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The flame retardant 2,2',4,4'-Tetrabromodiphenyl ether enhances the expression of corticotropin-releasing hormone in the placental cell model JEG-3.
Chemosphere 20170501
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Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Chemico-biological interactions 20150625
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Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
The Journal of biological chemistry 20140808
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A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
The Biochemical journal 20130415
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Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord.
The journal of pain : official journal of the American Pain Society 20121001
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Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.
American journal of physiology. Cell physiology 20120415
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Binding of BIS like and other ligands with the GSK-3β kinase: a combined docking and MM-PBSA study.
Journal of molecular modeling 20120201
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Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction.
Cancer science 20120101
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High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation.
American journal of physiology. Renal physiology 20120101
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Affinity-based chemoproteomics with small molecule-peptide conjugates.
Methods in molecular biology (Clifton, N.J.) 20120101
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Toll-like receptor 3 activation promotes desensitization of histamine response in human gingival fibroblasts: Poly (I:C) induces histamine receptor desensitization in human gingival fibroblasts.
Cellular immunology 20120101
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Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Molecular endocrinology (Baltimore, Md.) 20111201
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nature biotechnology 20111101
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Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Molecular and cellular neurosciences 20110901
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Biophoton emissions from cell cultures: biochemical evidence for the plasma membrane as the primary source.
General physiology and biophysics 20110901
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Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
The Journal of biological chemistry 20110826
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Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.
American journal of physiology. Endocrinology and metabolism 20110801
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A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701
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Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.
Proteomics 20110701
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The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.
Cytokine 20110601
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Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study.
European journal of medicinal chemistry 20100901
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Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43.
Journal of applied physiology (Bethesda, Md. : 1985) 20100801
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Piscine PTHrP regulation of calcium and phosphate transport in winter flounder renal proximal tubule primary cultures.
American journal of physiology. Regulatory, integrative and comparative physiology 20100801
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Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
The Journal of physiology 20100715
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Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.
The Prostate 20100701
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PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Turkish neurosurgery 20100701
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Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.
The Journal of biological chemistry 20100521
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Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression.
Toxicology in vitro : an international journal published in association with BIBRA 20100401
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Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.
The Journal of biological chemistry 20100205
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Filamin A is required for vimentin-mediated cell adhesion and spreading.
American journal of physiology. Cell physiology 20100201
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Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.
Molecular immunology 20100101
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Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates.
Journal of Asian natural products research 20100101
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Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Acta pharmacologica Sinica 20091001
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Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase.
Carcinogenesis 20090901
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Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR.
Antiviral research 20090801
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Inhibition of P2X receptor-mediated inward current by protein kinase C in small-diameter dorsal root ganglion neurons of adult rats.
Neuroscience bulletin 20090801
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Theoretical study of photophysical properties of bisindolylmaleimide derivatives.
The journal of physical chemistry. A 20090723
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Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes.
Molecular and cellular biochemistry 20090701
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Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
Bioorganic & medicinal chemistry 20090701
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Calcineurin and cytoskeleton in low-frequency depression.
Journal of neurochemistry 20090501
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Akt demoted in glioblastoma.
Science signaling 20090421
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PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2.
American journal of physiology. Gastrointestinal and liver physiology 20090201
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Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides.
Chemistry & biology 20090130
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Peroxynitrite participates in mechanisms involved in capacitation of cryopreserved cattle.
Animal reproduction science 20090101
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Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes.
Physiological research 20090101
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Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Autonomic & autacoid pharmacology 20090101
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Mechanism of ethanol-induced insulin secretion from INS-1 and INS-1E tumor cell lines.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101
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YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death.
Journal of biomedicine & biotechnology 20090101
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Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201
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Small-molecule inhibitors of PDK1.
ChemMedChem 20081201
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Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.
Bioorganic & medicinal chemistry letters 20081115
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Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.
Journal of pineal research 20081101
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Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.
American journal of physiology. Cell physiology 20081101
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Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways.
