1162-53-4 | Pregna-5,16-dien-20-one, 3-hydroxy-, (3b)-

Packsize	Purity	Availability	Price	Discounted Price
5mg	>98%(HPLC)	in stock	$63.00	$45.00
25mg	>98%(HPLC)	in stock	$156.00	$109.00
100mg	>98%(HPLC)	in stock	$394.00	$276.00
1g	98%	in stock	$2,566.00	$1,797.00

Description

• Catalog Number: AA15211
• Chemical Name: Pregna-5,16-dien-20-one, 3-hydroxy-, (3b)-
• CAS Number: 1162-53-4
• Molecular Formula: C21H30O2
• Molecular Weight: 314.4617
• MDL Number: MFCD00046219
• SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2C(=O)C)C)C1)C
• NSC Number: 15467

Computed Properties

• Complexity: 601
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 3.9

Literature

• Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone.

  Indian journal of pharmacology 20120101

• A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts.

  Journal of analytical methods in chemistry 20120101

• Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells.

  Journal of Asian natural products research 20120101

• Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition.

  Bioorganic & medicinal chemistry letters 20110415

• Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats.

  The Journal of pharmacy and pharmacology 20110101

• In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5alpha-reductase inhibitors.

  The Journal of steroid biochemistry and molecular biology 20080901

• Cytotoxic constituents from Solanum lyratum.

  Archives of pharmacal research 20060201

• A sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous quantification of 16-dehydropregnenolone and its major metabolites in rabbit plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

• Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.

  Steroids 20050701

• HPLC-UV method development and validation for 16-dehydropregnenolone, a novel oral hypolipidaemic agent, in rat biological matrices for application to pharmacokinetic studies.

  Journal of pharmaceutical and biomedical analysis 20031124

• Development of an enzyme immunoassay for serum 16-dehydropregnenolone.

  Biological & pharmaceutical bulletin 20010801