120-92-3 | Cyclopentanone

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$26.00	$18.00
25g	98%	in stock	$42.00	$30.00
100g	98%	in stock	$90.00	$63.00
500g	98%	in stock	$251.00	$176.00

Description

• Catalog Number: AA33547
• Chemical Name: Cyclopentanone
• CAS Number: 120-92-3
• Molecular Formula: C5H8O
• Molecular Weight: 84.1164
• MDL Number: MFCD00001409
• SMILES: O=C1CCCC1
• NSC Number: 4122

Computed Properties

• Complexity: 58.3
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 1
• XLogP3: 0.4

Literature

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• Synthesis of cyclopentenones via intramolecular HWE and the palladium-catalyzed reactions of allylic hydroxy phosphonate derivatives.

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• Total Synthesis of the Four Enantiomerically Pure Diasteroisomers of the Phytoprostanes E1Type II and of the 15-E2t-Isoprostanes.

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• Molecular mechanism of enzymatic allene oxide cyclization in plants.

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• Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis.

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• Feedback Control of the Arachidonate Cascade in Osteoblastic Cells by 15-deoxy-Delta-Prostaglandin J(2).

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• Cyclopentenone and furan derivative from the mycelia of Cordyceps cicadae.

  The Journal of antibiotics 20080101

• Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARgamma Agonists, 15-Deoxy-Delta 12, 14-Prostaglandin J(2).

  PPAR research 20080101

• Pro-apoptotic activity of cyclopentenone in cancer cells.

  Anticancer research 20080101

• Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.

  PPAR research 20080101

• PPAR Ligands for Cancer Chemoprevention.

  PPAR research 20080101

• JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

  Journal of inflammation (London, England) 20080101

• Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps.

  Algorithms for molecular biology : AMB 20080101

• Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists.

  PPAR research 20080101

• PPAR-gamma: Therapeutic Potential for Multiple Sclerosis.

  PPAR research 20080101

• The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic Cancer.

  PPAR research 20080101

• The PPAR-gamma Agonist 15-Deoxy-Delta-Prostaglandin J(2) Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease.

  PPAR research 20080101

• Macrophages, PPARs, and Cancer.

  PPAR research 20080101

• Synthesis of cyclopentenones from cyclopropanes and silyl ynol ethers.

  Angewandte Chemie (International ed. in English) 20080101

• Photooxygenation of masked o-benzoquinones: an efficient entry into highly functionalized cyclopentenones from 2-methoxyphenols.

  Angewandte Chemie (International ed. in English) 20080101

• 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases.

  Journal of inflammation (London, England) 20080101

• Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor gamma with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development.

  PPAR research 20080101

• Omega-3 Fatty Acids and PPARgamma in Cancer.

  PPAR research 20080101

• CXCR4 in Cancer and Its Regulation by PPARgamma.

  PPAR research 20080101

• To Live or to Die: Prosurvival Activity of PPARgamma in Cancers.

  PPAR research 20080101

• Recent advances in the investigation of curcuminoids.

  Chinese medicine 20080101

• Local and systemic gene expression responses of Atlantic salmon (Salmo salar L.) to infection with the salmon louse (Lepeophtheirus salmonis).

  BMC genomics 20080101

• Ex vivo promoter analysis of antiviral heat shock cognate 70B gene in Anopheles gambiae.

  Virology journal 20080101

• Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.

  Arthritis research & therapy 20080101

• Peroxisome proliferator-activated receptors in diabetic nephropathy.

  PPAR research 20080101

• A rapid microwell fluorescence immunoassay for cellular protein detection.

  Biological procedures online 20080101

• Repellent properties of delta-octalactone against the tsetse fly, Glossina morsitans morsitans.

  Journal of insect science (Online) 20080101

• Therapeutic Potential of PPARγ Activation in Stroke.

  PPAR research 20080101

• Synthesis of polysubstituted cyclopentenones via [4+1] reactions of TIPS-vinylketenes.

  The Journal of organic chemistry 20071221

• A novel, efficient, diastereo- and enantioselective Mukaiyama aldol-based synthesis of a vinyl cyclopentanone core derivative of viridenomycin.

  Organic letters 20071220

• Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots.

  Chembiochem : a European journal of chemical biology 20071217

• Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

  The EMBO journal 20071212

• ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes.

  Journal of Korean medical science 20071201

• A general and regioselective synthesis of cyclopentenone derivatives through nickel(0)-mediated [3 + 2] cyclization of alkenyl Fischer carbene complexes and internal alkynes.

  Journal of the American Chemical Society 20071121

• Modifications of the chemical structure of terpenes in antiplasmodial and antifungal drug research.

  Bioorganic & medicinal chemistry letters 20071115

• A domino-based approach toward stereodefined heavily functionalized cyclohexanes: synthesis of iridal's core structure.

  Organic letters 20071108

• Rh-catalyzed highly enantioselective formation of functionalized cyclopentanes and cyclopentanones.

  Organic & biomolecular chemistry 20071107

• Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes.

  Molecular pharmacology 20071101

• Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA1: focus on vimentin.

  Journal of mass spectrometry : JMS 20071101

• Endogenous lipid mediators in the resolution of airway inflammation.

  The European respiratory journal 20071101

• Unprecedented rearrangement of a 4-alkoxy-5-bromoalk-2-en-1-ol to a cyclopentenone via an iso-nazarov cyclization process.

  The Journal of organic chemistry 20071026

• Rate constants for the reaction of cl with a series of C4 to C6 ketones using the relative rate method.