Steroids 20081001
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Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism.
The Journal of pharmacology and experimental therapeutics 20081001
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Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.
Brain research bulletin 20080930
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Apical adenosine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells.
American journal of physiology. Cell physiology 20080601
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A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
The Journal of biological chemistry 20080523
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Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Bioorganic & medicinal chemistry letters 20080401
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Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of rapamycin pathways in mouse embryonic stem cells.
The international journal of biochemistry & cell biology 20080101
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Bisindolylmaleimides in anti-cancer therapy - more than PKC inhibitors.
Advances in medical sciences 20080101
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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proceedings of the National Academy of Sciences of the United States of America 20071218
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Effects of protein kinase C activation on cardiac repolarization and arrhythmogenesis in Langendorff-perfused rabbit hearts.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071101
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Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture.
Neurotoxicology 20071101
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Effect of parathyroid-hormone-related protein on human platelet activation.
Clinical science (London, England : 1979) 20071001
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Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.
Liver international : official journal of the International Association for the Study of the Liver 20071001
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Implication of PKC in the seasonal variation of the immune response of the hemocytes of Mytilus galloprovincialis Lmk. and its role in interleukin-2-induced nitric oxide synthesis.
IUBMB life 20071001
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Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury.
Canadian journal of physiology and pharmacology 20071001
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In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
Journal of neuroendocrinology 20070901
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Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy.
Current opinion in nephrology and hypertension 20070901
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Bisindolylmaleimides with large Stokes shift and long-lasting chemiluminescence properties.
Organic letters 20070830
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A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation.
Transplantation 20070627
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NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors.
Brain research 20070625
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Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes.
Cardiovascular research 20070601
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Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse.
The Journal of physiology 20070601
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Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators.
Biochimica et biophysica acta 20070601
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Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Molecular cancer therapeutics 20070601
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ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
Toxicology and applied pharmacology 20070515
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The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.
The Journal of investigative dermatology 20070501
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Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
Journal of dermatological science 20070501
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The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior.
Behavioural brain research 20070416
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Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I.
Journal of molecular endocrinology 20070401
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Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2.
American journal of physiology. Gastrointestinal and liver physiology 20070301
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Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade.
American journal of physiology. Heart and circulatory physiology 20070201
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Effects of calmodulin and protein kinase C modulators on transient Ca2+ increase and capacitative Ca2+ entry in human platelets: relevant to pathophysiology of bipolar disorder.
Progress in neuro-psychopharmacology & biological psychiatry 20070130
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Differential regulation of CREB and ERK phosphorylation through corticotropin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells.
Molecular and cellular endocrinology 20070115
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Dual mechanism of autoregulation of protein kinase C in myocardial ischemia.
Molecular and cellular biochemistry 20070101
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Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Journal of medicinal chemistry 20061214
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[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell].
Zhonghua yi xue za zhi 20061205
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Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Cellular signalling 20061201
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Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.
Biochemistry 20061128
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A practical method for the synthesis of indolylaryl- and bisindolylmaleimides.
Organic letters 20061012
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Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor.
American journal of physiology. Cell physiology 20061001
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Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.
Acta anaesthesiologica Scandinavica 20061001
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Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.
Molecular cancer research : MCR 20061001
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The chemiluminescence mechanism of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione, and the characteristics of chemiluminescence developed in the reaction with CH(3)CNH(2)O(2)NaOH.
Talanta 20060815
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Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.
Cell proliferation 20060801
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The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells.
The Journal of endocrinology 20060801
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Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells.
Toxicology and applied pharmacology 20060715
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Bryostatin enhancement of memory in Hermissenda.
The Biological bulletin 20060601
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Roles of Ca2+ and protein kinase C in the excitatory response to serotonin in embryonic molluscan ciliary cells.
Canadian journal of physiology and pharmacology 20060601
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Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases.
Analytical biochemistry 20060515
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Infection of HEp2 epithelial cells with Candida albicans: adherence and postadherence events.
