1177-87-3 | Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11b,16a)-

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$36.00	$25.00
1g	98%	in stock	$110.00	$77.00
5g	98%	in stock	$156.00	$110.00
25g	98%	in stock	$693.00	$485.00

Description

• Catalog Number: AI11134
• Chemical Name: Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11b,16a)-
• CAS Number: 1177-87-3
• Molecular Formula: C24H31FO6
• Molecular Weight: 434.4977431999998
• MDL Number: MFCD00287273
• SMILES: OCC(=O)[C@@]1(OC(=O)C)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F
• NSC Number: 39471

Computed Properties

• Complexity: 910
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.8

Literature

• Local drug delivery system: inhibition of inflammatory angiogenesis in a murine sponge model by dexamethasone-loaded polyurethane implants.

  Journal of pharmaceutical sciences 20110701

• Identification of clinically used drugs that activate pregnane X receptors.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers.

  Drug delivery 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate.

  Drug development and industrial pharmacy 20101001

• In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system.

  International journal of nanomedicine 20100101

• Drug packaging and delivery using perfluorocarbon nanoparticles for targeted inhibition of vascular smooth muscle cells.

  Acta pharmacologica Sinica 20091101

• Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090801

• Controlled release of dexamethasone acetate from biodegradable and biocompatible polyurethane and polyurethane nanocomposite.

  Journal of drug targeting 20090601

• Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery.

  Journal of microencapsulation 20080801

• Dexamethasone acetate encapsulation into Trojan particles.

  Journal of controlled release : official journal of the Controlled Release Society 20080522

• Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice.

  Molecular psychiatry 20080501

• Physicochemical properties and dissolution studies of dexamethasone acetate-beta-cyclodextrin inclusion complexes produced by different methods.

  AAPS PharmSciTech 20080301

• 999 abuse: do mothers know what they are using?

  The Journal of dermatological treatment 20080101

• Inhibitory efficacy of intravitreal dexamethasone acetate-loaded PLGA nanoparticles on choroidal neovascularization in a laser-induced rat model.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201

• [Preliminary study on brain-targeted drug delivery via inner ear].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• [Determination of the content of dexamethasone acetate in stomatology ulcer pasta].

  Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20070601

• Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles.

  Archives of pharmacal research 20070401

• Safety and pharmacokinetics of an intravitreal biodegradable implant of dexamethasone acetate in rabbit eyes.

  Current eye research 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment.

  Journal of chromatography. A 20050923

• CAR and PXR: xenosensors of endocrine disrupters?

  Chemico-biological interactions 20050815

• A comparative study of the action of dexamethasone sodium phosphate and dexamethasone acetate in steroid-eluting pacemaker leads.

  Pacing and clinical electrophysiology : PACE 20050401

• [Observations on the efficacy of Botai ointment in treating dermatosis common among armed forces receiving at-sea training].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20021201

• [Intravitreally injectable poly (D, L-Lactide) microspheres containing dexamethasone acetate for sustained release].

  Yao xue xue bao = Acta pharmaceutica Sinica 20011001

• Retrocorneal membrane after penetrating keratoplasty.

  Ophthalmic surgery and lasers 20010101

• Corticosteroid-induced suicide attempt.

  Annals of emergency medicine 19960901

• LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.

  Journal of pharmacological and toxicological methods 19931101