  The journal of physical chemistry. A 20071025

• Specific subcellular localization of siRNAs delivered by lipoplex in MCF-7 breast cancer cells.

  Biochimie 20071001

• Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism.

  Cellular signalling 20071001

• Synthesis of neuroprotective cyclopentenone prostaglandin analogs: suppression of manganese-induced apoptosis of PC12 cells.

  Bioorganic & medicinal chemistry letters 20071001

• 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways.

  Experimental cell research 20071001

• Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione.

  Chemical research in toxicology 20071001

• [Screening and function analysis of a cyclohexanone-degrading bacterium CN1 from deep sea sediment].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20071001

• Effect of cation absorption on ionization/dissociation of cycloketone molecules in a femtosecond laser field.

  The journal of physical chemistry. A 20070927

• Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.

  Bioorganic & medicinal chemistry letters 20070901

• Electrophilic cyclopentenone isoprostanes in neurodegeneration.

  Journal of molecular neuroscience : MN 20070901

• Cyclization of natural allene oxide in aprotic solvent: formation of the novel oxylipin methyl cis-12-oxo-10-phytoenoate.

  Chemistry and physics of lipids 20070801

• Formate as a CO surrogate for cascade processes: Rh-catalyzed cooperative decarbonylation and asymmetric Pauson-Khand-type cyclization reactions.

  Chemical communications (Cambridge, England) 20070707

• Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.

  Organic letters 20070705

• Recent developments in the synthesis of prostaglandins and analogues.

  Chemical reviews 20070701

• Synthesis of [60]fullerene acetals and ketals: reaction of [60]fullerene with aldehydes/ketones and alkoxides.

  The Journal of organic chemistry 20070622

• Antiinflammatory effects of the cyclopentenone isoprostane 15-A(2)-IsoP in human gestational tissues.

  Free radical biology & medicine 20070615

• Two-step formal [3+2] cycloaddition of enones/enals and allenyl MOM ether: gold-catalyzed highly diastereoselective synthesis of cyclopentanone enol ether containing an all-carbon quaternary center.

  Journal of the American Chemical Society 20070523

• 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression.

  Breast cancer research and treatment 20070501

• [Discharge ion mobility spectrometry of ketonic organic compounds].

  Guang pu xue yu guang pu fen xi = Guang pu 20070501

• 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors.

  Journal of immunology (Baltimore, Md. : 1950) 20070401

• Synthesis of the oxygenated pactamycin core.

  Organic letters 20070329

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain.

  Cancer research 20070315

• Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated.

  Pharmaceutical research 20070301

• Pulsed laser photolysis vacuum UV laser-induced fluorescence kinetic study of the gas-phase reactions of Cl(2P3/2) atoms with C3-C6 ketones.

  The journal of physical chemistry. A 20070222

• Bromomyrothenone B and botrytinone, cyclopentenone derivatives from a marine isolate of the fungus botrytis.

  Journal of natural products 20070201

• Synthesis of novel 2'-methyl carbovir analogues as potent antiviral agents.

  Archives of pharmacal research 20070201

• Dicobaltoctacarbonyl-mediated synthesis of tricyclic 5,6-diydropyran-2-one derivatives via tandem cycloaddition reaction between cis-epoxyalkynes, a tethered olefin, and carbon monoxide.

  The Journal of organic chemistry 20070119

• Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-L-hydroxyproline bioisostere.

  Bioorganic & medicinal chemistry 20070115

• Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival.

  Archives of biochemistry and biophysics 20070115

• Free-radical pathways in the decomposition of ketones over polycrystalline TiO(2): the role of organoperoxy radicals.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20070108

• Cyclopentanone ring-cleaved pleuromutilin derivatives.

  European journal of medicinal chemistry 20070101

• Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis.

  Molecular bioSystems 20070101

• Effects of low dose GM-CSF on microglial inflammatory profiles to diverse pathogen-associated molecular patterns (PAMPs).

  Journal of neuroinflammation 20070101

• Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro.

  Annals of the New York Academy of Sciences 20070101

• Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio.

  Cancer cell international 20070101

• Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions.

  International archives of allergy and immunology 20070101

• A catalytic method for converting vinylic furanoses into cyclopentenones.

  Angewandte Chemie (International ed. in English) 20070101

• Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.

  Arthritis research & therapy 20070101

• The use of silicon-based tethers for the Pauson-Khand reaction.

  Beilstein journal of organic chemistry 20070101

• Anopheles gambiae heat shock protein cognate 70B impedes o'nyong-nyong virus replication.

  BMC genomics 20070101

• 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells.

  Journal of neuroinflammation 20070101

• Peroxisome proliferator-activated receptors and acute lung injury.

  PPAR research 20070101

• The Role of PPARs in Lung Fibrosis.

  PPAR research 20070101

• Nitrosylcobalamin potentiates the anti-neoplastic effects of chemotherapeutic agents via suppression of survival signaling.

  PloS one 20070101

• Matrix-assisted laser desorption/ionization time-of-flight investigation of Nylon 6 and Nylon 66 thermo-oxidation products.

  European journal of mass spectrometry (Chichester, England) 20070101

• A convenient approach for access to both carbapentofuranoses and carbahexopyranoses. Stereocontrolled synthesis of enantiopure carba-D-ribofuranoses, carba-D-arabinofuranoses and carba-L-gulopyranose.

  The Journal of organic chemistry 20061222

• A plant-derived morphinan as a novel lead compound active against malaria liver stages.

  PLoS medicine 20061201

• Prostanoids with cyclopentenone structure as tools for the characterization of electrophilic lipid-protein interactomes.