FEMS immunology and medical microbiology 20060401
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Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.
American journal of physiology. Cell physiology 20060201
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Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201
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Development of autonomic receptors and their function in the chick heart and influence of continuous infusion of carbachol.
Prague medical report 20060101
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Role of protein kinase C in hydroxyapatite- induced phagocytosis by a murine macrophage cell line (RAW264.7).
Immunopharmacology and immunotoxicology 20060101
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Differential actin isoform reorganization in the contracting A7r5 cell.
Canadian journal of physiology and pharmacology 20060101
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Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms.
The Journal of biological chemistry 20051209
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Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A.
Chembiochem : a European journal of chemical biology 20051201
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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Journal of medicinal chemistry 20051201
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Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line.
Journal of neurochemistry 20051101
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Configurational stability of bisindolylmaleimide cyclophanes: from conformers to the first configurationally stable, atropisomeric bisindolylmaleimides.
Chemistry (Weinheim an der Bergstrasse, Germany) 20051021
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Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C.
The Journal of biological chemistry 20051021
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Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.
The Journal of pharmacology and experimental therapeutics 20051001
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Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
Journal of molecular biology 20050930
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The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
FEBS letters 20050829
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Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.
The Journal of biological chemistry 20050826
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Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.
The Journal of biological chemistry 20050826
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Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides.
Journal of the American Chemical Society 20050824
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PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 20050801
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Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors.
Peptides 20050801
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Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells.
Peptides 20050801
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Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Brain : a journal of neurology 20050701
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Activity-dependent subcellular localization of NAC1.
The European journal of neuroscience 20050701
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PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes.
Molecular and cellular biochemistry 20050701
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The protein kinase C inhibitor, bisindolylmaleimide (I), inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
Life sciences 20050617
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Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors.
Bioorganic & medicinal chemistry letters 20050615
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New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
Bioorganic & medicinal chemistry letters 20050602
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Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue.
American journal of physiology. Cell physiology 20050601
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The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels.
Anesthesia and analgesia 20050601
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Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil.
Neuroscience letters 20050513
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Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.
Life sciences 20050506
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Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C.
Cardiovascular research 20050501
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Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
The Journal of steroid biochemistry and molecular biology 20050501
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Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway.
Biochemical pharmacology 20050415
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IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.
The Journal of biological chemistry 20050408
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Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha.
Regulatory peptides 20050330
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Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
Oncogene 20050317
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In vivo effects of protein kinase and phosphatase inhibitors on CYP2B induction in rat liver.
Toxicology 20050214
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Moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst.
American journal of respiratory cell and molecular biology 20050201
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Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050126
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Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.
Journal of biomedical science 20050101
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Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase.
Journal of periodontal research 20041201
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Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes?
Biochemical pharmacology 20041115
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Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
The Journal of biological chemistry 20041105
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Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes.
Anesthesia and analgesia 20041101
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Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Bioorganic & medicinal chemistry letters 20041018
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Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides.
Organic & biomolecular chemistry 20041007
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Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Circulation research 20041001
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Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.
Molecular cancer therapeutics 20041001
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Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells.
International journal of oncology 20040901
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Development of a respiratory burst assay using zebrafish kidneys and embryos.
Journal of immunological methods 20040901
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Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.
Regulatory peptides 20040815
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Atypical protein-kinase Czeta, but neither conventional Ca2+ -dependent protein-kinase C isoenzymes nor Ca2+ -calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells.
Cancer chemotherapy and pharmacology 20040801
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LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22).
Blood 20040715
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Gender differences in ANG II levels and action on multiple K+ current modulation pathways in diabetic rats.
American journal of physiology. Heart and circulatory physiology 20040701
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PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth.
American journal of physiology. Heart and circulatory physiology 20040601
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Injured brain endothelial cells release neurotoxic thrombin.
Journal of Alzheimer's disease : JAD 20040601
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Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor.
