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Toluene exposure enhances acute and chronic formalin-induced nociception in rats: Participation of 5-HT(3) receptors.
Neurotoxicology 20171201
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Current and emerging drug options in the treatment of diarrhea predominant irritable bowel syndrome.
Expert opinion on pharmacotherapy 20150101
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'Pre-cebo': an unrecognized issue in the interpretation of adequate relief during irritable bowel syndrome drug trials.
Journal of clinical gastroenterology 20120901
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Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.
Alimentary pharmacology & therapeutics 20120901
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Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
Laboratory investigation; a journal of technical methods and pathology 20120501
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Evaluation of harm in the pharmacotherapy of irritable bowel syndrome.
The American journal of medicine 20120401
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Evaluation of treatment continuation with alosetron by IBS-D severity criteria.
Current medical research and opinion 20120301
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Quality of life in patients with irritable bowel syndrome.
Journal of clinical gastroenterology 20110801
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The risk of ischaemic colitis in irritable bowel syndrome patients treated with serotonergic therapies.
Drug safety 20110701
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Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving patient outcomes.
Current medical research and opinion 20110301
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Peripherally acting therapies for the treatment of irritable bowel syndrome.
Gastroenterology clinics of North America 20110301
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An electrochemical microfluidic platform for human P450 drug metabolism profiling.
Analytical chemistry 20101215
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In silico binary classification QSAR models based on 4D-fingerprints and MOE descriptors for prediction of hERG blockage.
Journal of chemical information and modeling 20100726
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Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidences.
The American journal of gastroenterology 20100401
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Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.
Expert review of gastroenterology & hepatology 20100201
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Using the incremental net benefit framework for quantitative benefit-risk analysis in regulatory decision-making--a case study of alosetron in irritable bowel syndrome.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101
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Quantifying women's stated benefit-risk trade-off preferences for IBS treatment outcomes.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101
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Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats.
British journal of pharmacology 20091101
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Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis.
The American journal of gastroenterology 20090701
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Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats.
European journal of pharmacology 20090315
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Pathogenesis and management of irritable bowel syndrome.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation 20090101
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Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats.
Digestive diseases and sciences 20081101
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Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study.
Alimentary pharmacology & therapeutics 20080801
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Effects of serotonin 5-HT(3) receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats.
European journal of pharmacology 20080610
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Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080501
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Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials.
Clinical therapeutics 20080501
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Clinical practice. Irritable bowel syndrome.
The New England journal of medicine 20080417
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Balancing drug risk and benefit: toward refining the process of FDA decisions affecting patient care.
The American journal of gastroenterology 20080401
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Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.
European journal of pharmacology 20071114
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A randomized, double-blind, placebo-controlled study to assess efficacy and safety of 0.5 mg and 1 mg alosetron in women with severe diarrhea-predominant IBS.
The American journal of gastroenterology 20070801
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Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070801
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The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: a comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes.
Xenobiotica; the fate of foreign compounds in biological systems 20070801
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The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human.
Xenobiotica; the fate of foreign compounds in biological systems 20070801
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Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia.
Pain 20070701
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Impact of 5-HT3 receptor blockade on colonic haemodynamic responses to ischaemia and reperfusion in the rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070701
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Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome.
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Orvosi hetilap 20070520
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Gastroenterologia y hepatologia 20070301
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The relationship between dosing of alosetron and discontinuation patterns reported by patients participating in a follow-up programme.
Alimentary pharmacology & therapeutics 20070201
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Is there an experimental basis for the development of ischaemic colitis as a result of 5-HT3 antagonist treatment?
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070201
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Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia.
Pain 20061215
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Irritable bowel syndrome: a practical review.
Southern medical journal 20061101
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A patient follow-up survey programme for alosetron: assessing compliance to and effectiveness of the risk management programme.
Alimentary pharmacology & therapeutics 20060901
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Nihon rinsho. Japanese journal of clinical medicine 20060801
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data.
The American journal of gastroenterology 20060501
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Alosetron: ischemic colitis and serious complications of constipation.
The American journal of gastroenterology 20060501
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Drug withdrawals and the lessons within.
Current opinion in drug discovery & development 20060101
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Acute hepatitis associated with alosetron (Lotronex).
Journal of clinical gastroenterology 20050801
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Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.
Journal of pharmacological sciences 20050801
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Intestinal propulsion of a solid non-deformable bolus.
Journal of theoretical biology 20050707
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Pharmacogenomics 20050701
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The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401
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Comparison between partial agonist (ME3412) and antagonist (alosetron) of 5-hydroxytryptamine 3 receptor on gastrointestinal function.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401
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Characterization of the metabolites of alosetron in experimental animals and human.
Xenobiotica; the fate of foreign compounds in biological systems 20050201
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A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS.
The American journal of gastroenterology 20050101
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Options for patients with irritable bowel syndrome: contrasting traditional and novel serotonergic therapies.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20041201
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Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome.
The American journal of gastroenterology 20041101
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Delayed Gastric Emptying in Functional Dyspepsia.