  Annals of the New York Academy of Sciences 20061201

• 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors.

  Biochemical pharmacology 20061130

• Synthesis of 1,2,4-trioxepanes and 1,2,4-trioxocanes via photooxygenation of homoallylic alcohols.

  The Journal of organic chemistry 20061124

• Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives.

  Chemistry, an Asian journal 20061120

• Addition of electrophilic lipids to actin alters filament structure.

  Biochemical and biophysical research communications 20061103

• Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.

  Molecular pharmacology 20061101

• Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines.

  Experimental & molecular medicine 20061031

• Radical trifluoromethylation of ketone silyl enol ethers by activation with dialkylzinc.

  Organic letters 20061012

• Enantioselective total synthesis of guanacastepene N using an uncommon 7-endo Heck cyclization as a pivotal step.

  Journal of the American Chemical Society 20061011

• Cyclopentenone: a special moiety for anticancer drug design.

  Anti-cancer drugs 20061001

• 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells.

  Neurochemical research 20061001

• o-Phenylene-bridged Cp/sulfonamido titanium complexes for ethylene/1-octene copolymerization.

  Dalton transactions (Cambridge, England : 2003) 20060907

• Identification of an allene oxide synthase (CYP74C) that leads to formation of alpha-ketols from 9-hydroperoxides of linoleic and linolenic acid in below-ground organs of potato.

  The Plant journal : for cell and molecular biology 20060901

• Cyclopentenones, scaffolds for organic syntheses produced by the endophytic fungus mitosporic dothideomycete sp. LRUB20.

  Journal of natural products 20060901

• Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate.

  The Journal of biological chemistry 20060818

• Stereoselective [4 + 1] annulation reactions with silyl vinylketenes derived from Fischer carbene complexes.

  The Journal of organic chemistry 20060818

• Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates.

  The Journal of biological chemistry 20060811

• First total synthesis of louisianin A.

  The Journal of organic chemistry 20060804

• 3'-Fluoro-3'-deoxy-5'-noraristeromycin derivatives: synthesis and antiviral analysis.

  Bioorganic & medicinal chemistry 20060715

• ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin.

  Genes to cells : devoted to molecular & cellular mechanisms 20060701

• 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis.

  Molecular cancer therapeutics 20060701

• Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.

  Journal of neurochemistry 20060601

• Pt-catalyzed tandem epoxide fragmentation/pentannulation of propargylic esters.

  Journal of the American Chemical Society 20060531

• Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species.

  American journal of physiology. Heart and circulatory physiology 20060501

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.

  Journal of lipid research 20060501

• Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia.

  Intensive care medicine 20060501

• Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylation.

  Angewandte Chemie (International ed. in English) 20060403

• Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes.

  Biochemical and biophysical research communications 20060310

• Analysis of fungal cyclopentenone derivatives from Hygrophorus spp. by liquid chromatography/electrospray-tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20060301

• Biochemistry of prostaglandins A.

  Biochemistry. Biokhimiia 20060301

• Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities.

  Bioscience, biotechnology, and biochemistry 20060301

• Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2.

  Cell stress & chaperones 20060301

• Cyclopentanone thiosemicarbazone, a new complexing agent for copper determination in biological samples by adsorptive stripping voltammetry.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060301

• Enantioselective synthesis of 2-aryl cyclopentanones by asymmetric epoxidation and epoxide rearrangement.

  Angewandte Chemie (International ed. in English) 20060220

• Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.

  Journal of medicinal chemistry 20060209

• Efficient synthesis of cyclopentenones from enynyl acetates via tandem Au(I)-catalyzed 3,3-rearrangement and the Nazarov reaction.

  Journal of the American Chemical Society 20060208

• Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation.

  The Journal of biological chemistry 20060203

• Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060201

• Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.

  Carcinogenesis 20060201

• 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats.

  Urology 20060201

• Effect of temperature on competitive adsorption of the solute and the organic solvent in reversed-phase liquid chromatography.

  Journal of chromatography. A 20060127

• Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).

  Bioorganic & medicinal chemistry letters 20060115

• Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency.

  Cell biochemistry and function 20060101

• Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton.

  Journal of the American Society of Nephrology : JASN 20060101

• NF-kappaB: a stress-regulated switch for cell survival.

  Antioxidants & redox signaling 20060101

• Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells.

  Biorheology 20060101

• Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.

  Respiratory research 20060101

• Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha.

  PPAR research 20060101

• Asymmetric sulfonium ylide mediated cyclopropanation: stereocontrolled synthesis of (+)-LY354740.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20051223

• Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051115

• Synthesis of 2H-1,2-benzothiazine 1,1-dioxides via heteroannulation reactions of 2-iodobenzenesulfonamide with ketone enolates under S(RN)1 conditions.

  The Journal of organic chemistry 20051111

• From cyclopentanone oximes to bis[1,2,3]dithiazolo-s-indacenes, cyclopenta[c][1,2]thiazine, pentathiepino-, tetrathiino-, and thienocyclopenta[1,2,3]dithiazoles as a rich source of new materials.

  The Journal of organic chemistry 20051111

• Microscale process evaluation of recombinant biocatalyst libraries: application to Baeyer-Villiger monooxygenase catalysed lactone synthesis.

  Bioprocess and biosystems engineering 20051101

• 12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis.

  Plant physiology 20051101

• New sesquiterpene lactones from Arnica tincture prepared from fresh flowerheads of Arnica montana.

  Planta medica 20051101

• Terpestacin core structure. control of stereochemistry.

