-
An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.
Toxicology in vitro : an international journal published in association with BIBRA 20170401
-
Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells.
Journal of biochemical and molecular toxicology 20160401
-
Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Toxicology and applied pharmacology 20150915
-
Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis.
Toxicology 20141003
-
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
-
Neuroprotective effect of resveratrol on ischemia/reperfusion injury in rats through TRPC6/CREB pathways.
Journal of molecular neuroscience : MN 20130701
-
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
The Biochemical journal 20130415
-
Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.
Molecular immunology 20120901
-
NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.
American journal of physiology. Cell physiology 20120801
-
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.
Neurochemical research 20120601
-
Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists.
Journal of medicinal chemistry 20120426
-
Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.
Kidney & blood pressure research 20120101
-
The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.
Journal of pharmacological sciences 20120101
-
Exocrine pancreatic carcinogenesis and autotaxin expression.
PloS one 20120101
-
Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?
Atherosclerosis 20111201
-
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116
-
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
British journal of pharmacology 20110901
-
Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes.
Neuropharmacology 20110601
-
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Behavioural brain research 20110516
-
TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.
Biochemical and biophysical research communications 20110506
-
Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists.
Toxicology and applied pharmacology 20110415
-
Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.
Biochemical and biophysical research communications 20110408
-
LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.
Journal of neurochemistry 20110201
-
Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
The Journal of endocrinology 20110101
-
4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
-
Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.
Cell biology international 20101201
-
Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.
American journal of physiology. Cell physiology 20101201
-
TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.
Biochimica et biophysica acta 20101101
-
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.
Bulletin of experimental biology and medicine 20100801
-
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
Synapse (New York, N.Y.) 20100501
-
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.
American journal of physiology. Cell physiology 20100301
-
Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106
-
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Physiological research 20100101
-
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
PloS one 20100101
-
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.
BMC systems biology 20100101
-
Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.
Bioorganic & medicinal chemistry letters 20091101
-
Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.
Pflugers Archiv : European journal of physiology 20091001
-
Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Acta pharmacologica Sinica 20091001
-
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
The Journal of membrane biology 20091001
-
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.
American journal of physiology. Endocrinology and metabolism 20090901
-
A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.
The European journal of neuroscience 20090901
-
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.
The Journal of biological chemistry 20090821
-
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Bioorganic & medicinal chemistry 20090715
-
Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.
FEBS letters 20090618
-
Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.
Cellular and molecular neurobiology 20090601
-
Antagonists of the P2X(7) receptor. From lead identification to drug development.
Journal of medicinal chemistry 20090528
-
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells.
Toxicology and applied pharmacology 20090515
-
The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.
Acta biochimica et biophysica Sinica 20090501
-
Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.
Glia 20090415
-
Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.
Bioorganic & medicinal chemistry letters 20090201
-
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.
Journal of medicinal chemistry 20081225
-
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.
Neuron 20081210
-
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
British journal of pharmacology 20081101
-
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.
Cell metabolism 20081101
-
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
American journal of physiology. Cell physiology 20080901
-
Silencing-induced metaplasticity in hippocampal cultured neurons.
Journal of neurophysiology 20080801
-
Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells.
The journal of physiological sciences : JPS 20080601
-
[Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
-
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
-
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs.
Current neurovascular research 20080501
-
Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway.
Journal of neurochemistry 20080301
-
A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.
The Journal of biological chemistry 20080208
-
Role for calcium in the development of ovarial patency in Heliothis virescens.
Journal of insect physiology 20080201
-
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.
British journal of pharmacology 20080201
-
Negative and positive allosteric modulators of the P2X(7) receptor.
British journal of pharmacology 20080201
-
Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor.
Bioorganic & medicinal chemistry letters 20080115
-
Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.
The Journal of biological chemistry 20071228
-
Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
The Journal of physiology 20071015
-
Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.
Biochemical pharmacology 20071015
-
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.
Cellular signalling 20071001
-
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Journal of cellular physiology 20070901
-
A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.
Journal of immunological methods 20070831
-
Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases.
Journal of neuroscience research 20070815
-
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal of medicinal chemistry 20070726
-
KN-62 analogues as potent differentiating agents of HL-60 cells.
Leukemia research 20070501
-
Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
American journal of physiology. Renal physiology 20070501
-
CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
The Journal of clinical investigation 20070501
-
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.
The Journal of endocrinology 20070501
-
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.
Biological chemistry 20070501
-
Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.
Journal of neurophysiology 20070301
-
The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function.
Neuroscience 20070209
-
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
American journal of physiology. Gastrointestinal and liver physiology 20070201
-
Microarray-based kinase inhibition assay by gold nanoparticle probes.
Analytical chemistry 20070115
-
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.
The FEBS journal 20070101
-
Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis.
Microbial pathogenesis 20070101
-
The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.
Blood cells, molecules & diseases 20070101
-
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.
Journal of cardiovascular pharmacology 20060701
-
Modulation by LL-37 of the responses of salivary glands to purinergic agonists.
Molecular pharmacology 20060601
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
-
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
European journal of pharmacology 20060318
-
Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.
The Journal of physiology 20060315
-
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II.
Journal of neurochemistry 20060201
-
Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
-
Cocaine inhibition of GABA(A) current: role of dephosphorylation.
Critical reviews in neurobiology 20060101
-
Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.
American journal of physiology. Cell physiology 20051201
-
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Journal of biomedical science 20051201
-
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
The Journal of pharmacology and experimental therapeutics 20051101
-
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Brain research. Molecular brain research 20051031
-
Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin.
