCPP) in vitro.

  Toxicology letters 20060220

• Elimination of organophosphate ester flame retardants and plasticizers in drinking water purification.

  Water research 20060201

• Determination of phosphoric acid triesters in human plasma using solid-phase microextraction and gas chromatography coupled to inductively coupled plasma mass spectrometry.

  Journal of chromatography. A 20060127

• Organophosphate triesters in indoor environments.

  Journal of environmental monitoring : JEM 20050901

• Organophosphorus flame retardants and plasticizers in air from various indoor environments.

  Journal of environmental monitoring : JEM 20050801

• Exposure to phthalate esters from indoor environment.

  Journal of exposure analysis and environmental epidemiology 20041101

• Organophosphorus flame retardants and plasticisers in surface waters.

  The Science of the total environment 20041001

• Organophosphate flame retardants and plasticisers in wastewater treatment plants.

  Journal of environmental monitoring : JEM 20040701

• Screening of organophosphorus compounds and their distribution in various indoor environments.

  Chemosphere 20031201

• Estimation of organophosphoric acid triesters in soft polyurethane foam using a concentrated sulfuric acid dissolution technique and gas chromatography with flame photometric detection.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20031201

• Monitoring of the three organophosphate esters TBP, TCEP and TBEP in river water and ground water (Oder, Germany).

  Journal of environmental monitoring : JEM 20030401

• Degradation of organophosphoric esters in leachate from a sea-based solid waste disposal site.

  Chemosphere 20020701

• Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance.

  Environmental science & technology 20020315

• Chlorinated ethyl and isopropyl phosphoric acid triesters in the indoor environment--an inter-laboratory exposure study.

  Indoor air 20010901

• NTP Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CAS No. 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

  National Toxicology Program technical report series 19910501

• Metabolism of tris(2-chloroethyl) phosphate in rats and mice.

  Drug metabolism and disposition: the biological fate of chemicals 19910101