1197196-48-7 | UNC0224

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$23.00	$17.00
5mg	98%	in stock	$81.00	$57.00
10mg	98%	in stock	$121.00	$85.00
25mg	98%	in stock	$203.00	$142.00
50mg	98%	in stock	$344.00	$241.00

Description

• Catalog Number: AE10371
• Chemical Name: UNC0224
• CAS Number: 1197196-48-7
• Molecular Formula: C26H43N7O2
• Molecular Weight: 485.6653
• MDL Number: MFCD18251564
• SMILES: COc1cc2c(cc1OCCCN(C)C)nc(nc2NC1CCN(CC1)C)N1CCCN(CC1)C

Computed Properties

• Complexity: 619
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 3.4

Literature

• Oncoepigenomics: making histone lysine methylation count.

  European journal of medicinal chemistry 20121001

• Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

  Journal of medicinal chemistry 20110908

• Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

  Journal of medicinal chemistry 20100812

• Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

  Journal of medicinal chemistry 20091224