Molecular endocrinology (Baltimore, Md.) 20050901
-
Human melanomas express functional P2 X(7) receptors.
Cell and tissue research 20050901
-
Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.
The Journal of investigative dermatology 20050901
-
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713
-
Effects of 17beta-estradiol on chemically induced long-term depression.
Neuropharmacology 20050701
-
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
The Journal of biological chemistry 20050610
-
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
British journal of pharmacology 20050601
-
Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition.
Hepatology (Baltimore, Md.) 20050601
-
Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.
Neuron 20050519
-
Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.
Journal of neurochemistry 20050401
-
Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216
-
Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
The European journal of neuroscience 20050201
-
Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved.
Cell biochemistry and function 20050101
-
Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.
The Journal of biological chemistry 20041210
-
AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.
Diabetes 20041201
-
Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4.
Journal of medical microbiology 20041201
-
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Bioorganic & medicinal chemistry letters 20041115
-
Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.
The Journal of biological chemistry 20041022
-
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
British journal of pharmacology 20041001
-
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Arteriosclerosis, thrombosis, and vascular biology 20040701
-
Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.
British journal of pharmacology 20040701
-
Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus.
Peptides 20040701
-
KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells.
Biochemical and biophysical research communications 20040625
-
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
Neurochemistry international 20040601
-
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Acta pharmacologica Sinica 20040501
-
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.
Journal of immunology (Baltimore, Md. : 1950) 20040415
-
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Journal of cellular biochemistry 20040401
-
Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331
-
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.
Diabetes 20040201
-
Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.
Journal of molecular endocrinology 20040201
-
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
Acta pharmacologica Sinica 20040201
-
A role for calcium/calmodulin kinase in insulin stimulated glucose transport.
Life sciences 20040102
-
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
Neuroscience research 20040101
-
Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.
Oncology research 20040101
-
Agonists and antagonists acting at P2X7 receptor.
Current topics in medicinal chemistry 20040101
-
Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors.
Current topics in medicinal chemistry 20040101
-
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.
European journal of pharmacology 20031215
-
Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.
Bioorganic & medicinal chemistry letters 20031117
-
Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
Journal of neurochemistry 20031101
-
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Neuroscience letters 20031009
-
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor.
The Journal of physiology 20030901
-
Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase.
Cardiovascular research 20030901
-
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Brain research. Molecular brain research 20030723
-
Regulation of ERK phosphorylation by ethanol in fetal cortical neurons.
Neurochemical research 20030501
-
Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.
Journal of neuroscience research 20030415
-
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal of medicinal chemistry 20030410
-
Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.
Circulation 20030325
-
Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.
Neuropharmacology 20030301
-
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Brain research 20030207
-
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Archives of biochemistry and biophysics 20030101
-
Formation of AP-1 transcription factors during learning in Helix.
Neuroscience and behavioral physiology 20030101
-
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Neuroscience 20030101
-
c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.
Anticancer research 20030101
-
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
The Journal of biological chemistry 20021122
-
Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.
European journal of biochemistry 20021001
-
Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive.
Journal of neurobiology 20021001
-
KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection.
FEMS microbiology letters 20020924
-
Purine and pyrimidine (P2) receptors as drug targets.
Journal of medicinal chemistry 20020912
-
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
The Journal of endocrinology 20020801
-
Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.
Archives of dermatological research 20020701
-
CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons.
Neuroreport 20020612
-
CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion.
Cellular signalling 20020201
-
Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.
Naunyn-Schmiedeberg's archives of pharmacology 20020201
-
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells.
Journal of andrology 20020101
-
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Arzneimittel-Forschung 20020101
-
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Journal of cellular physiology 20011201
-
Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons.
Endocrine 20011101
-
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
European journal of pharmacology 20010907
-
Functional characterization of P2Y and P2X receptors in human eosinophils.
Journal of cellular physiology 20010901
-
P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors.
European journal of pharmacology 20010831
-
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
Molecular pharmacology 20010701
-
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.
Journal of neurochemistry 20010701
-
Histamine production by cultured microglial cells of the mouse.
Neuroscience letters 20010615
-
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Brain research 20010608
-
CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats.
Neurobiology of learning and memory 20010501
-
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
Experimental hematology 20010501
-
Complexities of measuring antagonist potency at P2X(7) receptor orthologs.
The Journal of pharmacology and experimental therapeutics 20010301
-
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Journal of neurochemistry 20010301
-
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Molecular and cellular endocrinology 20010227
-
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
FEBS letters 20010209
-
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Oncogene 20010111
-
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Neurochemistry international 20010101
-
Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.
American journal of physiology. Cell physiology 20010101
-
A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
American journal of physiology. Cell physiology 20010101
-
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.
Biochemical pharmacology 20010101
-
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
Circulation research 20001110
-
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Molecular endocrinology (Baltimore, Md.) 20001101
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
The Biochemical journal 20001001
-
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.
Proceedings of the National Academy of Sciences of the United States of America 20000411
-
MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells.
Biochemical and biophysical research communications 19990624
-
Effects of antagonists at the human recombinant P2X7 receptor.
British journal of pharmacology 19980701
-
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.
The Journal of pharmacology and experimental therapeutics 19970801
-
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
British journal of pharmacology 19970401
-
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
Research in virology 19970101
-
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
The Journal of biological chemistry 19900315