1160561-31-8 | 3-Chloro-5-(trifluoromethyl)phenylboronic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$8.00	$5.00
1g	97%	in stock	$20.00	$14.00
5g	97%	in stock	$41.00	$29.00
10g	97%	in stock	$80.00	$56.00

Description

• Catalog Number: AA14703
• Chemical Name: 3-Chloro-5-(trifluoromethyl)phenylboronic acid
• CAS Number: 1160561-31-8
• Molecular Formula: C7H5BClF3O2
• Molecular Weight: 224.3726
• MDL Number: MFCD07778020
• SMILES: Clc1cc(cc(c1)C(F)(F)F)B(O)O

Computed Properties

• Complexity: 200
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1

Upstream Synthesis Route

(3-Chloro-5-(trifluoromethyl)phenyl)boronic acid, commonly referred to as $name$, is a versatile compound widely used in modern chemical synthesis. This boronic acid derivative plays a crucial role as a key building block in the production of various pharmaceuticals, agrochemicals, and materials due to its unique properties and reactivity.In organic synthesis, $name$ is frequently employed as a reagent in Suzuki-Miyaura cross-coupling reactions, a powerful and valuable method for forming carbon-carbon bonds. This reaction, catalyzed by palladium, allows for the efficient and selective construction of complex molecular structures. By utilizing (3-Chloro-5-(trifluoromethyl)phenyl)boronic acid as a boron source, chemists can access a wide range of aryl and heteroaryl-substituted compounds with high regioselectivity and functional group tolerance.Furthermore, (3-Chloro-5-(trifluoromethyl)phenyl)boronic acid is instrumental in the development of pharmaceuticals by enabling the introduction of diverse aromatic functionalities into drug-like molecules. Its incorporation often enhances the bioactivity, metabolic stability, and overall pharmacokinetic properties of the final compounds. Due to its compatibility with various reaction conditions and scalability, $name$ has become a valuable tool in medicinal chemistry for the synthesis of novel drug candidates.Beyond its applications in pharmaceuticals, (3-Chloro-5-(trifluoromethyl)phenyl)boronic acid also finds utility in the preparation of advanced materials, such as liquid crystals, polymers, and organic electronic devices. Its ability to serve as a versatile synthetic intermediate enables the construction of functionalized aryl motifs with desirable properties, contributing to the advancement of materials science and technology.In summary, the strategic use of (3-Chloro-5-(trifluoromethyl)phenyl)boronic acid in chemical synthesis highlights its importance as a valuable reagent for the efficient construction of complex molecular structures with diverse applications in the fields of organic chemistry, pharmaceuticals, and materials science.