1168091-68-6 | Gdc-0623

Packsize	Purity	Availability	Price	Discounted Price
1mg	99+%	in stock	$34.00	$24.00
2mg	99+%	in stock	$57.00	$40.00
5mg	99+%	in stock	$84.00	$59.00
10mg	99+%	in stock	$126.00	$88.00
50mg	99+%	in stock	$335.00	$235.00

Description

• Catalog Number: AE11221
• Chemical Name: Gdc-0623
• CAS Number: 1168091-68-6
• Molecular Formula: C16H14FIN4O3
• Molecular Weight: 456.2102
• MDL Number: MFCD25976760
• SMILES: OCCONC(=O)c1ccc2n(c1Nc1ccc(cc1F)I)cnc2

Computed Properties

• Complexity: 461
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 3.7

Literature

• Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.

  Bioorganic & medicinal chemistry letters 20141001

• Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.

  Nature 20130912

• MEK and the inhibitors: from bench to bedside.

  Journal of hematology & oncology 20130101