1245646-10-9 | tert-Butyl 4-hydroxy-2-oxopiperidine-1-carboxylate

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$6.00	$5.00
250mg	97%	in stock	$14.00	$10.00
1g	97%	in stock	$41.00	$29.00
25g	97%	in stock	$797.00	$558.00

Description

• Catalog Number: AA28676
• Chemical Name: tert-Butyl 4-hydroxy-2-oxopiperidine-1-carboxylate
• CAS Number: 1245646-10-9
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.2463
• MDL Number: MFCD16659601
• SMILES: OC1CCN(C(=O)C1)C(=O)OC(C)(C)C

Upstream Synthesis Route

To synthesize tert-Butyl 4-hydroxy-2-oxopiperidine-1-carboxylate, begin with the cyclization of di-tert-butyl dicarbonate (Boc2O) with 4-aminobutan-2-one to form a Boc-protected 4-piperidone intermediate. This process involves deprotonating the amine with a strong base such as sodium hydride (NaH) to form the corresponding imine, followed by an intramolecular nucleophilic addition to establish the piperidine ring.

Next, carry out an oxidation of the 4-piperidone using an appropriate oxidizing agent, such as Dess-Martin periodinane, to introduce the 2-oxo functionality.

Finally, install the hydroxyl group at the 4-position through a hydrolysis step. Protecting groups need to be considered, depending on the reaction conditions, to ensure that only the desired hydroxyl addition takes place. The target molecule, tert-Butyl 4-hydroxy-2-oxopiperidine-1-carboxylate, is achieved after the careful execution of these steps with adequate purification methods, such as column chromatography, to isolate the product.