115550-35-1 | Marbofloxacin

Packsize	Purity	Availability	Price	Discounted Price
1g	96%	in stock	$55.00	$39.00
5g	96%	in stock	$129.00	$90.00
10g	96%	in stock	$233.00	$163.00
25g	96%	in stock	$448.00	$314.00
100g	96%	in stock	$1,317.00	$922.00

Description

• Catalog Number: AA20732
• Chemical Name: Marbofloxacin
• CAS Number: 115550-35-1
• Molecular Formula: C17H19FN4O4
• Molecular Weight: 362.3556
• MDL Number: MFCD00864820
• SMILES: CN1CCN(CC1)c1c(F)cc2c3c1OCN(n3cc(c2=O)C(=O)O)C

Computed Properties

• Complexity: 636
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: -0.5

Literature

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  Water research 20121101

• Effect of marbofloxacin on Haemophilus parasuis nasal carriage.

  Veterinary microbiology 20120914

• Leishmania infantum infection in two captive barbary lions (Panthera leo leo).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20120901

• Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius.

  Veterinary dermatology 20120801

• Acute phase response to Mycoplasma haemofelis and 'Candidatus Mycoplasma haemominutum' infection in FIV-infected and non-FIV-infected cats.

  Veterinary journal (London, England : 1997) 20120801

• Determination of quinolones in milk samples using a combination of magnetic solid-phase extraction and capillary electrophoresis.

  Electrophoresis 20120701

• Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic indices of marbofloxacin after intravenous, subcutaneous, and intramuscular administrations in buffalo calves (<10 days old).

  Journal of veterinary pharmacology and therapeutics 20120601

• Canine leishmaniosis: in vitro efficacy of miltefosine and marbofloxacin alone or in combination with allopurinol against clinical strains of Leishmania infantum.

  Parasitology research 20120601

• Conservative management of pyothorax in an Amur tiger (Panthera tigris altaica).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20120601

• One-year clinical and parasitological follow-up of dogs treated with marbofloxacin for canine leishmaniosis.

  Veterinary parasitology 20120525

• Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography-tandem mass spectrometry using a QuEChERS extraction procedure.

  Talanta 20120515

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• Determination of (fluoro)quinolones in environmental water using online preconcentration with column switching linked to large sample volumes and fluorescence detection.

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• Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection.

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• Marbofloxacin disposition after intravenous administration of a single dose in wild mallard ducks (Anas platyrhynchos).

  Journal of avian medicine and surgery 20120301

• Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs.

  Veterinary microbiology 20120127

• Sunlight-induced degradation of soil-adsorbed veterinary antimicrobials Marbofloxacin and Enrofloxacin.

  Chemosphere 20120101

• Survey of marbofloxacin susceptibility of bacteria isolated from cattle with respiratory disease and mastitis in Europe.

  The Veterinary record 20120101

• Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs.

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• Mutant-prevention concentration and mechanism of resistance in clinical isolates and enrofloxacin/marbofloxacin-selected mutants of Escherichia coli of canine origin.

  Journal of medical microbiology 20111001

• Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110901

• Pharmacokinetic interactions of marbofloxacin with anti-inflammatory drugs in buffalo calves.

  The Veterinary record 20110813

• Oxidized multi-walled carbon nanotubes for the dispersive solid-phase extraction of quinolone antibiotics from water samples using capillary electrophoresis and large volume sample stacking with polarity switching.

  Journal of chromatography. A 20110805

• Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves.

  Journal of veterinary pharmacology and therapeutics 20110801

• Total ear canal ablation and lateral bulla osteotomy for treatment of otitis externa and media in a rabbit.

  Journal of the American Veterinary Medical Association 20110715

• Hollow fiber-based liquid phase microextraction (HF-LPME) as a new approach for the HPLC determination of fluoroquinolones in biological and environmental matrices.

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• Multiresidue determination of quinolones regulated by the European Union in bovine and porcine plasma. Application of chromatographic and capillary electrophoretic methodologies.

  Biomedical chromatography : BMC 20110501

• Quinolones control in milk and eggs samples by liquid chromatography using a surfactant-mediated mobile phase.

  Analytical and bioanalytical chemistry 20110501

• Disposition of marbofloxacin in vulture (Gyps fulvus) after intravenous administration of a single dose.

  Research in veterinary science 20110401

• The disposition of marbofloxacin after single dose intravenous, intramuscular and oral administration to Muscovy ducks.

  Journal of veterinary pharmacology and therapeutics 20110401

• Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection.