Biochemical and biophysical research communications 20040514
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Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function.
Chemical communications (Cambridge, England) 20040507
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Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.
Molecular & cellular proteomics : MCP 20040501
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Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.
European journal of pharmacology 20040405
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Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus.
Journal of cell science 20040401
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Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo.
American journal of physiology. Heart and circulatory physiology 20040301
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Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.
Structure (London, England : 1993) 20040201
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Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle.
European journal of pharmacology 20040112
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Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells.
Journal of neurophysiology 20040101
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Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation.
The Journal of investigative dermatology 20040101
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Signal transduction pathway in endothelial dysfunction.
Surgical infections 20040101
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Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Cellular signalling 20031201
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Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
Cellular signalling 20031201
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1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.
Cellular signalling 20031201
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Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.
Leukemia 20031001
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Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Bioorganic & medicinal chemistry letters 20030915
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Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Regulatory peptides 20030915
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ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.
The Journal of pharmacology and experimental therapeutics 20030901
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Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.
British journal of pharmacology 20030901
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Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Molecular cancer research : MCR 20030901
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Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity.
Calcified tissue international 20030901
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Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.
Naunyn-Schmiedeberg's archives of pharmacology 20030801
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Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.
The Biochemical journal 20030715
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Regulation of hyaluronan secretion into rabbit synovial joints in vivo by protein kinase C.
The Journal of physiology 20030715
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Role of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and mitogen-activated protein kinases in volatile anesthetic-induced relaxation in newborn rabbit pulmonary artery.
Anesthesiology 20030701
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High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15.
FEBS letters 20030619
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Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Bioorganic & medicinal chemistry letters 20030602
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Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes.
Journal of cellular biochemistry 20030601
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Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Journal of cardiovascular pharmacology and therapeutics 20030601
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Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity.
The Journal of biological chemistry 20030523
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Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.
The Journal of biological chemistry 20030516
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Multiprotein bridging factor 1 cooperates with c-Jun and is necessary for cardiac hypertrophy in vitro.
Experimental cell research 20030515
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Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor.
European journal of pharmacology 20030328
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Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats.
European journal of pharmacology 20030319
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Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D.
The Journal of rheumatology 20030301
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Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
Neuropharmacology 20030201
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Activation of microglia with lipopolysaccharide leads to the prolonged decrease of conventional protein kinase C activity.
Brain research. Molecular brain research 20030131
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Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels.
Diabetes research and clinical practice 20030101
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ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels.
Journal of cardiovascular pharmacology 20030101
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Pityrialactone- a new fluorochrome from the tryptophan metabolism of Malassezia furfur.
Antonie van Leeuwenhoek 20030101
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Phospholipase C axis is the preferential pathway leading to PKC activation following PTH or PTHrP stimulation in human term placenta.
Life sciences 20021129
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Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
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Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus.
Brain research 20020927
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Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways.
The Journal of biological chemistry 20020920
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Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.
The Journal of biological chemistry 20020906
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Role of protein phosphatases in hypoxic preconditioning.
American journal of physiology. Heart and circulatory physiology 20020901
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Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.
The Journal of biological chemistry 20020809
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Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent.
American journal of physiology. Gastrointestinal and liver physiology 20020801
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Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells.
Biochemical and biophysical research communications 20020719
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Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery.
Anesthesiology 20020701
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Angiotensin II inhibits renin gene transcription via the protein kinase C pathway.
Pflugers Archiv : European journal of physiology 20020701
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Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.
Molecular pharmacology 20020601
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Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.
Journal of neurochemistry 20020601
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Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
American journal of physiology. Cell physiology 20020401
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Nitric oxide production by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.
Oral microbiology and immunology 20020401
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Intracellular Ca(2+) modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells.
Endocrinology 20020201
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myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.
The Biochemical journal 20020201
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Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon.
The Journal of endocrinology 20020201
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Regulation of transepithelial phosphate transport by PTH in chicken proximal tubule epithelium.
