1218918-62-7 | Mk-7246

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$81.00	$57.00
5mg	98%	in stock	$324.00	$227.00
10mg	98%	in stock	$567.00	$397.00

Description

• Catalog Number: AB53595
• Chemical Name: Mk-7246
• CAS Number: 1218918-62-7
• Molecular Formula: C21H21FN2O4S
• Molecular Weight: 416.4658
• MDL Number: MFCD22741619
• SMILES: OC(=O)Cc1c2CC[C@H](Cn2c2c1cccc2)N(S(=O)(=O)c1ccc(cc1)F)C

Computed Properties

• Complexity: 704
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 2.8

Literature

• UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study.

  Clinical pharmacology and therapeutics 20120701

• CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development.

  The Journal of organic chemistry 20120302

• Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

  Journal of medicinal chemistry 20111027

• New indole amide derivatives as potent CRTH2 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20110601

• Azaindoles as potent CRTH2 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20110115

• Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.

  Molecular pharmacology 20110101

• Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

  Bioorganic & medicinal chemistry letters 20110101