1276110-06-5 | HS-173

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$12.00	$9.00
5mg	97%	in stock	$28.00	$19.00
10mg	97%	in stock	$40.00	$28.00
25mg	97%	in stock	$67.00	$47.00
50mg	97%	in stock	$113.00	$79.00

Description

• Catalog Number: AA42856
• Chemical Name: HS-173
• CAS Number: 1276110-06-5
• Molecular Formula: C21H18N4O4S
• Molecular Weight: 422.4570
• MDL Number: MFCD28023584
• SMILES: CCOC(=O)c1cnc2n1cc(cc2)c1cncc(c1)NS(=O)(=O)c1ccccc1

Computed Properties

• Complexity: 692
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 3.4

Literature

• HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis.

  Cancer letters 20130101

• HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis.

  Scientific reports 20130101

• Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis.

  Journal of medicinal chemistry 20110414