1260141-27-2 | TAK-438

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$44.00	$31.00
5g	95%	in stock	$151.00	$106.00

Description

• Catalog Number: AA34476
• Chemical Name: TAK-438
• CAS Number: 1260141-27-2
• Molecular Formula: C21H20FN3O6S
• Molecular Weight: 461.4634
• MDL Number: MFCD18633280
• SMILES: OC(=O)C=CC(=O)O.CNCc1cc(n(c1)S(=O)(=O)c1cccnc1)c1ccccc1F

Computed Properties

• Complexity: 629
• Covalently-Bonded Unit Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 7

Literature

• Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).

  Journal of medicinal chemistry 20120510

• High-throughput screening of potassium-competitive acid blockers.

  Journal of biomolecular screening 20120201

• Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438).

  The Journal of pharmacology and experimental therapeutics 20111101

• A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.

  The Journal of pharmacology and experimental therapeutics 20110601

• A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands.

  Biochemical pharmacology 20110501

• 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.

  The Journal of pharmacology and experimental therapeutics 20101001