  Organic letters 20051027

• Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26 S proteasome.

  Biochemistry 20051025

• Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione.

  FEBS letters 20051024

• Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.

  The Journal of biological chemistry 20051021

• Acid-catalyzed transannular cyclization of 3aH-cyclopentene[8]annulene-1,4-(5H,9aH)-diones and some proposed mechanisms.

  The Journal of organic chemistry 20051014

• Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.

  Journal of medicinal chemistry 20051006

• The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients.

  Experimental neurology 20051001

• Stereoselective synthesis of highly substituted cyclopentenones through [4+1] annulations of trialkylsilyl vinyl ketenes with alpha-benzotriazolyl organolithium compounds.

  Angewandte Chemie (International ed. in English) 20050912

• Ruthenium-catalyzed hydrative cyclization of 1,5-enynes.

  Journal of the American Chemical Society 20050907

• A Paterno-Büchi approach to the synthesis of merrilactone A.

  Organic letters 20050901

• The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.

  Journal of neuropathology and experimental neurology 20050901

• Synthesis and antiviral evaluation of novel 6'(alpha)-methyl-branched Carbovir analogues.

  Archiv der Pharmazie 20050901

• New cyclopentenone derivatives from an endophytic Streptomyces sp. isolated from the mangrove plant Aegiceras comiculatum.

  The Journal of antibiotics 20050901

• An improved approach to chiral cyclopentenone building blocks. Total synthesis of pentenomycin I and neplanocin A.

  The Journal of organic chemistry 20050819

• 2,2-dimethyl cyclopentanones by acid catalyzed ring expansion of isopropenylcyclobutanols. A short synthesis of (+/-)-alpha-cuparenone and (+/-)-herbertene.

  Chemical communications (Cambridge, England) 20050814

• Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.

  Journal of medicinal chemistry 20050811

• Diastereoselective intermolecular Pauson-Khand reactions of chiral cyclopropenes.

  Organic letters 20050804

• New odourless protocols for efficient Pauson-Khand annulations.

  Organic & biomolecular chemistry 20050707

• Phenols, quinolines, indoles, benzene, and 2-cyclopenten-1-ones are oviductal toxicants in cigarette smoke.

  Toxicological sciences : an official journal of the Society of Toxicology 20050701

• Identification of the major urinary metabolite of the highly reactive cyclopentenone isoprostane 15-A(2t)-isoprostane in vivo.

  The Journal of biological chemistry 20050701

• Highlight for phenols, quinolines, indoles, benzene and 2-cyclopenten-1-ones are oviduct toxicants in cigarette smoke, by Prue Talbot, Karen Riveles, and Ryan Rosa: list of tobacco-smoke constituents that are harmful for reproduction grows--passive smokers may be at risk.

  Toxicological sciences : an official journal of the Society of Toxicology 20050701

• Heterocyclic derivative syntheses by palladium-catalyzed oxidative cyclization-alkoxycarbonylation of substituted gamma-oxoalkynes.

  The Journal of organic chemistry 20050624

• Alpha-hydroxy cyclopentenones from alpha-diketones.

  Organic letters 20050623

• Stereoselective Nazarov cyclizations of bridged bicyclic dienones.

  Organic letters 20050623

• Ab initio MO study on [3 + 2] annulation using beta-phenylthio-acryloylsilanes with alkyl methyl ketone enolates and its through-space/bond interaction analysis.

  Organic & biomolecular chemistry 20050621

• 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications.

  The Journal of clinical endocrinology and metabolism 20050601

• Taste-active maillard reaction products: the 'tasty' world of nonvolatile maillard reaction products.

  Annals of the New York Academy of Sciences 20050601

• Absolute asymmetric photocyclization of isopropylbenzophenone derivatives using a cocrystal approach involving single-crystal-to-single-crystal transformation.

  The Journal of organic chemistry 20050527

• The intermolecular Pauson-Khand reaction.

  Angewandte Chemie (International ed. in English) 20050513

• Convenient route to both enantiomers of a highly functionalized trans-disubstituted cyclopentene. Synthesis of the carbocyclic core of the nucleoside BCA.

  The Journal of organic chemistry 20050513

• Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation.

  Shock (Augusta, Ga.) 20050501

• The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock.

  Intensive care medicine 20050501

• 3,3a-Dihydrocyclopenta[b]chromen-1(2H)-ones from the reaction of salicylaldehyde and 2-cyclopenten-1-one.

  Acta crystallographica. Section C, Crystal structure communications 20050501

• Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis.

  Journal of neuroscience research 20050401

• Myrothenones A and B, cyclopentenone derivatives with tyrosinase inhibitory activity from the marine-derived fungus Myrothecium sp.

  Chemical & pharmaceutical bulletin 20050401

• Hormone regulation of microglial cell activation: relevance to multiple sclerosis.

  Brain research. Brain research reviews 20050401

• The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation.

  Brain pathology (Zurich, Switzerland) 20050401

• Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity.

  Brain pathology (Zurich, Switzerland) 20050401

• Structural manifestations of the cheletropic reaction.

  Organic & biomolecular chemistry 20050321

• Rh(I)-catalyzed cyclization of 1-arylprop-2-yn-1-ol derivatives utilizing rhodium 1,4-migration.

  Journal of the American Chemical Society 20050316

• 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins.

  Blood 20050215

• Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds.

  Bioorganic & medicinal chemistry 20050215

• Reagent-free Nazarov cyclisations.

  Chemical communications (Cambridge, England) 20050207

• 15d-PGJ2: the anti-inflammatory prostaglandin?