Current treatment options in gastroenterology 20040801
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Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040801
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Pharmacodynamics and pharmacokinetics of oral contraceptives co-administered with alosetron (Lotronex).
Digestive diseases and sciences 20040801
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Alimentary pharmacology & therapeutics 20040715
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Alosetron use drops dramatically with risk management.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040615
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Advances in pharmacological treatments of IBS.
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Clinical evidence 20040601
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New drugs and dosage forms.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040415
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Therapy for irritable bowel syndrome.
The New England journal of medicine 20040318
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New options for soothing an irritable bowel.
The Johns Hopkins medical letter health after 50 20040301
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Study design issues in irritable bowel syndrome.
Alimentary pharmacology & therapeutics 20040101
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5-HT3-receptor antagonist inhibits visceral pain differently in chemical and mechanical stimuli in rats.
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Reassessing the benefits and risks of alosetron: what is its place in the treatment of irritable bowel syndrome?
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Advances in the management of irritable bowel syndrome.
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Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron.
The American journal of gastroenterology 20031201
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Alosetron and irritable bowel syndrome.
Expert opinion on pharmacotherapy 20031101
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Re: Brandt et al.--An evidence-based approach to the management of irritable bowel syndrome in North America.
The American journal of gastroenterology 20030901
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Irritable bowel syndrome: an overview of diagnosis and pharmacologic treatment.
Cleveland Clinic journal of medicine 20030601
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Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride.
The American journal of gastroenterology 20030501
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Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats.
European journal of pharmacology 20030425
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Safety, efficacy and costs of pharmacotherapy for functional gastrointestinal disorders: the case of alosetron and its implications.
Alimentary pharmacology & therapeutics 20030401
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Bad medicine. Why data from drug companies may be hard to swallow.
Scientific American 20030201
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Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20030201
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Alosetron for irritable bowel syndrome. Senior vice president of GlaxoSmithKline responds.
BMJ (Clinical research ed.) 20030104
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Alosetron for irritable bowel syndrome. Risks of using alosetron are still unknown.
BMJ (Clinical research ed.) 20030104
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Lipid-induced colonic hypersensitivity in irritable bowel syndrome: the role of 5-HT3 receptors.
Alimentary pharmacology & therapeutics 20030101
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Alosetron (Lotronex) is back: should I use it to treat my patients with irritable bowel syndrome?
Cleveland Clinic journal of medicine 20030101
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Irritable bowel syndrome genophenomics: correlation of serotonin-transporter polymorphisms and alosetron response.
The pharmacogenomics journal 20030101
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Tegaserod and other serotonergic agents: what is the evidence?
Reviews in gastroenterological disorders 20030101
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Alosetron in irritable bowel syndrome: strategies for its use in a common gastrointestinal disorder.
Drugs 20030101
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The American journal of gastroenterology 20021201
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Evidence-based position statement on the management of irritable bowel syndrome in North America.
The American journal of gastroenterology 20021101
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The American journal of gastroenterology 20021101
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Gastroenterology 20021001
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Health news (Waltham, Mass.) 20021001
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Alosetron for irritable bowel syndrome.
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Managed care interface 20020801
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Alimentary pharmacology & therapeutics 20020701
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FDA advisory panels recommend Lotronex be put back on market.
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Alimentary pharmacology & therapeutics 20020501
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Return of alosetron.
Expert opinion on drug safety 20020501
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FDA recommends bringing controversial IBS drug back.
Lancet (London, England) 20020427
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FDA consumer 20020101
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Pharmacological treatment of irritable bowel syndrome--from concept to sales.
The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 20020101
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American journal of physiology. Gastrointestinal and liver physiology 20011001
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Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20011001
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The FDA and The Lancet: an exchange.
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The FDA and The Lancet: an exchange.
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Possible mechanisms for ischemic colitis during alosetron therapy.
Gastroenterology 20010701
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Lancet (London, England) 20010519
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Gut 20010501
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So what happened to alosetron?
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Deutsche medizinische Wochenschrift (1946) 20010420
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Alimentary pharmacology & therapeutics 20010401
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Effect of alosetron on the pharmacokinetics of alprazolam.
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Effect of alosetron on the pharmacokinetics of fluoxetine.
Journal of clinical pharmacology 20010401
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Cleveland Clinic journal of medicine 20010301
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Tolerability and safety of alosetron during long-term administration in female and male irritable bowel syndrome patients.
The American journal of gastroenterology 20010301
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Alosetron and the rapid component of delayed rectifying potassium current in cardiac cells.
Life sciences 20010223
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Lotronex withdrawn from market.
Harvard women's health watch 20010201
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Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome.
The American journal of gastroenterology 20010201
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Alosetron withdrawn from market.
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Novel medications for the irritable bowel syndrome: motility and sensation.
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Irritable bowel syndrome. A poorly understood disorder.
FDA consumer 20010101
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FDA consumer 20010101
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Expert opinion on investigational drugs 20000101