  Veterinary microbiology 20110301

• Sensitivity to antibiotics of Arcanobacterium pyogenes and Escherichia coli from the uteri of cows with metritis/endometritis.

  Veterinary journal (London, England : 1997) 20110201

• Effects of fluoroquinolones on CYP4501A and 3A in male broilers.

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• Disseminated Mycobacterium avium subspecies infection in a cat.

  Journal of feline medicine and surgery 20110201

• Detection of feline haemoplasma species in experimental infections by in-situ hybridisation.

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• Pharmacokinetics of marbofloxacin in Muscovy ducks (Cairina moschata).

  Journal of veterinary pharmacology and therapeutics 20110201

• Marbofloxacin reaches high concentration in pig tonsils in a dose-dependent fashion.

  Journal of veterinary pharmacology and therapeutics 20110201

• Plasma and urine concentrations of marbofloxacin following single subcutaneous administration to cats.

  Berliner und Munchener tierarztliche Wochenschrift 20110101

• Estimation of transmission parameters of a fluoroquinolone-resistant Escherichia coli strain between pigs in experimental conditions.

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• Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis.

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• Risk factors for colonization of E. coli in Atlantic Bottlenose Dolphins (Tursiops truncatus) in the Indian River Lagoon, Florida.

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• Absorption of enrofloxacin and marbofloxacin after oral and subcutaneous administration in diseased koalas (Phascolarctos cinereus).

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• Room temperature ionic liquid-mediated molecularly imprinted polymer monolith for the selective recognition of quinolones in pork samples.

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• Short communication: Fluoroquinolone susceptibility of Staphylococcus aureus strains isolated from caprine clinical mastitis in southeast Spain.

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• Dispersive liquid-liquid microextraction combined with nonaqueous capillary electrophoresis for the determination of fluoroquinolone antibiotics in waters.

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• Plasma and tissue cage fluid pharmacokinetics of marbofloxacin after intravenous, intramuscular, and oral single-dose application in pigs.

  Journal of veterinary pharmacology and therapeutics 20101001

• Identification of Qnr and AAC(6')-1b-cr plasmid-mediated fluoroquinolone resistance determinants in multidrug-resistant Enterobacter spp. isolated from extraintestinal infections in companion animals.

  Veterinary microbiology 20100714

• Photochemical degradation of marbofloxacin and enrofloxacin in natural waters.

  Environmental science & technology 20100615

• Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats.

  Veterinary journal (London, England : 1997) 20100501

• Haemotropic mycoplasmas: what's their real significance in cats?

  Journal of feline medicine and surgery 20100501

• Single-step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk.

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• PK-PD integration and modeling of marbofloxacin in sheep.

  Research in veterinary science 20100201

• Influence of Pasteurella multocida infection on the pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in rabbits.

  Journal of veterinary pharmacology and therapeutics 20100201

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• Simultaneous determination of eleven quinolones in animal feed by liquid chromatography with fluorescence and ultraviolet absorbance detection.

  Journal of chromatography. A 20091113

• Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta).

  Research in veterinary science 20091001

• Solid-phase extraction and HPLC determination of fluoroquinolones in surface waters.

  Journal of separation science 20090901

• Pharmacokinetics of marbofloxacin in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular doses.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20090901

• Human-to-dog transmission of methicillin-resistant Staphylococcus aureus.

  Emerging infectious diseases 20090801

• Free-radical-induced oxidative and reductive degradation of fluoroquinolone pharmaceuticals: kinetic studies and degradation mechanism.

  The journal of physical chemistry. A 20090709

• Determination of marbofloxacin residues in beef and pork with an enzyme-linked immunosorbent assay.

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  Analytical chemistry 20090415

• Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?

  Rapid communications in mass spectrometry : RCM 20090401

• Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits.

  American journal of veterinary research 20090401

• Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090301

• Water-compatible molecularly imprinted polymer for the selective recognition of fluoroquinolone antibiotics in biological samples.

  Analytical and bioanalytical chemistry 20090101

• Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol.

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• Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry.

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• Tissue distribution of marbofloxacin after 'systemic' administration into the isolated perfused bovine udder.

  Veterinary journal (London, England : 1997) 20081001

• Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections.

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• Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver.

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• Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS.

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• Multiresidue determination of quinolones in animal and fishery products by HPLC.

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080601

• Efficacy of different treatment regimens of marbofloxacin in canine visceral leishmaniosis: a pilot study.