  Clinical immunology (Orlando, Fla.) 20050201

• The cyclopentenone prostaglandin PGA2 costimulates the maturation of human dendritic cells.

  Experimental hematology 20050201

• Fluorous mixture synthesis of 4-alkylidene cyclopentenones via a rhodium-catalyzed [2+2+1] cycloaddition of alkynyl allenes.

  Journal of combinatorial chemistry 20050101

• The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation.

  Antioxidants & redox signaling 20050101

• Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha.

  BMC physiology 20050101

• Synthesis of latanoprost diastereoisomers.

  Chirality 20050101

• The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series.

  Microvascular research 20050101

• [Role of prostaglandins in rheumatoid arthritis].

  Nihon rinsho. Japanese journal of clinical medicine 20050101

• Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.

  Journal of biomedical science 20050101

• Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.

  Respiratory research 20050101

• Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

• Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides.

  Nucleosides, nucleotides & nucleic acids 20050101

• Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2.

  Arthritis research & therapy 20050101

• A convenient synthesis of gamma-functionalized cyclopentenones.

  Beilstein journal of organic chemistry 20050101

• Total synthesis of (-)-incarvilline, (+)-incarvine C, and (-)-incarvillateine.

  Journal of the American Chemical Society 20041222

• The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock.

  Shock (Augusta, Ga.) 20041201

• Effects of cyclopentenone prostaglandins on the expression of heme oxygenase-1 in MCF-7 cells.

  Annals of the New York Academy of Sciences 20041201

• Synthesis of 4'-methyl and 4'-cyano carbocyclic 2',3'-didehydro nucleoside analogues via 1,4-addition to substituted cyclopentenones.

  The Journal of organic chemistry 20041126

• Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.

  Bioorganic & medicinal chemistry letters 20041115

• Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes.

  Molecular pharmacology 20041101

• Intramolecular aldol cyclization of C-4-ulopyranosyl-2'-oxoalkanes controlled by steric effects. Asymmetric synthesis of substituted 8-oxabicyclo[3.2.1]octanones and -octenones and cyclopentenones.

  Carbohydrate research 20041020

• Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2.

  Chemical research in toxicology 20041001

• [Study of in vitro cytotoxic activity of cyclopentanones derivatives].

  La Tunisie medicale 20041001

• Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.

  Brain research 20040924

• Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells.

  British journal of cancer 20040913

• 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria.

  European journal of pharmacology 20040913

• Catalytic intermolecular Pauson-Khand-type reaction: strong directing effect of pyridylsilyl and pyrimidylsilyl groups and isolation of Ru complexes relevant to catalytic reaction.

  Journal of the American Chemical Society 20040908

• A potential role of 15-deoxy-delta(12,14)-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis.

  The Journal of biological chemistry 20040903

• Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells.

  Prostaglandins, leukotrienes, and essential fatty acids 20040901

• S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2).

  Journal of neurochemistry 20040901

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications.

  Journal of immunology (Baltimore, Md. : 1950) 20040901

• Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism.

  Cancer research 20040801

• Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells.

  Cancer letters 20040728

• Effect of prostaglandins on the regulation of tumor growth.

  Current medicinal chemistry. Anti-cancer agents 20040701

• Carijenone, a novel class of bicyclic prostanoid from the eastern Pacific octocoral Carijoa multiflora.

  Organic letters 20040624

• Allenes and transition metals: a diverging approach to heterocycles.

  Organic letters 20040624

• Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK).

  AIDS (London, England) 20040618

• Reactions of some cyclopentenones with selected cysteine derivatives and biological activities of the product thioethers.

  Bioorganic & medicinal chemistry 20040615

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process.

  Journal of immunology (Baltimore, Md. : 1950) 20040615

• Palladium-catalyzed ring expansion reaction of (Z)-1-(1,3-butadienyl)cyclobutanols with aryl iodides. stereospecific synthesis of (Z)-2-(3-aryl-1-propenyl)cyclopentanones.

  Organic letters 20040610

• Antifungal cyclopentenediones from Piper coruscans.

  Journal of the American Chemical Society 20040609

• Theoretical study of the vinyl allene oxide to cyclopent-2-en-1-one rearrangement: mechanism, torquoselectivity and solvent effects.

  The Journal of organic chemistry 20040528

• Enantioselective total synthesis of (+)-brefeldin A and 7-epi-brefeldin A.

  The Journal of organic chemistry 20040528

• 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.

  The Journal of biological chemistry 20040521

• Phosphine catalyzed alpha-arylation of enones and enals using hypervalent bismuth reagents: regiospecific enolate arylation via nucleophilic catalysis.

  Journal of the American Chemical Society 20040505

• Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.

  Bioorganic & medicinal chemistry letters 20040503

• Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers.

  Bioorganic & medicinal chemistry 20040415

• Asymmetric synthesis of the carbocyclic nucleoside building block (R)-(+)-4-aminocyclopentenone using delta-amino beta-ketophosphonates and ring-closing metathesis (RCM).

  Organic letters 20040415

• Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity.

  Journal of medicinal chemistry 20040408

• The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells.

  Biochemical pharmacology 20040401

• New cytotoxic metabolites from a marine sponge Homaxinella sp.

  Journal of natural products 20040401

• Hygrophorones A-G: fungicidal cyclopentenones from Hygrophorus species (Basidiomycetes).

  Phytochemistry 20040401

• Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline.

  Organic letters 20040318

• Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

  The Biochemical journal 20040301

• Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells.

  Kidney international 20040301

• Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin.

