1161205-04-4 | N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$6.00	$4.00
10mg	98%	in stock	$8.00	$6.00
25mg	98%	in stock	$12.00	$9.00
50mg	98%	in stock	$20.00	$14.00
100mg	98%	in stock	$34.00	$24.00

Description

• Catalog Number: AA14941
• Chemical Name: N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide
• CAS Number: 1161205-04-4
• Molecular Formula: C13H11ClN2O2
• Molecular Weight: 262.6916
• MDL Number: MFCD16618402
• SMILES: COc1cc(ccc1Cl)NC(=O)c1ccccn1

Computed Properties

• Complexity: 288
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 2.6

Literature

• Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers.

  Molecular pharmacology 20120901

• Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.

  Journal of medicinal chemistry 20111110

• Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.

  Journal of medicinal chemistry 20110728

• Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

  Journal of medicinal chemistry 20110224

• Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

  Journal of medicinal chemistry 20090723