118525-40-9 | Icaritin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$15.00	$10.00
100mg	98%	in stock	$45.00	$31.00
250mg	98%	in stock	$75.00	$52.00
1g	98%	in stock	$295.00	$206.00
5g	98%	in stock	$1,030.00	$721.00

Description

• Catalog Number: AE11428
• Chemical Name: Icaritin
• CAS Number: 118525-40-9
• Molecular Formula: C21H20O6
• Molecular Weight: 368.3799
• MDL Number: MFCD08062152
• SMILES: COc1ccc(cc1)c1oc2c(CC=C(C)C)c(O)cc(c2c(=O)c1O)O

Computed Properties

• Complexity: 612
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 4.8

Literature

• Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

  Toxicology letters 20180915

• Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815

• Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: an in vitro efficacy study.

  Acta biomaterialia 20120801

• Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

  Bioorganic & medicinal chemistry letters 20120615

• A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein.

  Carcinogenesis 20120501

• Icaritin inhibits T cell activation and prolongs skin allograft survival in mice.

  International immunopharmacology 20120501

• [Effects of anhydroicaritin on the immunologic function of mouse macrophages].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120401

• Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.

  PloS one 20120101

• Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats.

  Journal of ethnopharmacology 20110901

• Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae.

  Molecular bioSystems 20110701

• An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells.

  European journal of pharmacology 20110511

• Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells.

  PloS one 20110101

• Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

  PloS one 20110101

• Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor.

  Planta medica 20101101

• Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin.

  Biomedical materials (Bristol, England) 20101001

• Icaritin induces growth inhibition and apoptosis of human prostatic smooth muscle cells in an estrogen receptor-independent manner.

  Amino acids 20100501

• [Study on preparation of icaritin by enzymolysis of icariin with snail hydrolase].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

• [Determination of icaritin in rat plasma by HPLC-MS/MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20091001

• Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.

  Bioorganic & medicinal chemistry letters 20090801

• Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner.

  Chemico-biological interactions 20090515

• A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner.

  Bone 20090201

• Potent inhibition of human phosphodiesterase-5 by icariin derivatives.

  Journal of natural products 20080901

• Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells.

  Journal of cellular biochemistry 20080401

• Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor.

  Journal of microbiology and biotechnology 20080101

• Sensitive and rapid method to quantify icaritin and desmethylicaritin in human serum using gas chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915

• Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro.

  Life sciences 20070816

• A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells.

  European journal of pharmacology 20070614

• [Directed differentiation of mouse embryonic stem cells into neuronal cells induced by icaritin in vitro].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501

• [Protective effect of icaritin on apoptosis of primarily cultured rat neurons induced by Abeta25-35 peptide].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501

• Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway.

  Neuroscience 20070330

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101

• Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro.

  Acta pharmacologica Sinica 20050401

• [Preparation of two derivatives from icariin and investigation of their estrogen-like effects].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050301

• Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.

  European journal of pharmacology 20041119