1252003-15-8 | Tubastatin a

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
5mg	98%	in stock	$41.00	$29.00
10mg	98%	in stock	$51.00	$36.00
50mg	98%	in stock	$135.00	$95.00
250mg	98%	in stock	$573.00	$401.00

Description

• Catalog Number: AE34873
• Chemical Name: Tubastatin a
• CAS Number: 1252003-15-8
• Molecular Formula: C20H21N3O2
• Molecular Weight: 335.3996
• MDL Number: MFCD18071463
• SMILES: ONC(=O)c1ccc(cc1)Cn1c2ccccc2c2c1CCN(C2)C

Computed Properties

• Complexity: 478
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 2.3

Literature

• Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.

  The Journal of biological chemistry 20171027

• Development and therapeutic implications of selective histone deacetylase 6 inhibitors.

  Journal of medicinal chemistry 20130822

• Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects.

  International immunopharmacology 20130501

• Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

  Journal of medicinal chemistry 20121126

• Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress.

  Toxicological sciences : an official journal of the Society of Toxicology 20120501

• Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

  Journal of the American Chemical Society 20100811