118081-34-8 | Ceftibuten dihydrate

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$47.00	$33.00
100mg	98%	in stock	$125.00	$88.00

Description

• Catalog Number: AD74787
• Chemical Name: Ceftibuten dihydrate
• CAS Number: 118081-34-8
• Molecular Formula: C15H18N4O8S2
• Molecular Weight: 446.4554
• MDL Number: MFCD00864918
• SMILES: OC(=O)CC=C(C(=O)NC1C(=O)N2C1SCC=C2C(=O)O)c1csc(n1)N.O.O

Computed Properties

• Complexity: 755
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 6

Literature

• Ceftibuten versus trimethoprim-sulfamethoxazole for oral treatment of febrile urinary tract infection in children.

  Pediatric nephrology (Berlin, Germany) 20090301

• Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis.

  European journal of pediatrics 20080901

• Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats.

  Drug metabolism and pharmacokinetics 20080101

• Recognition of 2-aminothiazole-4-acetic acid derivatives by the peptide transporters PEPT1 and PEPT2.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070901

• In vitro selection and characterization of mutants in TEM-1-producing Escherichia coli by ceftazidime and ceftibuten.

  Journal of chemotherapy (Florence, Italy) 20070401

• In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens.

  Journal of chemotherapy (Florence, Italy) 20070401

• Burkholderia cepacia complex nasal isolation in immunocompetent patients with sinonasal polyposis not associated with cystic fibrosis.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20070101

• Purification by p-aminobenzoic acid (PABA)-affinity chromatography and the functional reconstitution of the nateglinide/H+ cotransport system in the rat intestinal brush-border membrane.

  Biochemical and biophysical research communications 20060217

• Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.

  Chemotherapy 20060101

• A case of selective IgE-mediated hypersensitivity to ceftibuten.

  Allergy 20051101

• Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane.

  Biochimica et biophysica acta 20050830

• Computational modelling of H+-coupled peptide transport via human PEPT1.

  The Journal of physiology 20050601

• Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats.

  American journal of physiology. Gastrointestinal and liver physiology 20050401

• H+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine.

  The Journal of pharmacology and experimental therapeutics 20050101

• Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.

  Pflugers Archiv : European journal of physiology 20041101

• [Treatment mostly not in line with current knowledge. New guidelines for sinusitis therapy].

  MMW Fortschritte der Medizin 20040610

• Antibiotic use profile at paediatric clinics in two transitional countries.

  Pharmacoepidemiology and drug safety 20040301

• Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.

  The Journal of pharmacology and experimental therapeutics 20031101

• Comparison of ceftibuten transport across Caco-2 cells and rat jejunum mounted on modified Ussing chambers.

  Biopharmaceutics & drug disposition 20031001

• Urinary tract infections in South Croatia: aetiology and antimicrobial resistance.

  International journal of antimicrobial agents 20031001

• Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.

  Pharmaceutical research 20030901

• [Our experience with cedax (ceftibuten) in the obstetrical and gynecological practice].

  Akusherstvo i ginekologiia 20030101

• Transporters involved in apical and basolateral uptake of ceftibuten into Caco-2 cells.

  Biopharmaceutics & drug disposition 20021101

• [Treatment of obstetric and gynecologic diseases with anti-inflammatory drug cedax].

  Akusherstvo i ginekologiia 20020101

• [Therapeutic recommendation in acute suppurative sinusitis. Antibiotic plus topical steroid].

  MMW Fortschritte der Medizin 20011206

• [Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201

• The changing pattern of multi-drug resistant enteric fever--a physician's dilemma.

  The Journal of the Association of Physicians of India 20011001

• Comparative study of ceftibuten and cefixime in the treatment of complicated urinary tract infections.

  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20010901

• [Five days ceftibuten versus 10 days penicillin in the treatment of 2099 patients with A-streptococcal tonsillopharyngitis].

  Fortschritte der Medizin. Originalien 20010719

• Interpretive criteria of ceftibuten disk diffusion susceptibility tests according to the DIN 58 940 method.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010601

• [Patient adherence in respiratory tract infections: ceftibuten versus other antibiotics (PARTICULAR study)].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010601

• Oral ceftibuten switch therapy for acute pyelonephritis in children.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010601

• [Treatment of group A streptococcal tonsillopharyngitis. 5 days cephalosporin is as effective as 10 days penicillin].

  MMW Fortschritte der Medizin 20010503

• Ceftibuten stability to active-site serine and metallo-beta-lactamases.

  International journal of antimicrobial agents 20010101

• Fewer bacterial relapses after oral treatment with norfloxacin than with ceftibuten in acute pyelonephritis initially treated with intravenous cefuroxime.

  Scandinavian journal of infectious diseases 20010101

• Significance of substrate hydrophobicity for recognition by an oligopeptide transporter (PEPT1).

  Bioconjugate chemistry 20010101

• [Comparative clinical efficacy and tolerance of cefuroxime axetil (zinnat) and ceftibuten (cedex) in patients with acute sinusitis].

  Vestnik otorinolaringologii 20010101

• [Treatment with cedax in asymptomatic bacteriuria in the first trimester of pregnancy].

  Akusherstvo i ginekologiia 20010101

• Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.

  The American journal of physiology 19971101

• Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1.

  FEBS letters 19960930