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• In-line solid-phase extraction preconcentration in capillary electrophoresis-tandem mass spectrometry for the multiresidue detection of quinolones in meat by pressurized liquid extraction.

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• Improved determination of quinolones in milk at their MRL levels using LC-UV, LC-FD, LC-MS and LC-MS/MS and validation in line with regulation 2002/657/EC.

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• Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis.

  American journal of veterinary research 20080301

• Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats.

  Journal of veterinary internal medicine 20080101

• Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves.

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• Multiresidue method for simultaneous determination of quinolone antibacterials in pig kidney samples by liquid chromatography with fluorescence detection.

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• Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats.

  The Journal of antimicrobial chemotherapy 20071101

• Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis.

  Journal of veterinary pharmacology and therapeutics 20071001

• Comparative quantification of the in vitro activity of veterinary fluoroquinolones.

  Veterinary microbiology 20070920

• Pulmonary function and antimicrobial concentration after marbofloxacin inhalation in horses.

  The Veterinary record 20070908

• Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats.

  Veterinary journal (London, England : 1997) 20070901

• Pharmacokinetics of a single intravenous dose of marbofloxacin in adult donkeys.

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• [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20070701

• Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves.

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• Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.

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• In vitro antimicrobial activity of marbofloxacin and enrofloxacin against bacterial strains isolated from companion animals.

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• Simultaneous determination of trace levels of 10 quinolones in swine, chicken, and shrimp muscle tissues using HPLC with programmable fluorescence detection.

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• Stability of frozen stock solutions of beta-lactam antibiotics, cephalosporins, tetracyclines and quinolones used in antibiotic residue screening and antibiotic susceptibility testing.

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• Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples.

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• Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals.

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• Single-dose pharmacokinetics of marbofloxacin in Egyptian buffalo (Bubalus bubalis L.) steers.

  Berliner und Munchener tierarztliche Wochenschrift 20070101

• Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis.

  Journal of the American Animal Hospital Association 20070101

• Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin.

  Journal of the American Animal Hospital Association 20070101

• Determination of fluoroquinolones in milk samples by postcolumn derivatization liquid chromatography with luminescence detection.

  Journal of agricultural and food chemistry 20061227

• Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies.

  Journal of veterinary pharmacology and therapeutics 20061201

• Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves.

  Journal of veterinary science 20061201

• Multiresidue method for the determination of quinolone antibiotics in bovine raw milk by capillary electrophoresis-tandem mass spectrometry.

  Analytical chemistry 20061115

• Effect of chronic FIV infection, and efficacy of marbofloxacin treatment, on Mycoplasma haemofelis infection.

  Veterinary microbiology 20061031

• Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction.

  Journal of veterinary pharmacology and therapeutics 20061001

• Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation.

  Journal of veterinary pharmacology and therapeutics 20061001

• Epidemiology and susceptibility of pathogenic bacteria responsible for upper respiratory tract infections in pet rabbits.

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• Comparison of faecal and optimal growth conditions on in vitro pharmacodynamic activity of marbofloxacin against Escherichia coli.

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• Comparative pharmacokinetics of marbofloxacin after a single intramuscular administration at two dosages to camels (Camelus dromedarius).

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• The pharmacokinetic behaviour of marbofloxacin in Eurasian buzzards (Buteo buteo) after intraosseous administration.

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• Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA).

  Journal of agricultural and food chemistry 20060419

• Effect of chronic feline immunodeficiency infection, and efficacy of marbofloxacin treatment, on 'Candidatus Mycoplasma haemominutum' infection.

  Microbes and infection 20060301

• Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060301

• Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs.

  The Veterinary record 20060211

• Pharmacokinetic and pharmacodynamic interactions of tolfenamic acid and marbofloxacin in goats.

  Research in veterinary science 20060201

• Canine visceral leishmaniasis: comparison of in vitro leishmanicidal activity of marbofloxacin, meglumine antimoniate and sodium stibogluconate.

  Veterinary parasitology 20060130

• Inclusion of marbofloxacin in PMMA orthopaedic cement: an in vitro experimental study.

  Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20060101

• Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats.

  Journal of veterinary internal medicine 20060101

• Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs.

  American journal of veterinary research 20051201

• Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches.

  Veterinary journal (London, England : 1997) 20051101

• Rapid depletion of marbofloxacin residues in rabbit after therapeutic treatment.

  Journal of food protection 20051101

• A comparative study of two antimicrobial/anti-inflammatory formulations in the treatment of canine otitis externa.

  Veterinary dermatology 20051001

• Evaluation of the concentration of marbofloxacin in alveolar macrophages and pulmonary epithelial lining fluid after administration in dogs.