  Critical care medicine 20040301

• The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.

  Cardiovascular research 20040215

• 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB.

  Biochemical and biophysical research communications 20040213

• In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation.

  International journal of radiation oncology, biology, physics 20040201

• The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry.

  Organic letters 20040122

• The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione.

  Chemical research in toxicology 20040101

• Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma.

  European journal of immunology 20040101

• Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2.

  The Journal of biological chemistry 20031219

• An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome.

  Biochemistry 20031202

• Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20031201

• Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin.

  BioTechniques 20031201

• Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling.

  Journal of immunology (Baltimore, Md. : 1950) 20031115

• Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus).

  The Journal of organic chemistry 20031114

• 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells.

  Biochemical and biophysical research communications 20031107

• Isomerization-cyclization approach to the synthesis of 2-hydroxy-5-alkylidene-cyclopent-2-enones.

  Organic letters 20031030

• Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase.

  Organic letters 20031016

• One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs.

  Bioorganic & medicinal chemistry 20031015

• Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation.

  Biochemical pharmacology 20031015

• 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB.

  FEBS letters 20031009

• Molecular interactions in 3-carboxy-2-diphenylphosphinoylcyclopentanone.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031001

• Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut.

  British journal of pharmacology 20030901

• New method for synthesizing the intermediates to 5-HETE from yeast-mediated reduction products by employing Baeyer-Villiger oxidation with complete retention of enantiomeric excess.

  Bioscience, biotechnology, and biochemistry 20030901

• The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock.

  European journal of pharmacology 20030829

• Sulfonated microporous organic-inorganic hybrids as strong Bronsted acids.

  Journal of the American Chemical Society 20030827

• A --> J prostaglandin swap: a new tactic for cyclopentenone prostaglandin synthesis.

  The Journal of organic chemistry 20030822

• Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.

  Journal of medicinal chemistry 20030814

• Stereocontrol in the EtAlCl(2)-induced cyclization of chiral gamma,delta-unsaturated methyl ketones to form cyclopentanones.

  The Journal of organic chemistry 20030808

• A novel and efficient total synthesis of cephalotaxine.

  Organic letters 20030807

• Jasmonates and related oxylipins in plant responses to pathogenesis and herbivory.

  Current opinion in plant biology 20030801

• Identification of steroid sulfate transport processes in the human mammary gland.

  The Journal of clinical endocrinology and metabolism 20030801

• Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis.

  Biochemical and biophysical research communications 20030725

• First total synthesis of JS isoprostane.

  The Journal of organic chemistry 20030725

• Thioredoxin as a molecular target of cyclopentenone prostaglandins.

  The Journal of biological chemistry 20030711

• Parallel kinetic resolution of 4-alkynals catalyzed by Rh(I)/Tol-BINAP: synthesis of enantioenriched cyclobutanones and cyclopentenones.

  Journal of the American Chemical Society 20030709

• Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response.

  Molecular pharmacology 20030701

• Two new cyclopentenone derivatives and a new cyclooctadienone derivative from Erigeron annuus (L.) PERS., Erigeron philadelphicus L., and Erigeron sumatrensis RETZ.

  Chemical & pharmaceutical bulletin 20030701

• Antiviral activity of CTC-8 against herpes simplex virus (HSV-1) in cell culture: evidence for a selective antiviral effect via a cellular mechanism.

  Antiviral chemistry & chemotherapy 20030701

• Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.

  Bioorganic & medicinal chemistry letters 20030616

• Activation of nuclear receptors by prostaglandins.

  Thrombosis research 20030615

• The application of polymer-bound carbonylcobalt(0) species in linker chemistry and catalysis.

  Organic & biomolecular chemistry 20030607

• Structural properties of cyclopentanone-bridged bis-macrocyclic ligand dicopper(II) complexes in the solid and in solution: a successful test of the MM-EPR method.

  Inorganic chemistry 20030602

• Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030601

• Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress.

  The European journal of neuroscience 20030601

• Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2.

  The Journal of biological chemistry 20030523

• Novel acid-catalyzed rearrangement of methanofullerenes bearing an alpha-ylidic ester to cyclopentanofullerenes: a vinyl cyclopropane-type ring expansion.

  The Journal of organic chemistry 20030516

• Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.

  Biochemistry 20030513

• The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms.

  Journal of immunology (Baltimore, Md. : 1950) 20030501

• Regulation of heme oxygenase expression by cyclopentenone prostaglandins.

  Experimental biology and medicine (Maywood, N.J.) 20030501

• Pd-catalyzed asymmetric allylic alkylation. A short route to the cyclopentyl core of viridenomycin.

  Organic letters 20030501

• Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants.

  The Plant journal : for cell and molecular biology 20030501

• Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD).

  Journal of leukocyte biology 20030501

• Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation.

  Annals of the New York Academy of Sciences 20030501

• The Pauson-Khand reaction: the catalytic age is here!

  Angewandte Chemie (International ed. in English) 20030425

• Palladium-catalyzed carbonylative cyclization of unsaturated aryl iodides and dienyl triflates, iodides, and bromides to indanones and 2-cyclopentenones.

  Journal of the American Chemical Society 20030423

• The formation of bicyclo[n.2.0]alkan-1-ols from the reaction of the lithium enolates of simple ketones and phenyl vinyl sulfoxide.

  Organic & biomolecular chemistry 20030421

• The first example of Nazarov reactions of vinyl cumulenyl ketones.

  Organic letters 20030417

• Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.

  Journal of medicinal chemistry 20030410

• Intramolecular Pauson-Khand reactions of alpha,beta-unsaturated esters and related electron-deficient olefins.

