126-17-0 | Spirosol-5-en-3-ol, (3β,22α,25R)-

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$14.00	$10.00
10mg	98%	in stock	$45.00	$32.00

Description

• Catalog Number: AA34367
• Chemical Name: Spirosol-5-en-3-ol, (3β,22α,25R)-
• CAS Number: 126-17-0
• Molecular Formula: C27H45NO
• Molecular Weight: 399.6523
• MDL Number: MFCD00037844
• SMILES: C[C@@H]1CC[C@@]2(NC1)O[C@@H]1[C@H]([C@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC[C@@H]3[C@]([C@H]1CC2)(C)CCCC3)C

Computed Properties

• Complexity: 749
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 11
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• XLogP3: 5.4

Literature

• Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression.

  Chemico-biological interactions 20170425

• Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.

  Steroids 20120901

• Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer?

  Planta medica 20120301

• Synthesis of solasodine glycoside derivatives and evaluation of their cytotoxic effects on human cancer cells.

  Drug discoveries & therapeutics 20120201

• Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum.

  Phytochemical analysis : PCA 20120101

• Conversion of spirostane and solanidane into pregnane (1)introduction of oxygen function into C-23.

  Chemical & pharmaceutical bulletin 20120101

• In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides.

  Chembiochem : a European journal of chemical biology 20111104

• Anti-inflammatory activity of an alkaloid from Solanum trilobatum on acute and chronic inflammation models.

  Natural product research 20110701

• The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo.

  Neuroscience 20110602

• Technology of compact MAb and its application for medicinal plant breeding named as missile type molecular breeding.

  Current drug discovery technologies 20110301

• Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents.

  Pharmaceutical biology 20110201

• Elucidation of the mass fragmentation pathways of potato glycoalkaloids and aglycons using Orbitrap mass spectrometry.

  Journal of mass spectrometry : JMS 20100901

• Antinociceptive activity of steroid alkaloids isolated from Solanum trilobatum Linn.

  Journal of Asian natural products research 20100801

• Sequential injection analysis with lab-at-valve (SI-LAV) for the determination of solasodine in Solanum species.

  Talanta 20100415

• Biological activity of alkaloids from Solanum dulcamara L.

  Natural product research 20090101

• Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.

  FEBS letters 20080709

• [Induction and in vitro culture of hairy roots of Solanum nigrum L. var. pauciflorum Liou and its solasodine production].

  Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20080601

• Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study.

  International journal of dermatology 20080101

• Salinity stress enhances production of solasodine in Solanum nigrum L.

  Chemical & pharmaceutical bulletin 20080101

• Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.

  FEBS letters 20071222

• Efficient synthesis of solasodine, O-acetylsolasodine, and soladulcidine as anticancer steroidal alkaloids.

  Chemistry & biodiversity 20070101

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• A validated liquid chromatographic method for estimation of solasodine in various Solanum species and market formulations.

  Journal of AOAC International 20060101

• Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations.

  Pharmacology, biochemistry, and behavior 20050801

• Liquid-liquid systems for acid hydrolysis of glycoalkaloids from Solanum tuberosum L. tuber sprouts and solanidine extraction.

  Medical science monitor : international medical journal of experimental and clinical research 20050701

• [The preparation and quality control of Solanum lyratum Thunb Extract gel].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701

• Production of solasodine by Solanum laciniatum using plant tissue culture technique.

  Indian journal of experimental biology 20041001

• Potato glycoalkaloids: true safety or false sense of security?

  Trends in biotechnology 20040301

• Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants.

  Plant cell reports 20031201

• Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030101

• Evidence for essential histidine and dicarboxylic amino-acid residues in the active site of UDP-glucose : solasodine glucosyltransferase from eggplant leaves.

  Acta biochimica Polonica 20030101

• Effects of short-term treatment of solasodine on cauda epididymis in dogs.

  Indian journal of experimental biology 20020201

• Phospholipids modulate the substrate specificity of soluble UDP-glucose:steroid glucosyltransferase from eggplant leaves.

  Phytochemistry 20011101

• Isolation of solasodine and other steroidal alkaloids and sapogenins by direct hydrolysis-extraction of Solanum plants or glycosides therefrom.

  Phytochemistry 20011001

• Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions.

  In vivo (Athens, Greece) 20010101

• Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells.

  Anticancer research 20010101