  American journal of veterinary research 20051001

• Isolation of methicillin-resistant Staphylococcus aureus from a non-healing abscess in a cat.

  The Veterinary record 20050924

• Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats.

  Veterinary journal (London, England : 1997) 20050901

• Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs.

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• Antimicrobial drug susceptibility of Staphylococcus intermedius clinical isolates from canine pyoderma.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20050201

• Influence of marbofloxacin on the pharmacokinetics and pharmacodynamics of tolfenamic acid in calves.

  Journal of veterinary pharmacology and therapeutics 20050201

• Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.

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  Berliner und Munchener tierarztliche Wochenschrift 20050101

• A seven-year survey of susceptibility to marbofloxacin of pathogenic strains isolated from pets.

  International journal of antimicrobial agents 20041201

• Population pharmacokinetics of marbofloxacin in horses: preliminary analysis.

  Journal of veterinary pharmacology and therapeutics 20041001

• Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries.

  International journal of antimicrobial agents 20040901

• Treatment of canine pyoderma with ibafloxacin and marbofloxacin--fluoroquinolones with different pharmacokinetic profiles.

  Journal of veterinary pharmacology and therapeutics 20040601

• Multiresidue determination of fluoroquinolones in milk by column liquid chromatography with fluorescence and ultraviolet absorbance detection.

  Journal of chromatography. A 20040423

• Age-related changes in the pharmacokinetics of marbofloxacin after intravenous administration in goats.

  Journal of veterinary pharmacology and therapeutics 20040201

• Pharmacokinetics of marbofloxacin in lactating cows after repeated intramuscular administrations and pharmacodynamics against mastitis isolated strains.

  Journal of dairy science 20040101

• Clinical signs, diagnosis and treatment of three dogs with angiostrongylosis in Ireland.

  Irish veterinary journal 20040101

• Antibiotic susceptibilities of recent isolates of Mycoplasma bovis in Belgium.

  The Veterinary record 20031004

• Population pharmacokinetics of marbofloxacin in aqueous humor after intravenous administration in dogs.

  American journal of veterinary research 20030701

• The effect of orally administered marbofloxacin on the pharmacokinetics of theophylline.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030601

• In vitro susceptibility of Arcobacter butzleri and Arcobacter cryaerophilus to different antimicrobial agents.

  International journal of antimicrobial agents 20030501

• Influence of Escherichia coli endotoxin-induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats.

  Journal of veterinary pharmacology and therapeutics 20030201

• In vitro sensitivity of Hungarian Actinobaculum suis strains to selected antimicrobials.

  Acta veterinaria Hungarica 20030101

• Identification and antimicrobial susceptibility of coagulase positive staphylococci isolated from healthy dogs and dogs suffering from otitis externa.

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  Equine veterinary journal 20020701

• Pharmacokinetics of marbofloxacin in mature horses after single intravenous and intramuscular administration.

  Equine veterinary journal 20020701

• Pharmacokinetics of marbofloxacin in horses.

  Equine veterinary journal 20020701

• Pharmacokinetic characteristics and tissue residues for marbofloxacin and its metabolite N-desmethyl-marbofloxacin in broiler chickens.

  American journal of veterinary research 20020701

• Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin in calf serum, exudate and transudate.

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• In vitro antimicrobial susceptibility of 183 Pseudomonas aeruginosa strains isolated from dogs to selected antipseudomonal agents.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020501

• Multiresidue determination of (fluoro)quinolone antibiotics in swine kidney using liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20020405

• Using nonaqueous capillary electrophoresis to analyze several quinolones in pig kidney samples.

  Electrophoresis 20020201

• Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration.

  Journal of veterinary pharmacology and therapeutics 20020201

• Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats.

  Journal of veterinary pharmacology and therapeutics 20011201

• A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease.

  Journal of veterinary pharmacology and therapeutics 20011001

• Determination of residues of enrofloxacin and its metabolite ciprofloxacin in biological materials by capillary electrophoresis.

  Journal of chromatography. B, Biomedical sciences and applications 20010805

• Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates.

  Veterinary microbiology 20010703

• Evaluation of the clinical efficacy of marbofloxacin (Zeniquin) tablets for the treatment of canine pyoderma: an open clinical trial.

  Veterinary dermatology 20010601

• The disposition of marbofloxacin in Eurasian buzzards (Buteo buteo) after intravenous administration.

  Journal of veterinary pharmacology and therapeutics 20010401