121-19-7 | 4-Hydroxy-3-Nitrobenzenearsonic Acid

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$47.00	$33.00

Description

• Catalog Number: AB67638
• Chemical Name: 4-Hydroxy-3-Nitrobenzenearsonic Acid
• CAS Number: 121-19-7
• Molecular Formula: C6H6AsNO6
• Molecular Weight: 263.03654000000006
• MDL Number: MFCD00007112
• SMILES: O=N(=O)c1cc(ccc1O)[As](=O)(O)O

Computed Properties

• Complexity: 270
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1

Upstream Synthesis Route

Roxarsone, also known by its chemical name 3-nitro-4-hydroxyphenylarsonic acid, is a versatile compound that finds application in various chemical synthesis processes. As a source of organic arsenic, Roxarsone is utilized in the manufacturing of pesticides and herbicides due to its effectiveness in controlling pests and promoting plant growth. In addition, Roxarsone is used in the synthesis of pharmaceutical compounds, particularly in the development of antimicrobial agents and anti-parasitic medications. Its unique chemical properties make it a valuable reagent in organic synthesis, enabling the formation of complex molecular structures with arsenic-containing functionalities. With its diverse range of applications, Roxarsone plays a vital role in advancing the field of chemical synthesis and contributes to the development of innovative products across different industries.

Literature

• Tumor-promoting and pro-angiogenic effects of roxarsone via VEGFR2/PLCγ/PKC signaling.

  Chemico-biological interactions 20180825

• Earthworms as agents for ecotoxicity in roxarsone-contaminated soil ecosystem: a modeling study of ultrastructure and proteomics.

  Environmental science and pollution research international 20150801

• In vitro and ex vivo angiogenic effects of roxarsone on rat endothelial cells.

  Toxicology letters 20131125

• Microarray analysis revealed that immunity-associated genes are primarily regulated by roxarsone in promoting broiler chicken (Gallus gallus domesticus) growth.

  Poultry science 20121201

• Exocrine pancreatic carcinogenesis and autotaxin expression.

  PloS one 20120101

• Genome-wide expression analysis of roxarsone-stimulated growth of broiler chickens (Gallus gallus).

  Comparative biochemistry and physiology. Part D, Genomics & proteomics 20110901

• Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter.

  Foodborne pathogens and disease 20110501

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Methanogenic inhibition by roxarsone (4-hydroxy-3-nitrophenylarsonic acid) and related aromatic arsenic compounds.

  Journal of hazardous materials 20100315

• A proteome investigation of roxarsone degradation by Alkaliphilus oremlandii strain OhILAs.

  Metallomics : integrated biometal science 20100201

• Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic acid (roxarsone).

  Environmental health perspectives 20080401

• Transformation of inorganic and organic arsenic by Alkaliphilus oremlandii sp. nov. strain OhILAs.

  Annals of the New York Academy of Sciences 20080301

• Biotransformation of 3-nitro-4-hydroxybenzene arsonic acid (roxarsone) and release of inorganic arsenic by Clostridium species.

  Environmental science & technology 20070201

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Anaerobic biotransformation of roxarsone and related N-substituted phenylarsonic acids.

  Environmental science & technology 20060501

• Sensitive method for the determination of roxarsone using solid-phase microextraction with multi-detector gas chromatography.

  Journal of chromatography. A 20041119

• The effects of salinomycin and roxarsone on the performance of broilers when included in the feed for four, five, or six weeks and infected with Eimeria species during the starter or grower phase of production.

  Poultry science 20040501

• Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations.

  Avian diseases 20040101

• In vitro activity of therapeutic drugs against Histomonas meleagridis (Smith, 1895).

  Poultry science 20020801

• Oral treatment of mule ducks with arsenicals for inducing fatty liver.

  Poultry science 20010301

• Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

  Annals of tropical medicine and parasitology 19961201