1184-88-9 | Sodium pivalate

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$7.00	$5.00
5g	97%	in stock	$19.00	$13.00
25g	97%	in stock	$60.00	$42.00
100g	97%	in stock	$172.00	$121.00
500g	97%	in stock	$634.00	$444.00

Description

• Catalog Number: AB47036
• Chemical Name: Sodium pivalate
• CAS Number: 1184-88-9
• Molecular Formula: C5H9NaO2
• Molecular Weight: 124.1135
• MDL Number: MFCD00064202
• SMILES: [O-]C(=O)C(C)(C)C.[Na+]

Computed Properties

• Complexity: 82.9
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1

Literature

• Biosynthesis and metabolic pathways of pivalic acid.

  Applied microbiology and biotechnology 20120901

• Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates.

  Natural product communications 20120301

• Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces.

  Environmental microbiology 20110601

• Continuous synthesis of tert-butyl peroxypivalate using a single-channel microreactor equipped with orifices as emulsification units.

  ChemSusChem 20110321

• Nickel-catalyzed reductive cleavage of aryl-oxygen bonds in alkoxy- and pivaloxyarenes using hydrosilanes as a mild reducing agent.

  Chemical communications (Cambridge, England) 20110314

• Nickel-catalyzed amination of aryl pivalates by the cleavage of aryl C-O bonds.

  Angewandte Chemie (International ed. in English) 20100406

• An efficient protocol for alcohol protection under solvent- and catalyst-free conditions.

  The Journal of organic chemistry 20091120

• Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2.

  Chemico-biological interactions 20090814

• Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

• C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses.

  Angewandte Chemie (International ed. in English) 20090101

• Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.

  The Journal of toxicological sciences 20090101

• Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.

  Chemical research in toxicology 20080901

• Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates.

  Journal of the American Chemical Society 20080326

• Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents.

  The journal of physical chemistry. B 20080124

• Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment.

  Drug metabolism and pharmacokinetics 20080101

• Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions.

  Angewandte Chemie (International ed. in English) 20080101

• Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid.

  Pediatrics 20070901

• Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status.

  Reproductive toxicology (Elmsford, N.Y.) 20070701

• 5(6)-carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides.

  Bioconjugate chemistry 20070101

• Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design.

  Journal of the American Chemical Society 20061227

• Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones.

  Journal of the American Chemical Society 20061018

• Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.

  Pharmaceutical research 20060801

• Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst.

  The Journal of organic chemistry 20060721

• Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats.

  Toxicology and applied pharmacology 20060701

• Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions.

  The journal of physical chemistry. A 20060323

• 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.

  Bioorganic & medicinal chemistry 20060315

• 1,1,1-Tris(hydroxymethyl)propane in manganese carboxylate chemistry: synthesis, structure and magnetic properties of a mixed-valence [MnIII4MnII4] cluster featuring the novel [MnIII4MnII4(mu3-OR)6(mu2-OR)8]6+ core.

  Dalton transactions (Cambridge, England : 2003) 20060114

• Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism.

  Drugs in R&D 20060101

• Carnitine deficiency disorders in children.

  Annals of the New York Academy of Sciences 20041101

• Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway.

  Journal of applied microbiology 20040101

• A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids.

  Journal of the American Chemical Society 20031008

• Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid).

  Applied and environmental microbiology 20030301

• Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica.

  Phytochemistry 20030201

• Pivalate-generating prodrugs and carnitine homeostasis in man.

  Pharmacological reviews 20021201

• Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O.

  Carbohydrate research 20011207

• The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring.

  Life sciences 20010831

• Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.

  Pharmaceutical research 20010401

• Carnitine protects mitochondria and removes toxic acyls from xenobiotics.

  Drugs under experimental and clinical research 20010101