American journal of physiology. Regulatory, integrative and comparative physiology 20020101
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Role of PKC in isoflurane-induced biphasic contraction in skinned pulmonary arterial strips.
Anesthesiology 20020101
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The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils.
Cellular immunology 20020101
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Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells.
American journal of physiology. Cell physiology 20011201
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Accelerating the induction of Fas-mediated T cell apoptosis: a strategy for transplant tolerance?
Clinical and experimental immunology 20011201
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Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.
The Journal of biological chemistry 20011102
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Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
The Journal of pharmacology and experimental therapeutics 20011101
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Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons.
Neurobiology of learning and memory 20011101
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Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation.
Bioorganic & medicinal chemistry letters 20011022
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Protein kinase c increases the apparent affinity of the release machinery to Ca2+ by enhancing the release machinery downstream of the Ca2+ sensor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015
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Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor.
The Journal of biological chemistry 20011012
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Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines.
Apoptosis : an international journal on programmed cell death 20011001
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Pulmonary artery vasoconstriction but not [Ca2+]i signal stimulated by thromboxane A2 is partially resistant to NO.
Pediatric research 20011001
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Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells.
Biological chemistry 20011001
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Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.
Brain research 20010928
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Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Cell death and differentiation 20010901
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Effects of hydrogen peroxide on the transient outward current in rabbit atrial myocytes.
Clinical and experimental pharmacology & physiology 20010901
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Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation.
Hypertension (Dallas, Tex. : 1979) 20010901
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The protein kinase C pathway inhibits iodide uptake by calf thyroid cells via sodium potassium-adenosine triphosphatase.
Thyroid : official journal of the American Thyroid Association 20010901
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Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.
American journal of hypertension 20010901
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Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2+) sensitization in tracheal smooth muscle.
American journal of respiratory cell and molecular biology 20010901
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Neurotrophin secretion from cultured microglia.
Journal of neuroscience research 20010815
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Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.
Biochemical and biophysical research communications 20010727
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Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes.
Developmental biology 20010715
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In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries.
The Journal of physiology 20010715
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Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism.
American journal of physiology. Regulatory, integrative and comparative physiology 20010701
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Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha.
The Journal of clinical endocrinology and metabolism 20010701
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Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C.
European journal of medical research 20010628
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Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.
The Journal of biological chemistry 20010518
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Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Blood 20010415
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Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy.
European journal of pharmacology 20010413
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Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.
Experimental eye research 20010401
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Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.
European journal of immunology 20010401
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The role of protein kinase C in the regulation of serotonin-2A receptor expression.
Journal of neurochemistry 20010401
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Cyclization strategies for the synthesis of macrocyclic bisindolylmaleimides.
The Journal of organic chemistry 20010323
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Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.
Virology 20010301
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Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features.
The Prostate 20010301
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Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells.
Cellular signalling 20010301
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Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c.
Biochemistry 20010227
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Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration.
Hypertension (Dallas, Tex. : 1979) 20010201
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Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C.
Biochemical and biophysical research communications 20010126
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A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
American journal of physiology. Cell physiology 20010101
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Induction of vanilloid receptor channel activity by protein kinase C.
Nature 20001201
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Specificity and mechanism of action of some commonly used protein kinase inhibitors.
The Biochemical journal 20001001
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Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.
The Journal of biological chemistry 19991224
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Tumor necrosis factor-alpha stimulates attachment of small cell lung carcinoma to endothelial cells.
The Journal of laboratory and clinical medicine 19990301
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Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.
The Journal of pharmacology and experimental therapeutics 19980901
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Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Bioorganic & medicinal chemistry letters 19980505
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Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction.
Molecular pharmacology 19980401
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Transcriptional activity of the hamster CYP11B2 promoter in NCI-H295 cells stimulated by angiotensin II, potassium, forskolin and bisindolylmaleimide.
Journal of molecular endocrinology 19980401
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Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Biochemical and biophysical research communications 19971229