  The Journal of organic chemistry 20030404

• Trichloroacetylation of some cyclic enamines.

  Chemical & pharmaceutical bulletin 20030401

• Cloning of Baeyer-Villiger monooxygenases from Comamonas, Xanthobacter and Rhodococcus using polymerase chain reaction with highly degenerate primers.

  Environmental microbiology 20030301

• Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy.

  International journal of cancer 20030220

• Group 6 heteroatom- and non-heteroatom-stabilized carbene complexes. beta,beta'- and alpha,beta,beta'-annulation reactions of cyclic enamines.

  Journal of the American Chemical Society 20030219

• Total synthesis of (+)-4,5-deoxyneodolabelline.

  Journal of the American Chemical Society 20030219

• The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.

  British journal of pharmacology 20030201

• Biosynthesis of 14,15-dehydro-12-oxo-phytodienoic acid and related cyclopentenones via the phytoprostane D(1) pathway.

  Phytochemistry 20030201

• Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase.

  The Journal of biological chemistry 20030110

• Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2.

  BMC ophthalmology 20030101

• Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses.

  Critical reviews in immunology 20030101

• Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.

  Nucleosides, nucleotides & nucleic acids 20030101

• 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells.

  British journal of cancer 20021202

• Role of structure and pH in cyclization of allene oxide fatty acids: implications for the reaction mechanism.

  Chemistry and physics of lipids 20021201

• Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells.

  Journal of neurochemistry 20021201

• [Cyclopentenone prostaglandin derivatives as neuroprotective compounds].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20021201

• Dual effect of oxidative stress on NF-kappakB activation in HeLa cells.

  Experimental & molecular medicine 20021130

• Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids.

  The Journal of biological chemistry 20021129

• Tandem cyclization-cycloaddition behavior of rhodium carbenoids with carbonyl compounds: stereoselective studies on the construction of novel epoxy-bridged tetrahydropyranone frameworks.

  The Journal of organic chemistry 20021115

• 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells.

  Journal of lipid research 20021101

• Contribution of covalent protein modification to the antiinflammatory effects of cyclopentenone prostaglandins.

  Annals of the New York Academy of Sciences 20021101

• TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.

  Bioorganic & medicinal chemistry 20021001

• Synthesis and cytotoxicity of some rigid derivatives of methyl 2,5-dihydroxycinnamate.

  Archives of pharmacal research 20021001

• Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid.

  The Journal of biological chemistry 20020927

• Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione.

  Biochimica et biophysica acta 20020905

• Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli.

  Experimental hematology 20020901

• The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.

  Chemical research in toxicology 20020901

• 15-deoxy-delta12,14-Prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade.

  Thrombosis and haemostasis 20020901

• Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2).

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020901

• Asymmetric cyclopentannelation: camphor-derived auxiliary.

  Journal of the American Chemical Society 20020828

• A novel approach to the synthesis of bicyclic lactones via an interrupted Nazarov reaction of gem-divinyl dihydrofurans.

  Organic letters 20020822

• In vitro co-metabolism of ethanol and cyclic ketones.

  Toxicology 20020815

• Development of a new and practical route to chiral 3,4-disubstituted cyclopentanones: asymmetric alkylation and intramolecular cyclopropanation as key C-C bond-forming steps.

  The Journal of organic chemistry 20020809

• TiCl(4)-promoted Baylis-Hillman reactions of substituted 5-isoxazolecarboxaldehydes with cycloalkenones).

  The Journal of organic chemistry 20020809

• Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues.

  Bioorganic & medicinal chemistry letters 20020805

• Allene oxide synthases and allene oxides.

  Prostaglandins & other lipid mediators 20020801

• Cyclopentenone prostaglandin receptors.

  Prostaglandins & other lipid mediators 20020801

• Synthesis of 2-indanones via [4 + 1] annulation reactions of (trialkylsilyl)arylketenes.

  Organic letters 20020725

• Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701

• Enantioselective synthesis of 12-amino alkylidenecyclopentenone prostaglandins.

  The Journal of organic chemistry 20020628

• First total synthesis of A(2) isoprostane.

  The Journal of organic chemistry 20020614

• Effect of adjacent chiral tertiary and quaternary centers on the metal-catalyzed allylic substitution reaction.

  The Journal of organic chemistry 20020531

• Cobalt-phosphite-catalyzed asymmetric Pauson-Khand reaction.

  The Journal of organic chemistry 20020517

• A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition.

  Journal of immunology (Baltimore, Md. : 1950) 20020515

• Development of an enantioselective synthetic route to neocarzinostatin chromophore and its use for multiple radioisotopic incorporation.

  Journal of the American Chemical Society 20020515

• Peroxisome proliferator-activated receptor gamma agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects.

  The Journal of biological chemistry 20020510

• The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation.

  Molecular pharmacology 20020501

• Fatty acid-derived signals in plants.

  Trends in plant science 20020501

• Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation.

  Cellular and molecular life sciences : CMLS 20020501

• Volatile metabolites from actinomycetes.

  Journal of agricultural and food chemistry 20020424

• Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells.

  Oncogene 20020328

• Dynamic kinetic resolution via asymmetric conjugate reduction: enantio- and diastereoselective synthesis of 2,4-dialkyl cyclopentanones.

  Journal of the American Chemical Society 20020327

• Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta.

  The Journal of biological chemistry 20020301

• Resonant electron capture mass spectrometry of free fatty acids: examination of ion structures using deuterium-labeled fatty acids and collisional activation.

