1216744-19-2 | GSK4112

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$10.00	$7.00
5mg	98+%	in stock	$22.00	$16.00
10mg	98+%	in stock	$31.00	$22.00
50mg	98+%	in stock	$102.00	$71.00

Description

• Catalog Number: AE35909
• Chemical Name: GSK4112
• CAS Number: 1216744-19-2
• Molecular Formula: C18H21ClN2O4S
• Molecular Weight: 396.8883
• MDL Number: MFCD12027224
• SMILES: O=C(OC(C)(C)C)CN(Cc1ccc(s1)[N+](=O)[O-])Cc1ccc(cc1)Cl

Computed Properties

• Complexity: 487
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• XLogP3: 4.7

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.

  Bioorganic & medicinal chemistry letters 20120601

• Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.

  Nature 20120503

• Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.

  Biochemical and biophysical research communications 20120406

• Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.

  ACS chemical biology 20110218

• GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

  ACS chemical biology 20101015