120410-24-4 | Biapenem

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$8.00	$5.00
10mg	98%	in stock	$10.00	$7.00
50mg	98%	in stock	$13.00	$9.00
250mg	98%	in stock	$25.00	$17.00
1g	98%	in stock	$62.00	$43.00
5g	98%	in stock	$179.00	$125.00
25g	98%	in stock	$626.00	$438.00

Description

• Catalog Number: AB45625
• Chemical Name: Biapenem
• CAS Number: 120410-24-4
• Molecular Formula: C15H18N4O4S
• Molecular Weight: 350.3928
• MDL Number: MFCD00864863
• SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)[O-])SC1C[n+]2n(C1)cnc2)O

Computed Properties

• Complexity: 609
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.4

Literature

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  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120801

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  PloS one 20120101

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  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110201

• Improved RP-HPLC method to determine biapenem in human plasma/urine and its application to a pharmacokinetic study.

  Arzneimittel-Forschung 20110101

• In vitro activity of biapenem against Burkholderia pseudomallei.

  International journal of antimicrobial agents 20100501

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  Chemotherapy 20100101

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  The Journal of biological chemistry 20091009

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  Bioorganic & medicinal chemistry letters 20090901

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  The Japanese journal of antibiotics 20090201

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  Scandinavian journal of infectious diseases 20090101

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  International journal of antimicrobial agents 20081001

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  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20081001

• Pharmacokinetics and pharmacodynamics of biapenem in critically ill patients under continuous venovenous hemodiafiltration.

  The Japanese journal of antibiotics 20081001

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  The Japanese journal of antibiotics 20080401

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  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080201

• Pharmacokinetic-pharmacodynamic target attainment analysis of biapenem in adult patients: a dosing strategy.

  Chemotherapy 20080101

• [Analysis on the effective dosage regimens for meropenem, biapenem and doripenem against P. aeruginosa infection based on pharmacokinetics and pharmacodynamics theory].

  The Japanese journal of antibiotics 20071201

• Protonation state and substrate binding to B2 metallo-beta-lactamase CphA from Aeromonas hydrofila.

  Proteins 20071115

• [Comparison of ciprofloxacin with biapenem in patients with moderate or severe pneumonia].

  Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20070501

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  The Japanese journal of antibiotics 20070401

• A simple and rapid determination of biapenem in plasma by high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

• [Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from urine at one hospital to mainly carbapenem and fluoroquinolone drugs].

  The Japanese journal of antibiotics 20060401

• Catalytic mechanism of class B2 metallo-beta-lactamase.

  The Journal of biological chemistry 20060331

• [The combination effects of antibacterial agents against clinical isolated multiple-drug resistant Pseudomonas aeruginosa].

  The Japanese journal of antibiotics 20060201

• Antibiotic binding to monozinc CphA beta-lactamase from Aeromonas hydropila: quantum mechanical/molecular mechanical and density functional theory studies.

  Journal of medicinal chemistry 20051020

• Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

  Journal of pharmaceutical sciences 20050701

• A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.

  Journal of molecular biology 20050128

• Role for rpoS gene of Pseudomonas aeruginosa in antibiotic tolerance.

  FEMS microbiology letters 20050101

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  The Japanese journal of antibiotics 20040601

• Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040401

• Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040401

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  The Japanese journal of antibiotics 20040201

• Noncognitive symptoms and long-term treatment expectations for Alzheimer disease.

  Alzheimer disease and associated disorders 20040101

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  Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20030701

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  The Japanese journal of antibiotics 20030401

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  The Japanese journal of antibiotics 20020201

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  The Japanese journal of antibiotics 20011101

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  The Japanese journal of antibiotics 20010901

• Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.

  Toxicology letters 19950401