  Journal of mass spectrometry : JMS 20020301

• An improved catalyst for the asymmetric arylation of ketone enolates.

  Journal of the American Chemical Society 20020220

• Studies on a soft glycopyrrolate analog, SG-1.

  Die Pharmazie 20020201

• A highly enantioselective and general conjugate addition of thiols to cyclic enones with an organic catalyst.

  Angewandte Chemie (International ed. in English) 20020118

• Synthesis and antituberculosis activity of cycloalkylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of imidazo[2,1-b]thiazole.

  Arzneimittel-Forschung 20020101

• The T(1) (3)(pi-pi*)/S(0) intersections and triplet lifetimes of cyclic alpha,beta-enones.

  The Journal of organic chemistry 20011228

• Synthesis of carbocyclic orotidine analogs as potential orotidine decarboxylase inhibitors.

  Nucleosides, nucleotides & nucleic acids 20011201

• A three-component coupling approach to cyclopentanoids.

  The Journal of organic chemistry 20011116

• Role of cyclopentenone prostaglandins in rat carrageenin pleurisy.

  FEBS letters 20011109

• Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20011101

• Key tricyclic synthetic intermediates for the preparation of the sesquiterpenes alpha- and beta-cedrene.

  Acta crystallographica. Section C, Crystal structure communications 20011101

• Systematic studies on structure and physiological activity of cyclic alpha-keto enamines, a novel class of 'cooling' compounds.

  Journal of agricultural and food chemistry 20011101

• Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins.

  The Journal of biological chemistry 20011019

• 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors.

  The Journal of biological chemistry 20011012

• Antiproliferative prostaglandins and the MRP/GS-X pump role in cancer immunosuppression and insight into new strategies in cancer gene therapy.

  Biochemical pharmacology 20011001

• 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit.

  The Journal of biological chemistry 20010921

• Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides.

  The Journal of organic chemistry 20010921

• The first reported anionic oxy retro-ene reaction.

  Organic letters 20010920

• Determination by enantioselective synthesis of the absolute configuration of CPE, a potential intermediate in coronatine biosynthesis.

  Organic letters 20010920

• Synthesis and absolute stereochemistry of roseophilin.

  Journal of the American Chemical Society 20010905

• Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration.

  Journal of the American Chemical Society 20010905

• 1,4-Methano-11a-methyl-4,4a,11,11a-tetrahydro-1H-benzo[b]fluoren-11-one.

  Acta crystallographica. Section C, Crystal structure communications 20010901

• Multifunctionalized alpha,beta-cyclopentenones from C-2 and C-4-ulopyranosyl compounds: a stereospecific rearrangement initiated by base.

  Carbohydrate research 20010830

• Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells.

  The Journal of biological chemistry 20010817

• The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors.

  Blood 20010815

• Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway.

  The Journal of biological chemistry 20010810

• Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy.

  The Journal of biological chemistry 20010803

• Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells.

  Journal of the American Society of Nephrology : JASN 20010801

• The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells.

  Bioorganic & medicinal chemistry 20010801

• New bioactive cyclopentenone derivatives as inhibitors of the IL-6 dependent signal transduction.

  The Journal of antibiotics 20010801

• Regioselective nucleophilic additions to cross-conjugated dienone system bearing beta-fluorine: a versatile approach to highly substituted 2-cyclopentenones.

  Organic letters 20010726

• Simultaneous discrimination of diastereotopic groups and faces: the first example in intramolecular [3+2] and [2+2+1] cycloaddition reactions.

  The Journal of organic chemistry 20010601

• Explaining photodermatosis: cyclopentenone vs. alpha-methylene-gamma-lactone natural products.

  Fitoterapia 20010601

• Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection.

  Current opinion in infectious diseases 20010601

• X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE.

  Structure (London, England : 1993) 20010509

• Cyclopentenone prostaglandins: new insights on biological activities and cellular targets.

  Medicinal research reviews 20010501

• Stimulation of CFU-f formation by prostaglandin E2 is mediated in part by its degradation product, prostaglandin A2.

  Prostaglandins & other lipid mediators 20010501

• One-pot synthesis of enantiomerically enriched 2,3-disubstituted cyclopentanones via copper-catalyzed 1,4-reduction and alkylation.

  Organic letters 20010419

• Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress.

  The Journal of biological chemistry 20010413

• The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells.

  Journal of neuroimmunology 20010402

• Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins.

  Journal of neurochemistry 20010401

• Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation.

  Journal of leukocyte biology 20010401

• An experimental and computational study of 1,2-hydrogen migrations in 2-hydroxycyclopentylidene and its conjugate base.

  The Journal of organic chemistry 20010309

• The formation of 2-hydroxy-4-hydroxymethyl-3-(indol-3-yl)-cyclopent-2-enone derivatives from ascorbigens.

  Carbohydrate research 20010227

• Density functional studies on the Pauson--Khand reaction.

  Journal of the American Chemical Society 20010227

• Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative.

  Organic letters 20010222

• A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.

  Biochemical and biophysical research communications 20010216

• Potential adverse effects of cyclooxygenase-2 inhibition: evidence from animal models of inflammation.

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101

• Parallel synthesis and biocatalytic amplification of a cross-conjugated cyclopentenone library.

  Journal of combinatorial chemistry 20010101

• Heat shock proteins: novel therapeutic tools for HIV-infection?

  Expert opinion on biological therapy 20010101

• Inhibition of Mayaro virus replication by prostaglandin A(1) in Vero cells.

  Intervirology 20010101